Chemical physiology of oxidative stress-activated TRPM2 and TRPC5 channels
Abstract
The ability to sense and adapt to a wide variety of environmental changes is crucial for the survival of all cells. Transient receptor potential (TRP) channels play pivotal roles in these sensing and adaptation reactions. In vertebrates, there are about 30 TRP channels; these are divided into six subfamilies by homology of the protein sequences. We have previously revealed that a group of TRP channels senses oxidative stress and induces cellular signaling and gene expression. TRPM2, a member of the TRPM subfamily, is activated by reactive oxygen species (ROS) via second-messenger production. Recently, we demonstrated that Ca(2+) influx through TRPM2 activated by ROS induces chemokine production in monocytes, which aggravates inflammatory neutrophil infiltration. Additionally, we also revealed that nitric oxide, chemical compounds containing reactive disulfide, and inflammatory mediators directly activate the TRPC, TRPV, and TRPA subfamilies via oxidative modification of cysteine residues. In this review, we describe how these TRP channels sense oxidative stress and induce adaptation reactions, and we discuss the biological importance of oxidative stress-activated TRP channels.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
TRP channels responsive to ROS have been identified in a number of cell types and provide another route of entry for calcium.
“In addition, transient receptor potential (TRP) channels that are responsive to ROS have been identified in a number of cell types, and provide another route of entry for calcium (589).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [589]
Cites
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. J. (1997) · Nature · doi:10.1038/39807 · Cited by 9,132 · see citing works
Calcium signalling: dynamics, homeostasis and remodelling
Berridge, M., Bootman, M., & Roderick, H. (2003) · Nature reviews. Molecular cell biology · doi:10.1038/nrm1155 · Cited by 5,747 · see citing works
Chemokines — Chemotactic Cytokines That Mediate Inflammation
Luster, A. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802123380706 · Cited by 3,634 · see citing works
NOX enzymes and the biology of reactive oxygen
Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125 · see citing works
The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli
Tominaga, M., Caterina, M. J., Malmberg, A. B., Rosen, T. A., Gilbert, H., Skinner, K., Raumann, B. E., Basbaum, A. I., & Julius, D. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80564-4 · Cited by 3,086 · see citing works
TRP channels as cellular sensors
Clapham, D. E. (2003) · Nature · doi:10.1038/nature02196 · Cited by 2,779 · see citing works
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
McKemy, D. D., Neuhausser, W., & Julius, D. J. (2002) · Nature · doi:10.1038/nature719 · Cited by 2,716 · see citing works
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
Story, G. M., Peier, A. M., Reeve, A. J., Eid, S. R., Mosbacher, J., Hricik, T., Earley, T. J., Hergarden, A. C., Andersson, D. A., Hwang, S. W., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00158-2 · Cited by 2,494 · see citing works
A TRP Channel that Senses Cold Stimuli and Menthol
Peier, A. M., Moqrich, A., Hergarden, A. C., Reeve, A. J., Andersson, D. A., Story, G. M., Earley, T. J., Dragoni, I., McIntyre, P., Bevan, S., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00652-9 · Cited by 2,361 · see citing works
Protein S-nitrosylation: Purview and parameters
Hess, D. T., Matsumoto, A., Kim, S.-O., Marshall, H. E., & Stamler, J. S. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1569 · Cited by 2,153 · see citing works
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
Nauli, S. M., Alenghat, F. J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A. E. H., Lu, W., Brown, E. M., Quinn, S. J., et al. (2003) · Nature Genetics · doi:10.1038/ng1076 · Cited by 2,057 · see citing works
