Focal pancreatic parenchyma atrophy is a harbinger of pancreatic cancer and a clue to the intraductal spreading subtype

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

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Pancreatic cancer

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Estimated Projection of US Cancer Incidence and Death to 2040

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TNM Classification of Malignant Tumours.

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Japan Pancreatic Cancer Registry; 30th Year Anniversary

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New insights into pancreatic cancer-induced paraneoplastic diabetes

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Update on Familial Pancreatic Cancer

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A Novel Multivariate Index for Pancreatic Cancer Detection Based On the Plasma Free Amino Acid Profile

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Focal Parenchymal Atrophy of Pancreas: An Important Sign of Underlying High-Grade Pancreatic Intraepithelial Neoplasia Without Invasive Carcinoma, i.e., Carcinoma in Situ

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CT abnormalities of the pancreas associated with the subsequent diagnosis of clinical stage I pancreatic ductal adenocarcinoma more than 1 year later: a case-control study

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Computerized tomography scan in pre-diagnostic pancreatic ductal adenocarcinoma: stages of progression and potential benefits of early intervention: a retrospective study

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Prevention of Pancreatic Cancer and Strategies for Management of Familial Pancreatic Cancer

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Partial Pancreatic Parenchymal Atrophy Is a New Specific Finding to Diagnose Small Pancreatic Cancer (≤10 mm) Including Carcinoma in Situ: Comparison with Localized Benign Main Pancreatic Duct Stenosis Patients

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Acute pancreatitis-onset carcinoma in situ of the pancreas with focal fat replacement diagnosed using serial pancreatic-juice aspiration cytologic examination (SPACE)

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New-onset type 2 diabetes mellitus – A high-risk group suitable for the screening of pancreatic cancer?

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Development of pancreatic cancer is predictable well in advance using contrast-enhanced CT: a case–cohort study

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Metabolomics in pancreatic cancer biomarkers research

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Pancreatic Cancer Diagnosis and Management: Has the Time Come to Prick the Bubble?

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Missed pancreatic ductal adenocarcinoma: Assessment of early imaging findings on prediagnostic magnetic resonance imaging

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The Early State of Invasive Pancreatic Ductal Adenocarcinomas

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Dilatation of the main pancreatic duct as first manifestation of small pancreatic ductal adenocarcinomas detected in a hereditary pancreatic cancer surveillance program

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Diagnostic yield of the plasma free amino acid index for pancreatic cancer in patients with diabetes mellitus

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A primer on artificial intelligence in pancreatic imaging

Ahmed, T. M., Kawamoto, S., Hruban, R. H., Fishman, E. K., Soyer, P. A., & Chu, L. C. H. (2023) · Diagnostic and Interventional Imaging · doi:10.1016/j.diii.2023.03.002 · Cited by 43 · see citing works

Screening for pancreatic cancer has the potential to save lives, but is it practical?

Mazer, B. L., Lee, J. W., Roberts, N. J., Chu, L. C. H., Lennon, A. M., Klein, A. P., Eshleman, J. R., Fishman, E. K., Canto, M. I., Goggins, M., et al. (2023) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2023.2217354 · Cited by 23 · see citing works

Temporal progression of pancreatic cancer computed tomography findings until diagnosis: A large‐scale multicenter study

Gonda, M., Masuda, A., Kobayashi, T., Iemoto, T., Kakuyama, S., Ezaki, T., Ikegawa, T., Hirata, Y., Tsumura, H., Ogisu, K., et al. (2024) · United European Gastroenterology Journal · doi:10.1002/ueg2.12557 · Cited by 21 · see citing works

Development and validation of a model for predicting the expression of Ki-67 in pancreatic ductal adenocarcinoma with radiological features and dual-energy computed tomography quantitative parameters

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Hidden in plain sight: commonly missed early signs of pancreatic cancer on CT

Ahmed, T. M., Chu, L. C. H., Javed, A. A., Yasrab, M., Blanco, A., Hruban, R. H., Fishman, E. K., & Kawamoto, S. (2024) · Abdominal Radiology · doi:10.1007/s00261-024-04334-4 · Cited by 12 · see citing works

Association of pancreatic atrophy patterns with intraductal extension of early pancreatic ductal adenocarcinoma: a multicenter retrospective study

