Cited by 823Diabetes and associated disordersDiabetes Management and ResearchDiabetes Treatment and Management

Differentiation of diabetes by pathophysiology, natural history, and prognosis

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Skyler, Jay S., Bakris, George L., Bonifacio, Ezio, Darsow, Tamara, Eckel, Robert H., Groop, Leif, Groop, Per-Henrik, Handelsman, Yehuda +9 more·2017·Diabetes

Abstract

The American Diabetes Association, JDRF, the European Association for the Study of Diabetes, and the American Association of Clinical Endocrinologists convened a research symposium, "The Differentiation of Diabetes by Pathophysiology, Natural History and Prognosis" on 10-12 October 2015. International experts in genetics, immunology, metabolism, endocrinology, and systems biology discussed genetic and environmental determinants of type 1 and type 2 diabetes risk and progression, as well as complications. The participants debated how to determine appropriate therapeutic approaches based on disease pathophysiology and stage and defined remaining research gaps hindering a personalized medical approach for diabetes to drive the field to address these gaps. The authors recommend a structure for data stratification to define the phenotypes and genotypes of subtypes of diabetes that will facilitate individualized treatment.

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  1. [8]International Diabetes Federation. IDF Diabetes Atlas, 7th edition [Internet], 2015. Available from http://diabetesatlas.org. Accessed 7 January 2016

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Authors
Skyler, J. S., Bakris, G. L., Bonifacio, E., Darsow, T., Eckel, R. H., Groop, L., Groop, P.-H., Handelsman, Y., Insel, R. A., Mathieu, C., McElvaine, A. T., Palmer, J. P., Pugliese, A., Schatz, D. A., Sosenko, J. M., Wilding, J. P. H., & Ratner, R. E.
Affiliations
  • University of Miami (US)
  • University of Chicago (US)
  • Technische Universität Dresden (DE)
  • American Diabetes Association (US)
  • University of Colorado Anschutz (US)
  • Lund University (SE)
  • University of Helsinki (FI)
  • Metabolic Institute of America, Tarzana, CA
  • Breakthrough T1D (US)
  • KU Leuven (BE)
  • University of Washington (US)
  • University of Florida Health (US)
  • Aintree University Hospital (GB)
Corresponding author
McElvaine, Allison T.
Venue
Diabetes
Published
2016-12-15
Volume
66
Issue
2
Pages
241-255
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
OpenAlex
W2561206249
Cited by
823
References
181
Citations by year
2026: 42 · 2025: 67 · 2024: 111 · 2023: 120 · 2022: 110 · 2021: 142 · 2020: 112 · 2019: 55 · 2018: 37 · 2017: 26 · 2016: 1
FWCI
5.31
Type
journal article
Language
en
Open access
Locations
  • Diabetes (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Lirias (KU Leuven) (submittedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (U01DK085461, P30DK017047)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
type 1 diabetes, type 2 diabetes, diabetes pathophysiology, diabetes prognosis, diabetes complications, genetic risk factors, environmental risk factors, disease progression, personalized medicine, diabetes subtypes, data stratification
MeSH terms
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Genotype, Humans, Hypoglycemic Agents, Phenotype, Prognosis, Risk Factors, Disease Progression, Diabetes Complications, Precision Medicine

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