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
Bautista, D. M., Jordt, S. E., Nikai, T., Tsuruda, P. R., Read, A. J., Poblete, J., Yamoah, E. N., Basbaum, A. I., & Julius, D. J. (2006) · Cell · doi:10.1016/j.cell.2006.02.023 · Cited by 1,921 · see citing works
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
Jordt, S., Bautista, D. M., Chuang, H.-H., McKemy, D. D., Zygmunt, P. M., Högestätt, E. D., Meng, I. D., & Julius, D. J. (2004) · Nature · doi:10.1038/nature02282 · Cited by 1,896 · see citing works
A capsaicin-receptor homologue with a high threshold for noxious heat
Caterina, M. J., Rosen, T. A., Tominaga, M., Brake, A. J., & Julius, D. J. (1999) · Nature · doi:10.1038/18906 · Cited by 1,599 · see citing works
Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol
Hofmann, T., Obukhov, A. G., Schaefer, M., Harteneck, C., Gudermann, T. W., & Schultz, G. (1999) · Nature · doi:10.1038/16711 · Cited by 1,496 · see citing works
Protein S-nitrosylation: a physiological signal for neuronal nitric oxide
Jaffrey, S. R., Erdjument‐Bromage, H., Ferris, C. D., Tempst, P., & Snyder, S. H. (2001) · Nature Cell Biology · doi:10.1038/35055104 · Cited by 1,402 · see citing works
Liedtke, W., Choe, Y., Martı́-Renom, M. A., Bell, A. M., Denis, C. S., AndrejŠali, Hudspeth, A. J., Friedman, J. M., & Heller, S. (2000) · Cell · doi:10.1016/s0092-8674(00)00143-4 · Cited by 1,391 · see citing works
Lev, S., Moreno, H., Martinez, R., Canoll, P., Peles, E., Musacchio, J. M., Plowman, G. D., Rudy, B., & Schlessinger, J. (1995) · Nature · doi:10.1038/376737a0 · Cited by 1,381 · see citing works
The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors
Virág, L., & Szabó, C. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.3.375 · Cited by 1,373 · see citing works
Kwan, K. Y., Allchorne, A. J., Vollrath, M. A., Christensen, A. P., Zhang, D.-S., Woolf, C. J., & Corey, D. P. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.042 · Cited by 1,267 · see citing works
Montell, C., & Rubin, G. M. (1989) · Neuron · doi:10.1016/0896-6273(89)90069-x · Cited by 1,151 · see citing works
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
Macpherson, L. J., Dubin, A. E., Evans, M. J., Marr, F., Schultz, P. G., Cravatt, B. F., & Patapoutian, A. (2007) · Nature · doi:10.1038/nature05544 · Cited by 1,112 · see citing works
Heat-Evoked Activation of the Ion Channel, TRPV4
Güler, A. D., Lee, H., Iida, T., Shimizu, I., Tominaga, M., & Caterina, M. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06408.2002 · Cited by 1,033 · see citing works
OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity
Strotmann, R., Harteneck, C., Nunnenmacher, K., Schultz, G., & Plant, T. D. (2000) · Nature Cell Biology · doi:10.1038/35036318 · Cited by 1,023 · see citing works
A Heat-Sensitive TRP Channel Expressed in Keratinocytes
Peier, A. M., Reeve, A. J., Andersson, D. A., Moqrich, A., Earley, T. J., Hergarden, A. C., Story, G. M., Colley, S., Hogenesch, J. B., McIntyre, P., et al. (2002) · Science · doi:10.1126/science.1073140 · Cited by 968 · see citing works
LTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viability
Nadler, M. J. S., Hermosura, M. C., Inabe, K., Perraud, A., Zhu, Q., Stokes, A. J., Kurosaki, T., Kinet, J.-P., Penner, R., Scharenberg, A. M., et al. (2001) · Nature · doi:10.1038/35079092 · Cited by 923 · see citing works
TRPV3 is a calcium-permeable temperature-sensitive cation channel
Xu, H., Ramsey, I. S., Kotecha, S. A., Moran, M. M., Chong, J. A., Lawson, D., Ge, P., Lilly, J., Silos‐Santiago, I., Xie, Y., et al. (2002) · Nature · doi:10.1038/nature00882 · Cited by 920 · see citing works
ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology
Perraud, A., Fleig, A., Dunn, C., Bagley, L. A., Launay, P., Schmitz, C., Stokes, A. J., Zhu, Q., Bessman, M. J., Penner, R., et al. (2001) · Nature · doi:10.1038/35079100 · Cited by 895 · see citing works
