Adrenomedullin is a novel adipokine: adrenomedullin in adipocytes and adipose tissues
Abstract
Adrenomedullin (AM) is a multifunctional regulatory peptide that is produced and secreted by various types of cells. The production and the secretion of AM have been demonstrated in cultured adipocytes and adipose tissues. Inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and lipopolysaccharide are strong stimulators for AM expression in adipocytes. Furthermore, AM expression in the adipose tissue is increased in obesity, and plasma concentrations of AM are increased in obese subjects. One possible (patho)physiological role of AM secreted by adipose tissue may be actions against complications of the metabolic syndrome characterized by obesity, type 2 diabetic mellitus and hypertension, via its antioxidant and potent vasodilator effects. These findings indicate that AM is a new member of the adipokine family.
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ADM is expressed in adipocytes and is considered an adipokine.
“ADM is also considered an adipokine as it is expressed in adipocytes (3).”
From Effect of liraglutide on atrial natriuretic peptide, adrenomedullin, and copeptin in PCOS (2018) · cites this paper as [3]
Cites
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works
Self-citationDetection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Grundy, S. M., Becker, D. M., Clark, L. T., Cooper, R., Denke, M. A., Howard, J. L., Hunninghake, D. B., Illingworth, D. R., Luepker, R. V., McBride, P. E., et al. (2002) · Civil War Book Review · Cited by 12,198 · see citing works
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755 · see citing works
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617 · see citing works
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526 · see citing works
Adrenomedullin: A Novel Hypotensive Peptide Isolated from Human Pheochromocytoma
Kitamura, K., Kangawa, K., Kawamoto, M., Ichiki, Y., Nakamura, S., Matsuo, H., & Eto, T. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1451 · Cited by 2,192 · see citing works
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
McLatchie, L. M., Fraser, N. J., Main, M. J., Wise, A., Brown, J., Thompson, N., Solari, R., Lee, M. G., & Foord, S. M. (1998) · Nature · doi:10.1038/30666 · Cited by 2,134 · see citing works
Maeda, K., Okubo, K., Shimomura, I., Funahashi, T., Matsuzawa, Y., & Matsubara, K. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0587 · Cited by 2,081 · see citing works
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
Wang, G. L., & Semenza, G. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4304 · Cited by 1,468 · see citing works
Purification and biochemical characterization of the promoter-specific transcription factor, Sp1
Briggs, M. R., Kadonaga, J. T., Bell, S. P., & Tjian, R. (1986) · Science · doi:10.1126/science.3529394 · Cited by 1,435 · see citing works
Imagawa, M. (1987) · Cell · doi:10.1016/0092-8674(87)90152-8 · Cited by 1,384 · see citing works
Carr, D. B., Utzschneider, K. M., Hull, R. L., Kodama, K., Retzlaff, B. M., Brunzell, J. D., Shofer, J. B., Fish, B. E., Knopp, R. H., & Kahn, S. E. (2004) · Diabetes · doi:10.2337/diabetes.53.8.2087 · Cited by 993 · see citing works
Adrenomedullin, a Multifunctional Regulatory Peptide*
Hinson, J. P., Kapas, S., & Smith, D. M. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.2.0396 · Cited by 759 · see citing works
Cloning and Characterization of cDNA Encoding a Precursor for Human Adrenomedullin
Kitamura, K., Sakata, J., Kangawa, K., Kojima, M., Matsuo, H., & Eto, T. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1881 · Cited by 604 · see citing works
Adipose tissue as a source of hormones
Siiteri, P. K. (1987) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/45.1.277 · Cited by 600 · see citing works
Endothelial Cells Actively Synthesize and Secrete Adrenomedullin
Sugo, S., Minamino, N., Kangawa, K., Miyamoto, K., Kitamura, K., Sakata, J., Eto, T., & Matsuo, H. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1827 · Cited by 574 · see citing works
Williams, T., Admon, A., Lüscher, B., & Tjian, R. (1988) · Genes & Development · doi:10.1101/gad.2.12a.1557 · Cited by 573 · see citing works
Kingsley, C., & Winoto, A. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.10.4251 · Cited by 527 · see citing works
Ishimitsu, T., Nishikimi, T., Saito, Y., Kitamura, K., Eto, T., Kangawa, K., Matsuo, H., Omae, T., & Matsuoka, H. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117573 · Cited by 475 · see citing works
Roh, J., Chang, C. L., Bhalla, A., Klein, C., & Hsu, S. Y. T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m305332200 · Cited by 443 · see citing works
Adipsin: A Circulating Serine Protease Homolog Secreted by Adipose Tissue and Sciatic Nerve
Cook, K. S., Min, H. Y., Johnson, D., Chaplinsky, R. J., Flier, J. S., Hunt, C. R., & Spiegelman, B. M. (1987) · Science · doi:10.1126/science.3299705 · Cited by 427 · see citing works
Sugo, S., Minamino, N., Shoji, H., Kangawa, K., Kitamura, K., Eto, T., & Matsuo, H. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2241 · Cited by 372 · see citing works
Sugo, S., Minamino, N., Shoji, H., Kangawa, K., Kitamura, K., Eto, T., & Matsuo, H. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1148 · Cited by 330 · see citing works
Severely Impaired Adipsin Expression in Genetic and Acquired Obesity
Flier, J. S., Cook, K. S., Usher, P., & Spiegelman, B. M. (1987) · Science · doi:10.1126/science.3299706 · Cited by 329 · see citing works
An abundant and specific binding site for the novel vasodilator adrenomedullin in the rat
Owji, A. A., Smith, D. M., Coppock, H. A., Morgan, D. G., Bhogal, R., Ghatei, M. A., & Bloom, S. R. (1995) · Endocrinology · doi:10.1210/endo.136.5.7720662 · Cited by 310 · see citing works
Increased circulating adrenomedullin, a novel vasodilatory peptide, in sepsis
Hirata, Y., Mitaka, C., Sato, K., Nagura, T., Tsunoda, Y., Amaha, K., & Marumo, F. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.4.8636349 · Cited by 274 · see citing works
Vascular Abnormalities and Elevated Blood Pressure in Mice Lacking Adrenomedullin Gene
Shindo, T., Kurihara, Y., Nishimatsu, H., Moriyama, N., Kakoki, M., Wang, Y.-H., Imai, Y., Ebihara, A., Kuwaki, T., Ju, K., et al. (2001) · Circulation · doi:10.1161/hc4101.097111 · Cited by 273 · see citing works
Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator
Takei, Y., Inoue, K., Ogoshi, M., Kawahara, T., Bannai, H., & Miyano, S. (2004) · FEBS Letters · doi:10.1016/s0014-5793(03)01368-1 · Cited by 268 · see citing works
Insulin receptor synthesis and turnover in differentiating 3T3-L1 preadipocytes.
