Frequent detection of pancreatic lesions in asymptomatic high-risk individuals
Open accessAbstract
Background & aims The risk of pancreatic cancer is increased in patients with a strong family history of pancreatic cancer or a predisposing germline mutation. Screening can detect curable, noninvasive pancreatic neoplasms, but the optimal imaging approach is not known. We determined the baseline prevalence and characteristics of pancreatic abnormalities using 3 imaging tests to screen asymptomatic, high-risk individuals (HRIs).Methods We screened 225 asymptomatic adult HRIs at 5 academic US medical centers once, using computed tomography (CT), magnetic resonance imaging (MRI), and endoscopic ultrasonography (EUS). We compared results in a blinded, independent fashion.Results Ninety-two of 216 HRIs (42%) were found to have at least 1 pancreatic mass (84 cystic, 3 solid) or a dilated pancreatic duct (n = 5) by any of the imaging modalities. Fifty-one of the 84 HRIs with a cyst (60.7%) had multiple lesions, typically small (mean, 0.55 cm; range, 2-39 mm), in multiple locations. The prevalence of pancreatic lesions increased with age; they were detected in 14% of subjects younger than 50 years old, 34% of subjects 50-59 years old, and 53% of subjects 60-69 years old (P < .0001). CT, MRI, and EUS detected a pancreatic abnormality in 11%, 33.3%, and 42.6% of the HRIs, respectively. Among these abnormalities, proven or suspected neoplasms were identified in 85 HRIs (82 intraductal papillary mucinous neoplasms and 3 pancreatic endocrine tumors). Three of 5 HRIs who underwent pancreatic resection had high-grade dysplasia in less than 3 cm intraductal papillary mucinous neoplasms and in multiple intraepithelial neoplasias.Conclusions Screening of asymptomatic HRIs frequently detects small pancreatic cysts, including curable, noninvasive high-grade neoplasms. EUS and MRI detect pancreatic lesions better than CT.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
MRI is better for pancreatic cyst detection, and EUS is better for solid lesions.
“The question of what imaging modality to use was addressed in part by a comparative study by the Rotterdam group showing that MRI was better for pancreatic cyst detection, and EUS was better for solid lesions.74”
From Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review (2021) · cites this paper as [74]
The Results (Concordance of CT, MRI, and EUS Pancreatic Abnormalities; page unavailable) support the EUS portion: EUS detected three solid nodules missed by MRI. They do not support MRI being better for cyst detection: EUS detected slightly more subcentimeter cysts and more cysts over 1 cm. The Methods describe screening at five US medical centers, not a Rotterdam-group study. (LLM, conf=0.86)
Experimental — accuracy not yet measuredEUS and MRI have higher comparable diagnostic yield in a 3-way blinded comparison of EUS, MRI, and CT.
“A 3-way blinded comparison of EUS, MRI, and CT also showed that EUS and MRI had higher comparable diagnostic yield.75”
From Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review (2021) · cites this paper as [75]
The preference for EUS and MRI/MRCP over CT is based on their superiority at detecting subcentimetre pancreatic cysts and on avoiding ionising radiation.
“The preference for EUS and MRI/MRCP rather than CT is based on their superiority at detecting subcentimetre pancreatic cysts, and avoidance of ionising radiation.”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Tanaka, M., Chari, S. T., Adsay, V. N., Carlos, F.-D., Falconi, M., Shimizu, M., Yamaguchi, K., Yamao, K., & Matsuno, S. (2005) · Pancreatology · doi:10.1159/000090023 · Cited by 2,042 · see citing works
Pancreatitis and the Risk of Pancreatic Cancer
Lowenfels, A. B., Maisonneuve, P., Cavallini, G., Ammann, R., Lankisch, P. G., Andersen, J. R., DiMagno, E. P., Andrén‐Sandberg, Å., & Domellöf, L. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282001 · Cited by 1,753 · see citing works
Very high risk of cancer in familial Peutz–Jeghers syndrome
Giardiello, F. M., Brensinger, J. D., Tersmette, A. C., Goodman, S. N., Petersen, G. M., Booker, S. V., Cruz–Correa, M., & Offerhaus, G. J. A. (2000) · Gastroenterology · doi:10.1053/gast.2000.20228 · Cited by 1,435 · see citing works
Self-citationCancer risks in BRCA2 mutation carriers.
Olsson, H. (1999) · Journal of the National Cancer Institute · doi:10.1093/jnci/91.15.1310 · Cited by 1,404 · see citing works
Cancer Incidence in BRCA1 mutation carriers.
