A combination of omega-3 fatty acids, folic acid and B-group vitamins is superior at lowering homocysteine than omega-3 alone: A meta-analysis

Dawson, Samantha Loren; Bowe, Steven John; Crowe, Timothy Charles

doi:10.1016/j.nutres.2016.03.010

Cited by 27Folate and B Vitamins ResearchFatty Acid Research and HealthAntioxidant Activity and Oxidative Stress

A combination of omega-3 fatty acids, folic acid and B-group vitamins is superior at lowering homocysteine than omega-3 alone: A meta-analysis

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Dawson, Samantha Loren, Bowe, Steven John, Crowe, Timothy Charles·2016·Nutrition Research

DOI 10.1016/j.nutres.2016.03.010

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Abstract

The aim of the study was to assess whether omega-3 polyunsaturated fatty acid supplementation alone or in combination with folic acid and B-group vitamins is effective in lowering homocysteine. The Medline Ovid, Embase and Cochrane databases were searched for randomized-controlled trial studies that intervened with omega-3 supplementation (with or without folic acid) and measured changes in homocysteine concentration. Studies were pooled using a random effects model for meta-analysis. Three different models were analyzed: all trials combined, omega-3 polyunsaturated fatty acid trials, and omega-3 polyunsaturated fatty acids with folic acid and B-group vitamin trials. Nineteen studies were included, consisting of 3267 participants completing 21 trials. Studies were heterogeneous; varying by dose, duration and participant health conditions. Across all trials, omega-3 supplementation was effective in lowering homocysteine by an average of 1.18μmol/L (95%CI: (-1.89, -0.48), P=.001). The average homocysteine-lowering effect was greater when omega-3 supplementation was combined with folic acid and B-group vitamins (-1.37μmol/L, 95%CI: (-2.38, -0.36), P<.01) compared to omega-3 supplementation alone (-1.09μmol/L 95%CI: (-2.04, -0.13), P=.03). Omega-3 polyunsaturated fatty acid supplementation was associated with a modest reduction in homocysteine. For the purposes of reducing homocysteine, a combination of omega-3s (0.2-6g/day), folic acid (150 - 2500μg/day) and vitamins B6 and B12 may be more effective than omega-3 supplementation alone.

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Lifetime omega-3 fatty acid, vitamin, sulforaphane, and prebiotic supplementation are effective universal prevention interventions to support good mental health by reducing neuroinflammation, oxidative stress, and microbiota dysbiosis.
“lifetime omega-3 fatty acid [56–58], vitamin [57–59], sulforaphane [60], and prebiotic [61] supplementation to support good mental health by reducing neuroinflammation, oxidative stress, and microbiota dysbiosis”
From Prevention and early intervention in youth mental health: is it time for a multidisciplinary and trans-diagnostic model for care? (2020) · cites this paper as [57]

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Impact of Omega-3 supplementation on homocysteine levels in humans: A systematic review and meta-regression analysis of randomized controlled trials
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Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Homocysteine Lowering Trialists' Collaboration.
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Authors: Dawson, S. L., Bowe, S. J., & Crowe, T. C.
Affiliations: Deakin University (AU)
ORCID: Dawson, Samantha Loren
Bowe, Steven John
Venue: Nutrition Research
Publisher: Elsevier BV
Published: 2016-06
Volume: 36
Issue: 6
Pages: 499-508
ISSN: 0271-5317 (ISSN-L)
DOI: 10.1016/j.nutres.2016.03.010
OpenAlex: W2334964996
Cited by: 27
References: 47
Citations by year: 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 2
FWCI: 0.74
Type: journal article
Language: en
Open access: green
figshare.com
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Nutrition Research (publishedVersion)
PubMed (publishedVersion)
Figshare (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords: omega-3 fatty acids, folic acid, B vitamins, vitamin B6, vitamin B12, homocysteine, hyperhomocysteinemia, combination supplementation
MeSH terms: Animals, Drug Therapy, Combination, Folic Acid, Homocysteine, Humans, Sensitivity and Specificity, Vitamin B Complex, Fatty Acids, Omega-3, Randomized Controlled Trials as Topic, Dietary Supplements, Models, Animal

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A combination of omega-3 fatty acids, folic acid and B-group vitamins is superior at lowering homocysteine than omega-3 alone: A meta-analysis

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