Total sleep deprivation increases pain sensitivity, impairs conditioned pain modulation and facilitates temporal summation of pain in healthy participants

Staffe, Alexander Torp; Bech, Mathias Winther; Clemmensen, Sara Louise Kjær; Nielsen, Henriette Tranberg; Larsen, Dennis Boye; Petersen, Kristian Kjær

doi:10.1371/journal.pone.0225849

Cited by 150Pain Mechanisms and TreatmentsSleep and Work-Related FatiguePain Management and Treatment

Total sleep deprivation increases pain sensitivity, impairs conditioned pain modulation and facilitates temporal summation of pain in healthy participants

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Staffe, Alexander Torp, Bech, Mathias Winther, Clemmensen, Sara Louise Kjær, Nielsen, Henriette Tranberg, Larsen, Dennis Boye, Petersen, Kristian Kjær·2019·PLoS ONE

DOI 10.1371/journal.pone.0225849PMC PMC6892491

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Abstract

Chronic pain patients often suffer from insomnia or impaired sleep which has been associated with increased pain sensitivity, but a limited amount of studies have investigated the effects of total sleep deprivation on central pain mechanisms. Therefore, the aim of this study was to determine the effects of total sleep deprivation on temporal summation, conditioned pain modulation, thermal and pressure pain sensitivity in healthy participants. Twenty-four healthy participants took part in this two-session trial. The measurements were conducted after a night of habitual sleep (baseline) and following 24 hours of total sleep deprivation. Detection thresholds for cold and warmth and pain thresholds for cold and heat were assessed. Cuff induced pressure pain detection and tolerance thresholds, temporal summation and conditioned pain modulation were assessed with user-independent, computer-controlled cuff algometry. Conditioned pain modulation was significantly impaired, temporal summation was significantly facilitated and pain sensitivity to pressure and cold pain were significantly increased at follow-up compared with baseline. In conclusion, this study found that one night of total sleep deprivation impaired descending pain pathways, facilitated spinal excitability and sensitized peripheral pathways to cold and pressure pain. Future studies are encouraged to investigate if sleep therapy might normalize pain sensitivity in sleep-deprived chronic pain patients.

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Sleep-related variables predict pain-related outcomes such as disability, and sleep disruption is related to increased pain sensitivity and lowered pain thresholds.
“Sleep-related variables have been shown to predict pain-related outcomes such as disability [74], and sleep disruption is related to increased pain sensitivity and lowered pain thresholds [75].”
From ACTsmart: Guided Smartphone-Delivered Acceptance and Commitment Therapy for Chronic Pain—A Pilot Trial. (2021) · cites this paper as [75]

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The Underlying Mechanisms of Sleep Deprivation Exacerbating Neuropathic Pain
Zhu, M., & Huang, H. (2023) · Nature and Science of Sleep · doi:10.2147/nss.s414174 · Cited by 37 · see citing works
The association between temporomandibular disorders signs and symptoms, bruxism, and health variables: A cross‐sectional study
Kurup, S., Perez-Pino, A., & Litt, M. D. (2024) · CRANIO® · doi:10.1080/08869634.2024.2425918 · Cited by 34 · see citing works
The impact of sleep disturbance on pain perception: A systematic review examining the moderating effect of sex and age
Rouhi, S., Topcu, J., Egorova, N., & Jordan, A. S. (2023) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2023.101835 · Cited by 33 · see citing works
Alterations of pain pathways by experimental sleep disturbances in humans: central pain-inhibitory, cyclooxygenase, and endocannabinoid pathways
Haack, M., Engert, L. C., Besedovsky, L., Goldstein, M. R., Devine, J. K., Dang, R., Olia, K., Molina, V., Bertisch, S. M., Sethna, N. F., et al. (2023) · SLEEP · doi:10.1093/sleep/zsad061 · Cited by 32 · see citing works