Thompson, D., & Easton, D. (2002) · Journal of the National Cancer Institute · doi:10.1093/jnci/94.18.1358 · Cited by 1,231 · see citing works
Hruban, R. H., Takaori, K., Klimstra, D. S., Adsay, N. V., Albores-Saavedra, J., Biankin, A. V., Biankin, S. A., Compton, C., Fukushima, N., Furukawa, T., et al. (2004) · American Journal of Surgical Pathology · doi:10.1097/01.pas.0000126675.59108.80 · Cited by 1,091 · see citing works
Self-citationIntraductal Papillary Mucinous Neoplasms of the Pancreas: An Updated Experience
Sohn, T., Yeo, C., Cameron, J., Hruban, R., Fukushima, N., Campbell, K., & Lillemoe, K. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000128306.90650.aa · Cited by 915 · see citing works
Self-citationPrevalence of Unsuspected Pancreatic Cysts on MDCT
Laffan, T. A., Horton, K. M., Klein, A. P., Berlanstein, B. P., Siegelman, S. S., Kawamoto, S., Johnson, P. T., Fishman, E. K., & Hruban, R. H. (2008) · American Journal of Roentgenology · doi:10.2214/ajr.07.3340 · Cited by 882 · see citing works
Self-citationExomic Sequencing Identifies <i>PALB2</i> as a Pancreatic Cancer Susceptibility Gene
Jones, S., Hruban, R. H., Kamiyama, M., Borges, M., Zhang, X., Parsons, D. W., Lin, J. C.-H., Palmisano, E., Brune, K., Jaffee, E. M., et al. (2009) · Science · doi:10.1126/science.1171202 · Cited by 826 · see citing works
Self-citationSalvia, R., Castillo, C., Bassi, C., Thayer, S., Falconi, M., Mantovani, W., Pederzoli, P., & Warshaw, A. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000124386.54496.15 · Cited by 783 · see citing works
Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds
Klein, A. P., Brune, K. A., Petersen, G. M., Goggins, M., Tersmette, A. C., Offerhaus, G. J. A., Griffin, C., Cameron, J. L., Yeo, C. J., Kern, S., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3823 · Cited by 678 · see citing works
Self-citationIncreased Risk of Pancreatic Cancer in Melanoma-Prone Kindreds withp16INK4Mutations
Goldstein, A. M., Fraser, M. C., Struewing, J. P., Hussussian, C. J., Ranade, K., Zametkin, D. P., Fontaine, L. S., Organic, S. M., Dracopoli, N. C., Clark, W. H., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199510123331504 · Cited by 620 · see citing works
Risk of Pancreatic Cancer in Families With Lynch Syndrome
Kastrinos, F. (2009) · JAMA · doi:10.1001/jama.2009.1529 · Cited by 544 · see citing works
High Prevalence of Pancreatic Cysts Detected by Screening Magnetic Resonance Imaging Examinations
de Jong, K., Nio, C. Y., Hermans, J. J., Dijkgraaf, M. G. W., Gouma, D. J., van Eijck, C. H. J., van Heel, E., Klaß, G., Fockens, P., & Bruno, M. J. (2010) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2010.05.017 · Cited by 533 · see citing works
Screening for early pancreatic neoplasia in high-risk individuals: a prospective controlled study
Canto, M. I., Goggins, M., Hruban, R. H., Petersen, G. M., Giardiello, F. M., Yeo, C., Fishman, E. K., Brune, K., Axilbund, J., Griffin, C., et al. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.02.005 · Cited by 524 · see citing works
Self-citationBRCA2 germline mutations in familial pancreatic carcinoma
Hahn, S. A., Greenhalf, B., Ellis, I., Sina-Frey, M., Rieder, H., Korte, B., Gerdes, B., Kress, R., Ziegler, A., Raeburn, J. A., et al. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/95.3.214 · Cited by 480 · see citing works
Screening for pancreatic neoplasia in high-risk individuals: an EUS-based approach
Canto, M. I., Goggins, M., Yeo, C. J., Griffin, C., Axilbund, J. E., Brune, K., Ali, S. Z., Jagannath, S., Petersen, G. M., Fishman, E. K., et al. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00244-7 · Cited by 448 · see citing works
Self-citationAnalysis of small cystic lesions of the pancreas
Kimura, W., Nagai, H., Kuroda, A., Muto, T., & Esaki, Y. (1995) · International Journal of Pancreatology · doi:10.1007/bf02784942 · Cited by 419 · see citing works
Cancer risks in BRCA2 families: estimates for sites other than breast and ovary
van Asperen, C. J., Brohet, R. M., Meijers-Heijboer, E. J., Hoogerbrugge, N., Verhoef, S., Vasen, H. F. A., Ausems, M. G. E. M., Menko, F. H., Gómez-García, E. B., Klijn, J. G. M., et al. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2004.028829 · Cited by 419 · see citing works
Brentnall, T. A., Bronner, M. P., Byrd, D. R., Haggitt, R. C., & Kimmey, M. B. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-131-4-199908170-00003 · Cited by 391 · see citing works
Hruban, R. H., Pitman, M. B., & Klimstra, D. S. (2007) · American Registry of PathologyWashington, DC eBooks · doi:10.55418/9781933477022 · Cited by 371 · see citing works
Self-citation(2006) · PubMed · Cited by 347 · see citing works
Self-citationSahai, A. V., Zimmerman, M., Aabakken, L., Tarnasky, P. R., Cunningham, J. T., Velse, A. V., Hawes, R. H., & Hoffman, B. J. (1998) · Gastrointestinal Endoscopy · doi:10.1016/s0016-5107(98)70123-3 · Cited by 316 · see citing works
PALB2 mutations in European familial pancreatic cancer families
Slater, E., Langer, P., Niemczyk, E., Strauch, K., Butler, J., Habbe, N., Neoptolemos, J., Greenhalf, W., & Bartsch, D. (2010) · Clinical Genetics · doi:10.1111/j.1399-0004.2010.01425.x · Cited by 278 · see citing works
The Prevalence of BRCA2 Mutations in Familial Pancreatic Cancer
