Diffusion tensor imaging comparison of progressive supranuclear palsy and corticobasal syndromes
Abstract
Background Corticobasal syndrome (CBS) and progressive supranuclear palsy syndrome (PSPS) are atypical parkinsonian syndromes that are both associated with white matter tract degeneration. However, little is known about how patterns of degeneration compare across these two syndromes.Methods Twenty-seven subjects, nine with CBS and eighteen with probable or definite PSPS (9 pathologically confirmed) were prospectively recruited and underwent 3.0 T diffusion tensor imaging. A whole-brain voxel-based analysis was performed on fractional anisotropy (FA) and mean diffusivity (MD) images to compare both groups to each other and to 50 healthy controls.Results The two syndromes showed overlapping regions of reduced FA and increased MD in the body of the corpus callosum, middle cingulum bundle, and premotor and prefrontal white matter, with reduced FA also observed in the superior cerebellar peduncles in both syndromes. However, CBS showed a more supratentorial and posterior pattern of degeneration with greater involvement of the splenium of the corpus callosum, premotor, motor and parietal lobes than PSPS. Findings in CBS were also highly asymmetric. Conversely, PSPS showed a more symmetric and infratentorial pattern of degeneration, with greater involvement of the superior cerebellar peduncles and midbrain than CBS.Conclusions CBS and PSPS are both associated with striking white matter tract degeneration. Despite differences in the supratentorial and infratentorial distribution of degeneration, and in asymmetry, both tend to target a common structural network. Measurements of white matter tract diffusion could therefore be useful disease biomarkers in both of these syndromes.
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Subjects with CBS showed alterations in motor/parietal areas.
“Last, for the subjects with CBS, we found alterations in motor/parietal areas (Tovar-Moll et al., 2014; Whitwell et al., 2014)”
From Multiclass characterization of frontotemporal dementia variants via multimodal brain network computational inference (2023) · cites this paper as Whitwell et al., 2014
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Torralva, T., Báez, S., Soriano, F., Cuitiño, M. M., & Manes, F. F. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819641-0.00033-5
Introduction: Types of Parkinson’s Disease
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Diagnostic utility of tectal plate measures in clinical variants of progressive supranuclear palsy
Singh, N. A., Blakey, M., Satoh, R., Ali, F., Pham, N. T. T., Amrami, A., Stephens, Y. C., Dickson, D. W., Josephs, K. A., & Whitwell, J. L. (2025) · Journal of Neurology · doi:10.1007/s00415-025-13256-0
Self-citationAdvances in diffusion MRI in progressive supranuclear palsy
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Multimodel Diffusion MRI Signatures in Atypical Parkinsonian Disorders
Tian, Y.-Q., Ali, F., Machulda, M., Lowe, V., Josephs, K., & Whitwell, J. (2026) · Human Brain Mapping · doi:10.1002/hbm.70616 · Cited by 1 · see citing works
Self-citationDementia and Neurodegenerative Disease
Lee, N., & Roytman, M. (2026) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2026.07.006
- Authors
- Whitwell, J. L., Schwarz, C. G., Reid, R. I., Kantarci, K., Jack, C. R., & Josephs, K. A.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Whitwell, Jennifer L.
- ORCID
- Venue
- Parkinsonism & Related Disorders
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 20
- Issue
- 5
- Pages
- 493-498
- ISSN
- 1353-8020 (ISSN-L)
- OpenAlex
- W1980021480
- Cited by
- 66
- References
- 30
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 4 · 2022: 9 · 2021: 4 · 2020: 5 · 2019: 9 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 6
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Parkinsonism & Related Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Dana Foundation
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- progressive supranuclear palsy, corticobasal syndrome
- MeSH terms
- Aged, Aniline Compounds, Brain, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Supranuclear Palsy, Progressive, Thiazoles, Anisotropy, Neurodegenerative Diseases, Imaging, Three-Dimensional, Positron-Emission Tomography, Diffusion Tensor Imaging, White Matter
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