The DOI matches its Crossref record; 67 of the 70 references it cites were found in a registry or an index.
The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB1, TRPV1 and PPARγ receptors and neurotrophic factors
Abstract
Palmitoylethanolamide (PEA) is an endogenous lipid that is thought to be involved in endogenous protective mechanisms activated as a result of stimulation of inflammatory response. In spite of the well demonstrated anti-inflammatory properties of PEA, its involvement in controlling pain pathways still remains poorly characterized. On this basis, we tested the efficacy of PEA in vivo against a peculiar persistent pain, such as neuropathic one. PEA was administered i.p. to mice with chronic constriction injury of sciatic nerve (CCI) once a day for one week starting the day after the lesion. This therapeutic regimen evoked a relief of both thermal hyperalgesia and mechanical allodynia in neuropathic mice. Various selective receptor antagonists were used in order to clarify the relative contribution of cannabinoid, vanilloid and peroxisome proliferator-activated receptor to PEA-induced effects. The results indicated that CB(1), PPARgamma and TRPV1 receptors mediated the antinociception induced by PEA, suggesting that the most likely mechanism might be the so-called "entourage effect" due to the PEA-induced inhibition of the enzyme catalyzing the endocannabinoid anandamide (AEA) degradation that leads to an enhancement of its tissue levels thus increasing its analgesic action. In addition, the hypothesis that PEA might act through the modulation of local mast cells degranulation is sustained by our findings showing that PEA significantly reduced the production of many mediators such as TNFalpha and neurotrophic factors, like NGF. The findings presented here, in addition to prove the beneficial effects of PEA in chronic pain, identify new potential targets for analgesic medicine.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Interestingly, daily administration of PEA in a mouse model of CCI for a week produces a longlasting reduction of nociceptive behavior in nerve-injured animals after cessation of PEA treatment (Costa et al, 2008).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Costa et al, 2008
In the citing paper
“In addition, the fatty acid amide PEA, a substrate of FAAH and an endogenous PPARα ligand, produces antinociceptive effects in a rat pSNL model and in a mouse CCI model (Di Cesare Mannelli et al, 2013;Costa et al, 2008).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Costa et al, 2008
In the citing paper
“The fatty acid PEA, administered chronically, attenuated the development of thermal hyperalgesia and mechanical allodynia in the CCI model through CB1, PPARγ and TRPV1-mediated mechanisms.60”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [60]
In the citing paper
“Chronic administration of PEA also normalized levels of three neutrophic factors (NGF, GDNF, and NT-3) that were increased by CCI.60”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [60]
Citations
Cites
Ethical guidelines for investigations of experimental pain in conscious animals.
Zimmermann, M. (1983) · Pain · doi:10.1016/0304-3959(83)90201-4 · Cited by 7,762
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
Zygmunt, P. M., Petersson, J., Andersson, D. A., Chuang, H.-H., Sørgård, M., Di Marzo, V., Julius, D., & Högestätt, E. D. (1999) · Nature · doi:10.1038/22761 · Cited by 2,142
Control of pain initiation by endogenous cannabinoids
Calignano, A., Rana, G. L., Giuffrida, A., & Piomelli, D. (1998) · Nature · doi:10.1038/28393 · Cited by 1,069
NEUROTROPHINS: Mediators and Modulators of Pain
Pezet, S., & McMahon, S. B. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112929 · Cited by 890
Molecular Characterization of a Phospholipase D Generating Anandamide and Its Congeners
Okamoto, Y., Morishita, J., Tsuboi, K., Tonai, T., & Ueda, N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306642200 · Cited by 800
Immune and inflammatory mechanisms in neuropathic pain
Moalem‐Taylor, G., & Tracey, D. J. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.11.004 · Cited by 781
An anorexic lipid mediator regulated by feeding
de Fonseca, F. R., Navarro, M. A., de Heras, R. G., Escuredo, L., Nava, F. A., Fu, J., Murillo‐Rodríguez, E., Giuffrida, A., LoVerme, J., Gaetani, S., et al. (2001) · Nature · doi:10.1038/35102582 · Cited by 695
Nerve growth factor: from neurotrophin to neurokine
Levi‐Montalcini, R., Skaper, S. D., Toso, R. D., Petrelli, L., & Leon, A. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10058-8 · Cited by 686
Research works printed but not linked: 1
- Jack, 1996, Aliamides: a new approach to the treatment of inflammation., Drug News Perspectives, 9, 93
Cited by
Sorted by citations
Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications
Carta, G., Murru, E., Banni, S., & Manca, C. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00902 · Cited by 862
An update on PPAR activation by cannabinoids
O'Sullivan, S. E. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13497 · Cited by 449
Huggins, J. P., Smart, T. S., Langman, S., Taylor, L., & Young, T. (2012) · Pain · doi:10.1016/j.pain.2012.04.020 · Cited by 375
Iannotti, F. A., Marzo, V. D., & Petrosino, S. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.02.002 · Cited by 373
Petrosino, S., & Marzo, V. D. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13580 · Cited by 340
Metadata
- Authors
- Costa, B., Comelli, F., Bettoni, I., Colleoni, M., & Giagnoni, G.
- Affiliations
- University of Milano-Bicocca (IT)
- University of Milan (IT)
- Corresponding author
- Costa, Barbara
- ORCID
- Costa, Barbara
- Venue
- Pain
- Published
- 2008-10-31
- Volume
- 139
- Issue
- 3
- Pages
- 541-550
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2162105352
- Cited by
- 286
- References
- 70
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 11 · 2023: 11 · 2022: 15 · 2021: 20 · 2020: 17 · 2019: 17 · 2018: 20 · 2017: 18 · 2016: 18 · 2015: 19 · 2014: 22 · 2013: 23 · 2012: 19
- FWCI
- 10.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- palmitoylethanolamide, neuropathic pain, chronic constriction injury, thermal hyperalgesia, mechanical allodynia, CB1 receptor, TRPV1 receptor, PPARγ, entourage effect, mast cell degranulation, TNF-α, nerve growth factor, neurotrophic factors, analgesic mechanism
- MeSH terms
- Amides, Animals, Cytoplasmic Granules, Drug Evaluation, Preclinical, Ethanolamines, Hot Temperature, Hyperalgesia, Ligation, Mast Cells, Nerve Growth Factors, Palmitic Acids, Physical Stimulation, Sciatic Nerve, Sciatica, Spinal Cord, Touch, Tumor Necrosis Factor-alpha, NF-kappa B, Analgesics, Non-Narcotic, Receptor, Cannabinoid, CB1, PPAR alpha, PPAR gamma, TRPV Cation Channels, Mice, Endocannabinoids
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