The Impact of Sleep Disturbances on Endogenous Pain Modulation: A Systematic Review and Meta-Analysis
Babiloni, A. H., Brazeau, D., Jodoin, M., Theis-Mahon, N. R., Martel, M. O., Lavigne, G. J., & Moana-Filho, E. J. (2023) · Journal of Pain · doi:10.1016/j.jpain.2023.10.023 · Cited by 36 · see citing works
Pain profiles and variability in temporal summation of pain and conditioned pain modulation in pain‐free individuals and patients with low back pain, osteoarthritis, and fibromyalgia
Petersen, K. K., O’Neill, S. F. D., Blichfeldt‐Eckhardt, M. R., Nim, C. G., Arendt‐Nielsen, L., & Vægter, H. B. (2024) · European Journal of Pain · doi:10.1002/ejp.4741 · Cited by 29 · see citing works
Towards the endotyping of the sleep–pain interaction: a topical review on multitarget strategies based on phenotypic vulnerabilities and putative pathways
Babiloni, A. H., Beetz, G., Tang, N. K. Y., Heinzer, R. C., Nijs, J., Martel, M. O., & Lavigne, G. J. (2020) · Pain · doi:10.1097/j.pain.0000000000002124 · Cited by 30 · see citing works
Detection of altered pain facilitatory and inhibitory mechanisms in patients with knee osteoarthritis by using a simple bedside tool kit (QuantiPain)
Izumi, M., Hayashi, Y., Saito, R., Oda, S., Petersen, K. K., Arendt‐Nielsen, L., & Ikeuchi, M. (2022) · PAIN Reports · doi:10.1097/pr9.0000000000000998 · Cited by 31 · see citing works
The endocannabinoid N-arachidonoyl dopamine is critical for hyperalgesia induced by chronic sleep disruption
Ding, W., Yang, L., Shi, E., Kim, B., Low, S. A., Hu, K., Gao, L., Chen, P., Ding, W. Y., Borsook, D., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42283-6 · Cited by 29 · see citing works
The Role of Sleep in the Transition from Acute to Chronic Musculoskeletal Pain in Youth—A Narrative Review
Andreucci, A., Groenewald, C. B., Rathleff, M. S., & Palermo, T. M. (2021) · Children · doi:10.3390/children8030241 · Cited by 29 · see citing works
The effect of duloxetine on mechanistic pain profiles, cognitive factors and clinical pain in patients with painful knee osteoarthritis—A randomized, double‐blind , placebo‐controlled , crossover study
Petersen, K. K., Drewes, A. M., Olesen, A. E., Ammitzbøll, N., Bertoli, D., Brock, C., & Arendt‐Nielsen, L. (2022) · European Journal of Pain · doi:10.1002/ejp.1988 · Cited by 26 · see citing works
The complexities of the sleep-pain relationship in adolescents: A critical review
Albinni, B., de Zambotti, M., Iacovides, S., Baker, F. C., & King, C. D. (2022) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2022.101715 · Cited by 27 · see citing works
Gut Bless Your Pain—Roles of the Gut Microbiota, Sleep, and Melatonin in Chronic Orofacial Pain and Depression
Lassmann, Ł., Pollis, M., Żółtowska, A., & Manfredini, D. (2022) · Biomedicines · doi:10.3390/biomedicines10071528 · Cited by 25 · see citing works
Effects of multifocal transcranial direct current stimulation targeting the motor network during prolonged experimental pain
Gregoret, L., Zamorano, A. M., & Graven‐Nielsen, T. (2021) · European Journal of Pain · doi:10.1002/ejp.1743 · Cited by 24 · see citing works
Sleep deprivation and recovery sleep affect healthy male resident’s pain sensitivity and oxidative stress markers: The medial prefrontal cortex may play a role in sleep deprivation model
Chen, S., Xie, Y., Li, Y., Fan, X., Xing, F., Mao, Y., Xing, N., Wang, J., Yang, J., Wang, Z., et al. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.937468 · Cited by 26 · see citing works
Comprehensive quantitative sensory testing shows altered sensory function in women with chronic pelvic pain: results from the Translational Research in Pelvic Pain (TRiPP) Study
Coxon, L., Vollert, J., Perro, D., Lunde, C. E., Ferreira‐Gomes, J., Charrua, A., Abreu‐Mendes, P., Krassowski, M., Birch, J. V., Meijlink, J. M., et al. (2023) · Pain · doi:10.1097/j.pain.0000000000002955 · Cited by 27 · see citing works
ACTsmart: Guided Smartphone-Delivered Acceptance and Commitment Therapy for Chronic Pain—A Pilot Trial.