Reed, B. C., & Lane, M. D. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.1.285 · Cited by 262 · see citing works
Garayoa, M., Martı́nez, A., Lee, S., Pı́o, R., An, W. G., Neckers, L., Trepel, J. B., Montuenga, L. M., Ryan, H. E., Johnson, R. S., et al. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.6.0473 · Cited by 262 · see citing works
Bach1 Functions as a Hypoxia-inducible Repressor for the Heme Oxygenase-1 Gene in Human Cells
Kitamuro, T., Takahashi, K., Ogawa, K., Udono‐Fujimori, R., Takeda, K., Furuyama, K., Nakayama, M., Sun, J., Fujita, H., Hida, W., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209939200 · Cited by 261 · see citing works
Self-citationAdrenomedullin, a Multifunctional Regulatory Peptide
Hinson, J. P. (2000) · Endocrine Reviews · doi:10.1210/er.21.2.138 · Cited by 256 · see citing works
Hu, J. Y., Discher, D. J., Bishopric, N. H., & Webster, K. A. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8543 · Cited by 254 · see citing works
Sp1: Regulation of gene expression by phosphorylation
Chu, S., & Ferro, T. J. (2005) · Gene · doi:10.1016/j.gene.2005.01.013 · Cited by 231 · see citing works
Adrenomedullin as an Autocrine/Paracrine Apoptosis Survival Factor for Rat Endothelial Cells
Kato, H., Shichiri, M., Marumo, F., & Hirata, Y. (1997) · Endocrinology · doi:10.1210/endo.138.6.5197 · Cited by 228 · see citing works
Renal localization and actions of adrenomedullin: a natriuretic peptide
Jougasaki, M., Wei, C., Aarhus, L. L., Heublein, D. M., Sandberg, S. M., & Burnett, J. C. J. (1995) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1995.268.4.f657 · Cited by 225 · see citing works
Genomic Structure of Human Adrenomedullin Gene
Ishimitsu, T., Kojima, M., Kangawa, K., Hino, J., Matsuoka, H., Kitamura, K., Eto, T., & Matsuo, H. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2229 · Cited by 221 · see citing works
Guerre-Millo, M. (2002) · Journal of Endocrinological Investigation · doi:10.1007/bf03344048 · Cited by 209 · see citing works
Adrenomedullin as a novel antiproliferative factor of vascular smooth muscle cells
Kano, H., Kohno, M., Yasunari, K., Yokokawa, K., Horio, T., Ikeda, M., Minami, M., Hanehira, T., Takeda, T., & Yoshikawa, J. (1996) · Journal of Hypertension · doi:10.1097/00004872-199602000-00009 · Cited by 206 · see citing works
Szokodi, I., Kinnunen, P., Tavi, P., Weckström, M., Tóth, M., & Ruskoaho, H. J. (1998) · Circulation · doi:10.1161/01.cir.97.11.1062 · Cited by 202 · see citing works
Linscheid, P., Seboek, D., Zulewski, H., Keller, U. B., & Müller-Stich, B. P. (2005) · Endocrinology · doi:10.1210/en.2004-1424 · Cited by 197 · see citing works
Regulation of insulin secretion and blood glucose metabolism by adrenomedullin
Martı́nez, A., Weaver, C. L., López, J. M. G., Bhathena, S. J., Elsasser, T. H., Miller, M., Moody, T. W., Unsworth, E. J., & Cuttitta, F. F. (1996) · Endocrinology · doi:10.1210/endo.137.6.8641217 · Cited by 195 · see citing works
Adrenomedullin Reduces Endothelial Hyperpermeability
Hippenstiel, S., Witzenrath, M., Schmeck, B., Hocke, A. C., Krisp, M., Krüll, M., Seybold, J., Seeger, W., Rascher, W., Schütte, H., et al. (2002) · Circulation Research · doi:10.1161/01.res.0000036603.61868.f9 · Cited by 191 · see citing works
A novel vasoactive peptide, adrenomedullin, inhibits pituitary adrenocorticotropin release.
Samson, W. K., Murphy, T. C., & Schell, D. A. (1995) · Endocrinology · doi:10.1210/endo.136.5.7720684 · Cited by 174 · see citing works
The novel vasoactive hormone, adrenomedullin, inhibits water drinking in the rat.
Murphy, T. C., & Samson, W. K. (1995) · Endocrinology · doi:10.1210/endo.136.6.7750467 · Cited by 170 · see citing works
Satoh, F., Takahashi, K., Murakami, O., Totsune, K., Sone, M., Ohneda, M., Abe, K., Miura, Y., Hayashi, Y., & Sasano, H. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.5.7745031 · Cited by 154 · see citing works
Self-citationAdrenomedullin as a Novel Antimigration Factor of Vascular Smooth Muscle Cells
Horio, T., Kohno, M., Kano, H., Ikeda, M., Yasunari, K., Yokokawa, K., Minami, M., & Takeda, T. (1995) · Circulation Research · doi:10.1161/01.res.77.4.660 · Cited by 153 · see citing works
Identification and hypotensive activity of proadrenomedullin N‐terminal 20 peptide (PAMP)
Kitamura, K., Kangawa, K., Ishiyama, Y., Washimine, H., Ichiki, Y., Kawamoto, M., Minamino, N., Matsuo, H., & Eto, T. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00810-8 · Cited by 151 · see citing works
Kitamura, K., Kato, J., Kawamoto, M., Tanaka, M., Chino, N., Kangawa, K., & Eto, T. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8310 · Cited by 149 · see citing works
Waite, K. J., Floyd, Z. E., Arbour-Reily, P., & Stephens, J. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007894200 · Cited by 145 · see citing works
Regulation of Leptin Promoter Function by Sp1, C/EBP, and a Novel Factor1
Mason, M. M., He, Y., Chen, H., Quon, M. J., & Reitman, M. L. (1998) · Endocrinology · doi:10.1210/endo.139.3.5792 · Cited by 145 · see citing works
Cytokines induce catabolic effects in cultured adipocytes by multiple mechanisms
Doerrler, W. T., Feingold, K. R., & Grünfeld, C. (1994) · Cytokine · doi:10.1016/1043-4666(94)90074-4 · Cited by 137 · see citing works
Allaker, R. P., Zihni, C., & Kapas, S. (1999) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.1999.tb01250.x · Cited by 137 · see citing works
Memon, R. A., Feingold, K. R., Moser, A. H., Fuller, J., & Grünfeld, C. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.2.e210 · Cited by 137 · see citing works
Satoh, F., Takahashi, K., Murakami, O., Totsune, K., Sone, M., Ohneda, M., Sasano, H., & Mouri, T. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(95)12294-x · Cited by 133 · see citing works
Self-citationYin, H. H., Chao, L., & Chao, J. (2003) · Hypertension · doi:10.1161/01.hyp.0000103696.60047.55 · Cited by 129 · see citing works
Interferon inhibits the conversion of 3T3-L1 mouse fibroblasts into adipocytes.
