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Cited by 1Clinical Nutrition and GastroenterologyNutrition and Health in AgingCOVID-19 Clinical Research Studies

Nutritional and metabolic support in critically-ill patients with COVID-19 disease: A multicenter cohort study

Open access
Casas-Jaramillo, Felipe, Polania-Sandoval, Camilo A., Perez Rivera, Carlos J., Montoya, Christopher, García-Mendez, Juan Pablo, Velandia-Sanchez, Alejandro, Vergara, Arturo, Nuñez, Vera +3 more·2023·Clinical Nutrition Open Science
DOI 10.1016/j.nutos.2023.09.008
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Abstract

Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) develop an acute inflammatory response that leads to a catabolic state. This increases the nutritional requirements and, consequently, the risk of malnutrition and related complications. Severe infection also leads to increased length of hospital stay, patient deconditioning, and mortality. Therefore, this study aims to establish if existing nutritional parameters should be considered in the multidisciplinary treatment of patients severely infected with SARS-COV-2. A multicenter cross-sectional observational study was done. Adult patients with severe SARS-COV-2 infection who required management in the intensive care unit (ICU) needing invasive ventilatory support were included. A descriptive analysis was performed, followed by a bivariate data analysis. The primary outcomes were mortality and nutrition intolerance. One hundred ninety-four patients with severe SARS-COV-2 infection who required invasive mechanical ventilation were included. The overall mortality was 52.57%, and intolerance to nutrition was present in 24.74% of the patients. Mortality was higher in patients with lower caloric intake (p<0.001), energy deficit (p<0.001), higher APACHE score (p=0.026), and higher SOFA score at ICU admission (p=0.012). Achieving nutritional optimization for patients with severe SARS-CoV-2 infection is challenging. Nevertheless, interventions such as timely nutritional support and early recognition of caloric deficit and nutritional intolerance positively impact mortality, length of stay, and deconditioning for these individuals.

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Crossref · 10.1016/j.nutos.2023.09.008

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  • A recent study involving COVID-19 patients who reached a median maximum caloric goal of 1800 kcal by the 5th day demonstrated that higher severity scores correlated with increased prevalence of enteral feeding intolerance.

    “A recent study involving COVID-19 patients, who reached a median maximum caloric goal of 1800 kcal by the 5th day, demonstrated that higher severity scores correlated with increased prevalence of EFI [74].”

    From Gastrointestinal function and nutritional interventions in septic shock (2025) · cites this paper as [74]

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Authors
Casas-Jaramillo, F., Polania-Sandoval, C. A., Perez Rivera, C. J., Montoya, C., García-Mendez, J. P., Velandia-Sanchez, A., Vergara, A., Nuñez, V., Gonzalez, A., Varón, F., & Cabrera-Rivera, P. A.
Affiliations
  • Institute of Cardiology (CO)
  • Fundación Santa Fe de Bogotá (CO)
ORCID
Venue
Clinical Nutrition Open Science
Publisher
Elsevier BV
Published
2023-12
Volume
52
Pages
25-33
ISSN
2667-2685 (ISSN-L)
DOI
10.1016/j.nutos.2023.09.008
OpenAlex
W4387159181
Cited by
1
References
19
Citations by year
2025: 1
FWCI
0.18
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Nutrition Open Science (publishedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Keywords
COVID-19 pandemic, SARS-CoV-2, critically ill patients, nutritional support, metabolic support, mortality, caloric deficit, negative energy balance, mechanical ventilation, intensive care, APACHE score, SOFA score, malnutrition, catabolic state

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