Couch, F. J., Johnson, M. R., Rabe, K. G., Brune, K. A., de Andrade, M., Goggins, M., Rothenmund, H., Gallinger, S., Klein, A. P., Petersen, G. M., et al. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0783 · Cited by 273 · see citing works
Self-citationPoley, J. W., Kluijt, I., Gouma, D. J., Harinck, F., Wagner, A., Aalfs, C., van Eijck, C. H. J., Cats, A., Kuipers, E. J., Nio, Y., et al. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.276 · Cited by 257 · see citing works
Importance of Age of Onset in Pancreatic Cancer Kindreds
Brune, K. A., Lau, B., Palmisano, E., Canto, M., Goggins, M. G., Hruban, R. H., & Klein, A. P. (2010) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djp466 · Cited by 257 · see citing works
Self-citationLanger, P., Kann, P. H., Fendrich, V., Habbe, N., Schneider, M., Sina‐Frey, M., Slater, E. P., Heverhagen, J. T., Gress, T. M., Rothmund, Μ., et al. (2009) · Gut · doi:10.1136/gut.2008.171611 · Cited by 249 · see citing works
Lal, G., Liu, G., Schmocker, B., Kaurah, P., Özçelik, H., Narod, S. A., Redston, M. S., & Gallinger, S. (2000) · PubMed · Cited by 233 · see citing works
Increased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients
Shi, C., Klein, A. P., Goggins, M., Maitra, A., Canto, M. I., Ali, S. Z., Schulick, R. D., Palmisano, E., & Hruban, R. H. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0004 · Cited by 210 · see citing works
Self-citationVerna, E. C., Hwang, C., Stevens, P. D., Rotterdam, H., Stavropoulos, S. N., Sy, C. D., Prince, M. A., Chung, W. K., Fine, R. L., Chabot, J. A., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-3209 · Cited by 201 · see citing works
Tischkowitz, M. D., Sabbaghian, N., Hamel, N., Borgida, A., Rosner, C., Taherian, N., Srivastava, A., Holter, S., Rothenmund, H., Ghadirian, P., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.06.055 · Cited by 187 · see citing works
Feasibility and Yield of Screening in Relatives From Familial Pancreatic Cancer Families
Ludwig, E., Olson, S. H., Bayuga, S., Simon, J. A., Schattner, M. A., Gerdes, H., Allen, P. J., Jarnagin, W. R., & Kurtz, R. C. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.65 · Cited by 165 · see citing works
Vasen, H. F. A., Wasser, M., van Mil, A., Tollenaar, R. A., Konstantinovski, M., Gruis, N. A., Bergman, W., Hes, F. J., Hommes, D. W., Offerhaus, G. J. A., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.11.048 · Cited by 152 · see citing works
Pancreatic Cancer Genetic Epidemiology Consortium
Petersen, G. M., de Andrade, M., Goggins, M., Hruban, R. H., Bondy, M. L., Korczak, J. F., Gallinger, S., Lynch, H. T., Syngal, S., Rabe, K. G., et al. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0734 · Cited by 141 · see citing works
Self-citationHollerbach, S., Klamann, A., Topalidis, T., & Schmiegel, W. (2001) · Endoscopy · doi:10.1055/s-2001-17337 · Cited by 130 · see citing works
The prognosis of intraductal papillary mucinous tumors of the pancreas.
Yamao, K., Ohashi, K., Nakamura, T., Suzuki, T., Shimizu, Y., Nakamura, Y., Horibe, Y., Yanagisawa, A., Nakao, A., Nimuara, Y., et al. (2000) · PubMed · Cited by 100 · see citing works
Flagged first, then by citations
1 of the 38 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- [16]Slater EP Langer P Niemczyk E Strauch K Butler J Habbe N Neoptolemos J Greenhalf W Bartsch DK PALB2 mutations in European familial pancreatic cancer families. Clin Genet 20412113
- [28]Canto MI Goggins M Yeo CJ Griffin C Axilbund JE Brune K Ali SZ Jagannath S Petersen GM Fishman EK Piantadosi S Giardiello FM Hruban RH Screening for pancreatic neoplasia in high-risk individuals: an EUS-based approach. Clin Gastroenterol Hepatol 2004 2 606 21 15224285
- [29]Poley JW Kluijt I Gouma DJ Harinck F Wagner A Aalfs C van Eijck CH Cats A Kuipers EJ Nio Y Fockens P Bruno MJ The yield of first-time endoscopic ultrasonography in screening individuals at a high risk of developing pancreatic cancer. Am J Gastroenterol 2009 104 2175 81 19491823
- [31]Vasen HF Wasser M van Mil A Tollenaar RA Konstantinovski M Gruis NA Bergman W Hes FJ Hommes DW Offerhaus GJ Morreau H Bonsing BA de Vos tot Nederveen Cappel WH Magnetic resonance imaging surveillance detects early-stage pancreatic cancer in carriers of a p16-Leiden mutation. Gastroenterology 2011 140 850 6 21129377
Cited by
Sorted by citations
Ryan, D. P., Hong, T. S., & Bardeesy, N. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1404198 · Cited by 2,348 · see citing works
Mizrahi, J. D., Surana, R., Valle, J. W., & Shroff, R. T. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30974-0 · Cited by 2,559 · see citing works
Syngal, S., Brand, R. E., Church, J. M., Giardiello, F. M., Hampel, H. L., & Burt, R. W. (2015) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.435 · Cited by 1,662 · see citing works
Self-citationPancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors
Klein, A. P. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00457-x · Cited by 1,258 · see citing works
Self-citationLin, J. S., Bowles, E. J. A., Williams, S. B., & Morrison, C. C. (2017) · JAMA · doi:10.1001/jama.2017.0562 · Cited by 1,082 · see citing works
Recent progress in pancreatic cancer
