Alpha cell dysfunction in type 1 diabetes

The unique cytoarchitecture of human pancreatic islets has implications for islet cell function

Cabrera, O., Berman, D. M., Kenyon, N. S., Ricordi, C., Berggren, P.-O., & Caicedo, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510790103 · Cited by 1,312 · see citing works

Differentiation of diabetes by pathophysiology, natural history, and prognosis

Skyler, J. S., Bakris, G. L., Bonifacio, E., Darsow, T., Eckel, R. H., Groop, L., Groop, P.-H., Handelsman, Y., Insel, R. A., Mathieu, C., et al. (2017) · Diabetes · doi:10.2337/db16-0806 · Cited by 823 · see citing works

Assessment of Human Pancreatic Islet Architecture and Composition by Laser Scanning Confocal Microscopy

Brissova, M., Fowler, M. J., Nicholson, W. E., Chu, A., Hirshberg, B., Harlan, D. M., & Powers, A. C. (2005) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.5c6684.2005 · Cited by 797 · see citing works

GIP and GLP-1, the two incretin hormones: Similarities and differences

Seino, Y., Fukushima, M., & Yabe, D. (2010) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2010.00022.x · Cited by 746 · see citing works

Glucagonocentric restructuring of diabetes: A pathophysiologic and therapeutic makeover

Unger, R. H., & Cherrington, A. D. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60016 · Cited by 670 · see citing works

Physiology of the pancreatic α-cell and glucagon secretion: role in glucose homeostasis and diabetes

Quesada, I., Tudurí, E., Ripoll, C., & Nadal, Á. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0290 · Cited by 413 · see citing works

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes

Campbell‐Thompson, M., Fu, A. D., Kaddis, J. S., Wasserfall, C. H., Schatz, D., Pugliese, A., & Atkinson, M. A. (2015) · Diabetes · doi:10.2337/db15-0779 · Cited by 359 · see citing works

Somatostatin Inhibits Insulin and Glucagon Secretion via Two Receptor Subtypes: An in Vitro Study of Pancreatic Islets from Somatostatin Receptor 2 Knockout Mice

Strowski, M. Z., Parmar, R. M., Blake, A. D., & Schaeffer, J. M. (2000) · Endocrinology · doi:10.1210/endo.141.1.7263 · Cited by 358 · see citing works

Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice

Lee, Y., Wang, M.-Y., Du, X. Q., Charron, M. J., & Unger, R. H. (2011) · Diabetes · doi:10.2337/db10-0426 · Cited by 327 · see citing works

The Pathogenesis and Natural History of Type 1 DiabetesPreprint

Atkinson, M. A. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007641 · Cited by 318 · see citing works

Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.

Kumar, U., Sasi, R., Suresh, S., Patel, A., Thangaraju, M., Metrakos, P. P., Patel, S. C., & Patel, Y. (1999) · Diabetes · doi:10.2337/diabetes.48.1.77 · Cited by 284 · see citing works

Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system

Xu, E., Kumar, M., Zhang, Y., Ju, W., Obata, T., Zhang, N., Liu, S., Wendt, A., Deng, S., Ebina, Y., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2005.11.015 · Cited by 283 · see citing works

The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action

Hare, K. J., Vilsbøll, T., Asmar, M., Deacon, C. F., Knop, F. K., & Holst, J. J. (2010) · Diabetes · doi:10.2337/db09-1414 · Cited by 276 · see citing works

GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-Type Ca2+ Channel-Dependent Exocytosis

De Marinis, Y. Z., Salehi, A., Ward, C. E., Zhang, Q., Abdulkader, F., Bengtsson, M., Braha, O., Braun, M., Ramracheya, R., Amisten, S., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.007 · Cited by 257 · cited 2× · see citing works

Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes.

Orci, L., Baetens, D., Rufener, C., AMHERDT, M., Ravazzola, M., Studer, P., MALAISSE-LAGAE, F., & Unger, R. H. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.4.1338 · Cited by 254 · see citing works

A KATP Channel-Dependent Pathway within α Cells Regulates Glucagon Release from Both Rodent and Human Islets of Langerhans

MacDonald, P. E., Marinis, Y. Z. D., Ramracheya, R. D., Salehi, A. A., Ma, X., Johnson, P., Cox, R., Eliasson, L., & Rorsman, P. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050143 · Cited by 243 · see citing works

Regulation of glucagon release in mouse α‐cells by K_ATP channels and inactivation of TTX‐sensitive Na⁺ channels

Göpel, S. O., Kanno, T., Barg, S., Weng, X. ‐., Gromada, J., & Rorsman, P. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00509.x · Cited by 229 · see citing works

Role of KATP Channels in Glucose-Regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes

Zhang, Q., Ramracheya, R., Lahmann, C., Tarasov, A., Bengtsson, M., Braha, O., Braun, M., Brereton, M., Collins, S., Galvanovskis, J., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.10.014 · Cited by 225 · see citing works

