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Cited by 1,030Adenosine and Purinergic SignalingBiochemical and Molecular ResearchGout, Hyperuricemia, Uric Acid

The DOI matches its Crossref record; 744 of the 744 references it cites were found in a registry or an index.

Adenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation

Bours, M.J.L., Swennen, E.L.R., Di Virgilio, F., Cronstein, B.N., Dagnelie, P.C.·2006·Pharmacology & Therapeutics
DOI 10.1016/j.pharmthera.2005.04.013
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Abstract

Human health is under constant threat of a wide variety of dangers, both self and nonself. The immune system is occupied with protecting the host against such dangers in order to preserve human health. For that purpose, the immune system is equipped with a diverse array of both cellular and non-cellular effectors that are in continuous communication with each other. The naturally occurring nucleotide adenosine 5'-triphosphate (ATP) and its metabolite adenosine (Ado) probably constitute an intrinsic part of this extensive immunological network through purinergic signaling by their cognate receptors, which are widely expressed throughout the body. This review provides a thorough overview of the effects of ATP and Ado on major immune cell types. The overwhelming evidence indicates that ATP and Ado are important endogenous signaling molecules in immunity and inflammation. Although the role of ATP and Ado during the course of inflammatory and immune responses in vivo appears to be extremely complex, we propose that their immunological role is both interdependent and multifaceted, meaning that the nature of their effects may shift from immunostimulatory to immunoregulatory or vice versa depending on extracellular concentrations as well as on expression patterns of purinergic receptors and ecto-enzymes. Purinergic signaling thus contributes to the fine-tuning of inflammatory and immune responses in such a way that the danger to the host is eliminated efficiently with minimal damage to healthy tissues.

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Research works printed but not linked: 16

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Metadata

Authors
Bours, M. J. L., Swennen, E. L. R., Di Virgilio, F., Cronstein, B. N., & Dagnelie, P. C.
Affiliations
  • Maastricht University (NL)
  • New York University (US)
Corresponding author
Bours, M.J.L.
ORCID
Venue
Pharmacology & Therapeutics
Publisher
Elsevier BV
Published
2006-11
Volume
112
Issue
2
Pages
358-404
ISSN
0163-7258 (ISSN-L)
DOI
10.1016/j.pharmthera.2005.04.013
OpenAlex
W2042906495
Cited by
1,030
References
744
Citations by year
2026: 23 · 2025: 21 · 2024: 33 · 2023: 43 · 2022: 47 · 2021: 47 · 2020: 50 · 2019: 51 · 2018: 56 · 2017: 64 · 2016: 53 · 2015: 57 · 2014: 87 · 2013: 56 · 2012: 78
FWCI
2.33
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (submittedVersion)
  • Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
  • Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
Keywords
adenosine 5'-triphosphate, adenosine, purinergic signaling, purinergic receptors, endogenous signaling molecules, immunity, inflammation, immune regulation, immunostimulation, immune cell types, ectoenzymes, extracellular nucleotides
MeSH terms
Adenosine, Adenosine Triphosphate, Humans, Immune System, Immunity, Cellular, Macrophages, Neutrophils, Signal Transduction, Apoptosis

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