The cannabinoid CB1 receptor inverse agonist, rimonabant, modifies body weight and adiponectin function in diet-induced obese rats as a consequence of reduced food intake
Open accessAbstract
The cannabinoid CB1 receptor inverse agonist rimonabant induces hypophagia and body weight loss. Reduced body weight may potentially be due to decreased food intake or to direct metabolic effects of drug administration on energy expenditure. This study uses a paired-feeding protocol to quantify the contributions of energy intake to rimonabant-induced body weight loss. Diet-induced obese (DIO) rats were dosed with rimonabant (3, 10 mg/kg PO once daily) and matched with pair-fed controls. Food intake and body weight were measured daily. Blood samples and adipose tissue were collected on day 15 for measurement of plasma adiponectin and adiponectin mRNA levels. DIO rats treated with rimonabant and pair-fed controls showed very similar changes in body weight. Although tolerance developed to the anorectic effect of rimonabant, total food intake was significantly decreased over the 14-day study period and fully accounted for the observed reductions in body weight. Adiponectin mRNA and plasma adiponectin were elevated in vehicle-treated chow-fed animals compared to obese controls, and did not differ between rimonabant-treated and pair-fed animals. The similarities between rimonabant-treated and pair-fed animals in body weight loss and the absence of differences in measures of adiponectin activity between drug-treated and pair-fed animals suggest that the outcomes of this experiment were solely mediated by the drug-induced reduction in food intake.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Intraperitoneal administration of rimonabant reduces food intake and induces neuronal activation in hypothalamic nuclei involved in food intake regulation, such as the paraventricular nucleus.
“For instance, intraperitoneal administration of rimonabant (an antagonist for the cannabinoid receptor CB 1 ) reduces food intake (Thornton-Jones et al., 2006) and induces neuronal activation in several hypothalamic nuclei involved in food intake regulation, such as the paraventricular nucleus (Verty et al., 2009).”
From Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans (2016) · cites this paper as Thornton-Jones et al., 2006
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856 · see citing works
Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., & Tataranni, P. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7463 · Cited by 3,541 · see citing works
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238 · see citing works
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133 · see citing works
AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity
Hu, E., Liang, P., & Spiegelman, B. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10697 · Cited by 2,239 · see citing works
Novel Modulator for Endothelial Adhesion Molecules
Ouchi, N., Kihara, S., Arita, Y., Maeda, K., Kuriyama, H., Okamoto, Y., Hotta, K., Nishida, M., Takahashi, M., Nakamura, T., et al. (1999) · Circulation · doi:10.1161/01.cir.100.25.2473 · Cited by 2,139 · see citing works
Fruebis, J., Tsao, T., Javorschi, S., Ebbets-Reed, D., Erickson, M., Yen, F. T., Bihain, B. E., & Lodish, H. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.2005 · Cited by 1,987 · see citing works
Leptin-regulated endocannabinoids are involved in maintaining food intake
Di Marzo, V., Goparaju, S. K., Wang, L., Liu, J., Bátkai, S., Járai, Z., Fezza, F., Miura, G. I., Palmiter, R. D., Sugiura, T., et al. (2001) · Nature · doi:10.1038/35071088 · Cited by 1,559 · see citing works
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism
Berg, A. H., Combs, T. P., & Scherer, P. E. (2002) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00524-0 · Cited by 1,211 · see citing works
Cota, D., Marsicano, G., Tschöp, M. H., Grübler, Y., Flachskamm, C., Schubert, M. I., Auer, D. P., Yassouridis, A., Thöne‐Reineke, C., Ortmann, S., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17725 · Cited by 1,168 · see citing works
Peirson, S. N. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng073 · Cited by 841 · see citing works
Kirkham, T. C., Williams, C. M., Fezza, F., & Marzo, V. D. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704767 · Cited by 788 · see citing works
Bensaïd, M., Gary‐Bobo, M., Esclangon, A., Maffrand, J., Fur, G. L., Oury-Donat, F., & Soubrié, P. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.4.908 · Cited by 593 · see citing works
Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice
Ravinet‐Trillou, C., Arnone, M., Delgorge, C., Gonalons, N., Keane, P., Maffrand, J., & Soubrié, P. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00545.2002 · Cited by 565 · see citing works
Combs, T. P., Berg, A. H., Rajala, M. W., Klebanov, S., Iyengar, P., Jimenez-Chillaron, J. C., Patti, M. E., Klein, S. L., Weinstein, R. S., & Scherer, P. E. (2003) · Diabetes · doi:10.2337/diabetes.52.2.268 · Cited by 544 · see citing works
Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors
Williams, C. M., & Kirkham, F. J. (1999) · Psychopharmacology · doi:10.1007/s002130050953 · Cited by 508 · see citing works
Appetite suppression and weight loss after the cannabinoid antagonist SR 141716
Colombo, G., Agabio, R., Diaz, G., Lobina, C., Reali, R., & Gessa, G. L. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00322-1 · Cited by 486 · see citing works
Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats
Jamshidi, N., & Taylor, D. A. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704379 · Cited by 466 · see citing works
Rinaldi, M. L., Barth, F., Héaulme, M., Alonso, R., Shire, D. J., Congy, C., Soubrié, P., Brelière, J.-C., & Fur, G. L. (1995) · Life Sciences · doi:10.1016/0024-3205(95)00174-5 · Cited by 303 · see citing works
Adiponectin - Its Role in Metabolism and Beyond
Stefan, N., & Stümvoll, M. (2002) · Hormone and Metabolic Research · doi:10.1055/s-2002-34785 · Cited by 293 · see citing works
Shklyaev, S., Aslanidi, G., Tennant, M., Prima, V., Kohlbrenner, E., Kroutov, V., Campbell‐Thompson, M., Crawford, J. M., Shek, E. W., Scarpace, P. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2333912100 · Cited by 244 · see citing works
Endocannabinoids in the regulation of appetite and body weight
Kirkham, T. C. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200509000-00004 · Cited by 220 · see citing works
Vickers, S. P., Webster, L. J., Wyatt, A. C., Dourish, C. T., & Kennett, G. A. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1384-8 · Cited by 207 · see citing works
Self-citationStatnick, M. A., Beavers, L. S., Conner, L. J., Corominola, H., Johnson, D., Hammond, C. D., Rafaeloff-Phail, R., Seng, T. W., Suter, T. M., Sluka, J. P., et al. (2000) · Journal of Diabetes Research · doi:10.1155/edr.2000.81 · Cited by 205 · see citing works
Resistin and Adiponectin Expression in Visceral Fat of Obese Rats: Effect of Weight Loss
Milan, G., Granzotto, M., Scarda, A., Calcagno, A., Pagano, C., Federspil, G., & Vettor, R. (2002) · Obesity Research · doi:10.1038/oby.2002.149 · Cited by 199 · see citing works
Zhang, Y., Matheny, M. E., Zolotukhin, S., Tümer, N., & Scarpace, P. J. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(02)00298-6 · Cited by 170 · see citing works
Reversal of Δ9-THC hyperphagia by SR141716 and naloxone but not dexfenfluramine
Williams, C. M., & Kirkham, T. C. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00694-3 · Cited by 158 · see citing works
Higgs, S., Williams, C. M., & Kirkham, T. C. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1263-3 · Cited by 154 · see citing works
Rowland, N. E., Mukherjee, M., & Robertson, K. (2001) · Psychopharmacology · doi:10.1007/s002130100910 · Cited by 139 · see citing works
Importance of Adipocytokines in Obesity-Related Diseases
Matsuzawa, Y., Shimomura, I., Kihara, S., & Funahashi, T. (2003) · Hormone Research in Paediatrics · doi:10.1159/000074502 · Cited by 116 · see citing works
Verty, A. N. A., McFarlane, J. R., McGregor, I. S., & Mallet, P. E. (2004) · Endocrinology · doi:10.1210/en.2004-0059 · Cited by 100 · see citing works
Verty, A. N. A. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.10.035 · Cited by 97 · see citing works
Thornton-Jones, Z. D., Vickers, S. P., & Clifton, P. G. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2047-8 · Cited by 84 · see citing works
Self-citationCannabinoids and the Regulation of Ingestive Behaviour
Vickers, S. P., & Kennett, G. A. (2005) · Current Drug Targets · doi:10.2174/1389450053174514 · Cited by 74 · see citing works
Self-citationVry, J. D., Schreiber, R., Eckel, G., et al. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.10.012 · Cited by 72 · see citing works
Cannabinoid agonists and antagonists modulate lithium-induced conditioned gaping in rats
Parker, L. A., & Mechoulam, R. (2003) · Integrative Psychological and Behavioral Science · doi:10.1007/bf02688831 · Cited by 49 · see citing works
Naderali, E. K., Estadella, D., Rocha, M., Pickavance, L. C., Fatani, S. H., Denis, R., & Williams, G. (2003) · Clinical Science · doi:10.1042/cs20030094 · Cited by 46 · see citing works
Calorimetric measurements made on rats during repeated periods of weight gain and weight loss
Farrell, D. J., & Williams, V. J. (1989) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(89)90785-8 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Feed-forward mechanisms: Addiction-like behavioral and molecular adaptations in overeating
Alsiö, J., Olszewski, P. K., Levine, A. S., & Schiöth, H. B. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.01.002 · Cited by 81 · see citing works
Cedernaes, J., Fanelli, F., Fazzini, A., Pagotto, U., Broman, J.-E., Vogel, H., Dickson, S. L., Schiöth, H. B., & Benedict, C. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.09.014 · Cited by 59 · see citing works
- Authors
- Thornton-Jones, Z. D., Kennett, G. A., Benwell, K. R., Revell, D. F., Misra, A., Sellwood, D. M., Vickers, S. P., & Clifton, P. G.
- Affiliations
- University of Sussex (GB)
- Vernalis (R&D) Limited (United Kingdom) (GB)
- Corresponding author
- Clifton, Peter G.
- ORCID
- Clifton, Peter G.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 84
- Issue
- 2
- Pages
- 353-359
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2058364253
- Cited by
- 83
- References
- 40
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 1 · 2020: 1 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 6 · 2013: 6 · 2012: 5
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Keywords
- rimonabant, diet-induced obesity, weight loss, dietary intake, hypophagia, adiponectin, pair feeding, cannabinoid receptor antagonists, energy expenditure
- MeSH terms
- Rimonabant, Animals, Body Weight, Dietary Fats, Eating, Male, Obesity, Piperidines, Pyrazoles, Rats, Sprague-Dawley, Receptor, Cannabinoid, CB1, Rats, Adiponectin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review