The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Postural Orthostatic Tachycardia Syndrome: A Clinical Review
Abstract
Postural orthostatic tachycardia syndrome was defined in adult patients as an increase >30 beats per minute in heart rate of a symptomatic patient when moving from supine to upright position. Clinical signs may include postural tachycardia, headache, abdominal discomfort, dizziness/presyncope, nausea, and fatigue. The most common adolescent presentation involves teenagers within 1-3 years of their growth spurt who, after a period of inactivity from illness or injury, cannot return to normal activity levels because of symptoms induced by upright posture. Postural orthostatic tachycardia syndrome is complex and likely has numerous, concurrent pathophysiologic etiologies, presenting along a wide spectrum of potential symptoms. Nonpharmacologic treatment includes (1) increasing aerobic exercise, (2) lower-extremity strengthening, (3) increasing fluid/salt intake, (4) psychophysiologic training for management of pain/anxiety, and (5) family education. Pharmacologic treatment is recommended on a case-by-case basis, and can include beta-blocking agents to blunt orthostatic increases in heart rate, alpha-adrenergic agents to increase peripheral vascular resistance, mineralocorticoid agents to increase blood volume, and serotonin reuptake inhibitors. An interdisciplinary research approach may determine mechanistic root causes of symptoms, and is investigating novel management plans for affected patients.
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“The tachycardia of POTS is a sinus tachycardia.”
From Postural tachycardia syndrome: beyond orthostatic intolerance (2015) · cites this paper as [11]
In the citing paper
“This, combined with its high cost and the need for injection, makes it a less attractive option [11].”
From Postural tachycardia syndrome: beyond orthostatic intolerance (2015) · cites this paper as [11]
Citations
Cites
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Prevalence of Severe Hypovitaminosis D in Patients With Persistent, Nonspecific Musculoskeletal Pain
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Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies
Vernino, S., Low, P. A., Fealey, R. D., Stewart, J. D., Farrugia, G., & Lennon, V. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009213431204 · Cited by 674
Orthostatic Intolerance and Tachycardia Associated with Norepinephrine-Transporter Deficiency
Shannon, J. R., Flattem, N. L., Jordan, J., Jacob, G., Black, B. K., Biaggioni, I., Blakely, R. D., & Robertson, D. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002243420803 · Cited by 594 · cited 3×
“One specific gene mutation in patients with orthostatic intolerance is norepinephrine transporter protein deficiency, first reported in a family in 2000 [27].”
BackgroundInfluentialIdiopathic postural orthostatic tachycardia syndrome: An attenuated form of acute pandysautonomia?
Schondorf, R., & Low, P. A. (1993) · Neurology · doi:10.1212/wnl.43.1_part_1.132 · Cited by 548
Postural orthostatic tachycardia syndrome: the Mayo clinic experience
Thieben, M. J., Sandroni, P., Sletten, D. M., Benrud-Larson, L. M., Fealey, R. D., Vernino, S., Low, P. A., Lennon, V. A., & Shen, W.-K. (2007) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)61027-6 · Cited by 516
Dysautonomia in the joint hypermobility syndrome
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Long QT syndrome: from channels to cardiac arrhythmias
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Research works printed but not linked: 4
- Marsh AM, Fischer PR, Brands CK, et al. Dizziness in a pediatric and adolescent referral population. Presented at the Pediatric Academic Societies Annual Meeting, Washington, DC, 2005. Pediatric Academic Societies 2005;57:204.
- Fischer, 2005, High prevalence of orthostatic intolerance in adolescents in a general pediatric referral clinic, Clin Autonom Res, 15, 340
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Cited by
Sorted by citations
Pediatric Disorders of Orthostatic Intolerance
Stewart, J. M., Boris, J. R., Chelimsky, G., Fischer, P. R., Fortunato, J. E., Grubb, B. P., Heyer, G. L., Jarjour, I. T., Medow, M. S., Numan, M. T., et al. (2018) · Pediatrics · doi:10.1542/peds.2017-1673 · Cited by 222
Self-citationPostural tachycardia in children and adolescents: what is abnormal?
Singer, W., Sletten, D. M., Opfer-Gehrking, T. L., Brands, C. K., Fischer, P. R., & Low, P. A. (2012) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2011.08.054 · Cited by 209
Self-citationHomocysteine: Its Possible Emerging Role in At-Risk Population Groups
Azzini, E., Ruggeri, S., & Polito, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041421 · Cited by 164
Postural tachycardia syndrome: beyond orthostatic intolerance
Garland, E. M., Celedonio, J. E., & Raj, S. R. (2015) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-015-0583-8 · Cited by 160
Comorbidities in pediatric patients with postural orthostatic tachycardia syndrome
Ojha, A., Chelimsky, T. C., & Chelimsky, G. (2011) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.07.005 · Cited by 131
Metadata
- Authors
- Johnson, J. N., Mack, K. J., Kuntz, N. L., Brands, C. K., Porter, C. J., & Fischer, P. R.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Johnson, Jonathan N.
- Venue
- Pediatric Neurology
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 42
- Issue
- 2
- Pages
- 77-85
- ISSN
- 0887-8994 (ISSN-L)
- OpenAlex
- W1974651566
- Cited by
- 119
- References
- 47
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 4 · 2023: 4 · 2022: 9 · 2021: 2 · 2020: 8 · 2019: 4 · 2018: 7 · 2017: 8 · 2016: 10 · 2015: 14 · 2014: 13 · 2013: 7 · 2012: 2
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatric Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
- Keywords
- postural orthostatic tachycardia syndrome, orthostatic intolerance, adolescents, growth spurt, pathophysiology, non-pharmacological treatment, aerobic exercise, beta-blockers, alpha-adrenergic agents, mineralocorticoids, serotonin reuptake inhibitors, family education
- MeSH terms
- Autoimmune Diseases, Communicable Diseases, Humans, Postural Orthostatic Tachycardia Syndrome
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