Three-dimensional transmural organization of perimysial collagen in the heart
Open accessAbstract
There is strong support for the view that the ventricular myocardium has a laminar organization in which myocytes are grouped into branching layers separated by cleavage planes. However, understanding of the extent and functional implications of this architecture has been limited by the lack of a systematic three-dimensional description of the organization of myocytes and associated perimysial collagen. We imaged myocytes and collagen across the left ventricular wall at high resolution in seven normal rat hearts using extended volume confocal microscopy. We developed novel reconstruction and segmentation techniques necessary for the quantitative analysis of three-dimensional myocyte and perimysial collagen organization. The results confirm that perimysial collagen has an ordered arrangement and that it defines a laminar organization. Perimysial collagen is composed of three distinct forms: extensive meshwork on laminar surfaces, convoluted fibers connecting adjacent layers, and longitudinal cords. While myolaminae are the principal form of structural organization throughout most of the wall, they are not seen in the subepicardium, where perimysial collagen is present only as longitudinal cords.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In native heart, overlapping myocardial fibers are arranged into distinct laminae four to six myocytes thick and separated from adjacent laminae by an extracellular collagen network.
“In the native heart, overlapping myocardial fibers are arranged into distinct laminae four to six myocytes thick and separated from adjacent laminae by an extracellular collagen network42.”
From A tissue-engineered scale model of the heart ventricle (2018) · cites this paper as [42]
The Discussion (3-D perimysial collagen organization; page unavailable) describes branching myocardial layers grouped by perimysial collagen and reports them as approximately four cells thick, not four to six. The Results (page unavailable) show collagen between adjacent layers, but the paper also says laminar structure is not evident in the outer 10–20% of the rat left ventricle, so the claim is too general. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Cardiac interstitium in health and disease: The fibrillar collagen network
Weber, K. T. (1989) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(89)90360-4 · Cited by 1,060 · see citing works
LeGrice, I. J., Smaill, B. H., Chai, L. Z., Edgar, S. G., Gavin, J. B., & Hunter, P. J. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.269.2.h571 · Cited by 841 · see citing works
Self-citationCollagen remodeling of the pressure-overloaded, hypertrophied nonhuman primate myocardium.
Weber, K. T., Janicki, J. S., Shroff, S. G., Pick, R., Chen, R. M., & Bashey, R. I. (1988) · Circulation Research · doi:10.1161/01.res.62.4.757 · Cited by 556 · see citing works
Whittaker, P., Kloner, R. A., Boughner, D. R., & Pickering, J. G. (1994) · Basic Research in Cardiology · doi:10.1007/bf00788278 · Cited by 496 · see citing works
Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle.
Jalil, J., DOERING, C. W., Janicki, J. S., Pick, R., Shroff, S. G., & Weber, K. T. (1989) · Circulation Research · doi:10.1161/01.res.64.6.1041 · Cited by 491 · see citing works
(1979) · PubMed · Cited by 470 · see citing works
Shear properties of passive ventricular myocardium
Dokos, S., Smaill, B. H., Young, A. A., & LeGrice, I. J. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00111.2002 · Cited by 368 · see citing works
Self-citationCellular mechanisms of myocardial infarct expansion.
Weisman, H. F., Bush, D. E., Mannisi, J. A., Weisfeldt, M. L., & HEALY, B. P. (1988) · Circulation · doi:10.1161/01.cir.78.1.186 · Cited by 333 · see citing works
LeGrice, I. J., Takayama, Y., & Covell, J. W. (1995) · Circulation Research · doi:10.1161/01.res.77.1.182 · Cited by 315 · see citing works
Self-citationLaminar fiber architecture and three-dimensional systolic mechanics in canine ventricular myocardium
Costa, K. D., Takayama, Y., McCulloch, A. D., & Covell, J. W. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.276.2.h595 · Cited by 313 · see citing works
Rademakers, F. E., Rogers, W. J., Guier, W. H., Hutchins, G. M., SIU, C. O., Weisfeldt, M. L., Weiss, J. L., & Shapiro, E. P. (1994) · Circulation · doi:10.1161/01.cir.89.3.1174 · Cited by 310 · see citing works
Hunter, P. J., Pullan, A. J., & Smaill, B. H. (2003) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.5.040202.121537 · Cited by 292 · see citing works
Self-citationTorrent-Guasp, F., Ballester, M., Buckberg, G. D., Carreras, F., Flotats, A., Carrió, I., Ferreira, A., Samuels, L. E., & Narula, J. (2001) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1067/mtc.2001.113745 · Cited by 291 · see citing works
Rossi, M. A. (1998) · Journal of Hypertension · doi:10.1097/00004872-199816070-00018 · Cited by 285 · see citing works
Robb, J. S., & Robb, R. C. (1942) · American Heart Journal · doi:10.1016/s0002-8703(42)90291-6 · Cited by 281 · see citing works
Relation between transmural deformation and local myofiber direction in canine left ventricle.