Miki, M., Masuda, A., Takenaka, M., Shiomi, H., Iemoto, T., Tsumura, H., Tsujimae, M., Toyama, H., Sofue, K., Ueshima, E., et al. (2024) · Journal of Gastroenterology · doi:10.1007/s00535-024-02149-0 · Cited by 11 · see citing works

Suspicious findings observed retrospectively on CT imaging performed before the diagnosis of pancreatic cancer

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Early detection of pancreatic cancer in the era of precision medicine

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Pancreatic duct epithelial malignancy suggested by large focal pancreatic parenchymal atrophy in cystic diseases of the pancreas

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Focal pancreatic parenchymal atrophy could be a precursor of pancreatic cancer

Kikuyama, M., Nakahodo, J., Chiba, K., & Honda, G. (2025) · Pancreatology · doi:10.1016/j.pan.2025.01.003 · Cited by 7 · see citing works

Repeated pancreatic juice cytology via endoscopic nasopancreatic drainage catheter combined with clinical findings improves diagnostic ability for malignant cases of suspected pancreatic cancer with non-identifiable tumors

Satoh, T., Kaneko, J., Nakatani, E., Ishiwatari, H., Sato, J., Ohata, A., Yamada, R. E., Miwata, T., Ishikawa, K., Niiya, F., et al. (2024) · Pancreatology · doi:10.1016/j.pan.2024.11.022 · Cited by 7 · see citing works

Genetic medicine of familial and hereditary pancreatic cancer: Recent update in the era of precision cancer medicine

Matsubayashi, H., Kiyozumi, Y., & Ono, H. (2025) · Journal of Hepato-Biliary-Pancreatic Sciences · doi:10.1002/jhbp.12112 · Cited by 5 · see citing works

ACR Appropriateness Criteria® Screening, Locoregional Assessment, and Surveillance of Pancreatic Ductal Adenocarcinoma: 2025 Update

Fung, A., Zaheer, A., Porter, K. K., Bashir, M. R., Cash, B. D., Chiorean, E. G., Choi, Y., Ejaz, A. M., Gage, K. L., Russo, G. K., et al. (2025) · Journal of the American College of Radiology · doi:10.1016/j.jacr.2025.08.037 · Cited by 4 · see citing works

A Novel Diagnostic Imaging Method for the Early Detection of Pancreatic Cancer

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Pancreatic cancer: Future challenges and new perspectives for an early diagnosis

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Investigating the early diagnosis of pancreatic cancer by surveillance of patients with “K‐sign” of the pancreas by computed tomography: A prospective study

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Perilesional branch duct dilation as a hallmark MRCP feature for differentiating high-grade PanIN from low-grade PanIN

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Gastrointestinal: Pancreatic intra‐epithelial neoplasia from partial parenchymal atrophy

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Pancreatic ductal adenocarcinoma originating from focal pancreatic parenchymal atrophy demonstrated by transabdominal ultrasonography

Sakata, S., Hisa, T., Ito, Y., Nishiyama, S., Kudo, A., Yamada, T., Osera, S., Fukushima, H., Hamura, R., & Shiozawa, S. (2025) · Clinical Journal of Gastroenterology · doi:10.1007/s12328-025-02202-2 · Cited by 1 · see citing works

Extensive high-grade PanIN of the main pancreatic duct requiring total pancreatectomy diagnosed after long-term surveillance

Yaguchi, R., Hamura, R., Kodaira, N., Tsunematsu, M., Shirai, Y., Kudo, A., Nishiyama, S., Sakata, S., Hisa, T., & Abe, K. (2026) · Clinical Journal of Gastroenterology · doi:10.1007/s12328-026-02326-z · Cited by 1 · see citing works

Pancreatic Atrophy: A Narrative Review and Surgical Interpretation

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Early Pancreatic Cancer: Clinical Implications, Workup, and Imaging Findings with Histopathologic Correlation for Personalized Surveillance

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Artificial Intelligence Applications in Pancreatic Cancer Imaging

Ahmed, T. M., Lopez‐Ramirez, F., Fishman, E. K., & Chu, L. C. H. (2024) · Advances in Clinical Radiology · doi:10.1016/j.yacr.2024.04.003 · Cited by 1 · see citing works

