Photodynamic therapy for basal cell carcinoma: Clinical and pathological determinants of response
Open accessAbstract
BACKGROUND: Photodynamic therapy (PDT) is increasingly used in the treatment of basal cell carcinoma (BCC). However, scant information is available about the impact of both patient- and lesion-related characteristics on the effectiveness of therapy. Therefore, on the basis of the current data, it is difficult to draw clear-cut indications to use PDT for treatment of BCC in clinical practice. OBJECTIVE: To investigate the clinical and pathological determinants of response of BCC to PDT with methylaminolevulinate (MAL) and red light. METHODS: The clinical and pathological characteristics of 194 BCCs in 135 patients, treated with MAL-PDT, were evaluated. Lesions were treated with MAL-PDT according to established methods and the response was assessed by clinical follow-up of the patients. RESULTS: Complete response to PDT was 62%, with a better response for superficial BCC (95/116, 82%) than nodular BCC (26/78, 33%). When determinants of response were analysed, the nodular type and the location on the limbs emerged as significant clinical predictors of failure. Among the pathological characteristics, the nodular and infiltrative histotypes, as well as ulceration and tumour thickness were associated with a lower response to therapy. Patients' age and gender, as well as the size of the lesions, were not found to be significant predictors. CONCLUSIONS: Optimization of PDT procedure for BCC requires a careful selection of the lesions. In particular, superficial BCCs, preferentially located on the trunk, show the best therapeutic response.
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- Authors
- Fantini, F., Greco, A., Del Giovane, C., Cesinaro, A. M., Venturini, M., Zane, C., Surrenti, T., Peris, K., & Calzavara‐Pinton, P. G.
- Affiliations
- University of Modena and Reggio Emilia (IT)
- University of Brescia (IT)
- Bambino Gesù Children's Hospital (IT)
- University of L'Aquila (IT)
- Corresponding author
- Fantini, F.
- Venue
- Journal of the European Academy of Dermatology and Venereology
- Publisher
- Wiley
- Published
- 2010-11-04
- Volume
- 25
- Issue
- 8
- Pages
- 896-901
- ISSN
- 0926-9959 (ISSN-L)
- 1468-3083
- OpenAlex
- W1533521720
- Cited by
- 113
- References
- 26
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 6 · 2020: 6 · 2019: 12 · 2018: 13 · 2017: 7 · 2016: 13 · 2015: 11 · 2014: 6 · 2013: 11 · 2012: 6
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Journal of the European Academy of Dermatology and Venereology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Dermatology › Cancer and Skin Lesions
- Keywords
- photodynamic therapy, basal cell carcinoma, methyl aminolevulinate, red light, predictors of treatment response, superficial basal cell carcinoma, nodular basal cell carcinoma, tumor thickness, ulceration, histological subtypes, lesion localization, limb lesions
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Aminolevulinic Acid, Basal Cell Carcinoma, Extremities, Female, Head and Neck Neoplasms, Humans, Male, Middle Aged, Photochemotherapy, Retrospective Studies, Sex Factors, Skin Neoplasms, Treatment Outcome, Photosensitizing Agents, Torso
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