Keay, S. K., & Grossberg, S. E. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.7.4099 · Cited by 123 · see citing works
Takahashi, H., Watanabe, T. X., Nishimura, M., Nakanishi, T., Sakamoto, M., Yoshimura, M., Komiyama, Y., Masuda, M., & Murakami, T. (1994) · American Journal of Hypertension · doi:10.1093/ajh/7.5.478 · Cited by 119 · see citing works
Oliver, K. R., Kane, S. A., Salvatore, C., Mallee, J. J., Kinsey, A. M., Koblan, K. S., Keyvan‐Fouladi, N., HEAVENS, R. P., Wainwright, A., Jacobson, M. A., et al. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01688.x · Cited by 118 · see citing works
Adrenomedullin, a Newly Discovered Hypotensive Peptide, Is a Potent Bronchodilator
Kanazawa, H., Kurihara, N., Hirata, K., Kudoh, S., Kawaguchi, T., & Takeda, T. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2657 · Cited by 115 · see citing works
Nagae, T., Mukoyama, M., Sugawara, A., Mori, K., Yahata, K., Kasahara, M., Suganami, T., Makino, H., Fujinaga, Y., Yoshioka, T., et al. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2390 · Cited by 114 · see citing works
Increased plasma adrenomedullin levels in chronic congestive heart failure
Kobayashi, K., Kitamura, K., Etoh, T., Nagatomo, Y., Takenaga, M., Ishikawa, T., Imamura, T., Koiwaya, Y., & Eto, T. (1996) · American Heart Journal · doi:10.1016/s0002-8703(96)90185-4 · Cited by 109 · see citing works
Protective Effects of Endogenous Adrenomedullin on Cardiac Hypertrophy, Fibrosis, and Renal Damage
Niu, P., Shindo, T., Iwata, H., Iimuro, S., Takeda, N., Zhang, Y., Ebihara, A., Suematsu, Y., Kangawa, K., Hirata, Y., et al. (2004) · Circulation · doi:10.1161/01.cir.0000118466.47982.cc · Cited by 109 · see citing works
Self-citationDeficiency of Adrenomedullin Induces Insulin Resistance by Increasing Oxidative Stress
Shimosawa, T., Ogihara, T., Matsui, H., Asano, T., Ando, K., & Fujita, T. (2003) · Hypertension · doi:10.1161/01.hyp.0000066846.46422.2c · Cited by 109 · see citing works
Adrenomedullin-immunoreactive neurons in the paraventricular and supraoptic nuclei of the rat
Ueta, Y., Kitamura, K., Isse, T., Shibuya, I., Kabashima, N., Yamamoto, S., Kangawa, K., Matsuo, H., Eto, T., & Yamashita, H. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12204-4 · Cited by 107 · see citing works
Shichiri, M., Kato, H., Doi, M., Marumo, F., & Hirata, Y. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.8.0324 · Cited by 105 · see citing works
Wong, L. Y. F., Cheung, B. M. Y., Li, Y., & Tang, F. (2004) · Endocrinology · doi:10.1210/en.2004-1080 · Cited by 105 · see citing works
Self-citationAdrenomedullin Inhibits Salt Appetite1
Samson, W. K., & Murphy, T. C. (1997) · Endocrinology · doi:10.1210/endo.138.2.4943 · Cited by 104 · see citing works
Isumi, Y., Minamino, N., Katafuchi, T., Yoshioka, M., Tsuji, T., Kangawa, K., & Matsuo, H. (1998) · Endocrinology · doi:10.1210/endo.139.5.6004 · Cited by 101 · see citing works
Park, H. S., & Lee, K. (2005) · Diabetic Medicine · doi:10.1111/j.1464-5491.2004.01395.x · Cited by 100 · see citing works
Iwasaki, H., Eguchi, S., Shichiri, M., Marumo, F., & Hirata, Y. (1998) · Endocrinology · doi:10.1210/endo.139.8.6144 · Cited by 100 · see citing works
Culture of Adipose Tissue and Isolated Adipocytes
Fried, S. K., & Moustaïd‐Moussa, N. (2003) · Humana Press eBooks · doi:10.1385/1-59259-231-7:197 · Cited by 96 · see citing works
Plasma adrenomedullin in diabetes
Hayashi, M., Shimosawa, T., Isaka, M., Yamada, S., Fujita, R., Fujita, T., & Hayashi, M. (1997) · The Lancet · doi:10.1016/s0140-6736(05)64211-0 · Cited by 94 · see citing works
Chang, C.-L., Roh, J., & Hsu, S. (2004) · Peptides · doi:10.1016/j.peptides.2004.05.021 · Cited by 93 · see citing works
Induction of Adrenomedullin by Hypoxia and Cobalt Chloride in Human Colorectal Carcinoma Cells
Nakayama, M., Takahashi, K., Murakami, O., Shirato, K., & Shibahara, S. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8131 · Cited by 93 · see citing works
Self-citationIn vitro recordings from area postrema neurons demonstrate responsiveness to adrenomedullin
Allen, M. A., & Ferguson, A. V. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.270.4.r920 · Cited by 91 · see citing works
Immunoreactive Proadrenomedullin N-Terminal 20 Peptide in Human Tissue, Plasma and Urine
Washimine, H., Kitamura, K., Ichiki, Y., Yamamoto, Y., Kangawa, K., Matsuo, H., & Eto, T. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2039 · Cited by 89 · see citing works
Adrenomedullin Can Protect Against Pulmonary Vascular Remodeling Induced by Hypoxia
Matsui, H., Shimosawa, T., Itakura, K., Guanqun, X., Ando, K., & Fujita, T. (2004) · Circulation · doi:10.1161/01.cir.0000127950.13380.fd · Cited by 87 · see citing works
Hypoxia-induced adrenomedullin production in the kidney
Nagata, D., Hirata, Y., Suzuki, E., Kakoki, M., Hayakawa, H., Goto, A., Ishimitsu, T., Minamino, N., Ono, Y., Kangawa, K., et al. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00361.x · Cited by 87 · see citing works
Kato, J., Kitamura, K., Uemura, T., Kuwasako, K., Kita, T., Kangawa, K., & Eto, T. (2002) · Hypertension Research · doi:10.1291/hypres.25.887 · Cited by 86 · see citing works
Adrenomedullin microinjection into the area postrema increases blood pressure
Allen, M. A., Smith, P., & Ferguson, A. V. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.6.r1698 · Cited by 86 · see citing works
Autocrine/paracrine role of adrenomedullin in cultured endothelial and mesangial cells
Michibata, H., Mukoyama, M., Tanaka, I., Suga, S., Nakagawa, M., Ishibashi, R., Goto, M., Akaji, K., Fujiwara, Y., Kiso, Y., et al. (1998) · Kidney International · doi:10.1111/j.1523-1755.1998.00855.x · Cited by 85 · see citing works
