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Cited by 536Musculoskeletal pain and rehabilitationPain Mechanisms and TreatmentsNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Chronic pain patients are impaired on an emotional decision-making task

Apkarian, Vania A., Sosa, Yamaya, Krauss, Beth R., Thomas, Sebastian P., Fredrickson, Bruce E., Levy, Robert E., Harden, Norman R., Chialvo, Dante R.·2004·Pain
DOI 10.1016/j.pain.2003.12.015
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Abstract

Chronic pain can result in anxiety, depression and reduced quality of life. However, its effects on cognitive abilities have remained unclear although many studies attempted to psychologically profile chronic pain. We hypothesized that performance on an emotional decision-making task may be impaired in chronic pain since human brain imaging studies show that brain regions critical for this ability are also involved in chronic pain. Chronic back pain (CBP) patients, chronic complex regional pain syndrome (CRPS) patients, and normal volunteers (matched for age, sex, and education) were studied on the Iowa Gambling Task, a card game developed to study emotional decision-making. Outcomes on the gambling task were contrasted to performance on other cognitive tasks. The net number of choices made from advantageous decks after subtracting choices made from disadvantageous decks on average was 22.6 in normal subjects (n = 26), 13.4 in CBP patients (n = 26), and -9.5 in CRPS patients (n = 12), indicating poor performance in the patient groups as compared to the normal controls (P < 0.004). Only pain intensity assessed during the gambling task was correlated with task outcome and only in CBP patients (r = -0.75, P < 0.003). Other cognitive abilities, such as attention, short-term memory, and general intelligence tested normal in the chronic pain patients. Our evidence indicates that chronic pain is associated with a specific cognitive deficit, which may impact everyday behavior especially in risky, emotionally laden, situations.

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Crossref · 10.1016/j.pain.2003.12.015

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Metadata

Authors
Apkarian, V. A., Sosa, Y., Krauss, B. R., Thomas, S. P., Fredrickson, B. E., Levy, R. E., Harden, N. R., & Chialvo, D. R.
Affiliations
  • Northwestern University (US)
  • SUNY Upstate Medical University (US)
ORCID
Chialvo, Dante R.
Venue
Pain
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2004-03
Volume
108
Issue
1
Pages
129-136
ISSN
0304-3959 (ISSN-L)
DOI
10.1016/j.pain.2003.12.015
OpenAlex
W2144854156
Cited by
536
References
37
Citations by year
2026: 14 · 2025: 23 · 2024: 21 · 2023: 21 · 2022: 15 · 2021: 31 · 2020: 24 · 2019: 18 · 2018: 32 · 2017: 31 · 2016: 24 · 2015: 28 · 2014: 44 · 2013: 35 · 2012: 31
FWCI
9.21
Type
journal article
Language
en
Open access
closed
Locations
  • Pain (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (NS35115, R01NS035115)
Topics
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
chronic pain, emotional decision-making, Iowa Gambling Task, chronic back pain, complex regional pain syndrome, cognitive impairment, pain intensity, risk assessment
MeSH terms
Adult, Back Pain, Chronic Disease, Cognition, Decision Making, Emotions, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Complex Regional Pain Syndromes

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