Waldman, L. K., Nosan, D. K., Villarreal, F. J., & Covell, J. W. (1988) · Circulation Research · doi:10.1161/01.res.63.3.550 · Cited by 279 · see citing works
Measuring and Mapping Cardiac Fiber and Laminar Architecture Using Diffusion Tensor MR Imaging
Helm, P. A., Beg, M. F., Miller, M. I., & Winslow, R. L. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1341.026 · Cited by 250 · see citing works
Robinson, T. F., Cohen‐Gould, L., & Factor, S. M. (1983) · PubMed · Cited by 237 · see citing works
Remodeling of cardiac fiber structure after infarction in rats quantified with diffusion tensor MRI
Chen, J., Song, S., Liu, W., McLean, M., Allen, J. S., Tan, J., Wickline, S. A., & Yu, X. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00889.2002 · Cited by 207 · see citing works
Kočica, M. J., Corno, A. F., Carreras, F., Ballester-Rodés, M., Moghbel, M. C., Cueva, C. C., Lačković, V., Kanjuh, V., & Torrent-Guasp, F. (2006) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2006.03.011 · Cited by 206 · see citing works
Chen, J., Liu, W., Zhang, H., Lacy, L., Yang, X., Song, S., Wickline, S. A., & Yu, X. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00041.2005 · Cited by 197 · see citing works
On the muscular architecture of the ventricles of the human heart
Mall, F. P. (1911) · American Journal of Anatomy · doi:10.1002/aja.1000110302 · Cited by 196 · see citing works
Laminar Arrangement of Ventricular Myocytes Influences Electrical Behavior of the Heart
Hooks, D. A., Trew, M. L., Caldwell, B. J., Sands, G. B., LeGrice, I. J., & Smaill, B. H. (2007) · Circulation Research · doi:10.1161/circresaha.107.161075 · Cited by 186 · see citing works
Self-citationAn engineering analysis of myocardial fiber orientation in pig's left ventricle in systole
Streeter, D. D., & Bassett, D. L. (1966) · The Anatomical Record · doi:10.1002/ar.1091550403 · Cited by 184 · see citing works
Evidence of Structural Remodeling in the Dyssynchronous Failing Heart
Helm, P. A., Laurent Younes, B., Beg, M. F., Ennis, D. B., Leclercq, C., Faris, O., McVeigh, E. R., Kass, D. A., Miller, M. I., & Winslow, R. L. (2005) · Circulation Research · doi:10.1161/01.res.0000199396.30688.eb · Cited by 184 · see citing works
Extended confocal microscopy of myocardial laminae and collagen network
Young, Legrice, Young, & Smaill (1998) · Journal of Microscopy · doi:10.1046/j.1365-2818.1998.00414.x · Cited by 173 · see citing works
Relating myocardial laminar architecture to shear strain and muscle fiber orientation
Arts, T., Costa, K. D., Covell, J. W., & McCulloch, A. D. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.5.h2222 · Cited by 172 · see citing works
Diffusion tensor MRI of myocardial fibers and sheets: Correspondence with visible cut‐face texture
Tseng, W. I., Wedeen, V. J., Reese, T. G., Smith, R. N., & Halpern, E. F. (2002) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.10223 · Cited by 164 · see citing works
Cellular basis for volume related wall thickness changes in the rat left ventricle
Spotnitz, H. M. (1974) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(74)90074-1 · Cited by 149 · see citing works
Myocardial fiber architecture and left ventricular function
Ingels, N. B. (1997) · Technology and Health Care · doi:10.3233/thc-1997-51-205 · Cited by 145 · see citing works
Robinson, T. F., Geraci, M., Sonnenblick, E. H., & Factor, S. M. (1988) · Circulation Research · doi:10.1161/01.res.63.3.577 · Cited by 130 · see citing works
Gilbert, S., Benson, A. P., Li, P., & Holden, A. V. (2007) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2007.03.032 · Cited by 123 · see citing works
Automated imaging of extended tissue volumes using confocal microscopy
Sands, G. B., Gerneke, D., Hooks, D. A., Green, C. R., Smaill, B. H., & LeGrice, I. J. (2005) · Microscopy Research and Technique · doi:10.1002/jemt.20200 · Cited by 122 · see citing works
Self-citationOptimization of Cardiac Fiber Orientation for Homogeneous Fiber Strain During Ejection
Rijcken, J. M., Bovendeerd, P. H. M., Schoofs, A. J. G., van Campen, D. H., & Arts, T. G. J. (1999) · Annals of Biomedical Engineering · doi:10.1114/1.147 · Cited by 121 · see citing works
Morphology, composition, and function of struts between cardiac myocytes of rat and hamster
Robinson, T., Factor, S. M., Capasso, J. M., Wittenberg, B. A., Blumenfeld, O. O., & Seifter, S. (1987) · Cell and Tissue Research · doi:10.1007/bf00215507 · Cited by 108 · see citing works
Influence of endocardial-epicardial crossover of muscle fibers on left ventricular wall mechanics
Bovendeerd, P. H. M., Huyghe, J. M., Arts, T. G. J., van Campen, D. H., & Reneman, R. S. (1994) · Journal of Biomechanics · doi:10.1016/0021-9290(94)90266-6 · Cited by 104 · see citing works
Three‐dimensional architecture of the left ventricular myocardium
Lunkenheimer, P. P., Redmann, K., Kling, N., Jiang, X., Rothaus, K., Cryer, C. W., Wübbeling, F., Niederer, P. F., Heitz, P. U., Ho, S. Y., et al. (2006) · The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology · doi:10.1002/ar.a.20326 · Cited by 102 · see citing works
Jalil, J. (1988) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(88)90597-4 · Cited by 97 · see citing works
Takayama, Y., Costa, K. D., & Covell, J. W. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00261.2001 · Cited by 93 · see citing works
Robinson, T. F., Cohen‐Gould, L., Factor, S. M., Eghbali, M., & Blumenfeld, O. O. (1988) · PubMed · Cited by 88 · see citing works
Myocardial hypertrophy in Macaca fascicularis. Structural remodeling of the collagen matrix.
