Cited by 536Musculoskeletal pain and rehabilitationPain Mechanisms and TreatmentsNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Chronic pain patients are impaired on an emotional decision-making task

Apkarian, Vania A., Sosa, Yamaya, Krauss, Beth R., Thomas, Sebastian P., Fredrickson, Bruce E., Levy, Robert E., Harden, Norman R., Chialvo, Dante R.·2004·Pain

DOI 10.1016/j.pain.2003.12.015

Open this paper in CoChat — free account

Abstract

Chronic pain can result in anxiety, depression and reduced quality of life. However, its effects on cognitive abilities have remained unclear although many studies attempted to psychologically profile chronic pain. We hypothesized that performance on an emotional decision-making task may be impaired in chronic pain since human brain imaging studies show that brain regions critical for this ability are also involved in chronic pain. Chronic back pain (CBP) patients, chronic complex regional pain syndrome (CRPS) patients, and normal volunteers (matched for age, sex, and education) were studied on the Iowa Gambling Task, a card game developed to study emotional decision-making. Outcomes on the gambling task were contrasted to performance on other cognitive tasks. The net number of choices made from advantageous decks after subtracting choices made from disadvantageous decks on average was 22.6 in normal subjects (n = 26), 13.4 in CBP patients (n = 26), and -9.5 in CRPS patients (n = 12), indicating poor performance in the patient groups as compared to the normal controls (P < 0.004). Only pain intensity assessed during the gambling task was correlated with task outcome and only in CBP patients (r = -0.75, P < 0.003). Other cognitive abilities, such as attention, short-term memory, and general intelligence tested normal in the chronic pain patients. Our evidence indicates that chronic pain is associated with a specific cognitive deficit, which may impact everyday behavior especially in risky, emotionally laden, situations.

Integrity signals

Registry

Crossref · 10.1016/j.pain.2003.12.015

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803
Insensitivity to future consequences following damage to human prefrontal cortex
Bechara, A., Damasio, A. R., Damasio, H., & Anderson, S. W. (1994) · Cognition · doi:10.1016/0010-0277(94)90018-3 · Cited by 6,128
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006
Manual for the Wechsler Adult Intelligence Scale.
Wechsler, D. (1955) · Psychological Corp. eBooks · Cited by 4,941
The short-form McGill pain questionnaire
Melzack, R. (1987) · Pain · doi:10.1016/0304-3959(87)91074-8 · Cited by 4,368
Neuronal plasticity: Increasing the gain in pain
Woolf, C. J., & Salter, M. W. (2000) · Science · doi:10.1126/science.288.5472.1765 · Cited by 3,781
Emotion, Decision Making and the Orbitofrontal Cortex
Bechara, A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.295 · Cited by 3,589
From sensation to cognition
Mesulam, M. (1998) · Brain · doi:10.1093/brain/121.6.1013 · Cited by 3,072
Wisconsin Card Sorting Test Manual – Revised and Expanded
Heaton, R. K., Chelune, C., Talley, J., Kay, G., & Curtiss, G. (1981) · Medical Entomology and Zoology · Cited by 2,975
Classification of chronic pain
Merskey, H. (1994) · Medical Entomology and Zoology · Cited by 2,952