Endogenous Adrenomedullin Protects Against Vascular Response to Injury in Mice
Kawai, J., Ando, K., Tojo, A., Shimosawa, T., Takahashi, K., Onozato, M. L., Yamasaki, M., Ogita, T., Nakaoka, T., & Fujita, T. (2004) · Circulation · doi:10.1161/01.cir.0000117231.40057.6d · Cited by 85 · see citing works
Self-citationObesity-related Differential Gene Expression in the Visceral Adipose Tissue
Baranova, A. V., Collantes, R. S., Gowder, S., Elariny, H. A., Schlauch, K. A., Younoszai, A., King, S., Randhawa, M., Pusulury, S., Alsheddi, T., et al. (2005) · Obesity Surgery · doi:10.1381/0960892054222876 · Cited by 80 · see citing works
Negative Inotropic Effect of Adrenomedullin in Isolated Adult Rabbit Cardiac Ventricular Myocytes
Ikenouchi, H., Kangawa, K., Matsuo, H., & Hirata, Y. (1997) · Circulation · doi:10.1161/01.cir.95.9.2318 · Cited by 80 · see citing works
Vikman, K., Carlsson, B., Billig, H., & Edén, S. (1991) · Endocrinology · doi:10.1210/endo-129-3-1155 · Cited by 78 · see citing works
Barth, N., Langmann, T., Sch�lmerich, J., Schmitz, G., & Sch�ffler, A. (2003) · Diabetologia · doi:10.1007/s00125-002-0895-5 · Cited by 78 · see citing works
Interferon‐γ and interleukin‐1β inhibit adipoconversion in cultured rodent preadipocytes
Gregoire, F. M., de Broux, N., Hauser, N., Heremans, H., Damme, J. V., & Remacle, C. (1992) · Journal of Cellular Physiology · doi:10.1002/jcp.1041510211 · Cited by 75 · see citing works
Inotropic effect of adrenomedullin in the isolated perfused rat heart
Szokodi, I., Kinnunen, P., & Ruskoaho, H. J. (1996) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1996.454169000.x · Cited by 75 · see citing works
Upton, P. D., Austin, C., Taylor, G. M., Nandha, K. A., Clark, A., Ghatei, M. A., Bloom, S. R., & Smith, D. M. (1997) · Endocrinology · doi:10.1210/endo.138.6.5186 · Cited by 73 · see citing works
Kohno, M., Yokokawa, K., Kano, H., Yasunari, K., Minami, M., Hanehira, T., & Yoshikawa, J. (1997) · Hypertension · doi:10.1161/01.hyp.29.6.1309 · Cited by 72 · see citing works
Miyashita, K., Itoh, H., Sawada, N., Fukunaga, Y., Sone, M., Yamahara, K., Yurugi-Kobayashi, T., Park, K., & Nakao, K. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00484-8 · Cited by 70 · see citing works
Isumi, Y., Kubo, A., Katafuchi, T., Kangawa, K., & Minamino, N. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01615-4 · Cited by 69 · see citing works
Li, Y., Bujo, H., Takahashi, K., Shibasaki, M., Zhu, Y., Yoshida, Y., Otsuka, Y., Hashimoto, N., & Saito, Y. (2003) · Experimental Biology and Medicine · doi:10.1177/153537020322801004 · Cited by 68 · see citing works
Self-citationXia, C., Yin, H. H., Borlongan, C. V., Chao, J., & Chao, L. (2004) · Human Gene Therapy · doi:10.1089/hum.2004.15.1243 · Cited by 68 · see citing works
Production and Secretion of Adrenomedullin From Glial Cell Tumors and its Effects on cAMP Production
Takahashi, K., Satoh, F., Hara, E., Sone, M., Murakami, O., Kayama, T., Yoshimoto, T., & Shibahara, S. (1997) · Peptides · doi:10.1016/s0196-9781(97)00186-1 · Cited by 68 · see citing works
Self-citationAdrenomedullin Gene Delivery Reduces Blood Pressure in Spontaneously Hypertensive Rats.
Chao, J., Jin, L., Lin, K.-F., & Chao, L. (1997) · Hypertension Research · doi:10.1291/hypres.20.269 · Cited by 64 · see citing works
Expression of adrenomedullin2/intermedin in human brain, heart, and kidney
Morimoto, R., Satoh, F., Murakami, O., Totsune, K., Suzuki, T., Sasano, H., Ito, S., & Takahashi, K. (2007) · Peptides · doi:10.1016/j.peptides.2007.01.018 · Cited by 64 · see citing works
Self-citationIs adrenomedullin a causal agent in some cases of type 2 diabetes?
Martı́nez, A., Elsasser, T. H., Bhathena, S. J., Pı́o, R., Buchanan, T. A., Macri, C. J., & Cuttitta, F. F. (1999) · Peptides · doi:10.1016/s0196-9781(99)00158-8 · Cited by 63 · see citing works
Induction of adrenomedullin by hypoxia in cultured human coronary artery endothelial cells
Nakayama, M., Takahashi, K., Murakami, O., Shirato, K., & Shibahara, S. (1999) · Peptides · doi:10.1016/s0196-9781(99)00061-3 · Cited by 62 · see citing works
Self-citationExpression of Adrenomedullin mRNA in the Human Brain and Pituitary
Takahashi, K., Satoh, F., Sone, M., Murakami, O., Sasano, H., Mouri, T., & Shibahara, S. (1997) · Peptides · doi:10.1016/s0196-9781(97)00038-7 · Cited by 60 · see citing works
Self-citationSpecific Adrenomedullin Binding Sites in the Human Brain
Sone, M., Takahashi, K., Satoh, F., Murakami, O., Totsune, K., Ohneda, M., Sasano, H., Ito, H., & Mouri, T. (1997) · Peptides · doi:10.1016/s0196-9781(97)00143-5 · Cited by 59 · see citing works
Self-citationA novel vasoactive peptide, adrenomedullin, inhibits pituitary adrenocorticotropin release
Samson, W. K. (1995) · Endocrinology · doi:10.1210/en.136.5.2349 · Cited by 59 · see citing works
Increased Secretion of Adrenomedullin from Cultured Human Astrocytes by Cytokines
Takahashi, K., Nakayama, M., Totsune, K., Murakami, O., Sone, M., Kitamuro, T., Yoshinoya, A., & Shibahara, S. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0740099.x · Cited by 54 · see citing works
Self-citationEffects of gonadal and adrenal androgens in a novel androgen-responsive human osteoblastic cell line
Hofbauer, L. C., Hicok, K. C., & Khosla, S. (1998) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19981001)71:1 · Cited by 54 · see citing works
Transcriptional Regulation of Human Adrenomedullin Gene in Vascular Endothelial Cells
Ishimitsu, T., Miyata, A., Matsuoka, H., & Kangawa, K. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8110 · Cited by 53 · see citing works
Adrenomedullin in cultured human retinal pigment epithelial cells.