Abrahams, C., Janicki, J. S., & Kt, W. (1987) · PubMed · Cited by 85 · see citing works
Hanley, P. J., Young, A. A., LeGrice, I. J., Edgar, S. G., & Loiselle, D. S. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0831s.x · Cited by 84 · see citing works
Self-citationHort, W. (1960) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00956322 · Cited by 83 · see citing works
Computational cardiac anatomy using MRI
Beg, M. F., Helm, P. A., McVeigh, E. R., Miller, M. I., & Winslow, R. L. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20255 · Cited by 72 · see citing works
Gerneke, D., Sands, G. B., Ganesalingam, R., Joshi, P., Caldwell, B. J., Smaill, B. H., & LeGrice, I. J. (2007) · Microscopy Research and Technique · doi:10.1002/jemt.20491 · Cited by 61 · see citing works
Self-citationGraham, H. K., & Trafford, A. W. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00355.2006 · Cited by 53 · see citing works
Left ventricular perimysial collagen fibers uncoil rather than stretch during diastolic filling
MacKenna, D. A., Omens, J. H., & Covell, J. W. (1996) · Basic Research in Cardiology · doi:10.1007/bf00799683 · Cited by 52 · see citing works
Heuristic problems in defining the three‐dimensional arrangement of the ventricular myocytes
Anderson, R. H., Ho, S. Y., Sánchez‐Quintana, D., Redmann, K., & Lunkenheimer, P. P. (2006) · The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology · doi:10.1002/ar.a.20330 · Cited by 52 · see citing works
Transmural sheet strains in the lateral wall of the ovine left ventricle
Cheng, A., Langer, F., Rodriguez, F., Criscione, J. C., Daughters, G. T., Miller, D. C., & Ingels, N. B. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00119.2005 · Cited by 52 · see citing works
Epicardial Fiber Organization in Swine Right Ventricle and Its Impact on Propagation
Vetter, F. J., Simons, S. B., Mironov, S. F., Hyatt, C. J., & Pertsov, A. M. (2004) · Circulation Research · doi:10.1161/01.res.0000153979.71859.e7 · Cited by 50 · see citing works
Myocardial segment-specific model generation for simulating the electrical action of the heart
Hooks, D. A. (2007) · BioMedical Engineering OnLine · doi:10.1186/1475-925x-6-21 · Cited by 21 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Models of cardiac tissue electrophysiology: Progress, challenges and open questions
Clayton, R. H., Bernus, O., Cherry, E. M., Dierckx, H., Fenton, F. H., Mirabella, L., Panfilov, A. V., Sachse, F. B., Seemann, G., & Zhang, H. (2010) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2010.05.008 · Cited by 579 · see citing works
Synthesis, properties and biomedical applications of poly(glycerol sebacate) (PGS): A review
Rai, R., Tallawi, M., Grigore, A., & Boccaccini, A. R. (2012) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2012.02.001 · Cited by 477 · see citing works
Feiner, R., Engel, L., Fleischer, S., Malki, M., Gal, I., Shapira, A., Shacham‐Diamand, Y., & Dvir, T. (2016) · Nature Materials · doi:10.1038/nmat4590 · Cited by 460 · see citing works
Biomechanical properties and microstructure of human ventricular myocardium
Sommer, G., Schriefl, A. J., Andrä, M., Sacherer, M., Viertler, C., Wolinski, H., & Holzapfel, G. A. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.06.031 · Cited by 290 · see citing works
Biomimetic gradient hydrogels for tissue engineering
Sant, S., HANCOCK, M. J., Donnelly, J. P., Iyer, D., & Khademhosseini, A. (2010) · The Canadian Journal of Chemical Engineering · doi:10.1002/cjce.20411 · Cited by 251 · see citing works
Contribution of extracellular matrix to the mechanical properties of the heart
Fomovsky, G. M., Thomopoulos, S., & Holmes, J. W. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.08.003 · Cited by 243 · see citing works
Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture
Feinberg, A. W., Alford, P. W., Jin, H., Ripplinger, C. M., Werdich, A. A., Sheehy, S. P., Grosberg, A., & Parker, K. K. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.04.043 · Cited by 240 · see citing works
A tissue-engineered scale model of the heart ventricle
MacQueen, L. A., Sheehy, S. P., Chantre, C. O., Zimmerman, J. F., Pasqualini, F. S., Liu, X., Goss, J. A., Campbell, P. H., Gonzalez, G. M., Park, S.-J., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0271-5 · Cited by 227 · see citing works
Advanced Material Strategies for Tissue Engineering Scaffolds