Wolfgang, C. L., Herman, J. M., Laheru, D. A., Klein, A. P., Erdek, M. A., Fishman, E. K., & Hruban, R. H. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21190 · Cited by 918 · see citing works
Self-citationEarly Detection of Pancreatic Cancer: Opportunities and Challenges
Singhi, A. D., Koay, E. J., Chari, S. T., & Maitra, A. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.01.259 · Cited by 841 · see citing works
Canto, M. I., Harinck, F., Hruban, R. H., Offerhaus, G. J., Poley, J.-W., Kamel, I., Nio, Y., Schulick, R. S., Bassi, C., Kluijt, I., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303108 · Cited by 784 · see citing works
Self-citationThe role of stroma in pancreatic cancer: Diagnostic and therapeutic implications
Erkan, M., Hausmann, S., Michalski, C. W., Fingerle, A. A., Dobritz, M., Kleeff, J., & Friess, H. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.115 · Cited by 662 · see citing works
Goggins, M., Overbeek, K. A., Brand, R., Syngal, S., Del Chiaro, M., Bartsch, D. K., Bassi, C., Carrato, A., Farrell, J., Fishman, E. K., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-319352 · Cited by 659 · see citing works
Self-citationHu, C., Hart, S. N., Polley, E. C., Gnanaolivu, R., Shimelis, H., Lee, K. Y., Lilyquist, J., Na, J., Moore, R., Antwi, S. O., et al. (2018) · JAMA · doi:10.1001/jama.2018.6228 · Cited by 577 · see citing works
Self-citationOhtsuka, T., Castillo, C. F. F.-D., Furukawa, T., Hijioka, S., Jang, J., Lennon, A. M., Miyasaka, Y., Ohno, E., Salvia, R., Wolfgang, C. L., et al. (2023) · Pancreatology · doi:10.1016/j.pan.2023.12.009 · Cited by 549 · see citing works
Stoffel, E. M., Brand, R. E., & Goggins, M. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.02.012 · Cited by 540 · see citing works
Self-citationCancers associated with BRCA 1 and BRCA 2 mutations other than breast and ovarian
Mersch, J. A., Jackson, M., Park, M., Nebgen, D. R., Peterson, S. K., Singletary, C. N., Arun, B., & Litton, J. K. (2014) · Cancer · doi:10.1002/cncr.29041 · Cited by 513 · see citing works
Daly, M. B., Pilarski, R., Yurgelun, M. B. B., Berry, M. P., Buys, S. S., Dickson, P., Domchek, S. M., Elkhanany, A. M., Friedman, S., Garber, J. E., et al. (2020) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2020.0017 · Cited by 512 · see citing works
Self-citationDeleterious Germline Mutations in Patients With Apparently Sporadic Pancreatic Adenocarcinoma
Shindo, K., Yu, J., Suenaga, M., Fesharakizadeh, S., Cho, C., Macgregor-Das, A., Siddiqui, A., Witmer, P. D., Tamura, K., Song, T. J., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2017.72.3502 · Cited by 458 · see citing works
Self-citationAdvances in the epidemiology of pancreatic cancer: Trends, risk factors, screening, and prognosis
Cai, J., Chen, H., Lu, M., Zhang, Y., Lu, B., You, L., Zhang, T., Dai, M., & Zhao, Y. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.06.027 · Cited by 475 · see citing works
Kromrey, M., Bülow, R., Hübner, J., Paperlein, C., Lerch, M. M., Ittermann, T., Völzke, H., Mayerle, J. V., & Kühn, J. (2017) · Gut · doi:10.1136/gutjnl-2016-313127 · Cited by 433 · see citing works
US Preventive Services Task Force, Owens, D. K., Davidson, K. W., Krist, A. H., Barry, M. J., Cabana, M., Caughey, A. B., Curry, S. J., Doubeni, C. A., Epling, J. W., et al. (2019) · JAMA · doi:10.1001/jama.2019.10232 · Cited by 419 · see citing works
Canto, M. I., Almario, J. A., Schulick, R. D., Yeo, C. J., Klein, A., Blackford, A., Shin, E. J., Sanyal, A., Yenokyan, G., Lennon, A. M., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.05.035 · Cited by 414 · see citing works
Self-citationBernard, V., Semaan, A., Huang, J. H., Lucas, F. A. S., Mulu, F. C., Stephens, B. M., Guerrero, P. A., Huang, Y., Zhao, J., Kamyabi, N., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1955 · Cited by 387 · see citing works
Scheiman, J. M., Hwang, J. H., & Moayyedi, P. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.01.014 · Cited by 437 · see citing works
Improvement of surgical results for pancreatic cancer
Hartwig, W., Werner, J., Jäger, D., Debus, J., & Büchler, M. W. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70172-4 · Cited by 368 · see citing works
Early screening and diagnosis strategies of pancreatic cancer: a comprehensive review
Yang, J., Xu, R., Wang, C., Qiu, J., Ren, B., & You, L. (2021) · Cancer Communications · doi:10.1002/cac2.12204 · Cited by 379 · see citing works
CA 19-9: Biochemical and Clinical Aspects
Scarà, S., Bottoni, P., & Scatena, R. (2015) · Advances in Experimental Medicine and Biology · doi:10.1007/978-94-017-7215-0_15 · Cited by 351 · see citing works
Vasen, H., Ibrahim, I., Ponce, C. G., Slater, E. P., Matthäi, E., Carrato, A., Earl, J., Robbers, K., van Mil, A. M., Potjer, T., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2015.64.0730 · Cited by 344 · see citing works
Management of Incidental Pancreatic Cysts: A White Paper of the ACR Incidental Findings Committee
Megibow, A. J., Baker, M. E., Morgan, D. E., Kamel, I. R., Sahani, D. V., Newman, E., Brugge, W. R., Berland, L. L., & Pandharipande, P. V. (2017) · Journal of the American College of Radiology · doi:10.1016/j.jacr.2017.03.010 · Cited by 343 · see citing works
Self-citationPancreatic cancer: why is it so hard to treat?