Show all 37 references

Sorted by citations

Large-scale brain networks and psychopathology: a unifying triple network model
Menon, V. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.08.003 · Cited by 4,168
Cognitive and emotional control of pain and its disruption in chronic pain
Bushnell, M. C., Čeko, M., & Low, L. A. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3516 · Cited by 2,076
The Cerebral Signature for Pain Perception and Its Modulation
Tracey, I., & Mantyh, P. W. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.012 · Cited by 1,843
Chronic back pain is associated with decreased prefrontal and thalamic gray matter density
Apkarian, A. V., Sosa, Y., Sonty, S., Levy, R. M., Harden, R. N., Parrish, T. B., & Gitelman, D. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2541-04.2004 · Cited by 1,434
Self-citation
The effect of pain on cognitive function: A review of clinical and preclinical research
Moriarty, O., McGuire, B. E., & Finn, D. P. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.002 · Cited by 1,122
The somatic marker hypothesis: A critical evaluation
Dunn, B. D., Dalgleish, T., & Lawrence, A. D. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.07.001 · Cited by 894
Towards a theory of chronic pain
Apkarian, A. V., Baliki, M. N., & Geha, P. Y. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.09.018 · Cited by 876
Self-citation
Pain and emotion: a biopsychosocial review of recent research
Lumley, M. A., Cohen, J. L., Borszcz, G. S., Cano, A., Radcliffe, A. M., Porter, L. S., Schubiner, H., & Keefe, F. J. (2011) · Journal of Clinical Psychology · doi:10.1002/jclp.20816 · Cited by 836
Beyond Feeling: Chronic Pain Hurts the Brain, Disrupting the Default-Mode Network Dynamics
Baliki, M. N., Geha, P., Apkarian, A. V., & Chialvo, D. R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4123-07.2008 · Cited by 881
Self-citation
Pain and the brain: specificity and plasticity of the brain in clinical chronic pain
Apkarian, V. A., Hashmi, J. A., & Baliki, M. N. (2011) · Pain · doi:10.1016/j.pain.2010.11.010 · Cited by 782
Effective treatment of chronic low back pain in humans reverses abnormal brain anatomy and function
Seminowicz, D. A., Wideman, T. H., Naso, L., Hatami-Khoroushahi, Z., Fallatah, S., Ware, M. A., Jarzem, P., Bushnell, M. C., Shir, Y., Ouellet, J. A., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5280-10.2011 · Cited by 622
The Brain in Chronic CRPS Pain: Abnormal Gray-White Matter Interactions in Emotional and Autonomic Regions
Geha, P., Baliki, M. N., Harden, R. N., Bauer, W. R., Parrish, T. B., & Apkarian, A. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.08.022 · Cited by 564
Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application
Millan, M. J. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.11.006 · Cited by 569
Decisions under ambiguity and decisions under risk: Correlations with executive functions and comparisons of two different gambling tasks with implicit and explicit rules
Brand, M., Recknor, E. C., Fabian Grabenhorst, B., & Bechara, A. (2006) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390500507196 · Cited by 553
Abnormalities in Hippocampal Functioning with Persistent Pain
Mutso, A., Radzicki, D., Baliki, M. N., Huang, L. Q., Banisadr, G., Centeno, M. V., Radulović, J., Martina, M., Miller, R. J., & Apkarian, A. V. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0587-12.2012 · Cited by 517
Neuropsychological correlates of decision-making in ambiguous and risky situations
Brand, M., Labudda, K., & Markowitsch, H. J. (2006) · Neural Networks · doi:10.1016/j.neunet.2006.03.001 · Cited by 488
Construct validity of the iowa gambling task
Buelow, M. T., & Suhr, J. A. (2009) · Neuropsychology Review · doi:10.1007/s11065-009-9083-4 · Cited by 464
Decision making in pathological gambling: a comparison between pathological gamblers, alcohol dependents, persons with Tourette syndrome, and normal controls.
Goudriaan, A., Oosterlaan, J., de Beurs, E., & van den Brink, W. (2005) · Brain research. Cognitive brain research · doi:10.1016/j.cogbrainres.2005.01.017 · Cited by 473
Decision-making and impulse control after frontal lobe injuries
Bechara, A., & der Linden, M. V. (2005) · Current Opinion in Neurology · doi:10.1097/01.wco.0000194141.56429.3c · Cited by 426
Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain
Metz, A. E., Yau, H.-J., Centeno, M. V., Apkarian, A. V., & Martina, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809897106 · Cited by 407
Cognitive Impairment in Pain through Amygdala-Driven Prefrontal Cortical Deactivation