Regulation of calcium in pancreatic α- and β-cells in health and disease

Rorsman, P., Braun, M., & Zhang, Q. (2012) · Cell Calcium · doi:10.1016/j.ceca.2011.11.006 · Cited by 220 · see citing works

Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells

Vieira, E., Salehi, A., & Gylfe, E. (2007) · Diabetologia · doi:10.1007/s00125-006-0511-1 · Cited by 218 · see citing works

Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients With Type 2 Diabetes: 12- and 24-Week Phase 2 Studies

KAZDA, C. M., Ding, Y., Kelly, R. P., Garhyan, P., Shi, C., Lim, C. N., Fu, H., Watson, D. E., Lewin, A. J., Landschulz, W. H., et al. (2015) · Diabetes Care · doi:10.2337/dc15-1643 · Cited by 211 · see citing works

Mechanisms of hypoglycemia unawareness and implications in diabetic patients

Martín-Timón, I. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i7.912 · Cited by 204 · see citing works

Hypoglycemia unawareness

GERICH, J. E., MOKAN, M., VENEMAN, T., KORYTKOWSKI, M., & MITRAKOU, A. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-4-356 · Cited by 188 · see citing works

Paradoxical Stimulation of Glucagon Secretion by High Glucose Concentrations

Salehi, A., Vieira, E., & Gylfe, E. (2006) · Diabetes · doi:10.2337/db06-0080 · Cited by 159 · see citing works

glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis

Ye, L., Robertson, M. A., Hesselson, D., Stainier, D. Y. R., & Anderson, R. M. (2015) · Development · doi:10.1242/dev.117911 · Cited by 139 · see citing works

Conversion of Mature Human β-Cells Into Glucagon-Producing α-Cells

Spijker, H. S., Ravelli, R. B. G., Mommaas, A. M., van Apeldoorn, A. A., Engelse, M. A., Zaldumbide, A., Bonner‐Weir, S., Rabelink, T. J., Hoeben, R. C., Clevers, H. C., et al. (2013) · Diabetes · doi:10.2337/db12-1001 · Cited by 138 · see citing works

Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in α-Cells Inhibits Glucagon Secretion From Human Islets

Ramracheya, R., Ward, C., Shigeto, M., Walker, J. N., Amisten, S., Zhang, Q., Johnson, P. R., Rorsman, P., & Braun, M. (2010) · Diabetes · doi:10.2337/db09-1505 · Cited by 136 · see citing works

Glucagon Stimulates Exocytosis in Mouse and Rat Pancreatic α-Cells by Binding to Glucagon Receptors

Ma, X., Zhang, Y., Gromada, J., Sewing, S., Berggren, P., Buschard, K., Salehi, A. A., Vikman, J., Rorsman, P., & Eliasson, L. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0059 · Cited by 130 · see citing works

Glucagon and Type 2 Diabetes: the Return of the Alpha Cell

Lund, A., Bagger, J. I., Christensen, M., Knop, F. K., & Vilsbøll, T. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0555-4 · Cited by 127 · see citing works

Somatostatin inhibits exocytosis in rat pancreatic α‐cells by G _i2 ‐dependent activation of calcineurin and depriming of secretory granules

Gromada, J., Høy, M., Buschard, K., Salehi, A., & Rorsman, P. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00519.x · Cited by 120 · see citing works

A store-operated mechanism determines the activity of the electrically excitable glucagon-secreting pancreatic α-cell

Liu, Y.-J., Vieira, E., & Gylfe, E. (2004) · Cell Calcium · doi:10.1016/j.ceca.2003.10.002 · Cited by 118 · see citing works

Neuronostatin Encoded by the Somatostatin Gene Regulates Neuronal, Cardiovascular, and Metabolic Functions

Samson, W. K., Zhang, J. V., Avsian-Kretchmer, O., Cui, K., Yosten, G. L. C., Klein, C., Lyu, R., Wang, Y. X., Chen, X. Q., Yang, J., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804784200 · Cited by 111 · see citing works

Short‐term administration of the glucagon receptor antagonist <scp>LY2409021</scp> lowers blood glucose in healthy people and in those with type 2 diabetes

Kelly, R. P., Garhyan, P., Raddad, E., Fu, H., Lim, C. N., Prince, M. J., Pinaire, J. A., Loh, M. T., & Deeg, M. A. (2015) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12446 · Cited by 110 · see citing works

Pancreas islets in metabolic signaling - focus on the beta-cell

Suckale, J. (2008) · Frontiers in bioscience · doi:10.2741/3218 · Cited by 108 · see citing works

Adrenomedullin Gene Expression in the Rat Heart is Stimulated by Acute Pressure Overload: Blunted Effect in Experimental Hypertension