Gentili, C., Zetterqvist, V., Rickardsson, J., Holmström, L., Simons, L. E., & Wicksell, R. K. (2021) · Pain Medicine · doi:10.1093/pm/pnaa360 · Cited by 20 · see citing works
“Sleep-related variables have been shown to predict pain-related outcomes such as disability [74], and sleep disruption is related to increased pain sensitivity and lowered pain thresholds [75].”
Background
Exploring multidimensional characteristics in cervicogenic headache: Relations between pain processing, lifestyle, and psychosocial factors
Mingels, S., Dankaerts, W., van Etten, L. M. L. A., Bruckers, L. M., & Granitzer, M. (2021) · Brain and Behavior · doi:10.1002/brb3.2339 · Cited by 23 · see citing works
Predicting pain after standard pain therapy for knee osteoarthritis – the first steps towards personalized mechanistic-based pain medicine in osteoarthritis
Petersen, K. K.-S. (2023) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2022-0082 · Cited by 22 · see citing works
Inhibition of Piezo1/Ca2+/calpain signaling in the rat basal forebrain reverses sleep deprivation-induced fear memory impairments
Ma, T., Wang, Y., Lu, Y., Feng, L., Yang, Y., Li, G., Li, C., Chu, Y., Wang, W., & Zhang, H. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113594 · Cited by 22 · see citing works
Investigation of pain sensitivity following 3 nights of disrupted sleep in healthy individuals
Hertel, E., McPhee, M. E., & Petersen, K. K. (2023) · European Journal of Pain · doi:10.1002/ejp.2101 · Cited by 22 · see citing works
Pain Sensitization as a Potential Mediator of the Relationship Between Sleep Disturbance and Subsequent Pain in Rheumatoid Arthritis
Song, J., Muhammad, L. N., Neogi, T., Dunlop, D. D., Wohlfahrt, A., Bolster, M. B., Bingham, C. O., Clauw, D. J., Marder, W., & Lee, Y. (2022) · Arthritis Care & Research · doi:10.1002/acr.24888 · Cited by 20 · see citing works
Prevalence of chronic pelvic pain and primary dysmenorrhea in women of reproductive age in Ecuador
Rosero, C. Y. D. L. M. V., Mazin, S. C., Nogueira, A. A., Vargas-Costales, J. A., Silva, J. C. R. E., dos Reis, F. J. C., & Poli‐Neto, O. B. (2022) · BMC Women s Health · doi:10.1186/s12905-022-01948-y · Cited by 20 · see citing works
A Narrative Review of the Reciprocal Relationship Between Sleep Deprivation and Chronic Pain: The Role of Oxidative Stress
Chen, S., Xie, Y., Liang, Z., Lu, Y., Wang, J., Xing, F., Mao, Y., Wei, X., Wang, Z., Yang, J., et al. (2024) · Journal of Pain Research · doi:10.2147/jpr.s455621 · Cited by 20 · see citing works
Psychophysical predictors of experimental muscle pain intensity following fatiguing calf exercise
Kristensen, N. S., Hertel, E., Skadhauge, C. H., Kronborg, S. H., Petersen, K. K., & McPhee, M. E. (2021) · PLoS ONE · doi:10.1371/journal.pone.0253945 · Cited by 20 · see citing works
Prevalence of and risk factors for low back pain among professional drivers: a systematic review and meta-analysis
Jia, J., Zhang, M., Cao, Z., Yang, Z., Hu, X., Lei, S., Zhang, Y., Leng, W., & Kang, X. (2024) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-024-04999-z · Cited by 18 · see citing works
Indirect effect of sleep on abdominal pain through daytime dysfunction in adults with irritable bowel syndrome
Yang, P.-L., Burr, R. L., Buchanan, D. T., Pike, K. C., Kamp, K., & Heitkemper, M. M. (2020) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.8658 · Cited by 19 · see citing works
Sensitization in office workers with chronic neck pain in different pain conditions and intensities