Ji, G., Sun, H., Fu, Y., Li, Z., Pais-Vieira, M., Galhardo, V., & Neugebauer, V. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0225-10.2010 · Cited by 401
Chronic Pain-Related Remodeling of Cerebral Cortex – ‘Pain Memory‘: A Possible Target for Treatment of Chronic Pain
Lithwick, A., Lev, S., & Binshtok, A. M. (2012) · Pain Management · doi:10.2217/pmt.12.74 · Cited by 389
Understanding Migraine through the Lens of Maladaptive Stress Responses: A Model Disease of Allostatic Load
Borsook, D., Maleki, N., Becerra, L. R., & McEwen, B. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.001 · Cited by 370
Psychological processing in chronic pain: a neural systems approach
Simons, L. E., Elman, I., & Borsook, D. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.12.006 · Cited by 359
Forebrain pain mechanisms
Neugebauer, V., Galhardo, V., Maione, S., & Mackey, S. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.12.014 · Cited by 369
Evidence for working memory deficits in chronic pain: A systematic review and meta-analysis
Berryman, C. F., Stanton, T. R., Chalmers, J., Tabor, A., McFARLANE, A. C., & Moseley, G. L. (2013) · Pain · doi:10.1016/j.pain.2013.03.002 · Cited by 376
Cortical changes in chronic low back pain: Current state of the art and implications for clinical practice
Wand, B. M., Parkitny, L., O'Connell, N. E., Luomajoki, H. A., McAuley, J. H., Thacker, M. A., & Moseley, G. L. (2010) · Manual Therapy · doi:10.1016/j.math.2010.06.008 · Cited by 347
The Iowa Gambling Task in fMRI images
Li, X., Lu, Z., D’Argembeau, A., Ng, M., & Bechara, A. (2009) · Human Brain Mapping · doi:10.1002/hbm.20875 · Cited by 356
The Relationship Between Pain, Neuropsychological Performance, and Physical Function in Community-Dwelling Older Adults with Chronic Low Back Pain
Weiner, D. K., Rudy, T. E., Morrow, L. A., Slaboda, J. C., & Lieber, S. J. (2006) · Pain Medicine · doi:10.1111/j.1526-4637.2006.00091.x · Cited by 332
Do people with chronic pain have impaired executive function? A meta-analytical review
Berryman, C. F., Stanton, T. R., Bowering, K. J., Tabor, A., McFARLANE, A. C., & Moseley, G. L. (2014) · Clinical Psychology Review · doi:10.1016/j.cpr.2014.08.003 · Cited by 333
Decision-making impairments in patients with pathological gambling
Brand, M., Kalbe, E., Labudda, K., Fujiwara, E., Kessler, J., & Markowitsch, H. J. (2005) · Psychiatry Research · doi:10.1016/j.psychres.2004.10.003 · Cited by 316
The Cortical Rhythms of Chronic Back Pain
Baliki, M. N., Baria, A. T., & Apkarian, A. V. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1984-11.2011 · Cited by 291
Chronic Pain and Chronic Stress: Two Sides of the Same Coin?
Abdallah, C. G., & Geha, P. (2017) · Chronic Stress · doi:10.1177/2470547017704763 · Cited by 311
Structural Brain Anomalies and Chronic Pain: A Quantitative Meta-Analysis of Gray Matter Volume
Smallwood, R. F., Laird, A. R., Ramage, A. E., Parkinson, A. L., Lewis, J. D., Clauw, D. J., Williams, D. A., Schmidt‐Wilcke, T., Farrell, M. J., Eickhoff, S. B., et al. (2013) · Journal of Pain · doi:10.1016/j.jpain.2013.03.001 · Cited by 281
The cannabinoid system and pain
Woodhams, S. G., Chapman, V., Finn, D. P., Hohmann, A. G., & Neugebauer, V. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.06.015 · Cited by 285
MRI structural brain changes associated with sensory and emotional function in a rat model of long-term neuropathic pain
Seminowicz, D. A., Laferriere, A. L., Millecamps, M., Yu, J. S. C., Coderre, T. J., & Bushnell, M. C. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.068 · Cited by 280
Cognition and Pain: A Review
Khera, T., & Rangasamy, V. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.673962 · Cited by 246
Chronic pain: The role of learning and brain plasticity
Mansour, A. R., Farmer, M., Baliki, M. N., & Apkarian, A. V. (2014) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-139003 · Cited by 238
Predicting transition to chronic pain
Apkarian, A. V., Baliki, M. N., & Farmer, M. A. (2013) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32836336ad · Cited by 250
Abnormal cross-network functional connectivity in chronic pain and its association with clinical symptoms
Hemington, K. S., Wu, Q., Kucyi, A., Inman, R. D., & Davis, K. D. (2016) · Brain Structure and Function · doi:10.1007/s00429-015-1161-1 · Cited by 220
Overlapping Structural and Functional Brain Changes in Patients With Long‐Term Exposure to Fibromyalgia Pain
Jensen, K. B., Srinivasan, P., Spaeth, R. B., Tan, Y. H. V., Kosek, E., Petzke, F. W., Carville, S. F., Fransson, P., Marcus, H. E., Williams, S., et al. (2013) · Arthritis & Rheumatism · doi:10.1002/art.38170 · Cited by 225
