The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Calcium channel α2δ1 subunit mediates spinal hyperexcitability in pain modulation
Abstract
Mechanisms of chronic pain, including neuropathic pain, are poorly understood. Upregulation of voltage-gated calcium channel (VGCC) alpha2delta1 subunit (Ca(v)alpha2delta1) in sensory neurons and dorsal spinal cord by peripheral nerve injury has been suggested to contribute to neuropathic pain. To investigate the mechanisms without the influence of other injury factors, we have created transgenic mice that constitutively overexpress Ca(v)alpha2delta1 in neuronal tissues. Ca(v)alpha2delta1 overexpression resulted in enhanced currents, altered kinetics and voltage-dependence of VGCC activation in sensory neurons; exaggerated and prolonged dorsal horn neuronal responses to mechanical and thermal stimulations at the periphery; and pain behaviors. However, the transgenic mice showed normal dorsal horn neuronal responses to windup stimulation, and behavioral responses to tissue-injury/inflammatory stimuli. The pain behaviors in the transgenic mice had a pharmacological profile suggesting a selective contribution of elevated Ca(v)alpha2delta1 to the abnormal sensations, at least at the spinal cord level. In addition, gabapentin blocked VGCC currents concentration-dependently in transgenic, but not wild-type, sensory neurons. Thus, elevated neuronal Ca(v)alpha2delta1 contributes to specific pain states through a mechanism mediated at least partially by enhanced VGCC activity in sensory neurons and hyperexcitability in dorsal horn neurons in response to peripheral stimulation. Modulation of enhanced VGCC activity by gabapentin may underlie at least partially its antihyperalgesic actions.
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Cited by
Eroglu, Ç., Allen, N. J., Susman, M. W., O'Rourke, N. A., Park, C. Y., Özkan, E., Chakraborty, C., Mulinyawe, S. B., Annis, D. S., Huberman, A. D., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.025 · Cited by 893
Pharmacological disruption of calcium channel trafficking by the α 2 δ ligand gabapentin
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Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond
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Functional biology of the α2δ subunits of voltage-gated calcium channels
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Antidepressants and gabapentinoids in neuropathic pain: Mechanistic insights
Kremer, M., Salvat, E., Muller, A., Yalcin, I., & Barrot, M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.06.057 · Cited by 312
Metadata
- Authors
- Li, C.-Y., Zhang, X.-L., Matthews, E. A., Li, K.-W., Kurwa, A., Boroujerdi, A., Gross, J., Gold, M. S., Dickenson, A. H., Feng, G., & Luo, D. Z.
- Venue
- Pain
- Published
- 2006-11
- Volume
- 125
- Issue
- 1
- Pages
- 20-34
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W1981942371
- Cited by
- 273
- References
- 50
- FWCI
- 7.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, C.-Y., Zhang, X.-L., Matthews, E. A., Li, K.-W., Kurwa, A., Boroujerdi, A., Gross, J., Gold, M. S., Dickenson, A. H., Feng, G., & Luo, D. Z. (2006). Calcium channel α2δ1 subunit mediates spinal hyperexcitability in pain modulation. Pain. https://doi.org/10.1016/j.pain.2006.04.022
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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