Oberstein, P. E., & Olive, K. P. (2013) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x13478680 · Cited by 334 · see citing works
Cancer overdiagnosis: a biological challenge and clinical dilemma
Srivastava, S., Koay, E. J., Borowsky, A. D., Marzo, A. M. D., Ghosh, S., Wagner, P. D., & Kramer, B. S. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0142-8 · Cited by 339 · see citing works
Pancreatic ductal adenocarcinoma: Risk factors, screening, and early detection
Becker, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i32.11182 · Cited by 331 · see citing works
Diagnosis and Detection of Pancreatic Cancer
Chu, L. C. H., Goggins, M., & Fishman, E. K. (2017) · The Cancer Journal · doi:10.1097/ppo.0000000000000290 · Cited by 297 · see citing works
Self-citationLi, A., Yu, J., Kim, H., Wolfgang, C. L., Canto, M. I., Hruban, R. H., & Goggins, M. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3092 · Cited by 295 · see citing works
Self-citationImpact of endoscopic ultrasonography on diagnosis of pancreatic cancer
Kitano, M., Yoshida, T., Itonaga, M., Tamura, T., Hatamaru, K., & Yamashita, Y. (2019) · Journal of Gastroenterology · doi:10.1007/s00535-018-1519-2 · Cited by 316 · see citing works
Multicenter study of early pancreatic cancer in Japan
Kanno, A., Masamune, A., Hanada, K., Maguchi, H., Shimizu, Y., Ueki, T., Hasebe, O., Ohtsuka, T., Nakamura, M., Takenaka, M., et al. (2018) · Pancreatology · doi:10.1016/j.pan.2017.11.007 · Cited by 291 · see citing works
Li-Fraumeni syndrome: cancer risk assessment and clinical management
McBride, K. A., Ballinger, M. L., Killick, E., Kirk, J., Tattersall, M. H. N., Eeles, R. A., Thomas, D. M., & Mitchell, G. (2014) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.41 · Cited by 279 · see citing works
Lennon, A. M., Wolfgang, C. L., Canto, M. I., Klein, A. P., Herman, J. M., Goggins, M., Fishman, E. K., Kamel, I. R., Weiss, M. J., Diaz, L. A., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0734 · Cited by 263 · see citing works
Self-citationYurgelun, M. B., Chittenden, A. B., Morales-Oyarvide, V., Rubinson, D. A., Dunne, R. F., Kozak, M. M., Qian, Z. R., Welch, M. W., Brais, L. K., Da Silva, A., et al. (2019) · Genetics in Medicine · doi:10.1038/s41436-018-0009-5 · Cited by 217 · see citing works
Self-citationTime to progression of pancreatic ductal adenocarcinoma from low-to-high tumour stages
Yu, J., Blackford, A. L., dal Molin, M., Wolfgang, C. L., & Goggins, M. (2015) · Gut · doi:10.1136/gutjnl-2014-308653 · Cited by 224 · see citing works
Self-citationPancreatic Cystic Neoplasms: Management and Unanswered Questions
Farrell, J. J., & Castillo, C. F. F.-D. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.073 · Cited by 223 · see citing works
Self-citationEarly detection of pancreatic cancer: Where are we now and where are we going?
Zhou, B., Xu, J., Cheng, Y., Gao, J., Hu, S., Wang, L., & Zhan, H. (2017) · International Journal of Cancer · doi:10.1002/ijc.30670 · Cited by 209 · see citing works
Boursi, B., Finkelman, B., Giantonio, B. J., Haynes, K., Rustgi, A. K., Rhim, A. D., Mamtani, R., & Yang, Y.-X. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.11.046 · Cited by 202 · see citing works
Farrell, J. J. (2015) · Gut and Liver · doi:10.5009/gnl15063 · Cited by 197 · see citing works
Self-citationSăftoiu, A., Hassan, C., Areia, M., Bhutani, M., Bisschops, R., Bories, E., Cazacu, I., Dekker, E., Deprez, P., Pereira, S., et al. (2020) · Endoscopy · doi:10.1055/a-1104-5245 · Cited by 187 · see citing works
Evolution and dynamics of pancreatic cancer progression
Yachida, S., & Iacobuzio–Donahue, C. A. (2013) · Oncogene · doi:10.1038/onc.2013.29 · Cited by 185 · see citing works
Singhi, A. D., Zeh, H. J., Brand, R. E., Nikiforova, M. N., Chennat, J. S., Fasanella, K. E., Khalid, A., Papachristou, G. I., Slivka, A., Hogg, M. E., et al. (2015) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2015.12.009 · Cited by 177 · see citing works
Pancreatic Cancer Surveillance and Survival of High-Risk Individuals