Disrupted functional connectivity of the periaqueductal gray in chronic low back pain
Yu, R., Gollub, R. L., Spaeth, R. B., Napadow, V., Wasan, A. D., & Kong, J. (2014) · NeuroImage Clinical · doi:10.1016/j.nicl.2014.08.019 · Cited by 224
Pain and analgesia: the value of salience circuits
Borsook, D., Edwards, R., Elman, I., Becerra, L., & Levine, J. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.02.003 · Cited by 215
Pain-induced negative affect is mediated via recruitment of the nucleus accumbens kappa opioid system
Massaly, N., Copits, B. A., Wilson-Poe, A. R., Hipólito, L., Markovic, T., Yoon, H. J., Liu, S., Walicki, M. C., Bhatti, D. L., Sirohi, S., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.029 · Cited by 200
Altered Resting State in Diabetic Neuropathic Pain
Cauda, F., Sacco, K., Duca, S., Cocito, D., D’Agata, F., Geminiani, G. C., & Canavero, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004542 · Cited by 219
Brain resting state is disrupted in chronic back pain patients
Tagliazucchi, E., Balenzuela, P., Fraiman, D., & Chialvo, D. R. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.08.053 · Cited by 203
Self-citation
Decision-making and risk aversion among depressive adults
Smoski, M. J., Lynch, T. R., Rosenthal, M. Z., Cheavens, J. S., Chapman, A. L., & Krishnan, R. R. (2008) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/j.jbtep.2008.01.004 · Cited by 198
Reward, motivation, and emotion of pain and its relief
Porreca, F., & Navratilova, E. (2017) · Pain · doi:10.1097/j.pain.0000000000000798 · Cited by 210
Interactions of Pain Intensity and Cognitive Load: The Brain Stays on Task
Seminowicz, D. A., & Davis, K. D. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl052 · Cited by 206
The Natural History of Complex Regional Pain Syndrome
Schwartzman, R. J., Erwin, K. L., & Alexander, G. M. (2009) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e31818ecea5 · Cited by 191
Is deck B a disadvantageous deck in the Iowa Gambling Task?
Lin, C.-H., Chiu, Y.-C., Lee, P., & Hsieh, J. (2007) · Behavioral and Brain Functions · doi:10.1186/1744-9081-3-16 · Cited by 202
Reorganization of hippocampal functional connectivity with transition to chronic back pain
Mutso, A., Petre, B., Huang, L. Q., Baliki, M. N., Torbey, S., Herrmann, K. M., Schnitzer, T. J., & Apkarian, A. V. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00611.2013 · Cited by 188
Brain activity for spontaneous pain of postherpetic neuralgia and its modulation by lidocaine patch therapy
Geha, P., Baliki, M. N., Chialvo, D. R., Harden, R. N., Paice, J. A., & Apkarian, A. V. (2006) · Pain · doi:10.1016/j.pain.2006.09.014 · Cited by 193
Self-citation
Executive Function and Decision-Making in Women with Fibromyalgia
Verdejo‐García, A., López-Torrecillas, F., Calandre, E. P., Delgado-Rodriguez, A., & Bechara, A. (2009) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acp014 · Cited by 182
The Relationship Between Chronic Pain and Neurocognitive Function
Higgins, D. M., Martin, A. M., Baker, D. G., Vasterling, J. J., & Risbrough, V. B. (2017) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000536 · Cited by 182
When race matters: disagreement in pain perception between patients and their physicians in primary care.
Staton, L. J., Genao, I., Panda, M., Cykert, S., Carey, T., O'Rorke, J., Faeslis, C., Rosenberg, E. I., Kurz, J., Mechaber, A. J., et al. (2021) · PubMed Central · doi:10.17615/xbk1-am15 · Cited by 181
Pain and Cognitive Function Among Older Adults Living in the Community
van der Leeuw, G., Eggermont, L. H. P., Shi, L., Milberg, W., Gross, A. L., Hausdorff, J. M., Bean, J. F., & Leveille, S. G. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv166 · Cited by 183
fMRI reveals distinct CNS processing during symptomatic and recovered complex regional pain syndrome in children
Lebel, A., Becerra, L. R., Wallin, D. J., Moulton, E. A., Morris, S., Pendse, G., Jasciewicz, J., Stein, M. L., Aiello‐Lammens, M. E., Grant, P. E., et al. (2008) · Brain · doi:10.1093/brain/awn123 · Cited by 179
Review of Cognitive Dysfunction in Fibromyalgia: A Convergence on Working Memory and Attentional Control Impairments
Glass, J. M. (2009) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2009.06.002 · Cited by 176
Abnormal thalamocortical activity in patients with Complex Regional Pain Syndrome (CRPS) Type I
Walton, K. D., Dubois, M. Y., & Llinás, R. R. (2010) · Pain · doi:10.1016/j.pain.2010.02.023 · Cited by 176
Central Nervous System Reorganization in a Variety of Chronic Pain States: A Review
Henry, D. E., Chiodo, A. E., & Yang, W. (2011) · PM&R · doi:10.1016/j.pmrj.2011.05.018 · Cited by 172
A comprehensive literature review of chronic pain and memory