Freed, L. E., Engelmayr, G. C., Borenstein, J. T., Moutos, F. T., & Guilak, F. (2009) · Advanced Materials · doi:10.1002/adma.200900303 · Cited by 209 · see citing works
Serdar Göktepe, A., & Ellen Kuhl, A. (2009) · Computational Mechanics · doi:10.1007/s00466-009-0434-z · Cited by 208 · see citing works
Xie, Y., Garfinkel, A., Camelliti, P., Kohl, P. K., Weiss, J. N., & Qu, Z. (2009) · Heart Rhythm · doi:10.1016/j.hrthm.2009.08.003 · Cited by 164 · see citing works
Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip
McCain, M. L., Sheehy, S. P., Grosberg, A., Goss, J. A., & Parker, K. K. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304913110 · Cited by 163 · see citing works
Lipid Peroxidation in Atherosclerotic Cardiovascular Diseases
Gianazza, E., Brioschi, M., Fernandez, A. M., Casalnuovo, F., Altomare, A., Aldini, G., & Banfi, C. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7955 · Cited by 158 · see citing works
GDF15 and Cardiac Cells: Current Concepts and New Insights
Rochette, L., Dogon, G., Zeller, M., Cottin, Y., & Vergely, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168889 · Cited by 155 · see citing works
Modular assembly of thick multifunctional cardiac patches
Fleischer, S., Shapira, A., Feiner, R., & Dvir, T. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1615728114 · Cited by 149 · see citing works
Takahashi, H., Shimizu, T., Nakayama, M., Yamato, M., & Okano, T. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.06.033 · Cited by 138 · see citing works
Fibrous scaffolds for building hearts and heart parts
Capulli, A. K., MacQueen, L. A., Sheehy, S. P., & Parker, K. K. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.11.020 · Cited by 130 · see citing works
Image‐based models of cardiac structure in health and disease
Vadakkumpadan, F., Arevalo, H., Prassl, A. J., Chen, J., Kickinger, F., Kohl, P. K., Plank, G., & Trayanova, N. A. (2010) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.76 · Cited by 124 · see citing works
High-Resolution 3-Dimensional Reconstruction of the Infarct Border Zone
Rutherford, S. L., Trew, M. L., Sands, G. B., LeGrice, I. J., & Smaill, B. H. (2012) · Circulation Research · doi:10.1161/circresaha.111.260943 · Cited by 115 · see citing works
Self-citationThree-dimensional filamentous human diseased cardiac tissue model
Ma, Z., Koo, S.-M., Finnegan, M. A., Loskill, P., Huebsch, N., Marks, N. C., Conklin, B. R., Grigoropoulos, C. P., & Healy, K. E. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.10.052 · Cited by 114 · see citing works
Hales, P. W., Schneider, J. E., Burton, R. A. B., Wright, B. J., Bollensdorff, C., & Kohl, P. K. (2012) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2012.07.014 · Cited by 113 · see citing works
3D Structural Patterns in Scalable, Elastomeric Scaffolds Guide Engineered Tissue Architecture
Kolewe, M. E., Park, H., Gray, C. L., Ye, X., Langer, R., & Freed, L. E. (2013) · Advanced Materials · doi:10.1002/adma.201301016 · Cited by 102 · see citing works
Diffusion Tensor Cardiovascular Magnetic Resonance Imaging
Khalique, Z., Ferreira, P., Scott, A. D., Nielles‐Vallespin, S., Firmin, D. N., & Pennell, D. J. (2019) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2019.07.016 · Cited by 101 · see citing works
Ventricular structure–function relations in health and disease: Part I. The normal heart
Buckberg, G. D., Hoffman, J. I. E., Coghlan, H. C., & Nanda, N. C. (2014) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezu278 · Cited by 95 · see citing works
Cellular and Engineered Organoids for Cardiovascular Models
Thomas, D., Choi, S., Alamana, C., Parker, K. K., & Wu, J. C. (2022) · Circulation Research · doi:10.1161/circresaha.122.320305 · Cited by 95 · see citing works
Takahashi, H., Nakayama, M., Shimizu, T., Yamato, M., & Okano, T. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.08.006 · Cited by 89 · see citing works
The Many Faces of Hypertrophic Cardiomyopathy: From Developmental Biology to Clinical Practice
Olivotto, I., Girolami, F., Nistri, S., Rossi, A., Rega, L., Garbini, F., Grifoni, C., Cecchi, F., & Yacoub, M. H. (2009) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-009-9137-2 · Cited by 88 · see citing works
Dual-Phase Cardiac Diffusion Tensor Imaging with Strain Correction
Stoeck, C. T., Kalinowska, A., von Deuster, C., Harmer, J., Chan, R. W., Niemann, M., Manka, R., Atkinson, D., Sosnovik, D. E., Mekkaoui, C., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107159 · Cited by 88 · see citing works