Romppanen, H., Marttila, M., Magga, J., Vuolteenaho, O., Kinnunen, P., Szokodi, I., & Ruskoaho, H. (1997) · Endocrinology · doi:10.1210/endo.138.6.9105 · Cited by 105 · see citing works

KATP-channels and glucose-regulated glucagon secretion

Rorsman, P., Salehi, A. A., Abdulkader, F., Braun, M., & MacDonald, P. E. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.07.003 · Cited by 101 · see citing works

Glucose regulation of glucagon secretion

Gylfe, E., & Gilon, P. (2013) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2013.11.019 · Cited by 98 · see citing works

Role of Endogenous GLP-1 and GIP in Beta Cell Compensatory Responses to Insulin Resistance and Cellular Stress

Vasu, S., Moffett, R. C., Thorens, B., & Flatt, P. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101005 · Cited by 92 · see citing works

Three-Dimensional Imaging of Intact Isolated Islets of Langerhans With Confocal Microscopy

Brelje, T. C., Scharp, D. W., & Sorenson, R. L. (1989) · Diabetes · doi:10.2337/diab.38.6.808 · Cited by 88 · see citing works

Insulin Regulates Islet α-Cell Function by Reducing KATP Channel Sensitivity to Adenosine 5′-Triphosphate Inhibition

Leung, Y., Ahmed, I., Sheu, L., Gao, X., Hara, M., Tsushima, R. G., Diamant, N. E., & Gaisano, H. Y. (2006) · Endocrinology · doi:10.1210/en.2005-1249 · Cited by 83 · see citing works

The Prevalent Glu23Lys Polymorphism in the Potassium Inward Rectifier 6.2 (KIR6.2) Gene Is Associated With Impaired Glucagon Suppression in Response to Hyperglycemia

Tschritter, O., Stümvoll, M., Machicao, F. E., Holzwarth, M. G., Weisser, M., Maerker, E., Teigeler, A., Häring, H. U., & Fritsche, A. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2854 · Cited by 76 · see citing works

Incretin Receptor Null Mice Reveal Key Role of GLP-1 but Not GIP in Pancreatic Beta Cell Adaptation to Pregnancy

Moffett, R. C., Vasu, S., Thorens, B., Drucker, D. J., & Flatt, P. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096863 · Cited by 75 · see citing works

Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo

Matsuoka, T., Kawashima, S., Miyatsuka, T., Sasaki, S., Shimo, N., Katakami, N., Kawamori, D., Takebe, S., Herrera, P. L., Kaneto, H., et al. (2017) · Diabetes · doi:10.2337/db16-0887 · Cited by 70 · see citing works

Evidence for an interaction of neuronostatin with the orphan G protein-coupled receptor, GPR107

Yosten, G. L. C., Redlinger, L. J., & Samson, W. K. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00336.2012 · Cited by 69 · see citing works

Insulin inhibits glucagon secretion by the activation of PI3-kinase in In-R1-G9 cells

Kaneko, K. B., Shirotani, T., Araki, E., Matsumoto, K., Taguchi, T., Motoshima, H., Yoshizato, K., Kishikawa, H., & Shichiri, M. (1999) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(99)00021-2 · Cited by 57 · see citing works

Defective Counterregulation and Hypoglycemia Unawareness in Diabetes

Reno, C. M., Litvin, M., Clark, A. L., & Fisher, S. J. (2012) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2012.11.005 · Cited by 53 · see citing works

Immunohistochemical Localization of Somatostatin Receptor SST2A in the Rat Pancreas

Hunyady, B. (1997) · Endocrinology · doi:10.1210/en.138.6.2636 · Cited by 53 · see citing works

β-Cell Glucose Sensitivity Is Linked to Insulin/Glucagon Bihormonal Cells in Nondiabetic Humans

Mezza, T., Sorice, G. P., Conte, C., Sun, V. A., CEFALO, C. M. A., Moffa, S., Pontecorvi, A., Mari, A., Kulkarni, R., & Giaccari, A. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2802 · Cited by 48 · see citing works

Pharmacokinetics and pharmacodynamics of single and multiple doses of the glucagon receptor antagonist LGD‐6972 in healthy subjects and subjects with type 2 diabetes mellitus

Vajda, E. G., Logan, D. K., Lasseter, K. C., Armas, D. R., Plotkin, D. J., Pipkin, J., Li, Y.-X., Zhou, R., Klein, D. J., Wei, X., et al. (2016) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12752 · Cited by 48 · see citing works

Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic α-cells

Elrick, M. M., Samson, W. K., Corbett, J. A., Salvatori, A., Stein, L. M., Kolar, G. R., Naatz, A., & Yosten, G. L. C. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00369.2014 · Cited by 41 · see citing works

Islet Remodeling in Female Mice with Spontaneous Autoimmune and Streptozotocin-Induced Diabetes

Plesner, A., ten Holder, J. T., & Verchere, C. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102843 · Cited by 40 · see citing works

