Morphine withdrawal syndrome: involvement of the dopaminergic system in prepubertal male and female mice
Open accessAbstract
Morphine (MOR) withdrawal signs are more marked in males than in females. Considering that the influence of the dopaminergic system on these differences is unclear, we analyzed dopamine (DA) and dihydroxyphenylacetic-acid (DOPAC) brain levels during naloxone (NAL)-precipitated withdrawal as well as the involvement of D(1) and D(2) receptors in the expression of MOR withdrawal in either sex. Prepubertal Swiss-Webster mice received MOR (2 mg/kg, i.p.) twice daily for 9 days. On the tenth day, dependent animals received NAL (6 mg/kg, i.p.) after MOR and were sacrificed 30 min later. DA and DOPAC concentrations were determined in different brain areas using HPLC with electrochemical detection. Other pool of mice received either a D(1) (SCH 23390; 0.2 mg/kg, i.p.) or D(2) (raclopride; 0.3 mg/kg, i.p.) receptor antagonist before NAL and withdrawal signs were evaluated. DA and DOPAC levels only decreased in striatum and cortex of withdrawn males. Conversely, both DA receptor antagonists decreased the expression of MOR withdrawal signs in either sex. The neurochemical sex differences described here could partially explain the behavioral sex differences observed during MOR withdrawal. Additionally, SCH-23390 and raclopride effects suggest an important role of both DA receptors in the expression of MOR withdrawal in males and females.
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Some physical signs of opioid withdrawal are more pronounced in male mice than in female mice.
“and some physical signs of opioid withdrawal are more pronounced in male mice than in female mice (Diaz et al., 2005).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Diaz et al., 2005
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- Authors
- Diaz, S. L., Kemmling, A. K., Rubio, M. C., & Balerio, G. N.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Balerio, Graciela N.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 82
- Issue
- 4
- Pages
- 601-607
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2162428350
- Cited by
- 34
- References
- 41
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Funders
- Universidad de Buenos Aires
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- morphine withdrawal, dopaminergic system, sex differences, prepubertal mice, dopamine, DOPAC, dopamine D1 receptor, dopamine D2 receptor, naloxone-precipitated withdrawal, striatum, cortex, dopamine antagonists
- MeSH terms
- Animals, Behavior, Animal, Brain, Dopamine, Female, Male, Morphine, Sexual Maturation, Substance Withdrawal Syndrome, Receptors, Dopamine D1, Receptors, Dopamine D2, Mice
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