Kung, G. L., Nguyen, T. C., Itoh, A., Skare, S. T., Ingels, N. B., Miller, D. C., & Ennis, D. B. (2011) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.22725 · Cited by 82 · see citing works
Gilbert, S., Benoîst, D., Benson, A. P., White, E., Tanner, S. F., Holden, A. V., Dobrzynski, H., Bernus, O., & Radjenovic, A. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00824.2011 · Cited by 82 · see citing works
Tissue-specific parameters for the design of ECM-mimetic biomaterials
Tonti, O. R., Larson, H., Lipp, S. N., Luetkemeyer, C. M., Makam, M., Vargas, D., Wilcox, S. M., & Calve, S. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.04.017 · Cited by 81 · see citing works
The Development and Structure of the Ventricles in the Human Heart
Henderson, D. J., & Anderson, R. H. (2009) · Pediatric Cardiology · doi:10.1007/s00246-009-9390-9 · Cited by 76 · see citing works
State-of-Art Functional Biomaterials for Tissue Engineering
Sharma, K., Mujawar, M. A., & Kaushik, A. K. (2019) · Frontiers in Materials · doi:10.3389/fmats.2019.00172 · Cited by 75 · see citing works
Takahashi, H., & Okano, T. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500194 · Cited by 75 · see citing works
Spin echo versus stimulated echo diffusion tensor imaging of the in vivo human heart
von Deuster, C., Stoeck, C. T., Genet, M., Atkinson, D., & Kozerke, S. (2015) · Magnetic Resonance in Medicine · doi:10.1002/mrm.25998 · Cited by 75 · see citing works
Patterning of Structurally Anisotropic Composite Hydrogel Sheets
Prince, E., Alizadehgiashi, M., Campbell, M., Khuu, N., Albulescu, A., France, K. J. D., Ratkov, D., Li, Y., Hoare, T. R., & Kumacheva, E. (2018) · Biomacromolecules · doi:10.1021/acs.biomac.8b00100 · Cited by 75 · see citing works
Combined Technologies for Microfabricating Elastomeric Cardiac Tissue Engineering Scaffolds
Guillemette, M. D., Park, H., Hsiao, J. C., Jain, S. R., Larson, B. L., Langer, R., & Freed, L. E. (2010) · Macromolecular Bioscience · doi:10.1002/mabi.201000165 · Cited by 73 · see citing works
Avazmohammadi, R., Hill, M. R. S., Simon, M. A. M., Zhang, W., & Sacks, M. S. (2016) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-016-0837-7 · Cited by 73 · see citing works
Three-Dimensional Impulse Propagation in Myocardium
Smaill, B. H., Zhao, J., & Trew, M. L. (2013) · Circulation Research · doi:10.1161/circresaha.111.300157 · Cited by 72 · see citing works
Self-citationFeiner, R., Wertheim, L., Gazit, D., Kalish, O., Mishal, G., Shapira, A., & Dvir, T. (2019) · Small · doi:10.1002/smll.201805526 · Cited by 71 · see citing works
The generalized Hill model: A kinematic approach towards active muscle contraction
Serdar Göktepe, A., Menzel, A., & Ellen Kuhl, A. (2014) · Journal of the Mechanics and Physics of Solids · doi:10.1016/j.jmps.2014.07.015 · Cited by 70 · see citing works
LeGrice, I. J., Pope, A., Sands, G. B., WHALLEY, G. A., Doughty, R. N., & Smaill, B. H. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00748.2011 · Cited by 66 · see citing works
Self-citationImage-Based Personalization of Cardiac Anatomy for Coupled Electromechanical Modeling
Crozier, A., Augustin, C. M., Neic, A., Prassl, A. J., Höller, M., Fastl, T. E., Hennemuth, A., Bredies, K., Kühne, T., Bishop, M. J., et al. (2015) · Annals of Biomedical Engineering · doi:10.1007/s10439-015-1474-5 · Cited by 65 · see citing works
McEvoy, E., Holzapfel, G. A., & McGarry, P. (2018) · Journal of Biomechanical Engineering · doi:10.1115/1.4039947 · Cited by 65 · see citing works
Determinants of left ventricular shear strain
Bovendeerd, P. H. M., Kroon, W., & Delhaas, T. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01334.2008 · Cited by 63 · see citing works
Krishnan, A., Chilton, E., Raman, J., Saxena, P., McFarlane, C., Trollope, A. F., Kinobe, R. T., & Chilton, L. (2021) · Cells · doi:10.3390/cells10092501 · Cited by 58 · see citing works
Cardiac Diffusion: Technique and Practical Applications
Nielles‐Vallespin, S., Scott, A. D., Ferreira, P., Khalique, Z., Pennell, D. J., & Firmin, D. N. (2019) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.26912 · Cited by 57 · see citing works
Finsberg, H., Xi, C., Tan, J. L., Zhong, L., Genet, M., Sundnes, J., Lee, L., & Wall, S. (2018) · International Journal for Numerical Methods in Biomedical Engineering · doi:10.1002/cnm.2982 · Cited by 51 · see citing works
Role of the intercalated disc in cardiac propagation and arrhythmogenesis
