Cited by 54Neurotransmitter Receptor Influence on BehaviorPrenatal Substance Exposure EffectsHypothalamic control of reproductive hormones

Gonadal steroids mediate the opposite changes in cocaine-induced locomotion across adolescence in male and female rats

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Parylak, Sarah L., Caster, Joseph M., Walker, Q. David, Kuhn, Cynthia M.·2008·Pharmacology Biochemistry and Behavior

Abstract

Evidence from both human studies and animal models indicates that cocaine elicits more behavioral stimulation in females than males. The present study sought to determine whether sex-specific responses to cocaine emerge during adolescence and to determine if gonadal steroid action during puberty affects adult responsiveness to cocaine. We administered cocaine using an escalating dose model in male and female rats at ages postnatal (PN) 28, 42, and 65 days. To assess the effects of pubertal gonadal steroid action, we compared the effects of binge cocaine administration on intact and prepubertally gonadectomized male and female rats in adulthood. Cocaine responses changed in opposite directions in males and females as they progressed through adolescence. At most doses, adolescent males were more responsive than adult males whereas adult females were more responsive than adolescent females. Ambulatory activity was age-dependent in males whereas non-ambulatory activity was age-dependent in females. Prepubertal gonadectomy increased behavioral responsiveness to the highest dose of cocaine in males whereas it decreased behavioral responsiveness to lower doses of cocaine in females. We conclude that sex differences in behavioral responses to cocaine arise during adolescence from a concurrent decrease in male responsiveness and increase in female responsiveness. Our results suggest that gonadal steroids exert lasting and opposing effects on the sensitivity of males and females to psychostimulants during development.

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Crossref · 10.1016/j.pbb.2008.01.003

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  • Prepubertal (p25) gonadectomy produces opposite effects on cocaine-induced locomotion in adult (p65) male and female rats, suggesting that pubertal hormones play a role in regulating sex-specific responses to cocaine.

    “In addition, prepubertal (p25) gonadectomy produces opposite effects on cocaine-induced locomotion in adult (p65) male and female rats, suggesting that pubertal hormones play a role in regulating sex-specific responses to cocaine (Parylak et al., 2008).”
  • The stimulatory effects of estradiol on dopaminergic function are well-established for adult female rodents, while evidence in pubertal females comes largely from effects of prepubertal ovariectomy on responses to dopaminergic drugs such as cocaine.

    “While the stimulatory effects of estradiol on dopaminergic function are well-established for adult female rodents (Kuhn et al., 2010), evidence in pubertal females comes largely from the effects of prepubertal ovariectomy on responses to dopaminergic drugs such as cocaine (reviewed above; Parylak et al., 2008).”

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Authors
Parylak, S. L., Caster, J. M., Walker, Q. D., & Kuhn, C. M.
Affiliations
Duke Medical Center (US)
Corresponding author
Kuhn, Cynthia M.
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
2008-05
Volume
89
Issue
3
Pages
314-323
ISSN
0091-3057 (ISSN-L)
OpenAlex
W2036842877
Cited by
54
References
54
Citations by year
2025: 2 · 2024: 2 · 2022: 2 · 2021: 2 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 5 · 2013: 4 · 2012: 6
FWCI
3.32
Type
journal article
Language
en
Open access
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Drug Abuse (DA-09079, R01DA009079, R01DA019114)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
cocaine, locomotor activity, sex differences, adolescence, puberty, sex steroids, gonadectomy, psychostimulants, developmental sensitivity, ambulatory activity
MeSH terms
Age Factors, Animals, Cocaine, Female, Male, Motor Activity, Sex Characteristics, Gonadal Steroid Hormones, Sexual Maturation, Rats, Sprague-Dawley, Rats

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