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Cited by 352Bone health and osteoporosis researchBone fractures and treatmentsHip and Femur Fractures

Parathyroid hormone 1–84 accelerates fracture-healing in pubic bones of elderly osteoporotic women

Peichl, Peter, Holzer, Lukas A., Maier, Richard, Holzer, Gerold·2011·Journal of Bone and Joint Surgery
DOI 10.2106/jbjs.j.01379
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Abstract

BACKGROUND: Parathyroid hormone (PTH) has been shown to increase bone mineral density and to reduce the rate of fractures in patients with osteoporosis and also to improve fracture-healing. The purpose of the present prospective, randomized, controlled study was to evaluate the effect of PTH 1-84 on the course of pelvic fracture-healing and functional outcome in postmenopausal women. METHODS: Sixty-five patients had a dual x-ray absorptiometry scan, radiographs, and a computed tomography scan to document pelvic fractures. Twenty-one patients received a once-daily injection of 100 µg of PTH 1-84 starting within two days after admission to the hospital, and forty-four patients served as the control group. All patients received 1000 mg of calcium and 800 IU of vitamin D. Computed tomography scans were repeated every fourth week until radiographic evidence of cortical bridging at the fracture site was confirmed. Functional outcome was assessed with use of a visual analog scale for pain and a Timed "Up and Go" test. RESULTS: The mean time to fracture healing was 7.8 weeks for the treatment group, compared with 12.6 weeks for the control group (p < 0.001). At eight weeks, all fractures in the treatment group were healed and four fractures in the control group were healed (healing rate, 100% compared with 9.1%; p < 0.001). Both the visual analog scale score for pain and the result of the Timed "Up and Go" test improved in the study group as compared with the control group (p < 0.001). CONCLUSIONS: In elderly patients with osteoporosis, PTH 1-84 accelerates fracture-healing in pelvic fractures and improves functional outcome.

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  • There seems to be at least a promising beneficial effect of PTH for fracture-healing acceleration.

    “Although the evidence for fracture-healing acceleration is limited, there seems to be at least a promising beneficial effect that makes PTH an interesting candidate (18, 19, 85, 107, 108).”

    From Methods to accelerate fracture healing – a narrative review from a clinical perspective (2024) · cites this paper as [19]

  • In 65 postmenopausal women with pelvic fractures, PTH accelerated fracture healing by more than 30% (7.8 weeks in the PTH group compared with 12.6 weeks in the control group).

    “In 65 postmenopausal women with pelvic fractures, PTH accelerated fracture healing by more than 30% (7.8 weeks in the PTH group compared with 12.6 weeks in the control group) and improved functional outcomes (19).”

    From Methods to accelerate fracture healing – a narrative review from a clinical perspective (2024) · cites this paper as [19]

  • In 65 postmenopausal women with pelvic fractures, PTH improved functional outcomes.

    “In 65 postmenopausal women with pelvic fractures, PTH accelerated fracture healing by more than 30% (7.8 weeks in the PTH group compared with 12.6 weeks in the control group) and improved functional outcomes (19).”

    From Methods to accelerate fracture healing – a narrative review from a clinical perspective (2024) · cites this paper as [19]

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Authors
Peichl, P., Holzer, L. A., Maier, R., & Holzer, G.
Affiliations
Medical University of Vienna (AT)
ORCID
Venue
Journal of Bone and Joint Surgery
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2011-09-07
Volume
93
Issue
17
Pages
1583-1587
ISSN
  • 0021-9355 (ISSN-L)
  • 1535-1386
DOI
10.2106/jbjs.j.01379
OpenAlex
W1994169116
Cited by
352
References
27
Citations by year
2026: 8 · 2025: 11 · 2024: 18 · 2023: 10 · 2022: 16 · 2021: 22 · 2020: 22 · 2019: 24 · 2018: 22 · 2017: 44 · 2016: 30 · 2015: 34 · 2014: 23 · 2013: 33 · 2012: 27
FWCI
30.50
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Bone and Joint Surgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Epidemiology › Bone fractures and treatments
  • Health Sciences › Medicine › Surgery › Hip and Femur Fractures
Keywords
parathyroid hormone 1-84, fracture healing, pelvic fractures, osteoporosis, postmenopausal women, older women, pubic bone, functional outcome, pain, Timed Up and Go test, bone mineral density
MeSH terms
Aged, Aged, 80 and over, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Injections, Subcutaneous, Parathyroid Hormone, Pelvic Bones, Prospective Studies, Pubic Bone, Time Factors, Absorptiometry, Photon, Bone Density, Geriatric Assessment, Osteoporosis, Postmenopausal, Treatment Outcome, Fracture Healing, Risk Assessment, Fractures, Bone

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