Pathology for early diagnosis of pancreatic cancer

Omori, Y., & Furukawa, T. (2024) · Suizo · doi:10.2958/suizo.39.197

Role of endoscopic retrograde cholangiopancreatography in early diagnosis of pancreatic cancer

Ishii, Y., Serikawa, M., Nakamura, S., Ikemoto, J., & Oka, S. (2024) · Suizo · doi:10.2958/suizo.39.247

Minor papilla approach improves technical success of nasopancreatic drainage-based pancreatic juice cytology for early pancreatic cancer diagnosis

Satoh, T., Kawaguchi, S., Takahashi, H., Masui, Y., Matsuda, M., Kawai, A., Endo, S., Kurokami, T., Shirane, N., & Ohno, K. (2025) · Endoscopy International Open · doi:10.1055/a-2631-7957

A case of pancreatic carcinoma in situ detected based on focal pancreatic parenchymal atrophy seen on extracorporeal ultrasound

Kawabata, S., Obane, N., Nishimura, S., YOSHIKAWA, J., TSUMURA, K., SENZAKI, N., TAKUWA, S., TSUTSUMI, N., YOSHINAGA, K., & TSUBOI, H. (2025) · Choonpa Igaku · doi:10.3179/jjmu.jjmu.a.268

Diagnosis and treatment strategies for hereditary pancreatic cancer syndrome

Matsubayashi, H., Morizane, C., Kanai, M., Kiyozumi, Y., & Kitano, M. (2025) · International Journal of Clinical Oncology · doi:10.1007/s10147-025-02905-z

Focal Pancreatic Parenchymal Atrophy in Main Duct Intraductal Papillary Mucinous Neoplasms of the Pancreas

Sumiya, H., Koshita, S., Kanno, Y., Ogawa, T., Kusunose, H., Sakai, T., Oikawa, M., Sawai, T., Noda, Y., & Ito, K. (2025) · Cureus · doi:10.7759/cureus.98506

Response to the letter to the editor regarding “Concealed pancreatic cancer in acute pancreatitis: Early MRCP and EUS surveillance improves prognosis and identifies high-risk patients”

Yamao, K., Takenaka, M., Yoshida, A., Ishikawa, T., Kawashima, H., & Kudo, M. (2025) · Pancreatology · doi:10.1016/j.pan.2025.12.005

Comment on “Focal pancreatic parenchymal atrophy could be a precursor of pancreatic cancer”

Okumura, K. (2025) · Pancreatology · doi:10.1016/j.pan.2025.12.026

Clinical and imaging differences between pancreatic carcinoma in situ and T1a/T1b pancreatic ductal adenocarcinoma

Satoh, T., Kawaguchi, S., Nakatani, E., Takahashi, H., Endo, S., Shirane, N., Kanemoto, H., & Ohno, K. (2026) · Abdominal Radiology · doi:10.1007/s00261-026-05453-w

Characteristics of ill-demarcated small pancreatic ductal adenocarcinoma on MRI: a multi-institutional retrospective cohort study

Takeuchi, S., Fukukura, Y., Fukunaga, T., Sofue, K., Inoue, D., Urase, A., Sano, K., Fujinaga, Y., Fujita, N., Asayama, Y., et al. (2026) · Japanese Journal of Radiology · doi:10.1007/s11604-026-02003-8

Prevalence and Clinical Significance of Abnormal Findings on Pre-Diagnostic Imaging in Pancreatic Ductal Adenocarcinoma

Moy, B. M., Singer, J., Barajas, R., Miller, F. H., & Keswani, R. N. (2026) · Pancreas · doi:10.1097/mpa.0000000000002688

A case of small undifferentiated pancreatic carcinoma detected during follow-up for focal pancreatic parenchymal atrophy with fatty replacement

Agatsuma, N., Minaga, K., Nakayama, R., Ōno, K., Nakano, S., Matsumoto, H., Uenoyama, Y., Yamashita, Y., & Seno, H. (2026) · Clinical Journal of Gastroenterology · doi:10.1007/s12328-026-02368-3

Accurate Imaging Diagnosis of Small Pancreatic Carcinoma/High-Grade Pancreatic Intraepithelial Neoplasia Using Combined Indirect Imaging Findings

