The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.
Migraine pathophysiology: Anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain
Open accessAbstract
Scientific evidence support the notion that migraine pathophysiology involves inherited alteration of brain excitability, intracranial arterial dilatation, recurrent activation and sensitization of the trigeminovascular pathway, and consequential structural and functional changes in genetically susceptible individuals. Evidence of altered brain excitability emerged from clinical and preclinical investigation of sensory auras, ictal and interictal hypersensitivity to visual, auditory and olfactory stimulation, and reduced activation of descending inhibitory pain pathways. Data supporting the activation and sensitization of the trigeminovascular system include the progressive development of cephalic and whole-body cutaneous allodynia during a migraine attack. Also, structural and functional alterations include the presence of subcortical white mater lesions, thickening of cortical areas involved in processing sensory information, and cortical neuroplastic changes induced by cortical spreading depression. Here, we review recent anatomical data on the trigeminovascular pathway and its activation by cortical spreading depression, a novel understanding of the neural substrate of migraine-type photophobia, and modulation of the trigeminovascular pathway by the brainstem, hypothalamus and cortex.
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Cites
Cellular and Molecular Mechanisms of Pain
Basbaum, A. I., Bautista, D. M., Scherrer, G., & Julius, D. (2009) · Cell · doi:10.1016/j.cell.2009.09.028 · Cited by 4,344
Interplay between Cortical Spreading Depolarization and Seizures
Kramer, D. R., Fujii, T., Ohiorhenuan, I., & Liu, C. Y. (2017) · Stereotactic and Functional Neurosurgery · doi:10.1159/000452841 · Cited by 3,696
Phototransduction by retinal ganglion cells that set the circadian clock
Berson, D. M., Dunn, F. A., & Takao, M. (2002) · Science · doi:10.1126/science.1067262 · Cited by 3,629
SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEX
Leao, A. A. P. (1944) · Journal of Neurophysiology · doi:10.1152/jn.1944.7.6.359 · Cited by 2,679
Ophoff, R. A., Terwindt, G. M., Vergouwe, M. N., van Eijk, R., Oefner, P. J., Hoffman, S. M. G., Lamerdin, J. E., Mohrenweiser, H. W., Bulman, D. E., Ferrari, M., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81373-2 · Cited by 2,339
The International Classification of Headache Disorders
Olesen, J. (2008) · Headache: The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2008.01121.x · Cited by 2,321
Mechanisms of migraine aura revealed by functional MRI in human visual cortex
Hadjikhani, N., Sanchez del Rio, M., Wu, O., Schwartz, D., Bakker, D., Fischl, B., Kwong, K. K., Cutrer, F. M., Rosen, B. R., Tootell, R. B. H., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071582498 · Cited by 1,518
Brain stem activation in spontaneous human migraine attacks
Weiller, C., May, A., Limmroth, V., Jüptner, M., Kaube, H., Schayck, R. V., Coenen, H. H., & Dlener, H. C. (1995) · Nature Medicine · doi:10.1038/nm0795-658 · Cited by 1,384
Endogenous pain control mechanisms: Review and hypothesis
Basbaum, A. I., & Fields, H. L. (1978) · Annals of Neurology · doi:10.1002/ana.410040511 · Cited by 1,241
Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model
Bolay, H., Reuter, U., Dunn, A. K., Huang, Z., Boas, D. A., & Moskowitz, M. A. (2002) · Nature Medicine · doi:10.1038/nm0202-136 · Cited by 1,214
Cited by
CGRP and the Trigeminal System in Migraine
Iyengar, S., Johnson, K. W., Ossipov, M. H., & Aurora, S. K. (2019) · Headache: The Journal of Head and Face Pain · doi:10.1111/head.13529 · Cited by 486
Migraine pathophysiology: lessons from mouse models and human genetics
Ferrari, M. D., Klever, R. R., Terwindt, G. M., Ayata, C., & van den Maagdenberg, A. M. J. M. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70220-0 · Cited by 387
Overview of Neuropeptides: Awakening the Senses?
Russo, A. F. (2017) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13084 · Cited by 229
Applying a biopsychosocial model to migraine: rationale and clinical implications
Rosignoli, C., Ornello, R., Onofri, A., Caponnetto, V., Grazzi, L., Raggi, A., Leonardi, M., & Sacco, S. (2022) · The Journal of Headache and Pain · doi:10.1186/s10194-022-01471-3 · Cited by 138
Greco, R., Bandiera, T., Mangione, A., Demartini, C., Siani, F., Nappi, G., Sandrini, G., Guijarro, A., Armirotti, A., Piomelli, D., et al. (2015) · Cephalalgia · doi:10.1177/0333102414566862 · Cited by 63
Metadata
- Authors
- Noseda, R., & Burstein, R.
- Venue
- Pain
- Published
- 2013-12
- Volume
- 154
- Issue
- Supplement 1
- Pages
- S44-S53
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W46438429
- Cited by
- 871
- References
- 134
- FWCI
- 30.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Noseda, R., & Burstein, R. (2013). Migraine pathophysiology: Anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain. Pain. https://doi.org/10.1016/j.pain.2013.07.021
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
