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Cited by 38Cardiovascular Function and Risk FactorsElasticity and Material ModelingCardiac Fibrosis and Remodeling

Transmural gradients of myocardial structure and mechanics: Implications for fiber stress and strain in pressure overload

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Carruth, Eric D., McCulloch, Andrew D., Omens, Jeffrey H.·2016·Progress in Biophysics and Molecular Biology
DOI 10.1016/j.pbiomolbio.2016.11.004PMC PMC5161628
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Abstract

Although a truly complete understanding of whole heart activation, contraction, and deformation is well beyond our current reach, a significant amount of effort has been devoted to discovering and understanding the mechanisms by which myocardial structure determines cardiac function to better treat patients with cardiac disease. Several experimental studies have shown that transmural fiber strain is relatively uniform in both diastole and systole, in contrast to predictions from traditional mechanical theory. Similarly, mathematical models have largely predicted uniform fiber stress across the wall. The development of this uniform pattern of fiber stress and strain during filling and ejection is due to heterogeneous transmural distributions of several myocardial structures. This review summarizes these transmural gradients, their contributions to fiber mechanics, and the potential functional effects of their remodeling during pressure overload hypertrophy.

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Crossref · 10.1016/j.pbiomolbio.2016.11.004

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  • Helically aligned ventricles were hypothesized to display increased apical shortening and reduced basal displacement owing to differences in myofiber lengths.

    “It has been hypothesized that HA ventricles would display increased apical shortening (3, 36) and reduced basal displacement (9, 36), owing to differences in myofiber lengths.”

    From Recreating the heart's helical structure-function relationship with focused rotary jet spinning (2022) · cites this paper as [9]

    Section 3.1 describes helical fiber orientation and opposite rotations of the apex and base, but does not propose increased apical shortening or reduced basal displacement. Searches for those outcomes and for apex-to-base differences in myofiber length found no passage supporting the attributed hypothesis; section 2.1 instead discusses shortening across the ventricular wall. Page numbers were not available in our copy. (LLM, conf=0.76)

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Research works printed but not linked: 1

  1. Usyk T Mazhari R McCulloch A 2000 Effect of laminar orthotropic myofiber architecture on regional stress and strain in the canine left ventricle Journal of elasticity and the physical science of solids 61 143 164

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Related

Authors
Carruth, E. D., McCulloch, A. D., & Omens, J. H.
Affiliations
University of California San Diego (US)
Corresponding author
Omens, Jeffrey H.
ORCID
Venue
Progress in Biophysics and Molecular Biology
Publisher
Elsevier BV
Published
2016-12
Volume
122
Issue
3
Pages
215-226
ISSN
0079-6107 (ISSN-L)
DOI
10.1016/j.pbiomolbio.2016.11.004
PMC
PMC5161628
OpenAlex
W2555906728
Cited by
38
References
199
Citations by year
2026: 5 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 5 · 2018: 4 · 2017: 1 · 2016: 1
FWCI
0.35
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Progress in Biophysics and Molecular Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (HL103566, GM094503)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords
transmural gradient, myocardial structure, fiber stress, fiber strain, pressure overload, cardiac hypertrophy, cardiac remodeling, cardiac mechanics, myocardial deformation
MeSH terms
Animals, Heart, Humans, Myocardium, Pressure, Stress, Mechanical

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