Cited by 71Adipokines, Inflammation, and Metabolic DiseasesNeuropeptides and Animal PhysiologyAdipose Tissue and Metabolism

Adrenomedullin is a novel adipokine: adrenomedullin in adipocytes and adipose tissues

Li, Yin, Jiang, Changtao, Wang, Xian, Zhang, Yan, Shibahara, Shigeki, Takahashi, Kazuhiro·2007·Peptides

Abstract

Adrenomedullin (AM) is a multifunctional regulatory peptide that is produced and secreted by various types of cells. The production and the secretion of AM have been demonstrated in cultured adipocytes and adipose tissues. Inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and lipopolysaccharide are strong stimulators for AM expression in adipocytes. Furthermore, AM expression in the adipose tissue is increased in obesity, and plasma concentrations of AM are increased in obese subjects. One possible (patho)physiological role of AM secreted by adipose tissue may be actions against complications of the metabolic syndrome characterized by obesity, type 2 diabetic mellitus and hypertension, via its antioxidant and potent vasodilator effects. These findings indicate that AM is a new member of the adipokine family.

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Crossref · 10.1016/j.peptides.2007.03.005

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145 of 145 references verified0 citation errors · 0 not checkable

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Authors
Li, Y., Jiang, C., Wang, X., Zhang, Y., Shibahara, S., & Takahashi, K.
Affiliations
  • Tohoku University (JP)
  • Peking University (CN)
Corresponding author
Takahashi, Kazuhiro
Venue
Peptides
Publisher
Elsevier BV
Published
2007-05
Volume
28
Issue
5
Pages
1129-1143
ISSN
0196-9781 (ISSN-L)
OpenAlex
W2066377469
Cited by
71
References
143
Citations by year
2026: 2 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 12 · 2021: 2 · 2020: 7 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 5
FWCI
0.37
Type
journal article
Language
en
Open access
closed
Locations
  • Peptides (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
adrenomedullin, adipokines, adipocytes, adipose tissue, obesity, TNF-α, lipopolysaccharide, metabolic syndrome, type 2 diabetes, hypertension, antioxidant activity, vasodilation
MeSH terms
Adipose Tissue, Amino Acid Sequence, Animals, Gene Expression Regulation, Humans, Molecular Sequence Data, Obesity, Cytokines, Adipocytes, Adrenomedullin

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