Sagami, R., Mizukami, K., Nishikiori, H., Tsuji, H., Sato, T., Azuma, Y., Hiroshima, Y., Tsutsumi, K., Fukuda, M., Ozaka, S., et al. (2026) · Digestion · doi:10.1159/000552273

Focal Pancreatic Parenchymal Atrophy and Delayed Enhancement in Early Pancreatic Ductal Adenocarcinoma: A Narrative Review of Pathologic Basis, Diagnostic Pitfalls, and Evidence Limitations

Okumura, K., Kozaka, K., & Kobayashi, S. (2026) · Digestive Diseases and Sciences · doi:10.1007/s10620-026-10065-x

Unique Stroma of Higher-Grade Pancreatic Intraepithelial Neoplasia: Fibroblastic Cluster Formation and CD36 Downregulation

Aoki, Y., Fukumura, Y., Nakahodo, J., Mezawa, Y., Maimaitiaili, Y., Maimaitituerxun, M., & Yao, T. (2026) · Oncology · doi:10.1159/000553573

Diagnostic Method Advancement to Improve the Prognosis of Pancreatic Ductal Adenocarcinoma

Sapkota, P., Kikuyama, M., & Honda, G. (2026) · Diagnostics · doi:10.3390/diagnostics16142286

Diagnostic value of indirect imaging findings for high-grade pancreatic intraepithelial neoplasia: A multicenter study

Kawamoto, Y., Honda, G., Kikuyama, M., Takayama, Y., Saito, S., Itoh, T., Furukawa, T., Horiguchi, S., Nakahodo, J., Sagami, R., et al. (2026) · Pancreatology · doi:10.1016/j.pan.2026.08.011

Accelerated Pancreatic Volume Loss as a Potential Pre-Diagnostic Imaging Biomarker for Pancreatic Cancer Risk Enrichment: An AI-Assisted Volumetric Study

Nakahodo, J., Ujita, W., Sadato, D., Fukumura, Y., Aoki, Y., Kikuyama, M., Horiguchi, S., Suzuki, M., Chiba, K., Tabata, H., et al. (2026) · Cancers · doi:10.3390/cancers18183062

Focal pancreatic parenchymal atrophy could be a precursor of pancreatic cancer

Kikuyama, M., Nakahodo, J., Chiba, K., & Honda, G. (2025) · Pancreatology · doi:10.1016/j.pan.2025.01.003 · Cited by 7 · see citing works

Focal Parenchymal Atrophy of the Pancreas Is Frequently Observed on Pre-Diagnostic Computed Tomography in Patients with Pancreatic Cancer: A Case-Control Study

Miura, S., Takikawa, T., Kikuta, K., Hamada, S., Kume, K., Yoshida, N., Tanaka, Y., Matsumoto, R., Ikeda, M., Kataoka, F., et al. (2021) · Diagnostics · doi:10.3390/diagnostics11091693 · Cited by 38 · see citing works

Association of pancreatic atrophy patterns with intraductal extension of early pancreatic ductal adenocarcinoma: a multicenter retrospective study

Miki, M., Masuda, A., Takenaka, M., Shiomi, H., Iemoto, T., Tsumura, H., Tsujimae, M., Toyama, H., Sofue, K., Ueshima, E., et al. (2024) · Journal of Gastroenterology · doi:10.1007/s00535-024-02149-0 · Cited by 11 · see citing works

Effectiveness of Focal Pancreatic Parenchymal Atrophy in Diagnosing High-Grade Pancreatic Intraepithelial Neoplasia/Carcinoma in Situ

Kikuyama, M., Nakahodo, J., Honda, G., Horiguchi, S., Suzuki, M., Chiba, K., Tabata, H., Ome, Y., & Kamisawa, T. (2021) · Medical Research Archives · doi:10.18103/mra.v9i8.2522 · Cited by 6 · see citing works

Pancreatic ductal adenocarcinoma originating from focal pancreatic parenchymal atrophy demonstrated by transabdominal ultrasonography

Sakata, S., Hisa, T., Ito, Y., Nishiyama, S., Kudo, A., Yamada, T., Osera, S., Fukushima, H., Hamura, R., & Shiozawa, S. (2025) · Clinical Journal of Gastroenterology · doi:10.1007/s12328-025-02202-2 · Cited by 1 · see citing works