Udono, T., Takahashi, K., Nakayama, M., Murakami, O., Durlu, Y. K., Tamai, M., & Shibahara, S. (2000) · PubMed · Cited by 52 · see citing works
Self-citationThe novel vasoactive hormone, adrenomedullin, inhibits water drinking in the rat
Murphy, T. C. (1995) · Endocrinology · doi:10.1210/en.136.6.2459 · Cited by 52 · see citing works
Induction of Adrenomedullin During Hypoxia in Cultured Human Glioblastoma Cells
Kitamuro, T., Takahashi, K., Nakayama, M., Murakami, O., Hida, W., Shirato, K., & Shibahara, S. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751826.x · Cited by 49 · see citing works
Self-citationRegulation of Leptin Promoter Function by Sp1, C/EBP, and a Novel Factor
Mason, M. (1998) · Endocrinology · doi:10.1210/en.139.3.1013 · Cited by 49 · see citing works
Adrenomedullin Stimulates Interleukin-6 Production in Swiss 3T3 Cells
Isumi, Y., Minamino, N., Kubo, A., Nishimoto, N., Yoshizaki, K., Yoshioka, M., Kangawa, K., & Matsuo, H. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8261 · Cited by 46 · see citing works
Expression of the adrenomedullin gene in adipose tissue
Nambu, T., Arai, H., Komatsu, Y., Yasoda, A., Moriyama, K., Kanamoto, N., Itoh, H., & Nakao, K. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2005.07.006 · Cited by 45 · see citing works
Li, Y., Totsune, K., Takeda, K., Furuyama, K., Shibahara, S., & Takahashi, K. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1490231 · Cited by 45 · see citing works
Self-citationChung, S. S., Choi, H., Kim, K. W., Cho, Y., Lee, H. K., & Park, K. S. (2005) · Diabetologia · doi:10.1007/s00125-005-1762-y · Cited by 44 · see citing works
Concomitant expression of adrenomedullin and its receptor components in rat adipose tissues
Fukai, N., Yoshimoto, T., Sugiyama, T., Ozawa, N., Sato, R., Shichiri, M., & Hirata, Y. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00586.2003 · Cited by 43 · see citing works
Imai, Y., Shindo, T., Maemura, K., Sata, M., Saito, Y., Kurihara, Y., Akishita, M., Osuga, J.-I., Ishibashi, S., Tobe, K., et al. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000024685.92243.e7 · Cited by 43 · see citing works
Stachniak, T. J., & Krukoff, T. L. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01064.x · Cited by 43 · see citing works
Takahashi, K. (2001) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.193.79 · Cited by 42 · see citing works
Self-citationYanagita, T., Yamamoto, R., Sugano, T., Kobayashi, H., Uezono, Y., Yokoo, H., Shiraishi, S., Minami, S., & Wada, A. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703500 · Cited by 38 · see citing works
He, J., Jiang, H., Tansey, J. T., Tang, C., Pu, S., & Xu, G. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.02.001 · Cited by 36 · see citing works
Minami, J., Nishikimi, T., Ishimitsu, T., Makino, Y., Kawano, Y., Takishita, S., Kangawa, K., & Matsuoka, H. (2000) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200000006-00018 · Cited by 35 · see citing works
Harmancey, R., Sénard, J., Pathak, A., Desmoulin, F., Claparols, C., Rouet, P., & Smih, F. (2005) · The FASEB Journal · doi:10.1096/fj.04-2868fje · Cited by 35 · see citing works
Expression of adrenomedullin in adipose tissue of lean and obese women
Paulmyer‐Lacroix, O., Desbrière, R., Poggi, M., Achard, V., Alessi, M., Boudouresque, F., Ouafik, L., Vuaroqueaux, V., Labuhn, M., Dutourand, A., et al. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02170 · Cited by 34 · see citing works
Katsuki, A., Sumida, Y., Gabazza, E. C., Murashima, S., Urakawa, H., Morioka, K., Kitagawa, N., Tanaka, T., Araki-Sasaki, R., Hori, Y., et al. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1470071 · Cited by 32 · see citing works
Angiotensin II-Induced Insulin Resistance Is Enhanced in Adrenomedullin-Deficient Mice
Xing, G., Shimosawa, T., Ogihara, T., Matsui, H., Itakura, K., Xu, Q., Asano, T., Ando, K., & Fujita, T. (2004) · Endocrinology · doi:10.1210/en.2004-0027 · Cited by 31 · see citing works
Iwasaki, H. (1998) · Endocrinology · doi:10.1210/en.139.8.3432 · Cited by 30 · see citing works
Adrenomedullin in mammalian embryogenesis
Garayoa, M., Bodegas, M. E., Cuttitta, F. F., & Montuenga, L. M. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10050 · Cited by 29 · see citing works
Adrenomedullin Inhibits Salt Appetite
Samson, W. K. (1997) · Endocrinology · doi:10.1210/en.138.2.613 · Cited by 29 · see citing works
Nakayama, M., Takahashi, K., Kitamuro, T., Murakami, O., Shirato, K., & Shibahara, S. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01384.x · Cited by 28 · see citing works
Self-citationVariations of Human Adrenomedullin Gene and Its Relation to Cardiovascular Diseases
Ishimitsu, T., Tsukada, K., Minami, J., Ono, H., & Matsuoka, H. (2003) · Hypertension Research · doi:10.1291/hypres.26.s129 · Cited by 22 · see citing works
Decreased Expression of Adrenomedullin during Adipocyte-Differentiation of 3T3-L1 Cells
Li, Y., Totsune, K., Takeda, K., Furuyama, K., Shibahara, S., & Takahashi, K. (2003) · Hypertension Research · doi:10.1291/hypres.26.s41 · Cited by 21 · see citing works
Self-citationTHE EFFECTS OF INTERFERON ON 3T3‐L1 CELL DIFFERENTIATION*
Grossberg, S. E., & KEAY, S. K. (1980) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1980.tb20629.x · Cited by 18 · see citing works
Knerr, I., Schirl, C., Horbach, T., Stuppy, A., Carbon, R. T., Rascher, W., & Dötsch, J. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802885 · Cited by 17 · see citing works
Zhu, Q., & Liao, K. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2586 · Cited by 16 · see citing works
Adrenomedullin in adipocyte differentiation of human mesenchymal stem cells
Li, Y., Zhang, Y., Shibahara, S., & Takahashi, K. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.089 · Cited by 15 · see citing works
Self-citationHepatic heme and drug metabolism in rats with chronic mountain sickness
