Alterations in lipid profile of autistic boys: a case control study
Open accessAbstract
We hypothesize that autism is associated with alterations in the plasma lipid profile and that some lipid fractions in autistic boys may be significantly different than those of healthy boys. A matched case control study was conducted with 29 autistic boys (mean age, 10.1 +/- 1.3 years) recruited from a school for disabled children and 29 comparable healthy boys from a neighboring elementary school in South Korea. Fasting plasma total cholesterol (T-Chol), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), the LDL/HDL ratio, and 1-day food intakes were measured. Multiple regression analyses were performed to assess the association between autism and various lipid fractions. The mean TG level (102.4 +/- 52.4 vs 70.6 +/- 36.3; P = .01) was significantly higher, whereas the mean HDL-C level (48.8 +/- 11.9 vs 60.5 +/- 10.9 mg/dL; P = .003) was significantly lower in cases as compared to controls. There was no significant difference in T-Chol and LDL-C levels between cases and controls. The LDL/HDL ratio was significantly higher in cases as compared to controls. Multiple regression analyses indicated that autism was significantly associated with plasma TG (beta = 31.7 +/- 11.9; P = .01), HDL (beta = -11.6 +/- 2.1; P = .0003), and the LDL/HDL ratio (beta = 0.40 +/- 0.18; P = .04). There was a significant interaction between autism and TG level in relation to plasma HDL level (P = .02). Fifty-three percent of variation in th…
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Findings of lipid abnormalities have been inconsistent in reported ASD studies.
“Findings of lipid abnormalities have been inconsistent in reported ASD studies [56–59, 64], although this might be partially due to varying dietary intake in countries where the studies were performed.”
From Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits (2021) · cites this paper as [58]
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Esteban-Figuerola, P., Canals, J., Fernández-Cao, J. C., & Arija Val, V. (2019) · Autism · doi:10.1177/1362361318794179 · Cited by 181 · see citing works
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Scavenger receptor B1 post-translational modifications in Rett syndrome
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- Authors
- Kim, E.-K., Neggers, Y. H., Shin, C.-S., Kim, E., & Kim, E. M.
- Affiliations
- Gangneung–Wonju National University (KR)
- University of Alabama (US)
- Yonsei University (KR)
- Corresponding author
- Neggers, Yasmin H.
- Venue
- Nutrition Research
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 30
- Issue
- 4
- Pages
- 255-260
- ISSN
- 0271-5317 (ISSN-L)
- OpenAlex
- W1997180040
- Cited by
- 58
- References
- 2
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 1 · 2021: 9 · 2020: 8 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 1 · 2013: 4 · 2012: 2
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Nutrition Research (publishedVersion)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- autism spectrum disorder, dyslipidemia, plasma lipid profile, triglycerides, HDL cholesterol, LDL/HDL ratio, total cholesterol, lipid metabolism
- MeSH terms
- Autistic Disorder, Child, Humans, Lipids, Cholesterol, HDL, Cholesterol, LDL, Male, Regression Analysis, Triglycerides, Biomarkers, Case-Control Studies, Dyslipidemias, Republic of Korea
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