Dynamic Changes in Pancreatic Endocrine Cell Abundance, Distribution, and Function in Antigen-Induced and Spontaneous Autoimmune Diabetes

Pechhold, K., Zhu, X., Harrison, V. S., Lee, J. S., Chakrabarty, S., Koczwara, K., Gavrilova, O., & Harlan, D. M. (2009) · Diabetes · doi:10.2337/db08-0616 · Cited by 39 · see citing works

Differential molecular and cellular responses of GLP-1 secreting L-cells and pancreatic alpha cells to glucotoxicity and lipotoxicity

Vasu, S., Moffett, R. C., McClenaghan, N. H., & Flatt, P. R. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.05.022 · Cited by 37 · see citing works

Hypoglycemic Effect of Combined Ghrelin and Glucagon Receptor Blockade

Mani, B. K., Uchida, A., Lee, Y., Osborne-Lawrence, S. L., Charron, M. J., Unger, R. H., Berglund, E. D., & Zigman, J. M. (2017) · Diabetes · doi:10.2337/db16-1303 · Cited by 34 · see citing works

Quantitative Immunohistochemical Changes in the Endocrine Pancreas of Nonobese Diabetic (NOD) Mice

Dumm, C. L. A. G., Cónsole, G. M., Luna, G. C., Dardenne, M., & Goya, R. G. (1995) · Pancreas · doi:10.1097/00006676-199511000-00012 · Cited by 33 · see citing works

Two novel glucagon receptor antagonists prove effective therapeutic agents in high‐fat‐fed and obese diabetic mice

O'Harte, F. P. M., Franklin, Z. J., & Irwin, N. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12360 · Cited by 26 · see citing works

A 4-week study assessing the pharmacokinetics, pharmacodynamics, safety, and tolerability of the glucagon receptor antagonist PF-06291874 administered as monotherapy in subjects with type 2 diabetes mellitus

Bergman, A. J., Tan, B., Somayaji, V. R., Calle, R. A., & Kazierad, D. J. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.01.019 · Cited by 24 · see citing works

Neuronostatin inhibits glucose-stimulated insulin secretion via direct action on the pancreatic α-cell

Salvatori, A., Elrick, M. M., Samson, W. K., Corbett, J. A., & Yosten, G. L. C. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00599.2013 · Cited by 21 · see citing works

Treatment and Prevention of Hypoglycemia and its Unawareness in Type 1 Diabetes Mellitus

Bolli, G. B. (2003) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/a:1027397911746 · Cited by 20 · see citing works

Activin Enhances α- to β-Cell Transdifferentiation as a Source For β-Cells In Male FSTL3 Knockout Mice

Brown, M., Andrzejewski, D., Burnside, A., & Schneyer, A. L. (2016) · Endocrinology · doi:10.1210/en.2015-1793 · Cited by 19 · see citing works

Glucose regulation of glucagon secretion independent of B cell activity

Asplin, C. M., Raghu, P., Dornan, T., & Palmer, J. P. (1983) · Metabolism · doi:10.1016/0026-0495(83)90195-6 · Cited by 16 · see citing works

Responses of GLP1-secreting L-cells to cytotoxicity resemble pancreatic β-cells but not α-cells

Vasu, S., Moffett, R. C., McClenaghan, N. H., & Flatt, P. R. (2014) · Journal of Molecular Endocrinology · doi:10.1530/jme-14-0214 · Cited by 13 · see citing works

Glucagon receptor antagonist and GIP agonist combination for diet-induced obese mice

McShane, L. M., Irwin, N., O’Flynn, D., Franklin, Z. J., Hewage, C. M., & O'Harte, F. P. M. (2016) · Journal of Endocrinology · doi:10.1530/joe-15-0463 · Cited by 12 · see citing works

Hypoglycemia unawareness prevention: Targeting glucagon production

Samson, W. K., Stein, L. M., Elrick, M. M., Salvatori, A., Kolar, G. R., Corbett, J. A., & Yosten, G. L. C. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.04.012 · Cited by 11 · see citing works

Stimulation‐induced calcium signalling and ion transport in rat pancreatic acini

Gromada, J., Jørgensen, N. K., Nauntofte, B., & Dissing, S. (1997) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1997.545329000.x · Cited by 7 · see citing works

Dual self-regulated delivery of insulin and glucagon by a hybrid patch

Wang, Z., Wang, J., Li, H., Yu, J., Chen, G., Kahkoska, A. R., Wu, V., Zeng, Y., Wen, D., Miedema, J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2011099117 · Cited by 120 · see citing works

The Role of α-Cells in Islet Function and Glucose Homeostasis in Health and Type 2 Diabetes

Gilon, P. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.01.004 · Cited by 90 · see citing works

Pathophysiology of Physical Inactivity-Dependent Insulin Resistance: A Theoretical Mechanistic Review Emphasizing Clinical Evidence

Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2021) · Journal of Diabetes Research · doi:10.1155/2021/7796727 · Cited by 91 · see citing works

Management of Diabetic Ketoacidosis in Children and Adolescents with Type 1 Diabetes Mellitus

Castellanos, L. E., Tuffaha, M., Koren, D., & Levitsky, L. L. (2020) · Pediatric Drugs · doi:10.1007/s40272-020-00397-0 · Cited by 89 · see citing works

Phoenixin: More than Reproductive Peptide

Billert, M., Rak, A., Nowak, K. W., & Skrzypski, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218378 · Cited by 64 · see citing works

Human pancreatic afferent and efferent nerves: mapping and 3-D illustration of exocrine, endocrine, and adipose innervation.

Chien, H.-J., Chiang, T.-C., Peng, S.-J., Chung, M.-H., Chou, Y.-H., Lee, C.-Y., Jeng, Y., Yu-Wen, T., & Tang, S.-C. (2019) · American Journal of Physiology - Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00116.2019 · Cited by 51 · see citing works

Decellularized Tissue Matrix Enhances Self-Assembly of Islet Organoids from Pluripotent Stem Cell Differentiation

Bi, H., Karanth, S. S., Ye, K., Stein, R., & Jin, S. (2020) · ACS Biomaterials Science &amp; Engineering · doi:10.1021/acsbiomaterials.0c00088 · Cited by 56 · see citing works

Mini‐review: Glucagon responses in type 1 diabetes – a matter of complexity

Bengtsen, M. B., & Møller, N. (2021) · Physiological Reports · doi:10.14814/phy2.15009 · Cited by 50 · see citing works

Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes

Campbell-Thompson, M., Butterworth, E., Boatwright, J., Nair, M. A., Nasif, L., Nasif, K., Revell, A., Riva, A., Mathews, C., Gerling, I., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-85659-8 · Cited by 41 · see citing works

Hepatopathy Associated With Type 1 Diabetes: Distinguishing Non-alcoholic Fatty Liver Disease From Glycogenic Hepatopathy

Mertens, J., Block, C. E. M. D., Spinhoven, M. J., Driessen, A. L. C., Francque, S., & Kwanten, W. J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.768576 · Cited by 46 · see citing works

Pancreatic alpha-cell mass in the early-onset and advanced stage of a mouse model of experimental autoimmune diabetes

Bru-Tarí, E., Cobo‐Vuilleumier, N., Alonso‐Magdalena, P., dos Santos, R. S., Marroquí, L., Nadal, Á., Gauthier, B. R., & Quesada, I. (2019) · Scientific Reports · doi:10.1038/s41598-019-45853-1 · Cited by 43 · see citing works

Glycaemic thresholds for counterregulatory hormone and symptom responses to hypoglycaemia in people with and without type 1 diabetes: a systematic review

Verhulst, C. E. M., Fabricius, T. W., Teerenstra, S., Kristensen, P. L., Tack, C. J., McCrimmon, R. J., Heller, S., Evans, M. L., Amiel, S. A., Pedersen-Bjergaard, U., et al. (2022) · Diabetologia · doi:10.1007/s00125-022-05749-8 · Cited by 34 · see citing works

Glucagon‐like peptide ‐1 receptor agonists as adjunctive treatment for type 1 diabetes: Renewed opportunities through tailored approaches?

Kobayati, A., Haidar, A., & Tsoukas, M. A. (2022) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14637 · Cited by 36 · see citing works

From immunohistological to anatomical alterations of human pancreas in type 1 diabetes: New concepts on the stage

Nigi, L., Maccora, C., Dotta, F., & Sebastiani, G. (2019) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3264 · Cited by 24 · see citing works

A multigenerational study on phenotypic consequences of the most common causal variant of HNF1A-MODY

Kettunen, J. L. T., Rantala, E., Dwivedi, O. P., Isomaa, B., Sarelin, L., Kokko, P., Hakaste, L., Miettinen, P. J., Groop, L., & Tuomi, T. (2021) · Diabetologia · doi:10.1007/s00125-021-05631-z · Cited by 21 · see citing works

Impaired early‐phase suppression of glucagon secretion after glucose load is associated with insulin requirement during pregnancy in gestational diabetes

Horie, I., Haraguchi, A., Ito, A., Nozaki, A., Natsuda, S., Akazawa, S., Mori, Y., Ando, T., Higashijima, A., Hasegawa, Y., et al. (2019) · Journal of Diabetes Investigation · doi:10.1111/jdi.13096 · Cited by 18 · see citing works

Endocrine Pancreas Development and Dysfunction Through the Lens of Single-Cell RNA-Sequencing

Szlachcic, W. J., Ziojła, N. M., Kizewska, D. K., Kempa, M., & Borowiak, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.629212 · Cited by 15 · see citing works

