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Cited by 3Hypothalamic control of reproductive hormonesNeuroendocrine regulation and behaviorRegulation of Appetite and Obesity

Optogenetics studies of kisspeptin neurons

Open access
Ivanova, Deyana, O’Byrne, Kevin T.·2023·Peptides
DOI 10.1016/j.peptides.2023.170961
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Abstract

Optical systems and genetic engineering technologies have made it possible to control neurons and unravel neuronal circuit behavior with high temporal and spatial resolution. The application of optogenetic strategies to understand the physiology of kisspeptin neuronal circuits has evolved in recent years among the neuroendocrine community. Kisspeptin neurons are fundamentally involved in controlling mammalian reproduction but also are implicated in numerous other physiological processes, including but not limited to feeding, energy expenditure, core body temperature and behavior. We conducted a review aiming to shed light on the novel findings obtained from in vitro and in vivo optogenetic studies interrogating kisspeptin neuronal circuits to date. Understanding the function of kisspeptin networks in the brain can greatly inform a wide range of clinical studies investigating infertility treatments, gender identity, metabolic disorders, hot flushes and psychosexual disorders.

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Authors
Ivanova, D., & O’Byrne, K. T.
Affiliations
King's College London (GB)
Corresponding author
Ivanova, Deyana
ORCID
Ivanova, Deyana
Venue
Peptides
Publisher
Elsevier BV
Published
2023-04
Volume
162
Pages
170961
ISSN
0196-9781 (ISSN-L)
DOI
10.1016/j.peptides.2023.170961
OpenAlex
W4318567171
Cited by
3
References
10
Citations by year
2026: 1 · 2025: 1 · 2024: 1
FWCI
0.72
Type
journal article
Language
en
Open access
Licence
Locations
  • Peptides (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Medical Research Council
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
kisspeptin neurons, optogenetics, neural circuits, reproduction, neuroendocrine regulation, feeding, energy expenditure, core body temperature, infertility, gender identity, metabolic disorders, hot flashes, psychosexual disorders
MeSH terms
Animals, Brain, Female, Gender Identity, Humans, Male, Mammals, Neurons, Kisspeptins, Optogenetics

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