The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
One night of total sleep deprivation promotes a state of generalized hyperalgesia: A surrogate pain model to study the relationship of insomnia and pain
Abstract
Sleep disturbances are highly prevalent in chronic pain patients. Understanding their relationship has become an important research topic since poor sleep and pain are assumed to closely interact. To date, human experimental studies exploring the impact of sleep disruption/deprivation on pain perception have yielded conflicting results. This inconsistency may be due to the large heterogeneity of study populations and study protocols previously used. In addition, none of the previous studies investigated the entire spectrum of nociceptive modalities. To address these shortcomings, a standardized comprehensive quantitative sensory protocol was used in order to compare the somatosensory profile of 14 healthy subjects (6 female, 8 male, 23.5 ± 4.1 year; mean ± SD) after a night of total sleep deprivation (TSD) and a night of habitual sleep in a cross-over design. One night of TSD significantly increased the level of sleepiness (P<0.001) and resulted in higher scores of the State Anxiety Inventory (P<0.01). In addition to previously reported hyperalgesia to heat (P<0.05) and blunt pressure (P<0.05), study participants developed hyperalgesia to cold (P<0.01) and increased mechanical pain sensitivity to pinprick stimuli (P<0.05) but no changes in temporal summation. Paradoxical heat sensations or dynamic mechanical allodynia were absent. TSD selectively modulated nociception, since detection thresholds of non-nociceptive modalities remained unchanged. Our findings show that a single night of TSD is able to induce generalized hyperalgesia and to increase State Anxiety scores. In the future, TSD may serve as a translational pain model to elucidate the pathomechanisms underlying the hyperalgesic effect of sleep disturbances.
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“Exerciseinduced elevations of endocannabinoid levels have been proposed to account partially for anxiolytic (Tantimonaco et al., 2014;Fuss et al., 2015), anti-nociceptive (Galdino et al., 2014) and neuroprotective (Hill et al., 2010a) properties of exercise, which are all responses that instead are affected in a negative direction by sleep loss (e.g.Roy-Byrne et al., 1986;Schuh-Hofer et al., 2013;”
From Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans (2016) · cites this paper as Schuh-Hofer et al., 2013
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Neuropathic pain: an updated grading system for research and clinical practice
Finnerup, N. B., Haroutounian, S., Kamerman, P., Baron, R., Bennett, D. L. H., Bouhassira, D., Cruccu, G., Freeman, R., Hansson, P., Nurmikko, T., et al. (2016) · Pain · doi:10.1097/j.pain.0000000000000492 · Cited by 1,332
Evidence-Based Nonpharmacologic Strategies for Comprehensive Pain Care
Tick, H., Nielsen, A., Pelletier, K. R., Bonakdar, R. A., Simmons, S., Glick, R. M., Ratner, E. F., Lemmon, R., Wayne, P. M., & Zador, V. (2018) · EXPLORE · doi:10.1016/j.explore.2018.02.001 · Cited by 404
“Sleeplessness has been shown experimentally to induce a generalized state of hyperalgesia, a “fibromyalgialike syndrome”.(445) Both pain and pain medications can cause sleep disorders.”
BackgroundTomaso, C. C., Johnson, A. B., & Nelson, T. D. (2021) · SLEEP · doi:10.1093/sleep/zsaa289 · Cited by 282
Fibromyalgia: A Critical and Comprehensive Review
Borchers, A. T., & Gershwin, M. E. (2015) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-015-8509-4 · Cited by 279
“sleep deprivation in healthy volunteers [548, 549, 558] or patients with chronic pain [552, 559].”
BackgroundEffects of acute sleep deprivation on state anxiety levels: a systematic review and meta-analysis
Pires, G. N., Bezerra, A. G., Tufik, S. B., & Andersen, M. L. (2016) · Sleep Medicine · doi:10.1016/j.sleep.2016.07.019 · Cited by 276
Metadata
- Authors
- Schuh-Hofer, S., Wodarski, R., Pfau, D. B., Caspani, O., Magerl, W., Kennedy, J. D., & Treede, R.-D.
- Affiliations
- Eli Lilly (United States) (US)
- Heidelberg University (DE)
- Venue
- Pain
- Published
- 2013-09
- Volume
- 154
- Issue
- 9
- Pages
- 1613-1621
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2094084202
- Cited by
- 296
- References
- 109
- Citations by year
- 2026: 17 · 2025: 26 · 2024: 18 · 2023: 27 · 2022: 27 · 2021: 22 · 2020: 21 · 2019: 23 · 2018: 18 · 2017: 20 · 2016: 23 · 2015: 30 · 2014: 19 · 2013: 5
- FWCI
- 17.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- Innovative Medicines Initiative
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- total sleep deprivation, hyperalgesia, insomnia, pain perception, nociception, quantitative sensory testing, mechanical allodynia, state anxiety, sleepiness
- MeSH terms
- Adult, Anxiety, Female, Humans, Hyperalgesia, Male, Pain, Pain Measurement, Physical Stimulation, Sleep Deprivation, Pain Threshold, Cross-Over Studies, Young Adult, Pain Perception
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