Heparanase and Type 1 Diabetes

Simeonovic, C. J., Popp, S. K., Brown, D. J., Li, F.-J., Lafferty, A. R. A., Freeman, C. G., & Parish, C. R. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-34521-1_24 · Cited by 16 · see citing works

Unveiling the anti-senescence effects and senescence-associated secretory phenotype (SASP) inhibitory mechanisms of Scutellaria baicalensis Georgi in low glucose-induced astrocytes based on boolean network

Gao, L., Yang, W.-Y., Qi, H., Sun, C.-J., Qin, X., & Du, G. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.153990 · Cited by 15 · see citing works

The Role of Glucagon in Glycemic Variability in Type 1 Diabetes: A Narrative Review

Guo, K., Tian, Q., Yang, L., & Zhou, Z. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s343514 · Cited by 17 · see citing works

Mammalian D-Cysteine controls insulin secretion in the pancreas

Roychaudhuri, R., West, T., Bhattacharya, S., Saavedra, H. G., Lee, H., Albacarys, L. K., Gadalla, M. M., Amzel, L. M., Yang, P., & Snyder, S. H. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.102043 · Cited by 14 · see citing works

Amino acids and the changing face of the α-cell

Hamilton, A., Eliasson, L., & Knudsen, J. G. (2023) · Peptides · doi:10.1016/j.peptides.2023.171039 · Cited by 13 · see citing works

Altered microvasculature in pancreatic islets from subjects with type 1 diabetes

Granlund, L., Hedin, A., Korsgren, O., Skog, O., & Lundberg, M. (2022) · PLoS ONE · doi:10.1371/journal.pone.0276942 · Cited by 12 · see citing works

Setting the Stage for Insulin Granule Dysfunction during Type-1-Diabetes: Is ER Stress the Culprit?

Makam, A. A., Biswas, A., Kothegala, L., & Gandasi, N. R. (2022) · Biomedicines · doi:10.3390/biomedicines10112695 · Cited by 14 · see citing works

Vitamin D binding protein/GC‐globulin: a novel regulator of alpha cell function and glucagon secretion

Viloria, K., Hewison, M., & Hodson, D. (2021) · Journal of Physiology · doi:10.1113/jp280890 · Cited by 9 · see citing works

Sodium, Glucose and Dysregulated Glucagon Secretion: The Potential of Sodium Glucose Transporters

Armour, S. L., Frueh, A., & Knudsen, J. G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.837664 · Cited by 11 · see citing works

Decoding the Significance of Alpha Cell Function in the Pathophysiology of Type 1 Diabetes

Carroll, J., Chen, J. Z.-J., Mittal, R., Lemos, J. R. N., Mittal, M., Juneja, S., Assayed, A., & Hirani, K. (2024) · Cells · doi:10.3390/cells13221914 · Cited by 11 · see citing works

Heterogeneity and neurovascular integration of intraportally transplanted islets revealed by 3-D mouse liver histology

Chen, C., Peng, S.-J., Wu, P.-Y., Chien, H., Lee, C., Chung, M., & Tang, S. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00605.2020 · Cited by 9 · see citing works

Identification of Novel Disease-Relevant Genes and Pathways in the Pathogenesis of Type 1 Diabetes: A Potential Defect in Pancreatic Iron Homeostasis

Yip, L., Alkhataybeh, R., Taylor, C., Fuhlbrigge, R., & Fathman, C. G. (2022) · Diabetes · doi:10.2337/db21-0948 · Cited by 8 · see citing works

Biosensor platforms for detection of cardiovascular disease risk biomarkers

Pal, M., & Khan, R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-102555-0.00012-1 · Cited by 8 · see citing works

Changes in insulin requirements during pregnancy in Japanese women with type 1 diabetes

Kambara, M., Yanagisawa, K., Tanaka, S., Suzuki, T., & Babazono, T. (2018) · Diabetology International · doi:10.1007/s13340-018-0369-8 · Cited by 8 · see citing works

Effects of resistance training and turmeric supplementation on reactive species marker stress in diabetic rats

Júnior, A. S. S., Aidar, F. J., dos Santos, J. L., Estevam, C. D. S., dos SANTOS, J. D. M., Silva, A. M. D. O. E., Lima, F. B., de Araújo, S. S., & Marçal, A. C. (2020) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-020-00194-9 · Cited by 8 · see citing works

Insulin Resistance in Type 1 Diabetes: Concepts and Implications for Therapy

Bloomgarden, Z. T., & Accili, D. (2025) · Journal of Diabetes · doi:10.1111/1753-0407.70126 · Cited by 6 · see citing works

Comprehensive Characterization of Islet Remodeling in Development and in Diabetes Using Mass Cytometry

Toledo, M. P., Xie, G., & Wang, Y. J. (2024) · Endocrinology · doi:10.1210/endocr/bqae094 · Cited by 6 · see citing works