Nunes, A., Petersen, K. K., Espanha, M., & Arendt‐Nielsen, L. (2021) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2020-0107 · Cited by 17 · see citing works
Impact of Long-Term Evoked Compound Action Potential Controlled Closed-Loop Spinal Cord Stimulation on Sleep Quality in Patients With Chronic Pain: An EVOKE Randomized Controlled Trial Study Subanalysis
Costandi, S. J., Kapural, L., Mekhail, N. A., Jotwani, R., Bertisch, S. M., Li, S., Petersen, E., Abejón, D., Poree, L. R., Ouyang, Z., et al. (2022) · Neuromodulation Technology at the Neural Interface · doi:10.1016/j.neurom.2022.10.050 · Cited by 17 · see citing works
Perioperative Sleep Disturbance Following Mastectomy
Azizoddin, D. R., Soens, M., Beck, M. R., Flowers, K. M., Edwards, R. R., & Schreiber, K. L. (2023) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000001090 · Cited by 17 · see citing works
Disturbed sleep may be a core risk factor for jaw functional limitation in patients with painful temporomandibular disorders
Kim, H., & Kim, M. (2021) · Journal of Oral Rehabilitation · doi:10.1111/joor.13217 · Cited by 19 · see citing works
Association between peripheral neuropathy and sleep quality among colorectal cancer patients from diagnosis until 2-year follow-up: results from the PROFILES registry
Bonhof, C. S., van de Poll-Franse, L. V., de Hingh, I. H. J. T., Nefs, G., Vreugdenhil, G., & Mols, F. (2021) · Journal of Cancer Survivorship · doi:10.1007/s11764-021-01130-7 · Cited by 16 · see citing works
Obstructive sleep apnea is common in patients with high-impact chronic pain – an exploratory study from an interdisciplinary pain center
Larsen, D. B., Bendix, L., Abeler, K., Petersen, K. K., Sprehn, M., Bruun, K. D., Blichfeldt‐Eckhardt, M. R., & Vægter, H. B. (2021) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2021-0112 · Cited by 15 · see citing works
Characteristics of clusters with contrasting relationships between central sensitization-related symptoms and pain
Koga, M., Shigetoh, H., Tanaka, Y., & Morioka, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-06453-8 · Cited by 15 · see citing works
Palmitoylethanolamide for sleep disturbance. A double-blind, randomised, placebo-controlled interventional study
Rao, A., Ebelt, P., Mallard, A. R., & Briskey, D. R. (2021) · Sleep Science and Practice · doi:10.1186/s41606-021-00065-3 · Cited by 15 · see citing works
Pain thresholds and suprathreshold pain after sleep restriction in migraine – A blinded crossover study
Neverdahl, J. P., Uglem, M., Matre, D., Hansen, J. O., Engstrøm, M., Tronvik, E., Stovner, L. J., Sand, T., & Omland, P. M. (2021) · Cephalalgia · doi:10.1177/03331024211056565 · Cited by 15 · see citing works
Why sleep matters in chronic pain: evidence across the lifespan
Kelleher, E. M., Wall, A. J. W., Seymour, B., & Irani, A. (2026) · EBioMedicine · doi:10.1016/j.ebiom.2026.106158 · Cited by 17 · see citing works
Pain mechanistic networks: the development using supervised multivariate data analysis and implications for chronic pain
Giordano, R., Arendt‐Nielsen, L., Gerra, M. C., Kappel, A., Østgaard, S. E., Capriotti, C., Dallabona, C., & Petersen, K. K. (2024) · Pain · doi:10.1097/j.pain.0000000000003410 · Cited by 14 · see citing works
The influence of exercise on clinical pain and pain mechanisms in patients with subacromial pain syndrome