TRP channel activation by reversible covalent modification
Hinman, A., Chuang, H.-H., Bautista, D. M., & Julius, D. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609598103 · Cited by 893 · see citing works
TRPV3 is a temperature-sensitive vanilloid receptor-like protein
Smith, G. D., Gunthorpe, M. J., Kelsell, R. E., Hayes, P. D., Reilly, P., Facer, P., Wright, J. E., Jerman, J. C., Walhin, J., Ooi, L., et al. (2002) · Nature · doi:10.1038/nature00894 · Cited by 834 · see citing works
Hara, Y., Wakamori, M., Ishii, M., Maeno, E., Nishida, M., Yoshida, T., Yamada, H., Shimizu, S., Mori, E., Kudoh, J., et al. (2002) · Molecular Cell · doi:10.1016/s1097-2765(01)00438-5 · Cited by 816 · see citing works
Self-citationPoly(ADP-ribose) polymerase: a molecular nick-sensor
de MURCIA, G., & Murcia, J. M. (1994) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(94)90280-1 · Cited by 801 · see citing works
A Key Role for TRPM7 Channels in Anoxic Neuronal Death
Aarts, M. M., Iihara, K., Wei, W.-L., Xiong, Z.-G., Arundine, M., Cerwinski, W., MacDonald, J. F., & Tymianski, M. (2003) · Cell · doi:10.1016/s0092-8674(03)01017-1 · Cited by 784 · see citing works
TRPM4 Is a Ca2+-Activated Nonselective Cation Channel Mediating Cell Membrane Depolarization
Launay, P., Fleig, A., Perraud, A.-L., Scharenberg, A. M., Penner, R., & Kinet, J.-P. (2002) · Cell · doi:10.1016/s0092-8674(02)00719-5 · Cited by 745 · see citing works
Subunit composition of mammalian transient receptor potential channels in living cells
Hofmann, T., Schaefer, M., Schultz, G., & Gudermann, T. W. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102596199 · Cited by 743 · see citing works
TRPC1 and TRPC5 Form a Novel Cation Channel in Mammalian Brain
Strübing, C., Krapivinsky, G. B., Krapivinsky, L., & Clapham, D. E. (2001) · Neuron · doi:10.1016/s0896-6273(01)00240-9 · Cited by 729 · see citing works
Watanabe, H., Vriens, J., Suh, S. H., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208277200 · Cited by 704 · see citing works
trp, a Novel Mammalian Gene Family Essential for Agonist-Activated Capacitative Ca2+ Entry
Zhu, M. X., Jiang, M., Peyton, M., Boulay, G., Hurst, R. S., Stefani, E., & Birnbaumer, L. (1996) · Cell · doi:10.1016/s0092-8674(00)81233-7 · Cited by 687 · see citing works
TRPC1 forms the stretch-activated cation channel in vertebrate cells
Maroto, R., Raso, A., Wood, T. G., Kurosky, A., Martinac, B., & Hamill, O. P. (2005) · Nature Cell Biology · doi:10.1038/ncb1218 · Cited by 654 · see citing works
Nociceptor and Hair Cell Transducer Properties of TRPA1, a Channel for Pain and Hearing
Nagata, K., Duggan, A., Kumar, G., & Garcı́a-Añoveros, J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0013-05.2005 · Cited by 646 · see citing works
TRPM6 Forms the Mg2+ Influx Channel Involved in Intestinal and Renal Mg2+ Absorption
Voets, T., Nilius, B., Hoefs, S., van der Kemp, A. W. C. M., Droogmans, G., Bindels, R. J. M., & Hoenderop, J. G. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m311201200 · Cited by 636 · see citing works
Yamamoto, S., Shimizu, S., Kiyonaka, S., Takahashi, N., Wajima, T., Hara, Y., Negoro, T., Hiroi, T., Kiuchi, Y., Okada, T., et al. (2008) · Nature Medicine · doi:10.1038/nm1758 · Cited by 611 · see citing works
Self-citationInoue, R., Okada, T., Onoue, H., Hara, Y., Shimizu, S., Naitoh, S., Ito, Y., & Mori, Y. (2001) · Circulation Research · doi:10.1161/01.res.88.3.325 · Cited by 596 · see citing works
Self-citationReactive oxygen and mechanisms of inflammatory liver injury: Present concepts
Jaeschke, H. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06592.x · Cited by 594 · see citing works
Gene regulation mediated by calcium signals in T lymphocytes
Feske, S., Giltnane, J. M., Dolmetsch, R. E., Staudt, L. M., & Rao, A. (2001) · Nature Immunology · doi:10.1038/86318 · Cited by 591 · see citing works
Oxidation in rheumatoid arthritis.
