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Habituation to painful stimulation involves the antinociceptive system
Abstract
The perception of pain results from an interaction between nociceptive and antinociceptive mechanisms. A better understanding of the neural circuitry underlying these physiological interactions provides an important opportunity to develop better treatment strategies for and ultimately even prevent pain. Here, we investigated how repeated painful stimulation over several days is processed, perceived and finally modulated in the healthy human brain. Twenty healthy subjects were stimulated daily with a 20min pain paradigm for 8 consecutive days, and functional MRI performed on days 1, 8 and 22. Repeated painful stimulation over several days resulted in substantially decreased pain ratings to identical painful stimuli. The decreased perception of pain over time is reflected in decreased BOLD responses to nociceptive stimuli in classical pain areas, including thalamus, insula, SII and the putamen. In contrast to this finding, we found that pain-related responses in the rACC, specifically the subgenual anterior cingulate cortex (sgACC), significantly increased over time. Given this area's predominant role in endogenous pain control, this response pattern suggests that habituation to pain is at least in part mediated by increased antinociceptive activity.
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“However, it is important to note that responses to a cue could change over the course of the experimental session due to factors such as fatigue, habituation or learning23–28.”
From Boundary effects of expectation in human pain perception (2019) · cites this paper as [28]
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“Our interest in how perception changes across the experimental session was motivated by the observation that sensitivity to painful stimulation can vary over time15,16,28,29.”
From Boundary effects of expectation in human pain perception (2019) · cites this paper as [28]
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Metadata
- Authors
- Bingel, U., Schoell, E., Herken, W., Büchel, C., & May, A.
- Affiliations
- Universität Hamburg (DE)
- Corresponding author
- Bingel, U.
- Venue
- Pain
- Published
- 2007-09
- Volume
- 131
- Issue
- 1
- Pages
- 21-30
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2003102568
- Cited by
- 298
- References
- 66
- Citations by year
- 2026: 4 · 2025: 18 · 2024: 9 · 2023: 12 · 2022: 21 · 2021: 19 · 2020: 11 · 2019: 12 · 2018: 17 · 2017: 18 · 2016: 7 · 2015: 21 · 2014: 20 · 2013: 14 · 2012: 20
- FWCI
- 12.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Volkswagen Foundation
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- pain habituation, antinociception, endogenous pain control, subgenual anterior cingulate cortex, nociceptive processing, pain perception, thalamus, insula, somatosensory cortex, putamen
- MeSH terms
- Adult, Brain, Evoked Potentials, Somatosensory, Habituation, Psychophysiologic, Humans, Male, Pain, Physical Stimulation, Pain Threshold
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