Lyng, K. D., Andersen, J. S., Jensen, S. L., Olesen, J. L., Arendt‐Nielsen, L., Madsen, N. K., & Petersen, K. K. (2022) · European Journal of Pain · doi:10.1002/ejp.2010 · Cited by 13 · see citing works
Modulation of Exercise-Induced Hypoalgesia Following an Exercise Intervention in Healthy Subjects
Hansen, S., Dalgaard, R. C., Mikkelsen, P. S., Sørensen, M. B., & Petersen, K. K. (2020) · Pain Medicine · doi:10.1093/pm/pnaa212 · Cited by 15 · see citing works
The Modulatory Effect of Quantitative Sensory Testing in Shoulder Pain: A Systematic Review and Meta-Analysis
Lyng, K. D., Thorsen, J., Larsen, D. B., & Petersen, K. K. (2021) · Pain Medicine · doi:10.1093/pm/pnab155 · Cited by 14 · see citing works
Obstructive sleep apnea treatment improves temporomandibular disorder pain
Alessandri‐Bonetti, A., Lobbezoo, F., Mangino, G., Aarab, G., & Gallenzi, P. (2023) · Sleep And Breathing · doi:10.1007/s11325-023-02883-4 · Cited by 13 · see citing works
The relationship between sleep quality and emotional modulation of spinal, supraspinal, and perceptual measures of pain
Huber, F. A., Toledo, T. A., Newsom, G., & Rhudy, J. L. (2022) · Biological Psychology · doi:10.1016/j.biopsycho.2022.108352 · Cited by 13 · see citing works
The Use of Botulinum Toxin A as an Adjunctive Therapy in the Management of Chronic Musculoskeletal Pain: A Systematic Review with Meta-Analysis
Battista, S., Buzzatti, L., Gandolfi, M., Finocchi, C., Maistrello, L. F., Viceconti, A., Giardulli, B., & Testa, M. (2021) · Toxins · doi:10.3390/toxins13090640 · Cited by 12 · see citing works
Network analysis of sleep bruxism in the EPISONO adult general population
Chattrattrai, T., Aarab, G., Blanken, T. F., Pires, G. N., Babiloni, A. H., Fabbro, C. D., Someren, E. J. W. V., Lavigne, G. J., Maluly, M., Andersen, M. L., et al. (2023) · Journal of Sleep Research · doi:10.1111/jsr.13957 · Cited by 13 · see citing works
Distress and Sensitization as Main Mediators of Severity in Women with Fibromyalgia: A Structural Equation Model
Liew, B. X. W., Valera‐Calero, J. A., Varol, U., Nijs, J., Arendt‐Nielsen, L., Plaza‐Manzano, G., & Fernández‐de‐las‐Peñas, C. (2022) · Biomedicines · doi:10.3390/biomedicines10051188 · Cited by 12 · see citing works
The Effects of Recovery Sleep on Experimental Pain
Stroemel-Scheder, C., & Lautenbacher, S. (2022) · Journal of Pain · doi:10.1016/j.jpain.2022.10.009 · Cited by 11 · see citing works
Combining Ozonated Autohemotherapy with Pharmacological Therapy for Comorbid Insomnia and Myofascial Pain Syndrome: A Prospective Randomized Controlled Study
Shen, W., Liu, N., Ji, Z., Fang, H., Liu, F., Zhang, W. Y., Yu, X., Wang, M., Zhang, J., & Wang, X. (2022) · Pain Research and Management · doi:10.1155/2022/3562191 · Cited by 11 · see citing works
The role of symptoms severity, heart rate, and central sensitization for predicting sleep quality in patients with fibromyalgia
Lima, D., Pacheco‐Barrios, K., Slawka, E., Camargo, L., Castelo-Branco, L. E. C., Cardenas‐Rojas, A., Neto, M. S., & Fregni, F. (2023) · Pain Medicine · doi:10.1093/pm/pnad076 · Cited by 10 · see citing works
Neuroplasticity in the pathogenesis and treatment of chronic pain syndrome: new research and therapeutic perspectives
Lysetskyi, B., Kobyletskyi, O., Shchybovyk, D., Zubova, M., & Litvin, O. (2024) · Futurity Medicine. · doi:10.57125/fem.2024.03.30.05 · Cited by 9 · see citing works
Simultaneous measurement of intra-epidermal electric detection thresholds and evoked potentials for observation of nociceptive processing following sleep deprivation
