Creating a synergy effect: A cluster randomized controlled trial testing the effect of a tailored multimedia intervention on patient outcomes

Linn, Annemiek J.; van Dijk, Liset; van Weert, Julia C.M.; Gebeyehu, Beniam G.; van Bodegraven, Ad. A.; Smit, Edith G.

doi:10.1016/j.pec.2018.03.017

Cited by 31Medication Adherence and ComplianceMobile Health and mHealth ApplicationsPharmacy and Medical Practices

Creating a synergy effect: A cluster randomized controlled trial testing the effect of a tailored multimedia intervention on patient outcomes

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Linn, Annemiek J., van Dijk, Liset, van Weert, Julia C.M., Gebeyehu, Beniam G., van Bodegraven, Ad. A., Smit, Edith G.·2018·Patient Education and Counseling

DOI 10.1016/j.pec.2018.03.017

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Abstract

Objective Improving adherence is a challenge and multiple barriers are likely to explain non-adherence. These barriers differ per patient and over course of the regimen. Hence, personalized interventions tailored to the specific barriers are needed. In a theoretical and evidence-based Tailored Multimedia Intervention, technology (online preparatory assessment, text messaging) was used as an add-on to a tailored counseling session (learned during a communication skills training), with the expectation of synergistic effects.Methods A cluster randomized controlled trial was conducted in six hospitals, eight nurses and 160 chronic patients. Patient satisfaction with communication, beliefs about medication, self-efficacy and medication adherence were assessed at initiation of the treatment and after six months.Results Intervention effects were found for patient satisfaction with nurses' affective communication and self-efficacy at the initiation of treatment. The effect on self-efficacy remained after six months.Conclusion By combining tailored counseling with technology, this intervention resulted in positive changes in important prerequisites of medication adherence.Practical implications Technology can contribute significantly to health care providers' ability to tailor information to the patients' needs.

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Personalizing treatment across multiple fields of healthcare leads to higher treatment adherence and improved satisfaction.
“Studies across multiple fields of healthcare have shown that personalizing treatment leads to higher treatment adherence as well as improved satisfaction [20–23].”
From Personalized machine learning guided intervention for optimizing lifestyle behaviors in depression: a pilot study (2026) · cites this paper as [22]
In Results §3.2 (page unavailable), patients receiving the tailored intervention reported higher satisfaction with nurses’ affective communication at three weeks, but not higher satisfaction on the other measures or at six months. Results §3.4 found no significant increase in medication adherence. The study involved patients with inflammatory bowel disease, so it does not itself establish the claim across multiple healthcare fields. (LLM, conf=0.90)
Experimental — accuracy not yet measured
All personalized intervention studies use predictive models based on multi-subject data.
“Yet, of note, all of these personalized intervention studies use predictive models based on multi-subject data.”
From Personalized machine learning guided intervention for optimizing lifestyle behaviors in depression: a pilot study (2026) · cites this paper as [22]
The Introduction and Conclusion describe this study as testing a tailored intervention, and the Discussion says its content was tailored to patients’ self-reported adherence barriers. The paper does not say that its intervention used a predictive model based on multi-subject data, or establish that all personalized intervention studies do so. (LLM, conf=0.84)
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Authors: Linn, A. J., van Dijk, L., van Weert, J. C. M., Gebeyehu, B. G., van Bodegraven, A. A., & Smit, E. G.
Affiliations: University of Amsterdam (NL)
Corresponding author: Linn, Annemiek J.
ORCID: Linn, Annemiek J.
Smit, Edith G.
Venue: Patient Education and Counseling
Publisher: Elsevier BV
Published: 2018-08
Volume: 101
Issue: 8
Pages: 1419-1426
ISSN: 0738-3991 (ISSN-L)
DOI: 10.1016/j.pec.2018.03.017
OpenAlex: W2792519785
Cited by: 31
References: 41
Citations by year: 2026: 4 · 2025: 3 · 2024: 9 · 2023: 7 · 2022: 1 · 2021: 6 · 2020: 1
FWCI: 2.00
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Patient Education and Counseling (publishedVersion)
PubMed (publishedVersion)
UvA-DARE (University of Amsterdam) (acceptedVersion, other-oa)
Data Archiving and Networked Services (DANS) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Pure Amsterdam UMC (submittedVersion)
Funders: Amsterdam School of Communication Research/ASCoR
Merck Sharp & Dohme B.V. and Teva Pharmaceutical Industries
Topics: Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacy and Medical Practices
Keywords: medication adherence, patient satisfaction, self-efficacy, nurse-patient communication, emotional communication, communication skills training, barriers to adherence, chronic disease patients, text messaging, individualized counseling
MeSH terms: Adult, Counseling, Female, Gastrointestinal Agents, Humans, Inservice Training, Male, Middle Aged, Netherlands, Nurse-Patient Relations, Nursing Staff, Hospital, Patient Education as Topic, Surveys and Questionnaires, Inflammatory Bowel Diseases, Treatment Outcome, Patient Satisfaction, Multimedia, Self Efficacy, Medication Adherence, Text Messaging

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Creating a synergy effect: A cluster randomized controlled trial testing the effect of a tailored multimedia intervention on patient outcomes

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