The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Postural Orthostatic Tachycardia Syndrome: A Clinical Review
Abstract
Postural orthostatic tachycardia syndrome was defined in adult patients as an increase >30 beats per minute in heart rate of a symptomatic patient when moving from supine to upright position. Clinical signs may include postural tachycardia, headache, abdominal discomfort, dizziness/presyncope, nausea, and fatigue. The most common adolescent presentation involves teenagers within 1-3 years of their growth spurt who, after a period of inactivity from illness or injury, cannot return to normal activity levels because of symptoms induced by upright posture. Postural orthostatic tachycardia syndrome is complex and likely has numerous, concurrent pathophysiologic etiologies, presenting along a wide spectrum of potential symptoms. Nonpharmacologic treatment includes (1) increasing aerobic exercise, (2) lower-extremity strengthening, (3) increasing fluid/salt intake, (4) psychophysiologic training for management of pain/anxiety, and (5) family education. Pharmacologic treatment is recommended on a case-by-case basis, and can include beta-blocking agents to blunt orthostatic increases in heart rate, alpha-adrenergic agents to increase peripheral vascular resistance, mineralocorticoid agents to increase blood volume, and serotonin reuptake inhibitors. An interdisciplinary research approach may determine mechanistic root causes of symptoms, and is investigating novel management plans for affected patients.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The tachycardia of POTS is a sinus tachycardia.”
From Postural tachycardia syndrome: beyond orthostatic intolerance (2015) · cites this paper as [11]
In the citing paper
“This, combined with its high cost and the need for injection, makes it a less attractive option [11].”
From Postural tachycardia syndrome: beyond orthostatic intolerance (2015) · cites this paper as [11]
Citations
Cites
Hickie, I. B., Davenport, T. A., Wakefield, D., Vollmer-Conna, U. S., Cameron, B., Vernon, S. D., Reeves, W. C., & Lloyd, A. R. (2006) · BMJ · doi:10.1136/bmj.38933.585764.ae · Cited by 824
Prevalence of Severe Hypovitaminosis D in Patients With Persistent, Nonspecific Musculoskeletal Pain
Plotnikoff, G. A., & Quigley, J. M. (2003) · Mayo Clinic Proceedings · doi:10.4065/78.12.1463 · Cited by 691
Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies
Vernino, S., Low, P. A., Fealey, R. D., Stewart, J. D., Farrugia, G., & Lennon, V. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009213431204 · Cited by 674
Orthostatic Intolerance and Tachycardia Associated with Norepinephrine-Transporter Deficiency
Shannon, J. R., Flattem, N. L., Jordan, J., Jacob, G., Black, B. K., Biaggioni, I., Blakely, R. D., & Robertson, D. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002243420803 · Cited by 594 · cited 3×
“One specific gene mutation in patients with orthostatic intolerance is norepinephrine transporter protein deficiency, first reported in a family in 2000 [27].”
BackgroundInfluentialIdiopathic postural orthostatic tachycardia syndrome: An attenuated form of acute pandysautonomia?
Schondorf, R., & Low, P. A. (1993) · Neurology · doi:10.1212/wnl.43.1_part_1.132 · Cited by 548
Postural orthostatic tachycardia syndrome: the Mayo clinic experience
Thieben, M. J., Sandroni, P., Sletten, D. M., Benrud-Larson, L. M., Fealey, R. D., Vernino, S., Low, P. A., Lennon, V. A., & Shen, W.-K. (2007) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)61027-6 · Cited by 516
Dysautonomia in the joint hypermobility syndrome
Gazit, Y., Nahir, A. M., Grahame, R., & Jacob, G. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(03)00235-3 · Cited by 390
Verdon, F., Burnand, B., Stubi, C.-L. F., Bonard, C., Graff, M., Michaud, A., Bischoff, T., de Vevey, M., Studer, J.-P., Herzig, L., et al. (2003) · BMJ · doi:10.1136/bmj.326.7399.1124 · Cited by 320
Ornato, J. P., & Hand, M. M. (2001) · Circulation · doi:10.1161/01.cir.103.25.e124 · Cited by 294
Long QT syndrome: from channels to cardiac arrhythmias
Moss, A. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25537 · Cited by 293
Research works printed but not linked: 4
- Marsh AM, Fischer PR, Brands CK, et al. Dizziness in a pediatric and adolescent referral population. Presented at the Pediatric Academic Societies Annual Meeting, Washington, DC, 2005. Pediatric Academic Societies 2005;57:204.