van den Berg, B., Hijma, H. J., Koopmans, I. W., Doll, R. J., Zuiker, R. G. J. A., Groeneveld, G. J., & Buitenweg, J. R. (2022) · Experimental Brain Research · doi:10.1007/s00221-021-06284-5 · Cited by 10 · see citing works
Differential Gene Expression in Brain and Liver Tissue of Wistar Rats after Rapid Eye Movement Sleep Deprivation
Pandey, A., Oliver, R., & Kar, S. K. (2020) · Clocks & Sleep · doi:10.3390/clockssleep2040033 · Cited by 9 · see citing works
Psychophysical changes after total sleep deprivation and experimental muscle pain
Hertel, E., Sathiyalingam, E., Pilgaard, L., Brommann, S. J., Giordano, R., & Petersen, K. K. (2024) · Journal of Sleep Research · doi:10.1111/jsr.14329 · Cited by 9 · see citing works
Neuro-Nutritional Approach to Neuropathic Pain Management: A Critical Review
Cominelli, G., Sulas, F., Pinto, D., Rinaldi, F., Favero, G., & Rezzani, R. (2025) · Nutrients · doi:10.3390/nu17091502 · Cited by 9 · see citing works
Global research on cancer and sleep: A bibliometric and visual analysis of the last two decades
Sun, J., Wang, C., Hui, Z., Han, W., Wang, X., & Wang, M. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1139746 · Cited by 8 · see citing works
Poor quality of sleep and musculoskeletal pains among highly trained and elite athletes in Senegal
Ndongo, J. M., Lele, E. C. B., Ahmet, H. M. M., Guessogo, W. R., Wiliam, M. B., Guyot, J., Rozand, V., Ahmadou, Ayina, C. N. A., Foko, L. P. K., et al. (2024) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-023-00705-4 · Cited by 8 · see citing works
The Endogenous Pain Modulatory System as a Healing Mechanism: A Proposal on How to Measure and Modulate It
de Melo, P. S., Pacheco‐Barrios, K., Marduy, A., Vásquez-Ávila, K., Simis, M., Imamura, M., Cardenas‐Rojas, A., Navarro‐Flores, A., Battistella, L. R., & Fregni, F. (2024) · NeuroSci · doi:10.3390/neurosci5030018 · Cited by 8 · see citing works
Insomnia and cognitive behavioral therapy for chronic back pain
Parfenova, E. V. (2020) · Neurology neuropsychiatry Psychosomatics · doi:10.14412/2074-2711-2020-4-119-124 · Cited by 8 · see citing works
Changes in pain, daily occupations, lifestyle, and health following an occupational therapy lifestyle intervention: a secondary analysis from a feasibility study in patients with chronic high-impact pain
Nielsen, S. S., Skou, S. T., Larsen, A. E., Polianskis, R., Arendt-Nielsen, L., Østergaard, A. S., Kjær-Staal Petersen, K., Vægter, H. B., Søndergaard, J., & Christensen, J. R. (2024) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2023-0043 · Cited by 7 · see citing works
Youth With Functional Abdominal Pain Disorders Have More Sleep Disturbances. A School‐Based Study
Santucci, N. R., Benítez, C. A. V., Velasco‐Suárez, D. A., King, C. D., Byars, K. C., Dye, T. J., Li, J., & Saps, M. (2024) · Neurogastroenterology & Motility · doi:10.1111/nmo.14992 · Cited by 7 · see citing works
Sex and Sleep Quality Effects on the Relationship Between Sleep Disruption and Pain Sensitivity
Joensen, E. D. R., Frederiksen, L., Frederiksen, S. V., Valeur, E. S., Giordano, R., Hertel, E., & Petersen, K. K. (2025) · European Journal of Pain · doi:10.1002/ejp.70023 · Cited by 9 · see citing works
Mechanisms of the Native American pain inequity: predicting chronic pain onset prospectively at 5 years in the Oklahoma Study of Native American Pain Risk