Bonkovsky, H. L., Lincoln, B. C., Healey, J. F., Ou, L. C., Sinclair, P. R., & Müller‐Eberhard, U. (1986) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1986.251.4.g467 · Cited by 14 · see citing works
Letizia, C., Iacobellis, G., Caliumi, C., Leonetti, F., Cotesta, D., Ribaudo, M., Petramala, L., Cianci, R., Celi, M., D'Erasmo, E., et al. (2005) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2005-837519 · Cited by 11 · see citing works
Cancer and diabetes: two pathological conditions in which adrenomedullin may be involved
Pı́o, R., Martı́nez, A., & Cuttitta, F. F. (2001) · Peptides · doi:10.1016/s0196-9781(01)00530-7 · Cited by 10 · see citing works
Li, Y., Zhang, Y., Furuyama, K., Yokoyama, S., Takeda, K., Shibahara, S., & Takahashi, K. (2006) · Peptides · doi:10.1016/j.peptides.2005.11.009 · Cited by 10 · see citing works
Self-citationTakahashi, K., Totsune, K., Sone, M., Kikuchi, K., & Murakami, O. (2005) · Peptides · doi:10.1016/j.peptides.2004.12.007 · Cited by 7 · see citing works
Self-citationTakahashi, K., Totsune, K., Kikuchi, K., & Murakami, O. (2006) · Hypertension Research · doi:10.1291/hypres.29.443 · Cited by 6 · see citing works
Self-citationZhang, Y., Li, Y., Totsune, K., Kikuchi, K., Murakami, O., Shibahara, S., & Takahashi, K. (2006) · Peptides · doi:10.1016/j.peptides.2006.04.014 · Cited by 4 · see citing works
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Fain, J. N. (2010) · Mediators of Inflammation · doi:10.1155/2010/513948 · Cited by 286 · see citing works
Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue
Sagar, G., Sah, R. P., Javeed, N., Dutta, S. K., Smyrk, T. C., Lau, J. S., Giorgadze, N., Tchkonia, T., Kirkland, J. L., Chari, S. T., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-308350 · Cited by 247 · see citing works
The Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction
Packer, M. (2025) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2025.06.055 · Cited by 190 · see citing works
Watanabe, K., Wilmanski, T. M., Diener, C., Earls, J. C., Zimmer, A., Lincoln, B., Hadlock, J., Lovejoy, J. C., Gibbons, S. M., Magis, A. T., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02248-0 · Cited by 151 · see citing works
Tissue-Specific Effects of Loss of Estrogen during Menopause and Aging
Wend, K., Wend, P., & Krum, S. A. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00019 · Cited by 118 · see citing works
Epicardial Fat: Physiological, Pathological, and Therapeutic Implications
Salazar, J. J., Luzardo, E., Mejías, J. C., Rojas, J., Ferreira, A. M., Rivas-Ríos, J. R., & Bermúdez, V. (2016) · Cardiology Research and Practice · doi:10.1155/2016/1291537 · Cited by 107 · see citing works
Adrenomedullin – new perspectives of a potent peptide hormone
Schönauer, R. A.-R., Els‐Heindl, S., & Beck‐Sickinger, A. G. (2017) · Journal of Peptide Science · doi:10.1002/psc.2953 · Cited by 85 · see citing works
Genome-Wide Expression in Visceral Adipose Tissue from Obese Prepubertal Children
Aguilera, C. M., Gómez‐Llorente, C., Tofé, I., Gil‐Campos, M., Cañete, R., & Gil, Á. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16047723 · Cited by 85 · see citing works
Shared and separate functions of the RAMP-based adrenomedullin receptors
Kuwasako, K., Kitamura, K., Nagata, S., Hikosaka, T., Takei, Y., & Kato, J. (2011) · Peptides · doi:10.1016/j.peptides.2011.05.022 · Cited by 70 · see citing works
Adipocytes cause leukemia cell resistance to daunorubicin via oxidative stress response
Sheng, X., Tucci, J., Parmentier, J., Ji, L., Behan, J. W., Heisterkamp, N., & Mittelman, S. D. (2016) · Oncotarget · doi:10.18632/oncotarget.12246 · Cited by 61 · see citing works
Adrenomedullin – Current perspective on a peptide hormone with significant therapeutic potential
Fischer, J., Els‐Heindl, S., & Beck‐Sickinger, A. G. (2020) · Peptides · doi:10.1016/j.peptides.2020.170347 · Cited by 44 · see citing works
Seißler, J., Feghelm, N., Then, C., Meisinger, C., Herder, C., Köenig, W., Peters, A., Roden, M., Lechner, A., Kowall, B., et al. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0472 · Cited by 41 · see citing works
Potocki, M., Ziller, R., & Mueller, C. E. (2012) · Current Heart Failure Reports · doi:10.1007/s11897-012-0096-6 · Cited by 40 · see citing works
Effect of liraglutide on atrial natriuretic peptide, adrenomedullin, and copeptin in PCOS
Frøssing, S., Nylander, M., Kistorp, C., Skouby, S. O., & Faber, J. (2018) · Endocrine Connections · doi:10.1530/ec-17-0327 · Cited by 38 · see citing works
Plasma MR‐proADM Correlates to BMI and Decreases in Relation to Leptin After Gastric Bypass Surgery
Vila, G., Riedl, M., Maier, C., Struck, J., Morgenthaler, N. G., Handisurya, A., Prager, G., Ludvik, B. H., Clodi, M., & Luger, A. (2009) · Obesity · doi:10.1038/oby.2009.22 · Cited by 37 · see citing works
Pang, Y., Li, Y., Lv, Y., Sun, L., Zhang, S., Li, Y., Wang, Y., Liu, C., Xu, M., Wang, X., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.702654 · Cited by 35 · see citing works
Self-citationCardiac natriuretic peptides in plasma increase after dietary induced weight loss in obesity
Kistorp, C., Bliddal, H., Goetze, J. P., Christensen, R., & Faber, J. (2014) · BMC Obesity · doi:10.1186/s40608-014-0024-2 · Cited by 31 · see citing works
Adrenomedullin promotes human endothelial cell proliferation via HIF-1α
Chen, L., Qiu, J., Zhang, L., & Luo, X.-D. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1267-1 · Cited by 28 · see citing works
Hu, W., Zhou, P., Zhang, X., Xu, C., & Wang, W. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2345 · Cited by 28 · see citing works
Cheung, B. M. Y., Ong, K. L., Tso, A. W. K., Leung, R. Y. H., Cherny, S. S., Sham, P. C., Lam, T. H., & Lam, K. S. L. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0513 · Cited by 27 · see citing works
Neuroendocrine markers are expressed in human mammary glands.