Blackford, A. L., Canto, M. I., Dbouk, M. H., Hruban, R. H., Katona, B. W., Chak, A., Brand, R. E., Syngal, S., Farrell, J. J., Kastrinos, F., et al. (2024) · JAMA Oncology · doi:10.1001/jamaoncol.2024.1930 · Cited by 178 · see citing works
Self-citationKanda, M., Knight, S., Topazian, M. D., Syngal, S., Farrell, J. J., Lee, J. D., Kamel, I. R., Lennon, A. M., Borges, M. W., Young, A., et al. (2012) · Gut · doi:10.1136/gutjnl-2012-302823 · Cited by 170 · see citing works
Self-citationYu, J., Sadakari, Y., Shindo, K., Suenaga, M., Brant, A., Almario, J. A. N., Borges, M., Barkley, T., Fesharakizadeh, S., Ford, M., et al. (2017) · Gut · doi:10.1136/gutjnl-2015-311166 · Cited by 164 · see citing works
Self-citationLong-term yield of pancreatic cancer surveillance in high-risk individuals
Overbeek, K. A., Levink, I. J. M., Koopmann, B. D. M., Harinck, F., Konings, I. C. A. W., Ausems, M. G. E. M., Wagner, A., Fockens, P., van Eijck, C. H., Groot Koerkamp, B., et al. (2022) · Gut · doi:10.1136/gutjnl-2020-323611 · Cited by 164 · see citing works
Harinck, F., Konings, I. C. A. W., Kluijt, I., Poley, J. W., van Hooft, J. E., van Dullemen, H. M., Nio, C. Y., Krak, N. C., Hermans, J. J., Aalfs, C. M., et al. (2016) · Gut · doi:10.1136/gutjnl-2014-308008 · Cited by 185 · see citing works
Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review
Kenner, B., Chari, S. T., Kelsen, D., Klimstra, D. S., Pandol, S. J., Rosenthal, M., Rustgi, A. K., Taylor, J. A., Yala, A., Abul-Husn, N., et al. (2021) · Pancreas · doi:10.1097/mpa.0000000000001762 · Cited by 158 · see citing works
Self-citationKanda, M., Sadakari, Y., Borges, M., Topazian, M., Farrell, J., Syngal, S., Lee, J., Kamel, I., Lennon, A. M., Knight, S., et al. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.11.016 · Cited by 181 · see citing works
Self-citationFamilial pancreatic cancer—current knowledge
Bartsch, D. K., Gress, T. M., & Langer, P. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.111 · Cited by 151 · see citing works
Fibrosis imaging: Current concepts and future directions
Baues, M., Dasgupta, A., Ehling, J., Prakash, J., Boor, P., Tacke, F., Kiessling, F. M., & Lammers, T. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.10.013 · Cited by 151 · see citing works
Henrikson, N. B., Aiello Bowles, E. J., Blasi, P. R., Morrison, C. C., Nguyen, M., Pillarisetty, V. G., & Lin, J. S. (2019) · JAMA · doi:10.1001/jama.2019.6190 · Cited by 140 · see citing works
The Management of Peutz–Jeghers Syndrome: European Hereditary Tumour Group (EHTG) Guideline
Wagner, A., Aretz, S., Auranen, A., Bruno, M. J., Cavestro, G. M., Crosbie, E. J., Goverde, A., Jelsig, A. M., Latchford, A. R., van Leerdam, M. E., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030473 · Cited by 151 · see citing works
Pancreatic Cyst Prevalence and the Risk of Mucin-Producing Adenocarcinoma in US Adults
Gardner, T. B., Glass, L. M., Smith, K. D., Ripple, G. H., Barth, R. J., Klibansky, D. A., Colacchio, T. A., Tsapakos, M. J., Suriawinata, A. A., Tsongalis, G. J., et al. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.103 · Cited by 140 · see citing works
Identifying people at a high risk of developing pancreatic cancer
Klein, A. P. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3420 · Cited by 136 · see citing works
Self-citationEarly detection and prevention of pancreatic cancer: Is it really possible today?
Chiaro, M. D. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i34.12118 · Cited by 135 · see citing works
Capurso, G., Boccia, S., Salvia, R., Chiaro, M. D., Frulloni, L., Arcidiacono, P. G., Zerbi, A., Manta, R., Fabbri, C., Ventrucci, M., et al. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.42 · Cited by 130 · see citing works
Therapeutic options for the management of pancreatic cancer
Rossi, M. L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i32.11142 · Cited by 129 · see citing works
Pancreatic cancer in 2021: What you need to know to win
Tonini, V., & Zanni, M. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i35.5851 · Cited by 126 · see citing works
Pancreatic cancer surgery: past, present, and future.
