The emergence of gonadal hormone influences on dopaminergic function during puberty

Kuhn, Cynthia; Johnson, Misha; Thomae, Alex; Luo, Brooke; Simon, Sidney A; Zhou, Guiying; Walker, Q. David

doi:10.1016/j.yhbeh.2009.10.015

Cited by 113Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesHypothalamic control of reproductive hormones

The emergence of gonadal hormone influences on dopaminergic function during puberty

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Kuhn, Cynthia, Johnson, Misha, Thomae, Alex, Luo, Brooke, Simon, Sidney A, Zhou, Guiying, Walker, Q. David·2010·Hormones and Behavior

DOI 10.1016/j.yhbeh.2009.10.015PMC PMC2883625

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Abstract

Adolescence is the developmental epoch during which children become adults-intellectually, physically, hormonally and socially. Brain development in critical areas is ongoing. Adolescents are risk-taking and novelty-seeking and they weigh positive experiences more heavily and negative experiences less than adults. This inherent behavioral bias can lead to risky behaviors like drug taking. Most drug addictions start during adolescence and early drug-taking is associated with an increased rate of drug abuse and dependence. The hormonal changes of puberty contribute to physical, emotional, intellectual and social changes during adolescence. These hormonal events do not just cause maturation of reproductive function and the emergence of secondary sex characteristics. They contribute to the appearance of sex differences in non-reproductive behaviors as well. Sex differences in drug use behaviors are among the latter. The male predominance in overall drug use appears by the end of adolescence, while girls develop the rapid progression from first use to dependence (telescoping) that represent a female-biased vulnerability. Sex differences in many behaviors including drug use have been attributed to social and cultural factors. A narrowing gap in drug use between adolescent boys and girls supports this thesis. However, some sex differences in addiction vulnerability reflect biologic differences in brain circuits involved in addiction. The purpose of this review is to summarize the contribution of sex differences in the function of ascending dopamine systems that are critical to reinforcement, to briefly summarize the behavioral, neurochemical and anatomical changes in brain dopaminergic functions related to addiction that occur during adolescence and to present new findings about the emergence of sex differences in dopaminergic function during adolescence.

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Pubertal hormones influence a variety of drug-related behaviors in animal models.
“Pubertal hormones influence a variety of drug-related behaviors in animal models (reviewed below and in Kuhn et al., 2010)”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Kuhn et al., 2010
Peripubertal changes in drug sensitivity are likely related to peripubertal changes in dopaminergic function.
“Given the well-established role of dopaminergic function in drug- and other reward-related behaviors, peripubertal changes in drug sensitivity are likely related to peripubertal changes in dopaminergic function (Kuhn et al., 2010).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Kuhn et al., 2010
The dopamine system that innervates the frontal association cortex changes in complex ways around puberty, with distinct components showing distinct developmental trajectories.
“The dopamine system that innervates the frontal association cortex changes in complex ways around puberty, with distinct components showing distinct developmental trajectories (Benes et al., 1996; Kuhn et al., 2010; McCutcheon and Marinelli, 2009; Sinclair et al., 2014; Wahlstrom et al., 2010).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Kuhn et al., 2010
Literature on the effects of pubertal hormones on the development of the dopamine system suggests that some aspects of dopaminergic function respond to pubertal increases in circulating gonadal hormones.
“Thus, although scant, literature on the effects of pubertal hormones on the development of the dopamine system suggests that some aspects of dopaminergic function respond to pubertal increases in circulating gonadal hormones.”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Kuhn et al., 2010
Several rodent studies point to effects of pubertal estradiol and testosterone on dopaminergic function.
“several rodent studies point to effects of pubertal estradiol and testosterone on dopaminergic function (reviewed in Becker, 2009; Kuhn et al., 2010; Sinclair et al., 2014).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Kuhn et al., 2010

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Authors: Kuhn, C., Johnson, M., Thomae, A., Luo, B., Simon, S. A., Zhou, G., & Walker, Q. D.
Affiliations: Duke University (US)
Duke Medical Center (US)
Corresponding author: Kuhn, Cynthia
ORCID: Kuhn, Cynthia
Simon, Sidney A
Venue: Hormones and Behavior
Publisher: Elsevier BV
Published: 2010-06
Volume: 58
Issue: 1
Pages: 122-137
ISSN: 0018-506X (ISSN-L)
DOI: 10.1016/j.yhbeh.2009.10.015
PMC: PMC2883625
OpenAlex: W2082869602
Cited by: 113
References: 295
Citations by year: 2026: 3 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 7 · 2016: 5 · 2015: 12 · 2014: 9 · 2013: 16 · 2012: 9
FWCI: 2.76
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Hormones and Behavior (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Development Administration (DC-01065, 009079, DA019114)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: puberty, gonadal hormones, dopaminergic activity, adolescence, sex differences, drug addiction, adolescent drug use, dopaminergic reward system, brain development, addiction vulnerability
MeSH terms: Animals, Brain, Dopamine, Humans, Puberty, Sexual Maturation, Substance-Related Disorders, Gonadal Hormones

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The emergence of gonadal hormone influences on dopaminergic function during puberty

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