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Cited by 223Substance Abuse Treatment and OutcomesGambling Behavior and TreatmentsOpioid Use Disorder Treatment

Adolescent versus adult onset and the development of substance use disorders in males

Clark, Duncan B, Kirisci, Levent, Tarter, Ralph E·1998·Drug and Alcohol Dependence
DOI 10.1016/s0376-8716(97)00154-3
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Abstract

This study examines the influence of adolescent age of onset on the development of substance use disorders (SUD) by comparing adult males (n = 181) with SUD categorized into adolescent-onset, early-adult onset and late-adult onset groups on patterns of substance use and related disorders, time course of the development of substance dependence and rates of comorbid mental disorders. A sample of male adolescents (n = 81) with SUD was also included as a comparison group. The subjects were recruited from intervention programs in the community and participated in semistructured interviews with diagnoses determined by the best estimate method. Adolescent-onset adults, compared with other adult-onset groups, had higher lifetime rates of cannabis and hallucinogen use disorders, shorter times from first exposure to dependence, shorter times between the development of their first and second dependence diagnoses and higher rates of disruptive behavior disorders and major depression. Adolescents were similar to adolescent-onset adults. While the findings must be interpreted in light of methodological limitations, these results suggest that adolescent-onset SUD is a distinct subtype involving different substances and more rapid development than adult-onset SUD.

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  • Early drug use is consistently associated with higher risk of developing substance use disorders.

    “Early drug use is consistently associated with higher risk of developing substance use disorders (Chou and Pickering, 1992; Clark et al., 1998; DeWit et al., 2000; Grant and Dawson, 1998; Hawkins et al., 1997; Lynskey et al., 2003; O’Brien and Anthony, 2005; Prescott and Kendler, 1999; SAMHSA, 2013)”

    From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Clark et al., 1998

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Authors
Clark, D. B., Kirisci, L., & Tarter, R. E.
Affiliations
University of Pittsburgh (US)
Corresponding author
Clark, Duncan B
ORCID
Venue
Drug and Alcohol Dependence
Publisher
Elsevier BV
Published
1998-01
Volume
49
Issue
2
Pages
115-121
ISSN
0376-8716 (ISSN-L)
DOI
10.1016/s0376-8716(97)00154-3
OpenAlex
W1988965958
Cited by
223
References
28
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 8 · 2020: 7 · 2019: 10 · 2018: 4 · 2017: 10 · 2016: 8 · 2015: 12 · 2014: 10 · 2013: 9 · 2012: 8
FWCI
3.77
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Drug and Alcohol Dependence (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Pittsburgh
  • National Institute on Drug Abuse (P50-DA 05605, P50DA005605)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Keywords
substance use disorders, age of onset, adolescent boys, cannabis use disorder, substance dependence, comorbid mental disorders, disruptive behavior disorders, major depressive disorder
MeSH terms
Adolescent, Adult, Analysis of Variance, Marijuana Abuse, Depression, Humans, Male, Pennsylvania, Social Behavior Disorders, Time Factors, Comorbidity, Chi-Square Distribution, Likelihood Functions, Age of Onset, Disease Progression, Substance-Related Disorders, Alcohol-Related Disorders

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