Kléber, A. G., & Saffitz, J. E. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00404 · Cited by 52 · see citing works
Gan, Y., & Fleming, C. P. (2013) · Biomedical Optics Express · doi:10.1364/boe.4.002150 · Cited by 52 · see citing works
Images as drivers of progress in cardiac computational modelling
Lamata, P., Casero, R., Carapella, V., Niederer, S., Bishop, M. J., Schneider, J. E., Kohl, P. K., & Grau, V. (2014) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2014.08.005 · Cited by 51 · see citing works
Effect of fiber diameter on the assembly of functional 3D cardiac patches
Fleischer, S., Miller, J., Hurowitz, H., Shapira, A., & Dvir, T. (2015) · Nanotechnology · doi:10.1088/0957-4484/26/29/291002 · Cited by 50 · see citing works
Wang, X. S., Feiner, R., Luan, H., Zhang, Q., Zhao, S., Zhang, Y., Han, M., Li, Y., Sun, R., Wang, H., et al. (2020) · Extreme Mechanics Letters · doi:10.1016/j.eml.2020.100634 · Cited by 50 · see citing works
Structural Remodeling and Mechanical Function in Heart Failure
Leonard, B. L., Smaill, B. H., & LeGrice, I. J. (2012) · Microscopy and Microanalysis · doi:10.1017/s1431927611012438 · Cited by 49 · see citing works
Self-citationSack, K. L., Davies, N. H., Guccione, J. M., & Franz, T. (2016) · Heart Failure Reviews · doi:10.1007/s10741-016-9528-9 · Cited by 46 · see citing works
Cardiac Physiology of Aging: Extracellular Considerations
Horn, M. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140063 · Cited by 46 · see citing works
DePalma, S. J., Davidson, C. D., Stis, A. E., Helms, A. S., & Baker, B. M. (2020) · Biomaterials Science · doi:10.1039/d0bm01247e · Cited by 44 · see citing works
Tsai, M., Chiu, Y.-W., Lo, M. T., & Sun, C. (2010) · Journal of Biomedical Optics · doi:10.1117/1.3365943 · Cited by 43 · see citing works
Bernus, O., Radjenovic, A., Trew, M. L., LeGrice, I. J., Sands, G. B., Magee, D. R., Smaill, B. H., & Gilbert, S. (2015) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/s12968-015-0129-x · Cited by 43 · see citing works
Self-citationZhang, L., Allen, J. S., Hu, L., Caruthers, S. D., Wickline, S. A., & Chen, J. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00129.2012 · Cited by 42 · see citing works
Curl, C. L., Danes, V. R., Bell, J. R., Raaijmakers, A. J. A., Ip, W. T. K., Chandramouli, C., Harding, T. W., Porrello, E. R., Erickson, J. R., Charchar, F. J., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.007451 · Cited by 41 · see citing works
Engineering anisotropic 3D tubular tissues with flexible thermoresponsive nanofabricated substrates
Williams, N. P., Rhodehamel, M., Yan, C., Smith, A. S. T., Jiao, A., Murry, C. E., Scatena, M., & Kim, D. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.119856 · Cited by 41 · see citing works
Niestrawska, J., Augustin, C. M., & Plank, G. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.02.010 · Cited by 35 · see citing works
Label-free photoacoustic microscopy of myocardial sheet architecture
Zhang, C., Wang, L. V., Chen, J., Chen, J., & Wickline, S. A. (2012) · Journal of Biomedical Optics · doi:10.1117/1.jbo.17.6.060506 · Cited by 40 · see citing works
Carruth, E. D., McCulloch, A. D., & Omens, J. H. (2016) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2016.11.004 · Cited by 38 · see citing works
Kelly, A., Salerno, S., Connolly, A. J., Bishop, M. J., Charpentier, F., Stølen, T., & Smith, G. L. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx244 · Cited by 38 · see citing works
Walton, R. D., Benoîst, D., Hyatt, C. J., Gilbert, S., White, E., & Bernus, O. (2010) · Heart Rhythm · doi:10.1016/j.hrthm.2010.08.019 · Cited by 38 · see citing works
A murine experimental model for the mechanical behaviour of viable right‐ventricular myocardium
Valdez‐Jasso, D., Simon, M. A. M., Champion, H. C., & Sacks, M. S. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.233015 · Cited by 37 · see citing works
Model-Based Vasculature Extraction From Optical Fluorescence Cryomicrotome Images
Goyal, A., Lee, J., Lamata, P., van den Wijngaard, J. P. H. M., van Horssen, P., Spaan, J. A. E., Siebes, M., Grau, V., & Smith, N. P. (2012) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2012.2227275 · Cited by 37 · see citing works
Myocardial mesostructure and mesofunction
Wilson, A. J., Sands, G. B., LeGrice, I. J., Young, A. A., & Ennis, D. B. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00059.2022 · Cited by 36 · see citing works
