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Cited by 48Pain Mechanisms and TreatmentsPain Management and Placebo EffectPain Management and Treatment

Brain activation patterns underlying fast habituation to painful laser stimuli

Mobascher, A., Brinkmeyer, J., Warbrick, T., Musso, F., Schlemper, V., Wittsack, H.J., Saleh, A., Schnitzler, A. +1 more·2010·International Journal of Psychophysiology
DOI 10.1016/j.ijpsycho.2009.10.008
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Abstract

A painful experience is modified by processes like habituation/antinociception or sensitization. Altered habituation may be one characteristic of chronic pain syndromes. In the present study we sought to investigate the functional magnetic resonance imaging (fMRI) blood oxygen level dependent (BOLD) correlate of rapid habituation to pain using simultaneous single trial electrodermal activity (EDA)/fMRI measurements. A total of N=32 healthy subjects have been investigated. Subjects received painful laser stimulation of the left hand. The fMRI BOLD response was measured simultaneously with continuous EDA recordings. Single trial EDA responses to laser stimulation habituated over time with substantial subject-to-subject differences in the degree and speed of habituation. fMRI BOLD habituation was assessed by contrasting the first half of the experiment against the second half and was found in primary and secondary somatosensory cortices, the insula and the anterior cingulate cortex (ACC). We hypothesized that single trial EDA habituation would reflect BOLD habituation which was investigated separately in subjects with 'faster' (N=15) and 'slower' (N=14) EDA habituation. Significant habituation of the BOLD signal was only found in subjects with 'faster' EDA habituation that was accompanied by a signal increase in the rostral ACC and the periaqueductal grey. Furthermore, subjects with faster EDA habituation provided lower pain ratings. Therefore the EDA habituation profile to painful stimulation may constitute a pain-related (endo)phenotype and may be an informative additional endpoint measure in fMR-imaging of pain, especially when people suffering from chronic pain states in which pain processing is often altered are studied.

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  • Responses to a cue could change over the course of the experimental session due to factors such as fatigue, habituation or learning.

    “However, it is important to note that responses to a cue could change over the course of the experimental session due to factors such as fatigue, habituation or learning23–28.”

    From Boundary effects of expectation in human pain perception (2019) · cites this paper as [24]

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Authors
Mobascher, A., Brinkmeyer, J., Warbrick, T., Musso, F., Schlemper, V., Wittsack, H. J., Saleh, A., Schnitzler, A., & Winterer, G.
Affiliations
  • Forschungszentrum Jülich (DE)
  • Heinrich Heine University Düsseldorf (DE)
Corresponding author
Mobascher, A.
ORCID
Venue
International Journal of Psychophysiology
Publisher
Elsevier BV
Published
2010-01
Volume
75
Issue
1
Pages
16-24
ISSN
0167-8760 (ISSN-L)
DOI
10.1016/j.ijpsycho.2009.10.008
OpenAlex
W2139510046
Cited by
48
References
62
Citations by year
2025: 5 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 2 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 4 · 2013: 3 · 2012: 5
FWCI
2.65
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • International Journal of Psychophysiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords
pain habituation, electrodermal activity, BOLD signal, somatosensory cortex, insula, anterior cingulate cortex, periaqueductal gray, chronic pain, pain processing
MeSH terms
Adult, Brain, Brain Mapping, Female, Galvanic Skin Response, Habituation, Psychophysiologic, Humans, Image Processing, Computer-Assisted, Lasers, Magnetic Resonance Imaging, Male, Pain, Pain Measurement, Pain Threshold

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