Hitchon, C. A., & El-Gabalawy, H. S. (2004) · Arthritis Research · doi:10.1186/ar1447 · Cited by 583 · see citing works
Oliver, F. J., Murcia, J. M., Nacci, C., Decker, P., Andriantsitohaina, R., Muller, S., de la Rubia, G., Stoclet, J., & de MURCIA, G. (1999) · The EMBO Journal · doi:10.1093/emboj/18.16.4446 · Cited by 583 · see citing works
Freichel, M., Suh, S. H., Pfeifer, A., Schweig, U., Trost, C., Weißgerber, P., Biel, M., Philipp, S. E., Freise, D., Droogmans, G., et al. (2001) · Nature Cell Biology · doi:10.1038/35055019 · Cited by 577 · see citing works
Altered sexual and social behaviors in trp2 mutant mice
Leypold, B. G., Yu, C., Leinders‐Zufall, T., Kim, M. M., Zufall, F., & Axel, R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082127599 · Cited by 572 · see citing works
Nitric oxide activates TRP channels by cysteine S-nitrosylation
Yoshida, T., Inoue, R., Morii, T., Takahashi, N., Yamamoto, S., Hara, Y., Tominaga, M., Shimizu, S., Sato, Y., & Mori, Y. (2006) · Nature Chemical Biology · doi:10.1038/nchembio821 · Cited by 566 · see citing works
Self-citationA transient receptor potential channel expressed in taste receptor cells
Pérez, C. A., Huang, L., Rong, M., Kozak, J. A., Preuss, A. K., Zhang, H., Max, M., & Margolskee, R. F. (2002) · Nature Neuroscience · doi:10.1038/nn952 · Cited by 538 · see citing works
Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients
Videla, L. A., Rodrigo, R., Myriam Orellana, B., Fernández, V., Tapia, G., Quiñones, L. A., Varela, N., CONTRERAS, J., Lazarte, R. A., Csendes, A., et al. (2004) · Clinical Science · doi:10.1042/cs20030285 · Cited by 516 · see citing works
TRPM2 activation by cyclic ADP‐ribose at body temperature is involved in insulin secretion
Togashi, K., Hara, Y., Tominaga, T., Higashi, T., Konishi, Y., Mori, Y., & Tominaga, M. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601083 · Cited by 461 · see citing works
Self-citationOkada, T., Inoue, R., Yamazaki, K., Maeda, A., Kurosaki, T., Yamakuni, T., Tanaka, I., Shimizu, S., Ikenaka, K., Imoto, K., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.39.27359 · Cited by 457 · see citing works
Self-citationMolecular mechanism of interleukin-8 gene expression
Mukaida, N., Okamoto, S., Ishikawa, Y., & Matsushima, K. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.56.5.554 · Cited by 452 · see citing works
Induction of interleukin-8 preserves the angiogenic response in HIF-1α–deficient colon cancer cells
Mizukami, Y., Jo, W., Duerr, E., Gala, M. K., Li, J., Zhang, X., Zimmer, M. A., Iliopoulos, O., Zukerberg, L. R., Kohgo, Y., et al. (2005) · Nature Medicine · doi:10.1038/nm1294 · Cited by 405 · see citing works
Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis.