Griffin, J. F., Poruk, K. E., & Wolfgang, C. L. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.1000-9604.2015.06.07 · Cited by 123 · see citing works
Diagnostic strategies for early pancreatic cancer
Hanada, K., Okazaki, A., Hirano, N., Izumi, Y., Teraoka, Y., Ikemoto, J., Kanemitsu, K., Hino, F., Fukuda, T., & Yonehara, S. (2015) · Journal of Gastroenterology · doi:10.1007/s00535-014-1026-z · Cited by 121 · see citing works
The role of endoscopy in the evaluation and management of patients with solid pancreatic neoplasia
Eloubeidi, M. A., Decker, G. A., Chandrasekhara, V., Chathadi, K. V., Early, D. S., Evans, J. A., Fanelli, R. D., Fisher, D. A., Foley, K., Hwang, J. H., et al. (2016) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2015.09.009 · Cited by 146 · see citing works
Self-citationTonozuka, R., Itoi, T., Nagata, N., Kojima, H., Sofuni, A., Tsuchiya, T., Ishii, K., Tanaka, R., Nagakawa, Y., & Mukai, S. (2021) · Journal of Hepato-Biliary-Pancreatic Sciences · doi:10.1002/jhbp.825 · Cited by 129 · see citing works
A Multidisciplinary Approach to Pancreas Cancer in 2016: A Review
Fogel, E. L., Shahda, S., Sandrasegaran, K., DeWitt, J. M., Easler, J. J., Agarwal, D. M., Eagleson, M. A., Zyromski, N. J., House, M. G., Ellsworth, S. G., et al. (2017) · The American Journal of Gastroenterology · doi:10.1038/ajg.2016.610 · Cited by 120 · see citing works
Korsse, S. E., Harinck, F., van Lier, M. G., Biermann, K., Offerhaus, G. J. A., Krak, N. C., Looman, C. W. N., van Veelen, W., Kuipers, E. J., Wagner, A., et al. (2012) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2012-101277 · Cited by 118 · see citing works
Management of Biliary Strictures: State-of-the-Art Review
Kapoor, B. S., Mauri, G., & Lorenz, J. M. (2018) · Radiology · doi:10.1148/radiol.2018172424 · Cited by 117 · see citing works
Overbeek, K. A., Goggins, M. G., Dbouk, M., Levink, I. J. M., Koopmann, B. D. M., Chuidian, M., Konings, I. C. A. W., Paiella, S., Earl, J., Fockens, P., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2021.10.014 · Cited by 114 · see citing works
Self-citationCorral, J. E., Mareth, K. F., Riegert-Johnson, D. L., Das, A., & Wallace, M. B. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.04.065 · Cited by 113 · see citing works
Zhang, J., Zhu, L., Yao, L., Ding, X., Chen, D., Wu, H., Lu, Z., Zhou, W., Zhang, L., An, P., et al. (2020) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2020.04.071 · Cited by 110 · see citing works
Familial pancreatic cancer: Concept, management and issues
Matsubayashi, H., Takaori, K., Morizane, C., Maguchi, H., Mizuma, M., Takahashi, H., Wada, K., Hosoi, H., Yachida, S., Suzuki, M., et al. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i6.935 · Cited by 109 · see citing works
A sustainable approach to universal metabolic cancer diagnosis
Wang, R., Yang, S., Wang, M., Zhou, Y., Li, X., Chen, W., Liu, W., Huang, Y., Wu, J., Cao, J., et al. (2024) · Nature Sustainability · doi:10.1038/s41893-024-01323-9 · Cited by 109 · see citing works
Inherited pancreatic cancer syndromes
Solomon, S., Das, S., Brand, R., & Whitcomb, D. C. (2012) · The Cancer Journal · doi:10.1097/ppo.0b013e318278c4a6 · Cited by 120 · see citing works
Abe, T., Blackford, A. L., Tamura, K., Ford, M., McCormick, P., Chuidian, M., Almario, J. A., Borges, M., Lennon, A. M., Shin, E. J., et al. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.18.01512 · Cited by 102 · see citing works
Self-citationFamilial pancreatic cancer: genetic advancesPreprint
Rustgi, A. K. (2014) · Genes & Development · doi:10.1101/gad.228452.113 · Cited by 101 · see citing works
Force-dependent breaching of the basement membrane
Chang, T. T., Thakar, D., & Weaver, V. M. (2016) · Matrix Biology · doi:10.1016/j.matbio.2016.12.005 · Cited by 100 · see citing works
Elevated Polyamines in Saliva of Pancreatic Cancer
Asai, Y., Itoi, T., Sugimoto, M., Sofuni, A., Tsuchiya, T., Tanaka, R., Tonozuka, R., Honjo, M., Mukai, S., Fujita, M., et al. (2018) · Cancers · doi:10.3390/cancers10020043 · Cited by 100 · see citing works
Partyka, O., Pajewska, M., Kwaśniewska, D., Czerw, A. I., Deptała, A., Budzik, M. P., Cipora, E., Gąska, I., Gazdowicz, L., Mielnik, A., et al. (2023) · Cancers · doi:10.3390/cancers15143634 · Cited by 103 · see citing works
Intraductal Neoplasms of the Pancreas
Furukawa, T. (2022) · Springer eBooks · doi:10.1007/978-981-19-0063-1_10 · Cited by 97 · see citing works
Chiaro, M. D., Verbeke, C. S., Kartalis, N., Mucelli, R. P., Gustafsson, P., Hansson, J., Haas, S., Segersvärd, R., Andrén‐Sandberg, Å., & Löhr, M. J. (2015) · JAMA Surgery · doi:10.1001/jamasurg.2014.3852 · Cited by 92 · see citing works
Fischer, C. G., & Wood, L. D. (2018) · The Journal of Pathology · doi:10.1002/path.5154 · Cited by 92 · see citing works
Genetics of familial and sporadic pancreatic cancer
Wood, L. D., Yurgelun, M. B., & Goggins, M. G. (2019) · Gastroenterology · doi:10.1053/j.gastro.2018.12.039 · Cited by 91 · see citing works
Self-citationWong, J., Weber, J., Centeno, B. A., Vignesh, S., Harris, C. L., Klapman, J. B., & Hodul, P. (2012) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-012-2017-0 · Cited by 90 · see citing works
