Methyl aminolevulinate photodynamic therapy after partial debulking in the treatment of superficial and nodular basal cell carcinoma: 3-years follow-up
Abstract
Background The increase in the number of basal cell carcinoma (BCC) lesions has prompted use of minimally invasive therapies, including Photodynamic therapy (PDT). . The objective of the present work was to analyze the efficacy of methyl aminolevulinate-mediated photodynamic therapy (MAL-PDT) in patients suffering from superficial or nodular BCCs.Methods A total of 220 BCC lesions (76 superficial and 144 nodular), clinically diagnosed and confirmed by histopathology analysis, were treated in 174 patients (mean age 72.5). Debulking using curettage was performed before two or three MAL-PDT sessions (λ = 630 nm; 90 J/cm 2; 23 min) at 4-week intervals. Analyses of clinical clearance and cosmetic outcome were carried out by direct examination, dermoscopy, photographs, as well as by fluorescence diagnosis using a Wood's lamp. Evaluations were carried out at the different PDT sessions and follow-ups over a 3-year period.Results MAL-PDT was safe and highly tolerated. After an average of 2.6 MAL-PDT sessions, the overall clearance rate at 3-year follow-up was 96.1 % (95 % confidence interval [CI] 100 %-92 %) for superficial BCCs and 95.2 % (95 % [CI] 99 %-92 %) for nodular BCCs after an average of 2.7 sessions. Minimal side effects such as crushing, erythema and edema were reported. All BCC lesions showed excellent or good cosmetic results.Conclusion The protocol followed in the present study has shown that MAL-PDT is a safe and effective treatment for superficial and nodular types of BCC.
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The majority of published work on PDT for nonmelanoma skin cancers has studied efficacy in people with FST I-II.
“Where PDT has been used to treat nonmelanoma skin cancers, including BCC, SCC, Bowen’s disease, and AK, the majority of the published work has studied efficacy in people with FST I–II.112,122–125”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [123]
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- Authors
- Gómez, C., Cobos, P., & Alberdi, E.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Gómez, Clara
- ORCID
- Gómez, Clara
- Venue
- Photodiagnosis and Photodynamic Therapy
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 33
- Pages
- 102176
- ISSN
- 1572-1000 (ISSN-L)
- OpenAlex
- W3120065506
- Cited by
- 12
- References
- 33
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 1 · 2023: 4 · 2022: 1
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Photodiagnosis and Photodynamic Therapy (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- Fundación Eugenio Rodríguez Pascual
- Ministerio de Economía y Competitividad (MAT 2017-83856-C3)
- Ministerio de Ciencia e Innovación
- Topics
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- methyl aminolevulinate, photodynamic therapy, basal cell carcinoma, superficial basal cell carcinoma, nodular basal cell carcinoma, treatment efficacy, cosmetic outcome, long-term follow-up, treatment safety
- MeSH terms
- Aged, Aminolevulinic Acid, Carcinoma, Basal Cell, Basal Cell Carcinoma, Follow-Up Studies, Humans, Photochemotherapy, Skin Neoplasms, Treatment Outcome, Photosensitizing Agents, Cytoreduction Surgical Procedures
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