Duncan, L. M., Deeds, J. D., Hunter, J., Shao, J., Holmgren, L. M., Woolf, E. A., Tepper, R. I., & Shyjan, A. W. (1998) · PubMed · Cited by 396 · see citing works
Zitt, C., Zobel, A., Obukhov, A. G., Harteneck, C., Kalkbrenner, F., Lückhoff, A., & Schultz, G. (1996) · Neuron · doi:10.1016/s0896-6273(00)80145-2 · Cited by 394 · see citing works
TRPC5 is a regulator of hippocampal neurite length and growth cone morphology
Greka, A., Navarro, B., Oancea, E., Duggan, A., & Clapham, D. E. (2003) · Nature Neuroscience · doi:10.1038/nn1092 · Cited by 382 · see citing works
Integration of calcium and RAS signalling
Cullen, P. J., & Lockyer, P. J. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm808 · Cited by 380 · see citing works
Molecular and Functional Characterization of the Melastatin-related Cation Channel TRPM3
Grimm, C. M., Kraft, R., Sauerbruch, S., Schultz, G., & Harteneck, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300945200 · Cited by 362 · see citing works
Reactive oxygen and mechanisms of inflammatory liver injury
Jaeschke, H. (2000) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2000.02207.x · Cited by 358 · see citing works
Perraud, A.-L., Takanishi, C. L., Shen, B. W., Kang, S. J., Smith, M., Schmitz, C., Knowles, H. M., Ferraris, D. V., Li, W., Zhang, J., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411446200 · Cited by 358 · see citing works
Wehage, E., Eisfeld, J., Heiner, I., Jüngling, E., Zitt, C., & Lückhoff, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112096200 · Cited by 348 · see citing works
Kolísek, M., Beck, A., Fleig, A., & Penner, R. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.02.033 · Cited by 343 · see citing works
Boulay, G., Zhu, M. X., Peyton, M., Jiang, M., Hurst, R. S., Stefani, E., & Birnbaumer, L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.47.29672 · Cited by 337 · see citing works
Zhu, M. X., Jiang, M., & Birnbaumer, L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.133 · Cited by 330 · see citing works
Selective Association of TRPC Channel Subunits in Rat Brain Synaptosomes
Goel, M., Sinkins, W. G., & Schilling, W. P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207882200 · Cited by 330 · see citing works
Okada, T., Shimizu, S., Wakamori, M., Maeda, A., Kurosaki, T., Takada, N., Imoto, K., & Mori, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10279 · Cited by 296 · see citing works
Self-citationReactive Oxygen Species as Mediators in Asthma
Henricks, P. A. J., & Nijkamp, F. P. (2001) · Pulmonary Pharmacology & Therapeutics · doi:10.1006/pupt.2001.0319 · Cited by 295 · see citing works
Essential Role for TRPC5 in Amygdala Function and Fear-Related Behavior
Riccio, A., Li, Y., Moon, J., Kim, K., Smith, K. S., Rudolph, U., Gapon, S., Yao, G. L., Tsvetkov, E., Rodig, S. J., et al. (2009) · Cell · doi:10.1016/j.cell.2009.03.039 · Cited by 288 · see citing works
Fonfría, E., Marshall, I. C. B., Benham, C. D., Boyfield, I., Brown, J. D., Hill, K., Hughes, J. P., Skaper, S. D., & McNulty, S. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705914 · Cited by 283 · see citing works
Zitt, C., Obukhov, A. G., Strübing, C., Zobel, A., Kalkbrenner, F., Lückhoff, A., & Schultz, G. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.6.1333 · Cited by 249 · see citing works
Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators
Takahashi, N., Mizuno, Y., Kozai, D., Yamamoto, S., Kiyonaka, S., Shibata, T., Uchida, K., & Mori, Y. (2008) · Channels · doi:10.4161/chan.2.4.6745 · Cited by 244 · see citing works
Self-citationA Novel TRPM2 Isoform Inhibits Calcium Influx and Susceptibility to Cell Death
Zhang, W., Chu, X., Tong, Q., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300298200 · Cited by 235 · see citing works
Enhanced synthesis of neutrophil-activating peptide-I/interleukin-8 in active ulcerative colitis
Mahida, Y. R., Ceska, M., Effenberger, F., et al. (1992) · Clinical Science · doi:10.1042/cs0820273 · Cited by 204 · see citing works
TRPM2 Ca2+ permeable cation channels: from gene to biological function
Perraud, A., Schmitz, C., & Scharenberg, A. M. (2003) · Cell Calcium · doi:10.1016/s0143-4160(03)00057-5 · Cited by 176 · see citing works
Singer, M., & Sansonetti, P. J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.4197 · Cited by 172 · see citing works
Zeng, X., Dai, J., Remick, D. G., & Wang, X. (2003) · Circulation Research · doi:10.1161/01.res.0000087642.01082.e4 · Cited by 172 · see citing works
The Role of Oxidative Stress in the Pathogenesis??of COPD
Rahman, I. (2005) · Treatments in Respiratory Medicine · doi:10.2165/00151829-200504030-00003 · Cited by 171 · see citing works
Activation of the Melastatin-Related Cation Channel TRPM3 by d-erythro-Sphingosine
Grimm, C. M., Kraft, R., Schultz, G., & Harteneck, C. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.006734 · Cited by 158 · see citing works
Buelow, B. D., Song, Y., & Scharenberg, A. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802673200 · Cited by 142 · see citing works
TRP-ML1 Is a Lysosomal Monovalent Cation Channel That Undergoes Proteolytic Cleavage
Kiselyov, K. I., Chen, J., Rbaibi, Y., Oberdick, D., Tjon‐Kon‐Sang, S., Shcheynikov, N., Muallem, S., & Soyombo, A. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508210200 · Cited by 135 · see citing works
Sites of the NUDT9-H Domain Critical for ADP-ribose Activation of the Cation Channel TRPM2
Kühn, F. J. P., & Lückhoff, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407263200 · Cited by 121 · see citing works
Keshavarzian, A., Fusunyan, R. D., Jacyno, M., Winship, D. H., MacDermott, R. P., & Sanderson, I. R. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.00940.x · Cited by 108 · see citing works
A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint‐waddler phenotype
Kim, H. J., Li, Q., Tjon‐Kon‐Sang, S., et al. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.56 · Cited by 108 · see citing works
Jaramillo, M., & Olivier, M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.12.7026 · Cited by 96 · see citing works
TRPM7 and TRPM2—Candidate susceptibility genes for Western Pacific ALS and PD?