Mazza, S., Frot, M., & Rey, A. E. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.08.006 · Cited by 170
The role of motor learning and neuroplasticity in designing rehabilitation approaches for musculoskeletal pain disorders
Boudreau, S. A., Farina, D., & Falla, D. (2010) · Manual Therapy · doi:10.1016/j.math.2010.05.008 · Cited by 167
The Relationship Between Pain and Mental Flexibility in Older Adult Pain Clinic Patients
Karp, J. F., Reynolds, C. F., Butters, M. A., Dew, M. A., Mazumdar, S., Begley, A. E., Lenze, E. J., & Weiner, D. K. (2006) · Pain Medicine · doi:10.1111/j.1526-4637.2006.00212.x · Cited by 167
Pain, affective symptoms, and cognitive deficits in patients with cerebral dopamine dysfunction
Jarcho, J. M., Mayer, E. A., Jiang, Z. K., Feier, N. A., & London, E. D. (2012) · Pain · doi:10.1016/j.pain.2012.01.002 · Cited by 160
The effects of intra-oral pain on motor cortex neuroplasticity associated with short-term novel tongue-protrusion training in humans
Boudreau, S. A., Romaniello, A., Wang, K., Svensson, P. J., Sessle, B. J., & Arendt‐Nielsen, L. (2007) · Pain · doi:10.1016/j.pain.2007.07.019 · Cited by 154
Brain activity for chronic knee osteoarthritis: Dissociating evoked pain from spontaneous pain
Parksl, E. L., Gehal, P. Y., Balikil, M. N., Katzl, J., Schnitzerl, T. J., & Apkarian, A. V. (2011) · European Journal of Pain · doi:10.1016/j.ejpain.2010.12.007 · Cited by 150
Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABA A receptors
Ji, G., & Neugebauer, V. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00461.2011 · Cited by 152
Interoceptive awareness, positive affect, and decision making in Major Depressive Disorder
Furman, D. J., Waugh, C. E., Bhattacharjee, K., Thompson, R. J., & Gotlib, I. H. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.06.044 · Cited by 142
A Preliminary fMRI Study of Analgesic Treatment in Chronic Back Pain and Knee Osteoarthritis
Baliki, M. N., Geha, P., Jabakhanji, R., Harden, N., Schnitzer, T. J., & Apkarian, A. V. (2008) · Molecular Pain · doi:10.1186/1744-8069-4-47 · Cited by 150
Self-citation
Structure and Biology of the Intervertebral Disk in Health and Disease
Chan, W. C. W., Sze, K., Samartzis, D., Leung, V., & Chan, D. T.-M. (2011) · Orthopedic Clinics of North America · doi:10.1016/j.ocl.2011.07.012 · Cited by 146
S1 is Associated with Chronic Low Back Pain: A Functional and Structural MRI Study
Kong, J., Spaeth, B., Wey, H., Cheetham, A., Cook, A. H., Jensen, K. B., Tan, Y. H. V., Liu, H., Wang, D., Loggia, M. L., et al. (2013) · Molecular Pain · doi:10.1186/1744-8069-9-43 · Cited by 145
Neuroimaging-based biomarkers for pain: state of the field and current directions
van der Miesen, M. M., Lindquist, M. A., & Wager, T. D. (2019) · PAIN Reports · doi:10.1097/pr9.0000000000000751 · Cited by 145
Abnormal cortical activity in patients with temporomandibular disorder evoked by cognitive and emotional tasks
Weissman-Fogel, I., Moayedi, M., Tenenbaum, H. C., Goldberg, M. B., Freeman, B. V., & Davis, K. D. (2011) · Pain · doi:10.1016/j.pain.2010.10.046 · Cited by 140
Rodent versions of the Iowa gambling task: opportunities and challenges for the understanding of decision-making
de Visser, L. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00109 · Cited by 157
Economic Insecurity Increases Physical Pain
Chou, E. Y., Parmar, B. L., & Galinsky, A. D. (2016) · Psychological Science · doi:10.1177/0956797615625640 · Cited by 142
Cortical modulation of pain
Ohara, P. T., Vit, J., & Jasmin, L. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4283-9 · Cited by 136
Fibromyalgia: A Disorder of the Brain?
Schweinhardt, P., Sauro, K. M., & Bushnell, M. C. (2007) · The Neuroscientist · doi:10.1177/1073858407312521 · Cited by 131
Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior
Markovic, T., Pedersen, C. E., Massaly, N., Vachez, Y. M., Ruyle, B. C., Murphy, C. A., Abiraman, K., Shin, J. H., Garcia, J. J., Yoon, H. J., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00924-3 · Cited by 129
Cognitive Impairment in Patients with Chronic Neuropathic or Radicular Pain: An Interaction of Pain and Age
Moriarty, O., Ruane, N., O’Gorman, D. A., Maharaj, C. H., Mitchell, C., Sarma, K. M., Finn, D. P., & McGuire, B. E. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00100 · Cited by 128
Reward‐aversion circuitry in analgesia and pain: Implications for psychiatric disorders
Borsook, D., Becerra, L. R., Carlezon, W. A., Shaw, M. E., Renshaw, P. F., Elman, I., & Levine, J. D. (2006) · European Journal of Pain · doi:10.1016/j.ejpain.2005.12.005 · Cited by 124