Krishna, S., Rao, B., Ugbarugba, E. E., Shah, Z., Blaszczak, A. M., Hinton, A., Conwell, D., & Hart, P. (2017) · Surgical Endoscopy · doi:10.1007/s00464-017-5516-y · Cited by 69 · see citing works
Screening for pancreatic cancer in familial high-risk individuals: A systematic review
Lu, C. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i28.8678 · Cited by 86 · see citing works
Kim, H., Saka, B., Knight, S., Borges, M. W., Childs, E. J., Klein, A. P., Wolfgang, C. L., Herman, J. M., Adsay, V. N., Hruban, R. H., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1239 · Cited by 85 · see citing works
Self-citationWong, J. Y., Weber, J., Centeno, B. A., Vignesh, S., Harris, C. L., Klapman, J. B., & Hodul, P. J. (2012) · Gastroenterology · doi:10.1016/s0016-5085(12)63985-7 · Cited by 85 · see citing works
Comparison of Society Guidelines for the Management and Surveillance of Pancreatic Cysts
Aziz, H., Acher, A. W., Krishna, S. G., Cloyd, J. M., & Pawlik, T. M. (2022) · JAMA Surgery · doi:10.1001/jamasurg.2022.2232 · Cited by 86 · see citing works
Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma
Neeße, A., Gress, T. M., Tuveson, D. A., Michl, P., & Krug, S. (2013) · OncoTargets and Therapy · doi:10.2147/ott.s38111 · Cited by 85 · see citing works
Yabar, C. S., & Winter, J. M. (2016) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2016.04.003 · Cited by 84 · see citing works
Slater, E. P., Strauch, K., Rospleszcz, S., Ramaswamy, A., Esposito, I., Klöppel, G., Matthäi, E., Heeger, K., Fendrich, V., Langer, P., et al. (2014) · Translational Oncology · doi:10.1016/j.tranon.2014.05.007 · Cited by 83 · see citing works
Eshleman, J. R., Norris, A. L., Sadakari, Y., Debeljak, M., Borges, M. W., Harrington, C. T., Lin, E. I., Brant, A., Barkley, T., Almario, J. A., et al. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.11.028 · Cited by 82 · see citing works
Self-citationCanto, M. I., Kerdsirichairat, T., Yeo, C. J., Hruban, R. H., Shin, E. J., Almario, J. A., Blackford, A. L., Ford, M., Klein, A. P., Javed, A. A., et al. (2019) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-019-04230-z · Cited by 82 · see citing works
Self-citationToshima, F., Watanabe, R., Inoue, D., Yoneda, N., Yamamoto, T., Sasahira, N., Sasaki, T., Matsuyama, M., Minehiro, K., Tateishi, U., et al. (2021) · American Journal of Roentgenology · doi:10.2214/ajr.21.26014 · Cited by 81 · see citing works
Precancerous lesions of the pancreas
Zamboni, G., Hirabayashi, K., Castelli, P., & Lennon, A. M. (2013) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2013.04.001 · Cited by 81 · see citing works
Suenaga, M., Yu, J., Shindo, K., Tamura, K., Almario, J. A., Zaykoski, C., Witmer, P. D., Fesharakizadeh, S., Borges, M., Lennon, A.-M., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2463 · Cited by 81 · see citing works
Self-citationStatin Use and Risk of Pancreatic Cancer
Zhang, Y., Liang, M., Sun, C., Qu, G., Shi, T., Min, M., Wu, Y., & Sun, Y. (2019) · Pancreas · doi:10.1097/mpa.0000000000001226 · Cited by 81 · see citing works
Endoscopic ultrasound (EUS) and the management of pancreatic cancer
Yousaf, M. N., Chaudhary, F. S., Ehsan, A., Suarez, A. L., Muniraj, T., Jamidar, P. A., Aslanian, H. R., & Farrell, J. J. (2020) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2020-000408 · Cited by 81 · see citing works
Self-citation
- Authors
- Canto, M. I., Hruban, R. H., Fishman, E. K., Kamel, I. R., Schulick, R., Zhang, Z., Topazian, M., Takahashi, N., Fletcher, J., Petersen, G., Klein, A. P., Axilbund, J., Griffin, C., Syngal, S., Saltzman, J. R., Mortele, K. J., Lee, J., Tamm, E., Vikram, R., Bhosale, P., Margolis, D., Farrell, J., & Goggins, M.
- Affiliations
- Johns Hopkins University (US)
- Mayo Clinic (US)
- Brigham and Women's Hospital (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of California, Los Angeles (US)
- Corresponding author
- Canto, Marcia Irene
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 142
- Issue
- 4
- Pages
- 796-804
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC3321068
- OpenAlex
- W2055276888
- Cited by
- 648
- References
- 38
- Citations by year
- 2026: 21 · 2025: 22 · 2024: 42 · 2023: 42 · 2022: 39 · 2021: 47 · 2020: 37 · 2019: 52 · 2018: 55 · 2017: 65 · 2016: 54 · 2015: 63 · 2014: 39 · 2013: 43 · 2012: 27
- FWCI
- 27.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P50 CA62924)
- Lustgarten Foundation
- Olympus
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Keywords
- pancreatic cancer screening, high-risk individuals, pancreatic cysts, intraductal papillary mucinous neoplasm, pancreatic neuroendocrine tumors, pancreatic duct dilatation, endoscopic ultrasound, magnetic resonance imaging, computed tomography, pancreatic neoplasms, familial pancreatic cancer, germline mutations, intraepithelial neoplasia, pancreatic resection
- MeSH terms
- Academic Medical Centers, Aged, Diagnostic Imaging, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Pancreatic Cyst, Pancreatic Neoplasms, Pedigree, Predictive Value of Tests, Prognosis, Prospective Studies, Risk Factors, Tomography, X-Ray Computed, United States, Prevalence, Multivariate Analysis, Chi-Square Distribution, Logistic Models, Risk Assessment, Endosonography, Genetic Predisposition to Disease, Heredity, Asymptomatic Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