Grönberg, M., Amini, R., Stridsberg, M., Janson, E., & Saras, J. (2010) · Regulatory Peptides · doi:10.1016/j.regpep.2009.12.011 · Cited by 24 · see citing works
Christensen, H. M., Kistorp, C., Schou, M., Keller, N., Zerahn, B., Frystyk, J., Flyvbjerg, A., & Faber, J. O. (2013) · Metabolism · doi:10.1016/j.metabol.2013.09.017 · Cited by 26 · see citing works
Eggers, K. M., Venge, P., Lindahl, B., & Lind, L. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.05.005 · Cited by 21 · see citing works
Mid-regional-pro-adrenomedullin plasma levels are increased in obese adolescents
Ry, S. D., Cabiati, M., Bianchi, V., Caponi, L., Cecco, P. D., Marchi, B., Randazzo, E., Caselli, C., Prescimone, T., Clerico, A., et al. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0938-6 · Cited by 20 · see citing works
Dai, H., Wang, H., Wang, F., Qian, P., Gao, Q., Zhou, Y., & Zhou, Y. (2022) · Acta Diabetologica · doi:10.1007/s00592-021-01840-5 · Cited by 20 · see citing works
Epicardial Adipose Tissue as an Independent Cardiometabolic Risk Factor for Coronary Artery Disease
Karampetsou, N., Alexopoulos, L. G., Minia, A., Pliaka, V., Tsolakos, N., Kontzoglou, K., Perrea, D. N., & Patapis, P. (2022) · Cureus · doi:10.7759/cureus.25578 · Cited by 20 · see citing works
Adipokines and the clinical laboratory: what to measure, when and how?
Hill, M. J., Kumar, S., & McTernan, P. G. (2009) · Journal of Clinical Pathology · doi:10.1136/jcp.2007.049171 · Cited by 19 · see citing works
Ong, K. L., Tso, A. W. K., Leung, R. Y. H., Cherny, S. S., Sham, P. C., Lam, T. H., Cheung, B. M. Y., & Lam, K. S. L. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.11.007 · Cited by 18 · see citing works
Adrenomedullin and glucagon-like peptide-1 have additive effects on food intake in mice
Bech, E. M., Voldum-Clausen, K., Pedersen, S. L., Fabricius, K., Rudkjær, L. C. B., Hansen, H. H., & Jelsing, J. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.10.040 · Cited by 18 · see citing works
Dai, H., Wang, F., Kang, Y., Sun, J. Y., Zhou, Y., Gao, Q., Li, Z., Qian, P., Zhu, G., & Zhou, Y. (2020) · Obesity · doi:10.1002/oby.23012 · Cited by 18 · see citing works
Chen, Q., Chen, P., Pang, X., Hu, Y., & Zhang, Y. (2015) · International Journal of Gynecological Cancer · doi:10.1097/igc.0000000000000465 · Cited by 18 · see citing works
Self-citationThe Analysis of a Genome-Wide Association Study (GWAS) of Overweight and Obesity in Psoriasis
Kisielnicka, A., Sobalska‐Kwapis, M., Purzycka-Bohdan, D., Nedoszytko, B., Zabłotna, M., Seweryn, M. T., Strapagiel, D., Nowicki, R. J., Reich, A., Samotij, D., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137396 · Cited by 17 · see citing works
Adipose organ dysfunction and type 2 diabetes: Role of nitric oxide
Bahadoran, Z., Mirmiran, P., & Ghasemi, A. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116043 · Cited by 17 · see citing works
Bhandari, S., Davies, J. E., Struck, J., & Ng, L. L. (2011) · Biomarkers · doi:10.3109/1354750x.2011.553750 · Cited by 17 · see citing works
Brain-derived neurotrophic factor: a new adipokine
Sornelli, F., Fiore, M., Chaldakov, G. N., & Aloe, L. (2007) · Biomedical Reviews · doi:10.14748/bmr.v18.72 · Cited by 17 · see citing works
Funke-Kaiser, A., Mann, K., Colquhoun, D., Zeller, T., Hunt, D. U., Simes, J. R., SULLIVAN, D. R., Sydow, K., West, M., White, H. D., et al. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.01.064 · Cited by 16 · see citing works
Associations of Body Mass Index With Laboratory and Biomarkers in Patients With Acute Heart Failure
Streng, K. W., ter Maaten, J. M., Cleland, J. G. F., O’Connor, C. M., Davison, B. A., Metra, M., Givertz, M. M., Teerlink, J. R., Ponikowski, P. P., Bloomfield, D. M., et al. (2017) · Circulation Heart Failure · doi:10.1161/circheartfailure.116.003350 · Cited by 16 · see citing works
Antimicrobial peptides and proteins in human biological fluids
Иксанова, А. М., Arzumanian, V. G., Konanykhina, S. Y., & Samoylikov, P. V. (2022) · Microbiology Independent Research Journal (MIR Journal) · doi:10.18527/2500-2236-2022-9-1-37-55 · Cited by 16 · see citing works
Bell, D., Gordon, B. J., Lavery, A., Megaw, K., Kinney, M. O., & Harbinson, M. (2016) · Peptides · doi:10.1016/j.peptides.2015.12.003 · Cited by 15 · see citing works
Zhang, Y., Zhang, S., Hai, S., Pang, X., & Zhao, Y. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2009.07.007 · Cited by 14 · see citing works
Self-citationGar, C., Thorand, B., Herder, C., Sujana, C., Heier, M., Meisinger, C., Peters, A., Köenig, W., Rathmann, W., Roden, M., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262330 · Cited by 10 · see citing works
Yıldırım, E. K., Dedeoğlu, Z., Kaya, M., & Üner, A. G. (2020) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2020.1825726 · Cited by 9 · see citing works
Wong, H. K., Ong, K. L., Leung, R. Y. H., Cheung, T. T., Xu, A., Lam, T. H., Lam, K. S. L., & Cheung, B. M. Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070335 · Cited by 9 · see citing works
Verdonschot, J. A. J., Ferreira, J. P., Pizard, A., Pellicori, P., Rocca, H. B., Clark, A. L., Cosmi, F., Cuthbert, J. J., Girerd, N., Waring, O. J., et al. (2021) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2021.12.005 · Cited by 8 · see citing works
Wang, F., Qian, P., Liu, M.-Y., Ding, L., Wang, H., Wang, Q., Ding, Z.-Y., Jin, F.-Y., Li, R.-G., & Zhou, Y. (2022) · Journal of Hypertension · doi:10.1097/hjh.0000000000003301 · Cited by 8 · see citing works
A single nucleotide polymorphism of interleukin‐6 gene is related to plasma adrenomedullin levels
Wong, H. K., Ong, K. L., Leung, R. Y. H., Lam, T. H., Thomas, G. N., Lam, K. S. L., & Cheung, B. M. Y. (2012) · Clinical Endocrinology · doi:10.1111/cen.12078 · Cited by 7 · see citing works