An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes

Derr, A. G., Arowosegbe, A., Satish, B., Redick, S. D., Qaisar, N., Guo, Z., Vanderleeden, E., Trombly, M. I., Baer, C. E., Harlan, D. M., et al. (2022) · Diabetes · doi:10.2337/db22-0521 · Cited by 5 · see citing works

Why Glucagon Matters for Hypoglycemia and Physical Activity in Individuals With Type 1 Diabetes

Colberg, S. R. (2022) · Frontiers in Clinical Diabetes and Healthcare · doi:10.3389/fcdhc.2022.889248 · Cited by 5 · see citing works

Evaluation of Trace Elements Levels and Construction of Auxiliary Prediction Model in Patients with Diabetes Ketoacidosis in Type 1 Diabetes

Chai, J., Sun, Z., Zhou, Q., & Xu, J. (2023) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s425156 · Cited by 4 · see citing works

Vasodilatory effects of glucagon: A possible new approach to enhanced subcutaneous insulin absorption in artificial pancreas devices

Teigen, I. A., Riaz, M., Åm, M. K., Christiansen, S. C., & Carlsen, S. M. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.986858 · Cited by 4 · see citing works

Hypoglycaemia in endocrine, diabetic, and internal diseases [Hipoglikemia w schorzeniach endokrynologicznych, diabetologicznych i internistycznych]

Rokicka, D., Marek, B., Kajdaniuk, D., Wróbel, M. P., Szymborska‐Kajanek, A., Ogrodowczyk-Bobik, M., Urbanek, A., Janyga, S., Borgiel−Marek, H., & Strojek, K. (2019) · Endokrynologia Polska · doi:10.5603/ep.a2019.0020 · Cited by 5 · see citing works

Distribution of glutathione peroxidase-1 immunoreactive cells in pancreatic islets from type 1 diabetic donors and non-diabetic donors with and without islet cell autoantibodies is variable and independent of disease

Pala, K., Sun, K. X., Krogvold, L., Dahl‐Jørgensen, K., & Reddy, S. (2025) · Cell and Tissue Research · doi:10.1007/s00441-025-03955-5 · Cited by 3 · see citing works

Advances in clinical research on glucagon

Horie, I., & Abiru, N. (2024) · Diabetology International · doi:10.1007/s13340-024-00705-w · Cited by 3 · see citing works

Pancreatic polypeptide in patients with type 1 diabetes and exocrine failure or chronic pancreatitis. The DIAPP study

Dehghani, L., Bonnet-Serrano, F., Abdul, H., Alexandre‐Heymann, L., Guibourdenche, J., & Larger, É. (2025) · Diabetes & Metabolism · doi:10.1016/j.diabet.2025.101712 · Cited by 2 · see citing works

Effects of Low-Dose Glucagon on Subcutaneous Insulin Absorption in Pigs

Teigen, I. A., Åm, M. K., Riaz, M., Christiansen, S. C., & Carlsen, S. M. (2024) · Current Therapeutic Research · doi:10.1016/j.curtheres.2024.100736 · Cited by 2 · see citing works

Drugs stimulating insulin secretion in early clinical development for the treatment of type 1 diabetes: what’s new?

Ning, X., Munir, K. M., & Davis, S. N. (2024) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2024.2439501 · Cited by 1 · see citing works

Unveiling the Significance of the ‘Bathtub’ Shape in Blood Glucose Curve Analysis

Fetian, I. R. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1003746 · Cited by 1 · see citing works

Scaffold-free endocrine tissue engineering: role of islet organization and implications in type 1 diabetes

Bal, T. (2025) · BMC Endocrine Disorders · doi:10.1186/s12902-025-01919-y · Cited by 1 · see citing works

Small molecule glucagon release inhibitors with activity in human islets

Kalwat, M. A., Rodrigues-dos-Santos, K., Binns, D. D., Wei, S., Zhou, A., Evans, M. R., Posner, B. A., Roth, M. G., & Cobb, M. H. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1114799 · Cited by 1 · see citing works

The Effects of a Progressive Dehydration Protocol on Glycaemic Response During and Following Exercise in Patients with Type 1 Diabetes

Wilson, A. (2019) · Stirling Online Research Repository (University of Stirling)

Hepatic Expression of the Na+-Coupled Citrate Transporter (NaCT/Slc13a5) and Cellular Uptake of Citrate in a Mouse Model of Type 1 Diabetes Induced by Streptozotocin

Goto, M., Kono, Y., Ohno, K., & Fujita, T. (2020) · BPB Reports · doi:10.1248/bpbreports.3.3_97

«Badewannenkurve» ist ein Schlüsselwort für die Interpretation von Blutzuckerkurven “Bathtub” shape is a key term for interpreting the course of blood glucose curves

Fetian, I. R., Maziukas, R., Pisarcikova, Z., Zechmann, S., Dolinar, M., Dolinar, S., & Villiger, L. (2022) · doi:10.36000//hbt.2022.05.001

The association of fasting and postprandial GIP and glucagon levels with glycemic variability evaluated by flash glucose monitoring system in type 1 diabetes

Babayeva, A., Coşkun, M., Yalçın, M. M., Aktürk, M., Törüner, F. B., Karakoç, M. A., & Altınova, A. E. (2024) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-024-01367-9

Glucagon change rate after glucose load: a potential key for tailoring treatment in gestational diabetes mellitus

Joko, S., Hashimoto, T., Yamashita, M., Tsuriya, D., Maekawa, M., & Iwaizumi, M. (2025) · Diabetology International · doi:10.1007/s13340-025-00797-y

A Computational Model for Intracellular Calcium Dynamics in $$\alpha $$-Cell Regulating ATP Production

Vaishali, V., & Adlakha, N. (2025) · Innovations in Sustainable Technologies and Computing · doi:10.1007/978-981-97-6794-6_1

Treatment of Diabetic Patients with Functionalized Biomaterials

Priyam, J. (2025) · doi:10.1002/9781394214143.ch14

Recurrent Hypoglycemia as an Unusual Finding in Pediatric New-Onset Type 1 Diabetes: A Case Report and Review of the Literature

Maines, E., Fanti, S., Cauvin, V., Soffiati, M., Urru, S. A. M., & Franceschi, R. (2026) · Diabetology · doi:10.3390/diabetology7030041

Hyaluronan induces ERK activation with minimal transcriptomic changes in pancreatic α-cells

Sonoyama, S., Mizokami, A., Sano, T., Jimi, E., Moriyama, M., & Kanematsu, T. (2026) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2026.102525

Progression from Stage 1 to Stage 3 Type 1 Diabetes Characterized by Hypoglycemia

Nagarapu, A. N., & Felton, J. L. (2025) · JCEM Case Reports · doi:10.1210/jcemcr/luaf317

Beyond Insulin

Ni, H., SNAITH, J. R., & Greenfield, J. R. (2026) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2026.04.001

eNAMPT induces alpha-cell mass expansion but impaired glucagon counter regulatory response

Sayers, S. R., Gesheva, V., Varghese, J. J., Beavil, R., Zhao, M., Cheah, Y., Hopkins, D., Fine, N. H. F., Hasib, A., Hodson, D. J., et al. (2026) · Endocrinology · doi:10.1210/endocr/bqag061

Insulin, Semaglutide and Dapagliflozin in Adults With Type 1 Diabetes: Design and Methods of Triple Therapy for Type 1 Diabetes ( TTT1 )—An International Phase 3 Clinical Trial

Timmons, J. G., Ghanim, H., Boyle, J. G., Greenlaw, N., Chaudhuri, A., Batra, M., Lindsay, R. S., Jolly, L., Bonner, C., McConnachie, A., et al. (2026) · Diabetes Obesity and Metabolism · doi:10.1111/dom.71076

Early loss and progressive deterioration of glucagon responses to hypoglycemia in children with type 1 diabetes

Harvengt, A., Beckers, M., Iakovidou, I., Maure, A., Syed, Z., Boutsen, L., Beckers, D., & Lysy, P. A. (2026) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2026-005959

Intra‐Islet Paracrine Regulation of Glucagon Secretion During Hypoglycemia, Euglycemia, and Hyperglycemia

FATEHI, S., Rocheleau, J. V., & Riddell, M. C. (2026) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.70384

Alpha cell function in type 1 diabetes

Hughes, D. S., & Narendran, P. (2014) · The British Journal of Diabetes · doi:10.15277/bjdvd.2014.014 · Cited by 23 · see citing works

Decoding the Significance of Alpha Cell Function in the Pathophysiology of Type 1 Diabetes

Carroll, J., Chen, J. Z.-J., Mittal, R., Lemos, J. R. N., Mittal, M., Juneja, S., Assayed, A., & Hirani, K. (2024) · Cells · doi:10.3390/cells13221914 · Cited by 11 · see citing works

alpha Cell Function and Gene Expression Are Compromised in Type 1 Diabetes

Briššová, M., Blodgett, D. M., Greiner, D. L., Harlan, D. M., & Powers, A. C. (2018) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · Cited by 3 · see citing works

Alpha cell dysfunction in early type 1 diabetesPreprint

Doliba, N. M., Rozo, A. V., Roman, J., Qin, W. D., Traum, D., Gao, L., Liu, J., Manduchi, E., Liu, C., Golson, M. L., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.15.464545

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes

Briššová, M., Haliyur, R., Saunders, D. C., Shrestha, S., Dai, C., Blodgett, D. M., Bottino, R., Campbell‐Thompson, M., Aramandla, R., Poffenberger, G., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.032 · Cited by 206 · see citing works