Self-citationStephenson, R. S., Agger, P., Lunkenheimer, P. P., Zhao, J., Smerup, M., Niederer, P., Anderson, R. H., & Jarvis, J. C. (2016) · Clinical Anatomy · doi:10.1002/ca.22661 · Cited by 33 · see citing works
Dall’Armellina, E., Ennis, D. B., Axel, L., Croisille, P., Ferreira, P., Gotschy, A., Lohr, D., Moulin, K., Nguyen, C. T., Nielles-Vallespin, S., et al. (2024) · Journal of Cardiovascular Magnetic Resonance · doi:10.1016/j.jocmr.2024.101109 · Cited by 33 · see citing works
Anomalous Diffusion in Cardiac Tissue as an Index of Myocardial Microstructure
Bueno‐Orovio, A., Teh, I., Schneider, J. E., Burrage, K., & Grau, V. (2016) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2016.2548503 · Cited by 33 · see citing works
Three-dimensional collagen fiber mapping and tractography of human uterine tissue using OCT
McLean, J. P., Fang, S., Gallos, G., Myers, K. M., & Hendon, C. P. (2020) · Biomedical Optics Express · doi:10.1364/boe.397041 · Cited by 31 · see citing works
Engineered circulatory scaffolds for building cardiac tissue
Huang, S., Yang, Y., Yang, Q., Zhao, Q., & Ye, X. (2018) · Journal of Thoracic Disease · doi:10.21037/jtd.2017.12.92 · Cited by 31 · see citing works
Anisotropic conduction in the myocardium due to fibrosis: the effect of texture on wave propagation
Nezlobinsky, T. V., Solovyova, O. E., & Panfilov, A. V. (2020) · Scientific Reports · doi:10.1038/s41598-020-57449-1 · Cited by 30 · see citing works
Kléber, A. G., & Jin, Q. (2021) · Biophysics Reviews · doi:10.1063/5.0050192 · Cited by 29 · see citing works
Epicardial origin of cardiac arrhythmias: clinical evidences and pathophysiology
Chaumont, C., Suffee, N., Gandjbakhch, E., Balse, E., Anselme, F., & Hatem, S. N. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab213 · Cited by 29 · see citing works
Modular Assembly Approach to Engineer Geometrically Precise Cardiovascular Tissue
Lee, B. W., Liu, B., Pluchinsky, A., Kim, N., Eng, G. M., & Vunjak‐Novakovic, G. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201500956 · Cited by 29 · see citing works
Kučera, J., Rohr, S., & Kléber, A. G. (2017) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.117.004665 · Cited by 28 · see citing works
Cheng, Y., Lang, D., Caruthers, S. D., Efimov, I. R., Chen, J., & Wickline, S. A. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00321.2012 · Cited by 27 · see citing works
The end of the unique myocardial band: Part II. Clinical and functional considerations
MacIver, D. H., Partridge, J. B., Agger, P., Stephenson, R. S., Boukens, B. J., Omann, C., Jarvis, J. C., & Zhang, H. (2017) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezx335 · Cited by 27 · see citing works
Schmid, H., Pauli, L., Paulus, A., Ellen Kuhl, A., & Itskov, M. (2011) · Computer Methods in Biomechanics & Biomedical Engineering · doi:10.1080/10255842.2010.548325 · Cited by 27 · see citing works
Cardiac multi-scale investigation of the right and left ventricle ex vivo: a review
Dejea, H., Bonnin, A., Cook, A. C., & García‐Canadilla, P. (2020) · Cardiovascular Diagnosis and Therapy · doi:10.21037/cdt-20-269 · Cited by 27 · see citing works
Organization and collateralization of a subendocardial plexus in end-stage human heart failure
van den Wijngaard, J. P. H. M., van Horssen, P., ter Wee, R., Coronel, R., de Bakker, J. M. T., de Jonge, N., Siebes, M., & Spaan, J. A. E. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00654.2009 · Cited by 24 · see citing works
Cardiomyopathy in young adults with classic mitral valve prolapse
Malev, E. G., Вениаминовна, Р. С., Васильевна, В. Л., Тимофеев, Е. В., Pshepiy, A., Korshunova, A., Prokudina, M., & Zemtsovsky, E. V. (2013) · Cardiology in the Young · doi:10.1017/s1047951113001042 · Cited by 24 · see citing works
DePalma, S. J., Jilberto, J., Stis, A. E., Huang, D. D., Lo, J., Davidson, C. D., Chowdhury, A., Kent, R. N., Jewett, M. E., Kobeissi, H., et al. (2024) · Advanced Science · doi:10.1002/advs.202309740 · Cited by 23 · see citing works
Dynamic interactions between the cellular components of the heart and the extracellular matrix
Borg, T. K., & Baudino, T. A. (2011) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-0940-7 · Cited by 23 · see citing works
(INVITED) Reaction–diffusion waves in cardiovascular diseases
Panfilov, A. V., Dierckx, H., & Volpert, V. A. (2019) · Physica D Nonlinear Phenomena · doi:10.1016/j.physd.2019.04.001 · Cited by 23 · see citing works
How are the cardiomyocytes aggregated together within the walls of the left ventricular cone?
