The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
Neurobehavioral mechanisms of impulsivity: Fronto-striatal systems and functional neurochemistry
Abstract
Impulsive acts and decisions are a part of everyday normal behavior. However, in its pathological forms, impulsivity can be a debilitating disorder often associated with a number of neuropsychiatric disorders, including attention-deficit hyperactivity disorder (ADHD). This article reviews recent progress in our understanding of the neurobiology of impulsivity using examples from recent investigations in experimental animals. Evidence is reviewed from several well-established paradigms with putative utility in assessing distinct forms of impulsive behavior in rodents, including the 5-choice serial reaction time (5CSRT) task and the delay discounting paradigm. We discuss, in particular, recent psychopharmacological and in-vivo neurochemical data in task-performing rats showing functional heterogeneity of the forebrain dopamine (DA), noradrenaline (NA), serotonin (5-HT) and acetylcholine (ACh) systems and identify how these systems normally function to facilitate flexible goal-directed behavior in situations that tax basic attentional functions and inhibitory response control mechanisms. We also discuss future research needs in terms of understanding the functional diversity of different sub-regions of prefrontal cortex (PFC) and how these systems normally interact with the striatum and main nuclei of origin of DA and NA neurons. Finally, we argue in line with others that animal paradigms are unlikely to model all aspects of complex psychiatric conditions such as ADHD but components of such syndromes may be amenable to investigation using sophisticated animal models based on highly-defined psychiatric endophenotypes.
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“The deficits activity of the striatum and frontal areas may contribute to impulsivity and inflexibility (Dalley et al., 2008; Sakagami and Pan, 2007; Trempler et al., 2017)”
From Predictive coding in neuropsychiatric disorders: a systematic transdiagnostic review. (2025) · cites this paper as Dalley et al., 2008
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Inverted-U–Shaped Dopamine Actions on Human Working Memory and Cognitive Control
Cools, R., & D'Esposito, M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.03.028 · Cited by 1,673
Function in the human connectome: task-fMRI and individual differences in behavior
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REVIEW: Understanding the construct of impulsivity and its relationship to alcohol use disorders
Dick, D. M., Smith, G. T., Olausson, P., Mitchell, S. H., Leeman, R. F., O’Malley, S. S., & Sher, K. J. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2009.00190.x · Cited by 748
Aldao, A., Gee, D. G., De Los Reyes, A., & Seager, I. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000638 · Cited by 636
Metadata
- Authors
- Dalley, J. W., Mar, A. C., Economidou, D., & Robbins, T. W.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Dalley, Jeffrey W.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 90
- Issue
- 2
- Pages
- 250-260
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2074006378
- Cited by
- 467
- References
- 121
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 15 · 2021: 14 · 2020: 64 · 2019: 16 · 2018: 26 · 2017: 21 · 2016: 33 · 2015: 35 · 2014: 35 · 2013: 41 · 2012: 31
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (076274/Z04/Z)
- University of Cambridge
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Keywords
- impulsivity, dopamine, norepinephrine, serotonin, acetylcholine, prefrontal cortex, striatum, 5-choice serial reaction time task, delay discounting, attention deficit hyperactivity disorder, goal-directed behavior, animal models of psychiatric disorders, endophenotypes
- MeSH terms
- Acetylcholine, Animals, Attention Deficit Disorder with Hyperactivity, Conditioning, Operant, Corpus Striatum, Dopamine, Humans, Impulsive Behavior, Reaction Time, Serotonin, Prefrontal Cortex
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