Rhudy, J. L., Kell, P. A., Brown, T. V., Ventresca, H. M., Vore, C. N., Trevino, K. N., Jones, B. W., Lowe, T. S., & Shadlow, J. O. (2024) · Pain · doi:10.1097/j.pain.0000000000003442 · Cited by 7 · see citing works
The Sleep-Reward-Pain Pathway Model: an Integrative Review
Reid, M. J., Climent‐Sanz, C., & Finan, P. H. (2022) · Current Sleep Medicine Reports · doi:10.1007/s40675-022-00232-7 · Cited by 7 · see citing works
Spontaneous Pain and Pain Sensitivity in Response to Prolonged Experimental Sleep Disturbances—Potential Sex Differences
Olia, K., Goldstein, M. R., Engert, L. C., Besedovsky, L., Dang, R., Bertisch, S. M., Sethna, N. F., & Haack, M. (2025) · European Journal of Pain · doi:10.1002/ejp.4789 · Cited by 7 · see citing works
Efficacy and Safety of Preoperative Melatonin for Women Undergoing Cesarean Section: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials
Albzea, W., Almonayea, L., Aljassar, M., Atmeh, M., Sadder, K. A. A., Alqattan, Y., Alhajaji, R., AlNadwi, H., Alnami, I., & Alhajaji, F. (2023) · Medicina · doi:10.3390/medicina59061065 · Cited by 5 · see citing works
UK medical cannabis registry: A clinical outcome analysis of medical cannabis therapy in chronic pain patients with and without co‐morbid sleep impairment
Datta, I., Erridge, S., Holvey, C., Coomber, R., Guru, R., Holden, W., Medniuk, A. D., Sajad, M., Searle, R. D., Usmani, A., et al. (2024) · Pain Practice · doi:10.1111/papr.13438 · Cited by 5 · see citing works
Shoulder pain phenotyping: A guide for clinicians to determine predominant nociceptive, neuropathic, or nociplastic shoulder pain
Baets, L. D., Kuppens, K., Labie, C., Haik, M. N., Kapreli, E., Bilika, P., Struyf, F., Borms, D., Fernández‐de‐las‐Peñas, C., Kosek, E., et al. (2025) · Brazilian Journal of Physical Therapy · doi:10.1016/j.bjpt.2025.101240 · Cited by 5 · see citing works
Acute sleep deprivation induces hyperalgesia through P2X4-mediated microglial activation in mice
Huang, S., Cheng, W., Lai, P., Liu, X., Peng, S., Yang, X., & Du, X. (2025) · European journal of medical research · doi:10.1186/s40001-025-03326-4 · Cited by 5 · see citing works
Exercise-Induced Hypoalgesia in Patients with Chronic Whiplash-Associated Disorders: Differences between Subgroups Based on the Central Sensitization Inventory
Hendriks, E. P., Coppieters, I., Voogt, L. P., Cools, W., & Ickmans, K. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13020482 · Cited by 5 · see citing works
Evidence-Based Opinions from Multidisciplinary Experts on Use of Naturopathic Herbal Remedies in Pain Management
Mobasheri, A., Spring-Charles, A., Gamaleri, F. C., McSwan, J., Garg, M. L., & Sethi, V. S. (2024) · Journal of Pain Research · doi:10.2147/jpr.s432090 · Cited by 5 · see citing works
A simple, bed-side tool to assess evoked pressure pain intensity
Hostrup, S. N., O’Neill, S. F. D., Larsen, J. B., Arendt‐Nielsen, L., & Petersen, K. K. (2022) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2022-0055 · Cited by 5 · see citing works
Impact of Anxiety Levels and Sleep Patterns on Perceived Pain During Intravitreal Bevacizumab Injections
Wieder, M. S., Szlechter, M., Fischman, N., Inker, S., Rusu, I., & Mbekeani, J. N. (2021) · Ophthalmic surgery, lasers & imaging retina · doi:10.3928/23258160-20210819-02 · Cited by 5 · see citing works
A crossover study evaluating the sex‐dependent and sensitizing effects of sleep deprivation using a nociceptive test battery in healthy subjects