Hermosura, M. C., & Garruto, R. M. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2007.02.008 · Cited by 94 · see citing works
Chiu, L., Perng, D., Yu, C.-H., Su, S., & Chow, L. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.5237 · Cited by 88 · see citing works
Tanuma, S.-I., Yagi, T., & Johnson, G. S. (1985) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(85)90251-6 · Cited by 59 · see citing works
Korenaga, D., Takesue, F., Kido, K., et al. (2002) · Journal of Surgical Research · doi:10.1006/jsre.2001.6314 · Cited by 49 · see citing works
ANEZAKI, K., Asakura, H., Honma, T., et al. (1998) · Internal Medicine · doi:10.2169/internalmedicine.37.253 · Cited by 47 · see citing works
Araki, Y., Sugihara, H., & Hattori, T. (2006) · International Journal of Molecular Medicine · doi:10.3892/ijmm.17.2.331 · Cited by 43 · see citing works
COPD: is there light at the end of the tunnel?
Barnes, P. J. (2004) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.03.001 · Cited by 42 · see citing works
Importance of post-transcriptional regulation of chemokine genes by oxidative stress
Josse, C., Boelaert, J. R., Best‐Belpomme, M., & Piette, J. G. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3600321 · Cited by 34 · see citing works
Blackburn, A. C., Doe, W. F., & Buffinton, G. D. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00068-9 · Cited by 33 · see citing works
Wilson, L., Butcher, C., & Kellie, S. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81092-e · Cited by 32 · see citing works
Seimiya, H., & TSURUO, T. (1993) · PubMed · Cited by 25 · see citing works
Lee, K., & Esselman, W. J. (2001) · Cellular Signalling · doi:10.1016/s0898-6568(01)00178-4 · Cited by 19 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717 · see citing works
Ion channels and transporters in lymphocyte function and immunity
Feske, S., Skolnik, E. Y., & Prakriya, M. (2012) · Nature Reviews Immunology · doi:10.1038/nri3233 · Cited by 441 · see citing works
TRPM2: a multifunctional ion channel for calcium signalling
Sumoza‐Toledo, A., & Penner, R. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.201855 · Cited by 290 · see citing works
- Authors
- Yamamoto, S., Takahashi, N., & Mori, Y.
- Affiliations
- Kyoto University (JP)
- Corresponding author
- Mori, Yasuo
- Venue
- Progress in Biophysics and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 103
- Issue
- 1
- Pages
- 18-27
- ISSN
- 0079-6107 (ISSN-L)
- OpenAlex
- W2080349747
- Cited by
- 67
- References
- 100
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 5 · 2017: 1 · 2016: 3 · 2015: 5 · 2014: 7 · 2013: 12 · 2012: 8
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Biophysics and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Kyoto University Research Information Repository (Kyoto University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- TRPM2, TRPC5, TRP channels, oxidative stress, reactive oxygen species, calcium influx, chemokine production, monocytes, neutrophil infiltration, inflammation, nitric oxide, cysteine oxidation, cellular adaptation, second messenger signaling
- MeSH terms
- Animals, Humans, Reactive Oxygen Species, Oxidative Stress, Calcium Signaling, Transient Receptor Potential Channels, TRPC Cation Channels, TRPM Cation Channels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
