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Cited by 24Cell Adhesion Molecules ResearchNeuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Integrin Signaling in the Central Nervous System in Animals and Human Brain Diseases

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Ikeshima-Kataoka, Hiroko, Sugimoto, Chikatoshi, Tsubokawa, Tatsuya·2022·International Journal of Molecular Sciences
DOI 10.3390/ijms23031435PMC PMC8836133
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Abstract

The integrin family is involved in various biological functions, including cell proliferation, differentiation and migration, and also in the pathogenesis of disease. Integrins are multifunctional receptors that exist as heterodimers composed of α and β subunits and bind to various ligands, including extracellular matrix (ECM) proteins; they are found in many animals, not only vertebrates (e.g., mouse, rat, and teleost fish), but also invertebrates (e.g., planarian flatworm, fruit fly, nematodes, and cephalopods), which are used for research on genetics and social behaviors or as models for human diseases. In the present paper, we describe the results of a phylogenetic tree analysis of the integrin family among these species. We summarize integrin signaling in teleost fish, which serves as an excellent model for the study of regenerative systems and possesses the ability for replacing missing tissues, especially in the central nervous system, which has not been demonstrated in mammals. In addition, functions of astrocytes and reactive astrocytes, which contain neuroprotective subpopulations that act in concert with the ECM proteins tenascin C and osteopontin via integrin are also reviewed. Drug development research using integrin as a therapeutic target could result in breakthroughs for the treatment of neurodegenerative diseases and brain injury in mammals.

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  • β1 integrins are the predominant integrin subunit in the central nervous system.

    “β1 integrins are the predominant integrin subunit in the central nervous system.”

    From The Serine/Threonine Kinase <scp>NDR2</scp> Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus (2025) · cites this paper as Ikeshima‐Kataoka et al. 2022

    Section 3.2 calls β1 the largest integrin subfamily and says it is highly expressed in mammalian neural stem cells. It does not establish that β1 is the predominant integrin subunit across the central nervous system. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • β1 integrins are developmentally upregulated.

    “They are developmentally upegulated (Pinkstaff et al. 1999; Ikeshima‐Kataoka et al. 2022; Milner and Campbell 2002)”

    From The Serine/Threonine Kinase <scp>NDR2</scp> Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus (2025) · cites this paper as Ikeshima‐Kataoka et al. 2022

    Section 3.2 says β1 integrin is highly expressed in mammalian neural stem cells and helps shape the developing cortex, but it does not say its expression increases during development. Searches for developmental upregulation and expression changes across developmental stages found no passage establishing that trend. (LLM, conf=0.72)