Hijma, H. J., Koopmans, I. W., Klaassen, E. S., Doll, R. J., Zuiker, R. G. J. A., & Groeneveld, G. J. (2022) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.15505 · Cited by 6 · see citing works
Insomnia and short sleep duration, but not chronotype, is associated with chronic widespread pain: Mendelian randomization study
Williams, J., Hum, R. M., Alam, U., & Zhao, S. S. (2024) · Rheumatology International · doi:10.1007/s00296-024-05636-y · Cited by 6 · see citing works
Mediation of the frailty index, the relationship between sleep duration and chronic pain in different body regions: insights from the CHARLS cross-sectional study
Li, C., Ding, H., Zhang, L., Ma, C., Ma, C., Wen, H., & Zhao, X. (2025) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-025-06157-5 · Cited by 4 · see citing works
Patient Sleep Quality in Acute Inpatient Rehabilitation
Davis, S. M., Mekany, M. A., Kim, J. J., & Han, J. J. (2021) · PM&R · doi:10.1002/pmrj.12550 · Cited by 4 · see citing works
Analgesic efficacy of a portable, disposable, and self‐applied transcutaneous electrical nerve stimulation device during migraine attacks: A real‐life randomized controlled trial
Domingues, F. S., Gayoso, M. V., Sikandar, S., da Silva, L. M., Fonseca, R. G., & de Barros, G. A. M. (2021) · Pain Practice · doi:10.1111/papr.13042 · Cited by 4 · see citing works
Differential pain perception among females with or without nonspecific chronic low back pain and comorbid insomnia: a quantitative sensory testing analysis
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TO SLEEP OR NOT TO SLEEP: A preliminary report on the impact of total sleep deprivation on peripheral and central pain mechanisms
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Sleep Deprivation Affects Thermal Pain Thresholds but Not Somatosensory Thresholds in Healthy Volunteers
Phd, S. L. (2013)

Authors: Staffe, A. T., Bech, M. W., Clemmensen, S. L. K., Nielsen, H. T., Larsen, D. B., & Petersen, K. K.
Affiliations: Aalborg University (DK)
Corresponding author: Petersen, Kristian Kjær
ORCID: Staffe, Alexander Torp
Bech, Mathias Winther
Larsen, Dennis Boye
Petersen, Kristian Kjær
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2019-12-04
Volume: 14
Issue: 12
Pages: e0225849
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0225849
PMC: PMC6892491
OpenAlex: W2991704716
Cited by: 150
References: 70
Citations by year: 2026: 22 · 2025: 30 · 2024: 21 · 2023: 22 · 2022: 25 · 2021: 22 · 2020: 6 · 2019: 1 · 2018: 1
FWCI: 9.23
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: PLoS ONE (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
VBN Forskningsportal (Aalborg Universitet) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Funders: Danmarks Grundforskningsfond (DNRF121)
Aalborg Universitet (771126)
Topics: Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: total sleep deprivation, pain sensitivity, conditioned pain modulation, temporal summation, descending pain modulation, thermal pain, pressure pain, cold pain, pain detection threshold, pain tolerance, spinal cord excitability, chronic pain, insomnia, sleep therapy
MeSH terms: Adult, Denmark, Female, Humans, Male, Pain Measurement, Sleep, Sleep Deprivation, Thermosensing, Pain Threshold, Young Adult, Public Health Surveillance

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Total sleep deprivation increases pain sensitivity, impairs conditioned pain modulation and facilitates temporal summation of pain in healthy participants

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