Impact of adrenomedullin blockage on lipid metabolism in female mice exposed to high-fat diet
Dong, Y., van der Walt, N., Pennington, K. A., & Yallampalli, C. (2019) · Endocrine · doi:10.1007/s12020-019-01927-8 · Cited by 7 · see citing works
Synergistic activation of the human adrenomedullin gene promoter by Sp1 and AP-2α
Zhang, Y., Li, Y., Shibahara, S., & Takahashi, K. (2007) · Peptides · doi:10.1016/j.peptides.2007.07.015 · Cited by 7 · see citing works
Self-citationClinical Role of Epicardial Adipose Tissue
Raggi, P., & Stillman, A. E. (2025) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2025.02.021 · Cited by 8 · see citing works
Adrenomedullin as a Protein with Multifunctional Behavior and Effects in Various Organs and Tissues
Özçelik, F., Pençe, H. H., Ozturkeri, H. Y., & Sertoğlu, E. (2019) · International Journal of Negative Results · doi:10.14302/issn.2641-9181.ijnr-19-2771 · Cited by 6 · see citing works
CARDIOVASCULAR ADIPOBIOLOGY: A NOVEL
Chaldakov, G. N. (2008) · Cited by 6 · see citing works
Çetin, N., Kiraz, Z. K., & Gençler, A. (2020) · Indian Pediatrics · doi:10.1007/s13312-020-1914-7 · Cited by 5 · see citing works
Koyama, T., Kuriyama, N., & Uehara, R. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17113968 · Cited by 5 · see citing works
Kato, J., & Kitamura, K. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-385095-9.00185-8 · Cited by 5 · see citing works
Sujana, C., Salomaa, V. V., Kee, F., Seißler, J., Jousilahti, P., Neville, C. E., Then, C., Köenig, W., Kuulasmaa, K., Reinikainen, J., et al. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01513-9 · Cited by 3 · see citing works
The secretome of brown adipose tissue
Hansen, I. R. (2014) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 3 · see citing works
Zhou, P., Shi, L., Hu, W., Zhang, X., Wang, W., & Zhang, L. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3418 · Cited by 2 · see citing works
van Oers, J. A. H., Pouwels, S., Ramnarain, D., Kluiters, Y., Bons, J. A. P., de Lange, D. W., de Grooth, H., & Girbes, A. R. J. (2022) · International Journal of Obesity · doi:10.1038/s41366-022-01184-2 · Cited by 2 · see citing works
Tony, E. E., Eldeen, M. E. E., Tony, A., El-Shereif, T., & Abdou, M. A. (2018) · Journal of The Egyptian Society of Nephrology and Transplantation · doi:10.4103/jesnt.jesnt_4_18 · Cited by 2 · see citing works
Plasma adrenomedullin levels in migraine: A registry for migraine (REFORM) study
Domínguez-Moreno, R., Karlsson, W. K., Al‐Khazali, H. M., Christensen, R. H., Ashina, H., & Ashina, M. (2025) · Cephalalgia · doi:10.1177/03331024251360234 · Cited by 1 · see citing works
Lương, K. V. Q., Nguyễn, L., Nguyen, S., & Nguyen, N. T. (2011) · International Journal of Clinical Medicine · doi:10.4236/ijcm.2011.23034 · Cited by 1 · see citing works
Антимикробные пептиды и белки в биожидкостях человека
Иксанова, А. М., Arzumanian, V. G., Konanykhina, S. Y., & Samoilikov, P. V. (2022) · Microbiology Independent Research Journal (MIR Journal) · doi:10.18527/2500-2236-2022-9-1-37-55.ru · Cited by 1 · see citing works
Li, H., Xiao, C., Bian, Y., Bai, R., & Fen, G. (2017) · European Journal of Inflammation · doi:10.1177/1721727x17744096 · Cited by 1 · see citing works
Órgano especificidad de los biomarcadores de sepsis
Ledesma, C. A. (2021) · doi:10.35376/10324/46428 · Cited by 1 · see citing works
Watanabe, K., Wilmanski, T. M., Diener, C., Earls, J. C., Zimmer, A., Lincoln, B., Hadlock, J., Lovejoy, J. C., Gibbons, S. M., Magis, A. T., et al. (2022) · medRxiv · doi:10.1101/2022.01.20.22269601 · Cited by 1 · see citing works
Investigation of angiogenic factors in obese rats exposed to low oxygen pressure
Dağ, M., & Yürekli, M. (2020) · Medical Science and Discovery · doi:10.36472/msd.v7i3.360
Elias, S. O., & Bamgbade, I. Y. (2020) · European Journal of Medical and Health Sciences · doi:10.24018/ejmed.2020.2.2.191
Cacciapuoti, F. (2022) · Current Research in Diabetes & Obesity Journal · doi:10.19080/crdoj.2022.16.555926
Sujana, C., Salomaa, V. V., Kee, F., Seissler, J., Jousilahti, P., Neville, C., Then, C., Koenig, W., Kuulasmaa, K., Reinikainen, J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20046011
James, C., Fang, L., Wu, Z., Hope, J. C., Coffey, M., & Li, B. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.07.704532
Impaired peptide amidation and risk of incident dementia in the Malmoe preventive project cohort
Kaufmann, P., Ilina, Y., Giontella, A., Press, M., Nägga, K., Hansson, O., Hampel, H. J., Bergmann, A., & Melander, O. (2026) · Alzheimer s Research & Therapy · doi:10.1186/s13195-026-02173-7
- Authors
- Li, Y., Jiang, C., Wang, X., Zhang, Y., Shibahara, S., & Takahashi, K.
- Affiliations
- Tohoku University (JP)
- Peking University (CN)
- Corresponding author
- Takahashi, Kazuhiro
- Venue
- Peptides
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 28
- Issue
- 5
- Pages
- 1129-1143
- ISSN
- 0196-9781 (ISSN-L)
- OpenAlex
- W2066377469
- Cited by
- 71
- References
- 143
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 12 · 2021: 2 · 2020: 7 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 5
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Peptides (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- adrenomedullin, adipokines, adipocytes, adipose tissue, obesity, TNF-α, lipopolysaccharide, metabolic syndrome, type 2 diabetes, hypertension, antioxidant activity, vasodilation
- MeSH terms
- Adipose Tissue, Amino Acid Sequence, Animals, Gene Expression Regulation, Humans, Molecular Sequence Data, Obesity, Cytokines, Adipocytes, Adrenomedullin
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