    Experimental — accuracy not yet measured

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  1. [1]Harrison R.G. Observations on the livining developing nerve fiber Proc. Soc. Exp. Biol. Med. 1907 4 140 143 10.3181/00379727-4-98 · DOI
  2. [2]Hynes R.O. Pearistein E.S. Investigations of the possible role of proteases in altering surface proteins of virally transformed hamster fibroblasts J. Supramol. Struct. 1976 4 1 14 10.1002/jss.400040102 1256058 · DOI
  3. [3]Schwarzbauer J.E. Paul J.I. Hynes R.O. On the origin of species of fibronectin (RNA splicing/protein variants/fusion pr oteins) Proc. Natl. Acad. Sci. USA 1985 82 1424 1428 10.1073/pnas.82.5.1424 3856272 PMC397274 · DOI
  4. [4]Hynes R.O. Destree A.T. Relationships between fibronectin (LETS protein) and actin Cell 1978 15 875 886 10.1016/0092-8674(78)90272-6 365353 · DOI
  5. [5]Horwitz A. Duggan K. Buck C. Beckerle M.C. Burridge K. Interaction of plasma membrane fibronectin receptor with talin—A transmembrane linkage Nature 1986 320 531 533 10.1038/320531a0 2938015 · DOI
  6. [6]Horwitz A.R. The Origins of the Molecular Era of Adhesion Research Nat. Rev. Mol. Cell Biol. 2012 13 805811 10.1038/nrm3473 PMC3692278 23151664 · DOI
  7. [7]Tamkun J.W. DeSimone D.W. Fonda D. Patel R.S. Buck C. Horwitz A.F. Hynes R.O. Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin Cell 1986 46 271 282 10.1016/0092-8674(86)90744-0 3487386 · DOI
  8. [8]Spinardi L. Ren Y.L. Sanders R. Giancotti F.G. The β4 Subunit Cytoplasmic Domain Mediates the Interaction of α6β4 Integrin with the Cytoskeleton of Hemidesmosomes Mol. Biol. Cell 1993 4 871 884 10.1091/mbc.4.9.871 8257791 PMC275718 · DOI
  9. [9]Mezu-Ndubuisi O.J. Maheshwari A. The Role of Integrins in Inflammation and Angiogenesis Pediatr. Res. 2021 89 1619 1626 10.1038/s41390-020-01177-9 33027803 PMC8249239 · DOI
  10. [10]Chen Z. Shen G. Tan X. Qu L. Zhang C. Ma L. Luo P. Cao X. Yang F. Liu Y. ID1/ID3 Mediate the Contribution of Skin Fibroblasts to Local Nerve Regeneration through Itgα6 in Wound Repair Stem Cells Transl. Med. 2021 10 1637 1649 10.1002/sctm.21-0093 34520124 PMC8641086 · DOI
  11. [11]Kawano H. Kimura-Kuroda J. Komuta Y. Yoshioka N. Li H.P. Kawamura K. Li Y. Raisman G. Role of the Lesion Scar in the Response to Damage and Repair of the Central Nervous System Cell Tissue Res. 2012 349 169 180 10.1007/s00441-012-1336-5 22362507 PMC3375417 · DOI
  12. [12]Eva R. Fawcett J. Integrin Signalling and Traffic during Axon Growth and Regeneration Curr. Opin. Neurobiol. 2014 27 179 185 10.1016/j.conb.2014.03.018 24793179 · DOI
  13. [13]Petrova V. Eva R. The Virtuous Cycle of Axon Growth: Axonal Transport of Growth-Promoting Machinery as an Intrinsic Determinant of Axon Regeneration Dev. Neurobiol. 2018 78 898 925 29989351
  14. [14]Fawcett J.W. Verhaagen J. Intrinsic Determinants of Axon Regeneration Dev. Neurobiol. 2018 78 890 897 10.1002/dneu.22637 30345655 · DOI
  15. [15]Nieuwenhuis B. Haenzi B. Andrews M.R. Verhaagen J. Fawcett J.W. Integrins Promote Axonal Regeneration after Injury of the Nervous System Biol. Rev. 2018 93 1339 1362 10.1111/brv.12398 29446228 PMC6055631 · DOI
  16. [16]Park Y.K. Goda Y. Integrins in synapse regulation Nat. Rev. Neurosci. 2016 17 745 765 10.1038/nrn.2016.138 27811927 · DOI · Paper page
  17. [17]Lilja J. Ivaska J. Integrin Activity in Neuronal Connectivity J. Cell Sci. 2018 131 jcs212803 10.1242/jcs.212803 29907643 · DOI
  18. [18]De Arcangelis A. Georges-Labouesse E. Integrin and ECM Functions in Vertebrate Development Trends Genet. 2000 16 389 395 10.1016/S0168-9525(00)02074-6 10973067 · DOI
  19. [19]Allen N.J. Eroglu C. Cell Biology of Astrocyte-Synapse Interactions Neuron 2017 96 697 708 10.1016/j.neuron.2017.09.056 29096081 PMC5687890 · DOI
  20. [20]Verkhratsky A. Nedergaard M. Physiology of Astroglia Physiol. Rev. 2018 98 239 389 10.1152/physrev.00042.2016 29351512 PMC6050349 · DOI · Paper page
  21. [21]Khakh B.S. Deneen B. The Emerging Nature of Astrocyte Diversity Annu. Rev. Neurosci. 2019 42 187 207 10.1146/annurev-neuro-070918-050443 31283899 · DOI