Abnormal medial prefrontal cortex functional connectivity and its association with clinical symptoms in chronic low back pain
Tu, Y., Jung, M., Gollub, R. L., Napadow, V., Gerber, J. A., Ortiz, A., Lang, C., Mawla, I., Shen, W., Chan, S., et al. (2019) · Pain · doi:10.1097/j.pain.0000000000001507 · Cited by 127
Rescue of Impaired mGluR5-Driven Endocannabinoid Signaling Restores Prefrontal Cortical Output to Inhibit Pain in Arthritic Rats
Kiritoshi, T., Ji, G., & Neugebauer, V. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4047-15.2016 · Cited by 121
Cognition in the Chronic Pain Experience: Preclinical Insights
Phelps, C. E., Navratilova, E., & Porreca, F. (2021) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2021.01.001 · Cited by 126
Chronic neuropathic pain-like behavior correlates with IL-1β expression and disrupts cytokine interactions in the hippocampus
del Rey, A., Yau, H., Randolf, A., Centeno, M. V., Wildmann, J., Martina, M., Besedovsky, H. O., & Apkarian, A. V. (2011) · Pain · doi:10.1016/j.pain.2011.09.013 · Cited by 118
Pain and Attention: Attentional Disruption or Distraction?
Veldhuijzen, D. S., Kenemans, J. L., de Bruin, C. M., Olivier, B., & Volkerts, E. R. (2006) · The Journal of Pain · doi:10.1016/j.jpain.2005.06.003 · Cited by 116
d-Cycloserine reduces neuropathic pain behavior through limbic NMDA-mediated circuitry ☆
Millecamps, M., Centeno, M. V., Berra, H. H., Rudick, C. N., Lavarello, S., Tkatch, T., & Apkarian, A. V. (2007) · Pain · doi:10.1016/j.pain.2007.03.003 · Cited by 116
The Missing P in Psychiatric Training
Elman, I., Zubieta, J.-K., & Borsook, D. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.174 · Cited by 115
Effects of stress on the corticolimbic system: implications for chronic pain
Vachon‐Presseau, É. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.10.014 · Cited by 123
Altered associative learning and emotional decision making in fibromyalgia
Walteros, C., Sánchez‐Navarro, J. P., Muñoz, M. Á., Martínez‐Selva, J. M., Chialvo, D. R., & Montoya, P. (2010) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2010.07.013 · Cited by 113
Self-citation
Cognitive impairment of prefrontal-dependent decision-making in rats after the onset of chronic pain
Pais-Vieira, M., Sousa, M. M., Lima, D., & Galhardo, V. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.04.011 · Cited by 111
Evidence of Specific Cognitive Deficits in Patients with Chronic Low Back Pain under Long-Term Substitution Treatment of Opioids
Wang, H. (2014) · Pain Physician · doi:10.36076/ppj.2014/17/9 · Cited by 110
Rapid treatment-induced brain changes in pediatric CRPS
Erpelding, N., Simons, L., Lebel, A., Serrano, P., Pielech, M., Prabhu, S., Becerra, L., & Borsook, D. (2016) · Brain Structure and Function · doi:10.1007/s00429-014-0957-8 · Cited by 108
Unlearning chronic pain: A randomized controlled trial to investigate changes in intrinsic brain connectivity following Cognitive Behavioral Therapy
Shpaner, M., Kelly, C. A. M., Lieberman, G., Perelman, H., Davis, M., Keefe, F. J., & Naylor, M. R. (2014) · NeuroImage Clinical · doi:10.1016/j.nicl.2014.07.008 · Cited by 113
Is physiotherapy integrated virtual walking effective on pain, function, and kinesiophobia in patients with non-specific low-back pain? Randomised controlled trial
Yilmaz Yelvar, G. D., Çırak, Y., Dalkılınç, M., Parlak Demir, Y., Guner, Z., & Boydak, A. (2017) · European Spine Journal · doi:10.1007/s00586-016-4892-7 · Cited by 107
Effect of environment on the long-term consequences of chronic pain
Bushnell, M. C., Case, L. K., Čeko, M., Cotton, V. A., Gracely, J. L., Low, L. A., Pitcher, M. H., & Villemure, C. (2015) · Pain · doi:10.1097/01.j.pain.0000460347.77341.bd · Cited by 112
Cortical and white matter alterations in patients with neuropathic pain after spinal cord injury
Yoon, E. J., Kim, Y. K., Shin, H., Lee, Y., & Kim, S. E. (2013) · Brain Research · doi:10.1016/j.brainres.2013.10.007 · Cited by 108
Expression of IL-1β in supraspinal brain regions in rats with neuropathic pain
Apkarian, A. V., Lavarello, S., Randolf, A., Berra, H. H., Chialvo, D. R., Besedovsky, H. O., & del Rey, A. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.08.034 · Cited by 103
Self-citation
Peripheral Nerve Injury is Accompanied by Chronic Transcriptome-Wide Changes in the Mouse Prefrontal Cortex
Alvarado, S. G., Tajerian, M., Millecamps, M., Suderman, M. J., Stone, L. S., & Szyf, M. (2013) · Molecular Pain · doi:10.1186/1744-8069-9-21 · Cited by 105
Cerebral interactions of pain and reward and their relevance for chronic pain
Becker, S., Gandhi, W., & Schweinhardt, P. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.03.013 · Cited by 103