Anderson, R. H., Niederer, P. F., Sanchez‐Quintana, D., Stephenson, R. S., & Agger, P. (2019) · Journal of Anatomy · doi:10.1111/joa.13027 · Cited by 22 · see citing works
Anatomic Considerations and Examination of Cardiovascular Specimens (Excluding Devices)
Maleszewski, J. J., Lai, C. K., & Veinot, J. P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420219-1.00001-x · Cited by 22 · see citing works
Collagenous Skeleton of the Rat Mystacial Pad
Haidarliu, S., Simony, E., Golomb, D., & Ahissar, E. (2011) · The Anatomical Record · doi:10.1002/ar.21371 · Cited by 22 · see citing works
Two‐photon microscopy of healthy, infarcted and stem‐cell treated regenerating heart
Wallenburg, M. A., Wu, J., Li, R., & Vitkin, I. A. (2010) · Journal of Biophotonics · doi:10.1002/jbio.201000059 · Cited by 21 · see citing works
Dileep, D., Syed, T. A., Sloan, T. F. W., Dhandapany, P. S., Kaleem Siddiqi, A., & Sirajuddin, M. (2023) · The EMBO Journal · doi:10.15252/embj.2022113288 · Cited by 21 · see citing works
Tschöpe, C., & Senni, M. (2019) · Heart Failure Reviews · doi:10.1007/s10741-019-09853-7 · Cited by 21 · see citing works
Allen, P. S., Dell’Italia, L. J., Esvelt, M. A., Conte, M. L., Cadillac, J. M., & Myers, D. D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814338-4.00025-8 · Cited by 21 · see citing works
Cardiac Response to Low-Energy Field Pacing Challenges the Standard Theory of Defibrillation
Caldwell, B. J., Trew, M. L., & Pertsov, A. M. (2015) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.114.002661 · Cited by 21 · see citing works
Resolving the True Ventricular Mural Architecture
Stephenson, R. S., Agger, P., Omann, C., Sánchez‐Quintana, D., Jarvis, J. C., & Anderson, R. H. (2018) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd5020034 · Cited by 20 · see citing works
Models of Ventricular Structure and Function Reviewed for Clinical Cardiologists
Lunkenheimer, P. P., Niederer, P. F., Sánchez‐Quintana, D., Murillo, M., & Smerup, M. (2012) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-012-9440-1 · Cited by 19 · see citing works
The collagenous microstructure of cardiac ventricular trabeculae carneae
Sands, G. B., Goo, S., Gerneke, D., LeGrice, I. J., & Loiselle, D. S. (2010) · Journal of Structural Biology · doi:10.1016/j.jsb.2010.06.020 · Cited by 18 · see citing works
Self-citation
- Authors
- Pope, A. J., Sands, G. B., Smaill, B. H., & LeGrice, I. J.
- Affiliations
- University of Auckland (NZ)
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2008-09
- Volume
- 295
- Issue
- 3
- Pages
- H1243-H1252
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- PMC
- PMC2544485
- OpenAlex
- W2117433444
- Cited by
- 205
- References
- 51
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 4 · 2023: 8 · 2022: 9 · 2021: 16 · 2020: 16 · 2019: 14 · 2018: 12 · 2017: 10 · 2016: 11 · 2015: 15 · 2014: 12 · 2013: 15 · 2012: 18
- FWCI
- 7.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ResearchSpace (University of Auckland) (submittedVersion)
- Funders
- National Heart Foundation of New Zealand
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- left ventricular wall, 3D reconstruction, collagen fiber arrangement, subepicardium, rat heart
- MeSH terms
- Animals, Collagen, Endocardium, Heart Ventricles, Image Processing, Computer-Assisted, Male, Myocardium, Pericardium, Rats, Inbred WKY, Rats, Wistar, Microscopy, Confocal, Myocytes, Cardiac, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