- Fischer, 2005, High prevalence of orthostatic intolerance in adolescents in a general pediatric referral clinic, Clin Autonom Res, 15, 340
- Skinner, 2007, Normal reference ranges for orthostatic changes in heart rate and blood pressure response in adolescents, Clin Autonom Res, 17, 307
- Burkhardt, 2007, Heart rate response to exercise in adolescents with autonomic dysfunction, Clin Autonom Res, 17, 266
Cited by
Sorted by citations
Items 101–119 of 119
Syncope and Postural Orthostatic Tachycardia Syndrome
Moodley, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-37101-8.00086-2 · Cited by 1
Shahi, N., Shirek, G. P., Pickett, K. L., Schwartz, A., Shoop, J., Phillips, R. C., Workman, R., Kaplan, D., Pitula, C. E., & Moulton, S. L. (2020) · Cardiology in the Young · doi:10.1017/s1047951120002905 · Cited by 1
Clinical Aspects of Paediatric PoTS
Fischer, P. R., Kavi, L., & Whitehouse, W. P. (2020) · Springer eBooks · doi:10.1007/978-3-030-54165-1_36 · Cited by 1
Self-citationAnxiety and depression emotion is involved in the pathogenesis of postural tachycardia syndromePreprint
Shao, W., Li, H., Gao, L., Han, Z., & Yuan, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-2059525/v1 · Cited by 1
Barary, M., Afshar, Z. M., Mazaherinia, H., Rostami, H. N., Babazadeh, A., Hashemi, E., & Ebrahimpour, S. (2023) · doi:10.22541/au.168620792.28853317/v1 · Cited by 1
Khan, M. I., Perkins, K., & Joseph, F. (2013) · Endocrine Abstracts · doi:10.1530/endoabs.31.p68
Acetylcholine receptors antibodies in postural tachycardia syndrome
(2015) · Receptors & Clinical Investigation · doi:10.14800/rci.516
Living with postural orthostatic tachycardia syndrome
Busmer, L. (2011) · British Journal of Cardiac Nursing · doi:10.12968/bjca.2011.6.7.358
Bettini, E. (2016) · UA Campus Repository (The University of Arizona)
Syncope: Primary Care Office Evaluation and Workup
Hricz, C., & Tzizik, D. M. (2017) · Physician Assistant Clinics · doi:10.1016/j.cpha.2017.06.012
A 15-year-old Girl with Syncope
Niaz, T., & Klaas, K. M. (2020) · Pediatrics in Review · doi:10.1542/pir.2018-0063
Postural orthostatic tachycardia syndrome following open thoracoabdominal aortic aneurysm repair
Manuel, L., Fong, L. S., Mamo, A., Varcoe, R. L., Saw, W., & Grant, P. W. (2021) · Journal of Surgical Case Reports · doi:10.1093/jscr/rjab012
Benito, K., Ramanathan, A., Lobato, D. J., Jandasek, B. N., Mamaril, E., McBride, H., & Feit, L. R. (2022) · Children s Health Care · doi:10.1080/02739615.2022.2047049
Syncope and Postural Orthostatic Tachycardia Syndrome
Moodley, M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-10944-7.00108-6
Go, S., Kasuga, A., Hayashi, K., Murakami, M., Minami, S., Matsumoto, W., Takahashi, R., Watanabe, Y., Saito, N., Ohno, K., et al. (2025) · Clinical Autonomic Research · doi:10.1007/s10286-025-01169-x
Griffith, G. J., Holst, B., Myers, J., & Ward, K. M. (2026) · Pediatric Exercise Science · doi:10.1123/pes.2025-0074
Arroyo, H. A., Torres, A. R., Vidaurre, J. A., Rugilo, C., & Ho, M.-L. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-28722-0.00004-6
Treatment of Headache in Children and Adolescents with POTS
Nayak, K., Rahman, S., & Oakley, C. B. (2026) · Current Pain and Headache Reports · doi:10.1007/s11916-026-01516-1
Tamilson, B., Fenske, O., Morrin, H., Coebergh, J. A., Agrawal, N., Owens, A. P., Lim, P. B., & Poole, N. A. (2026) · Swiss Archives of Neurology Psychiatry and Psychotherapy · doi:10.3390/sanpp176020010
Metadata
- Authors
- Johnson, J. N., Mack, K. J., Kuntz, N. L., Brands, C. K., Porter, C. J., & Fischer, P. R.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Johnson, Jonathan N.
- Venue
- Pediatric Neurology
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 42
- Issue
- 2
- Pages
- 77-85
- ISSN
- 0887-8994 (ISSN-L)
- OpenAlex
- W1974651566
- Cited by
- 119
- References
- 47
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 4 · 2023: 4 · 2022: 9 · 2021: 2 · 2020: 8 · 2019: 4 · 2018: 7 · 2017: 8 · 2016: 10 · 2015: 14 · 2014: 13 · 2013: 7 · 2012: 2
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatric Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
- Keywords
- postural orthostatic tachycardia syndrome, orthostatic intolerance, adolescents, growth spurt, pathophysiology, non-pharmacological treatment, aerobic exercise, beta-blockers, alpha-adrenergic agents, mineralocorticoids, serotonin reuptake inhibitors, family education
- MeSH terms
- Autoimmune Diseases, Communicable Diseases, Humans, Postural Orthostatic Tachycardia Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