Authors: Apkarian, V. A., Sosa, Y., Krauss, B. R., Thomas, S. P., Fredrickson, B. E., Levy, R. E., Harden, N. R., & Chialvo, D. R.
Affiliations: Northwestern University (US)
SUNY Upstate Medical University (US)
ORCID: Chialvo, Dante R.
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2004-03
Volume: 108
Issue: 1
Pages: 129-136
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/j.pain.2003.12.015
OpenAlex: W2144854156
Cited by: 536
References: 37
Citations by year: 2026: 14 · 2025: 23 · 2024: 21 · 2023: 21 · 2022: 15 · 2021: 31 · 2020: 24 · 2019: 18 · 2018: 32 · 2017: 31 · 2016: 24 · 2015: 28 · 2014: 44 · 2013: 35 · 2012: 31
FWCI: 9.21
Type: journal article
Language: en
Open access: closed
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS35115, R01NS035115)
Topics: Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: chronic pain, emotional decision-making, Iowa Gambling Task, chronic back pain, complex regional pain syndrome, cognitive impairment, pain intensity, risk assessment
MeSH terms: Adult, Back Pain, Chronic Disease, Cognition, Decision Making, Emotions, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Complex Regional Pain Syndromes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Chronic pain patients are impaired on an emotional decision-making task

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks