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Cited by 220Pancreatic function and diabetesIon channel regulation and functionCalcium signaling and nucleotide metabolism

Regulation of calcium in pancreatic α- and β-cells in health and disease

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Rorsman, Patrik, Braun, Matthias, Zhang, Quan·2012·Cell Calcium
DOI 10.1016/j.ceca.2011.11.006PMC PMC3334273
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Abstract

The glucoregulatory hormones insulin and glucagon are released from the β- and α-cells of the pancreatic islets. In both cell types, secretion is secondary to firing of action potentials, Ca(2+)-influx via voltage-gated Ca(2+)-channels, elevation of [Ca(2+)](i) and initiation of Ca(2+)-dependent exocytosis. Here we discuss the mechanisms that underlie the reciprocal regulation of insulin and glucagon secretion by changes in plasma glucose, the roles played by different types of voltage-gated Ca(2+)-channel present in α- and β-cells and the modulation of hormone secretion by Ca(2+)-dependent and -independent processes. We also consider how subtle changes in Ca(2+)-signalling may have profound impact on β-cell performance and increase risk of developing type-2 diabetes.

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  • There is good agreement between GIIS in vitro and in vivo in humans.

    “As we have previously reported (569), there is also a good agreement between GIIS in vitro and in vivo in humans.”

    From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [569]

    The section ‘The consensus model for glucose-induced insulin secretion’ describes glucose-triggered electrical activity and calcium responses in human β-cells, but does not compare insulin secretion in vitro with secretion in vivo. Searches for an in vitro–in vivo comparison and for agreement in human glucose-induced insulin secretion found no passage addressing the claim; page numbers were unavailable in our copy. (LLM, conf=0.73)

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Cited by

Sorted by citations

Authors
Rorsman, P., Braun, M., & Zhang, Q.
Affiliations
  • Churchill Hospital (GB)
  • University of Alberta (CA)
Corresponding author
Rorsman, Patrik
ORCID
Venue
Cell Calcium
Publisher
Elsevier BV
Published
2012-03
Volume
51
Issue
3-4
Pages
300-308
ISSN
0143-4160 (ISSN-L)
DOI
10.1016/j.ceca.2011.11.006
PMC
PMC3334273
OpenAlex
W2089125273
Cited by
220
References
13
Citations by year
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FWCI
2.53
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Calcium (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Wellcome Trust, the Medical Research Council, Diabetes UK
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords
calcium signaling, alpha cells, pancreatic beta cells, insulin secretion, glucagon secretion, voltage-gated calcium channels, intracellular calcium, action potential, exocytosis, glucose regulation, type 2 diabetes, pancreatic islets
MeSH terms
Action Potentials, Animals, Calcium, Diabetes Mellitus, Type 2, Glucagon, Humans, Insulin, Calcium Channels, Calcium Signaling, Receptor Cross-Talk, Feedback, Physiological, Glucagon-Secreting Cells, Insulin-Secreting Cells

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