To the limit of extreme malnutrition
Abstract
Extreme malnutrition with body mass index (BMI) as low as 10 kg/m(2) is not uncommon in anorexia nervosa, with survival enabled through complex metabolic adaptations. In contrast, outcomes from hunger strikes and famines are usually fatal after weight loss to about 40% below expected body weight, corresponding to BMI 12 to 13 kg/m(2) in adults. Thus, many years of adaptation in adolescent-onset anorexia nervosa, supported by supplements of vitamins and treatment of intercurrent diseases, may allow survival at a much lower BMI. However, in the literature only a few cases of survival in patients with BMI <9 kg/m(2) have been described. We report on the case of a 29-y-old woman who was successfully treated in a specialized unit. She had a BMI of 7.8 kg/m(2). To our knowledge, this level of extreme malnutrition has not previously been reported. The present case emphasizes the importance of adherence to guidelines to decrease refeeding complications.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Literature concerning starvation describes only a few cases of survival in patients with BMI less than 9 kg/m2.
“For example, literature concerning starvation describes only a few cases of survival in patients with BMI < 9 kg/m2 [23].”
Cites
Increased Bone Marrow Fat in Anorexia Nervosa
Bredella, M. A., Fazeli, P. K., Miller, K. K., Misra, M., Torriani, M., Thomas, B. J., Ghomi, R. H., Rosen, C. J., & Klibanski, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2532 · Cited by 387 · see citing works
Refeeding syndrome: Treatment considerations based on collective analysis of literature case reports
Boateng, A. A., Sriram, K., Meguid, M. M., et al. (2010) · Nutrition · doi:10.1016/j.nut.2009.11.017 · Cited by 260 · see citing works
The clinical biochemistry of anorexia nervosa
Winston, A. P. (2012) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2011.011185 · Cited by 141 · see citing works
The hematology of anorexia nervosa
Hütter, G., Ganepola, S., & Hofmann, W. (2008) · International Journal of Eating Disorders · doi:10.1002/eat.20610 · Cited by 132 · see citing works
Onur, S., Haas, V. K., Bosy‐Westphal, A., Hauer, M., Paul, T., Nutzinger, D. O., Klein, H., & Müller, M. J. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01850 · Cited by 106 · see citing works
Haas, V. K., Onur, S., Paul, T., Nutzinger, D. O., Bosy‐Westphal, A., Hauer, M., Brabant, G. E., Klein, H., & Müller, M. J. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.4.889 · Cited by 102 · see citing works
Basal metabolic rate in anorexia nervosa: relation to body composition and leptin concentrations
Polito, A., Fabbri, A., Ferro-Luzzi, A., Cuzzolaro, M., Censi, L., Ciarapica, D., Fabbrini, E., & Giannini, D. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.6.1495 · Cited by 95 · see citing works
Reduced hemodynamic load and cardiac hypotrophy in patients with anorexia nervosa
Romano, C., Chinali, M., Pasanisi, F., Greco, R., Celentano, A., Rocco, A., Palmieri, V., Signorini, A., Contaldo, F., & SIMONE, G. D. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.2.308 · Cited by 86 · see citing works
Liver Autophagy in Anorexia Nervosa and Acute Liver Injury
Kheloufi, M., Boulanger, C. M., Durand, F., & Rautou, P. (2014) · BioMed Research International · doi:10.1155/2014/701064 · Cited by 77 · see citing works
The limit of human adaptation to starvation
Collins, S. (1995) · Nature Medicine · doi:10.1038/nm0895-810 · Cited by 76 · see citing works
Altered energy metabolism in anorexia nervosa
Russell, J. D., Baur, L. A., Beumont, P. J. V., et al. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(00)00036-6 · Cited by 76 · see citing works
Kosmiski, L. A., Schmiege, S. J., Mascolo, M., Gaudiani, J. L., & Mehler, P. S. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1694 · Cited by 69 · see citing works
Peel, M. (1997) · BMJ · doi:10.1136/bmj.315.7112.829 · Cited by 47 · see citing works
Haemolytic Anaemia in a Patient with Anorexia nervosa
Kaiser, U., & Barth, N. (2001) · Acta Haematologica · doi:10.1159/000046604 · Cited by 42 · see citing works
Reversible tubular dysfunction that mimicked Fanconi's syndrome in a patient with anorexia nervosa
Alexandridis, G. H., Liamis, G. L., & Elisaf, M. (2001) · International Journal of Eating Disorders · doi:10.1002/eat.1078 · Cited by 39 · see citing works
Prognosis in 41 severely malnourished anorexia nervosa patients
Rigaud, D., Tallonneau, I., Brindisi, M., et al. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.02.016 · Cited by 28 · see citing works
Severe hypophosphatemia in a patient with anorexia nervosa during oral feeding.
Jt, V. D., Hj, G., & Ae, M. (1992) · PubMed · Cited by 28 · see citing works
Reversible severe hepatitis in anorexia nervosa
Ramsoekh, D., Taimr, P., & Vanwolleghem, T. (2014) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000030 · Cited by 20 · see citing works
Central pontine myelinolysis associated with a hypoglycemic coma in anorexia nervosa
Bando, N., Watanabe, K., Tomotake, M., et al. (2005) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2005.03.004 · Cited by 19 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Sharpe, S. L., Adams, M., Smith, E. K., Urban, B., & Silverstein, S. (2023) · Journal of Eating Disorders · doi:10.1186/s40337-023-00791-2 · Cited by 29 · see citing works
Yager, J., Gaudiani, J. L., & Treem, J. (2022) · Journal of Eating Disorders · doi:10.1186/s40337-022-00659-x · Cited by 24 · see citing works
Suszko, M., Sobocki, J., & Imieliński, C. (2022) · Psychiatria Polska · doi:10.12740/pp/126233 · Cited by 10 · see citing works
- Authors
- Frølich, J., Palm, C. V. B., & Støving, R. K.
- Affiliations
- Odense University Hospital (DK)
- Corresponding author
- Frølich, Jacob
- Venue
- Nutrition
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 32
- Issue
- 1
- Pages
- 146-148
- ISSN
- 0899-9007 (ISSN-L)
- OpenAlex
- W1802212648
- Cited by
- 16
- References
- 19
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 2 · 2022: 3 · 2020: 2 · 2018: 1 · 2017: 2 · 2015: 1
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Keywords
- anorexia nervosa, body mass index, refeeding syndrome, metabolic adaptation
- MeSH terms
- Adult, Anorexia Nervosa, Body Weight, Female, Humans, Severity of Illness Index, Body Mass Index, Malnutrition, Refeeding Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review