  22. [22]Morita M. Ikeshima-Kataoka H. Kreft M. Vardjan N. Zorec R. Noda M. Metabolic Plasticity of Astrocytes and Aging of the Brain Int. J. Mol. Sci. 2019 20 941 10.3390/ijms20040941 30795555 PMC6413111 · DOI
  23. [23]Zhang Z. Ma Z. Zou W. Guo H. Liu M. Ma Y. Zhang L. The Appropriate Marker for Astrocytes: Comparing the Distribution and Expression of Three Astrocytic Markers in Different Mouse Cerebral Regions BioMed Res. Int. 2019 2019 9605265 10.1155/2019/9605265 31341912 PMC6613026 · DOI
  24. [24]Johnson M.S. Lu N. Denessiouk K. Heino J. Gullberg D. Integrins during Evolution: Evolutionary Trees and Model Organisms Biochim. Biophys. Acta Biomembr. 2009 1788 779 789 10.1016/j.bbamem.2008.12.013 19161977 · DOI
  25. [25]Sebé-Pedrósa A. Rogerb A.J. Langc F.B. Kingd N. Ruiz-Trillo I. Ancient origin of the integrin-mediated adhesion and signaling machinery Proc. Natl. Acad. Sci. USA 2010 107 10142 10147 10.1073/pnas.1002257107 20479219 PMC2890464 · DOI
  26. [26]Ikeshima-Kataoka H. Saito S. Yuasa S. Tenascin-C Is Required for Proliferation of Astrocytes in Primary Culture In Vivo 2007 21 629 634 17708357
  27. [27]Ikeshima-Kataoka H. Yuasa S. Selective Ablation of an Astroglial Subset by Toxic Gene Expression Driven by Tenascin Promoter Neurol. Res. 2008 30 701 709 10.1179/174313208X289552 18489816 · DOI
  28. [28]Ikeshima-Kataoka H. Shen J.-S. Eto Y. Saito S. Yuasa S. Alteration of Inflammatory Cytokine Production in the Injured Central Nervous System of Tenascin-Deficient Mice In Vivo 2008 22 409 414 18712165
  29. [29]Ikeshima-Kataoka H. Abe Y. Abe T. Yasui M. Immunological Function of Aquaporin-4 in Stab-Wounded Mouse Brain in Concert with a pro-Inflammatory Cytokine Inducer, Osteopontin Mol. Cell. Neurosci. 2013 56 65 75 10.1016/j.mcn.2013.02.002 23428384 · DOI
  30. [30]Ikeshima-Kataoka H. Matsui Y. Uede T. Osteopontin Is Indispensable for Activation of Astrocytes in Injured Mouse Brain and Primary Culture Neurol. Res. 2018 40 1071 1079 10.1080/01616412.2018.1517995 30246619 · DOI
  31. [31]Nakashima M. Gotoh M. Hashimoto K. Endo M. Murakami-Murofushi K. Ikeshima-Kataoka H. Miyamoto Y. The Neuroprotective Function of 2-Carba-Cyclic Phosphatidic Acid: Implications for Tenascin-C via Astrocytes in Traumatic Brain Injury J. Neuroimmunol. 2021 361 577749 10.1016/j.jneuroim.2021.577749 34688067 · DOI
  32. [32]Xu S. Zhang T. Cao Z. Zhong W. Zhang C. Li H. Song J. Integrin-α9β1 as a Novel Therapeutic Target for Refractory Diseases: Recent Progress and Insights Front. Immunol. 2021 12 638400 10.3389/fimmu.2021.638400 33790909 PMC8005531 · DOI
  33. [33]Tamura K. Stecher G. Kumar S. MEGA11: Molecular Evolutionary Genetics Analysis Version 11 Mol. Biol. Evol. 2021 38 3022 3027 10.1093/molbev/msab120 33892491 PMC8233496 · DOI
  34. [34]Bonar N.A. Petersen C.P. Integrin Suppresses Neurogenesis and Regulates Brain Tissue Assembly in Planarian Regeneration Development 2017 144 784 794 10.1242/dev.139964 28126842 PMC5374345 · DOI
  35. [35]Hisamoto N. Shimizu T. Asai K. Sakai Y. Pastuhov S.I. Hanafusa H. Matsumoto K.C. Elegans Tensin Promotes Axon Regeneration by Linking the Met-like SVH-2 and Integrin Signaling Pathways J. Neurosci. 2019 39 5662 5672 10.1523/JNEUROSCI.2059-18.2019 31109965 PMC6636086 · DOI
  36. [36]Pastuhov S.I. Fujiki K. Tsuge A. Asai K. Ishikawa S. Hirose K. Matsumoto K. Hisamoto N. The Core Molecular Machinery Used for Engulfment of Apoptotic Cells Regulates the JNK Pathway Mediating Axon Regeneration in Caenorhabditis Elegans J. Neurosci. 2016 36 9710 9721 10.1523/JNEUROSCI.0453-16.2016 27629720 PMC6601946 · DOI
  37. [37]Sakai Y. Tsunekawa M. Ohta K. Shimizu T. Pastuhov S.I. Hanafusa H. Hisamoto N. Matsumoto K. The Integrin Signaling Network Promotes Axon Regeneration via the Src–Ephexin–RhoA GTPase Signaling Axis J. Neurosci. 2021 41 4754 4767 10.1523/JNEUROSCI.2456-20.2021 33963050 PMC8260174 · DOI
  38. [38]Sammut M. Cook S.J. Nguyen K.C.Q. Felton T. Hall D.H. Emmons S.W. Poole R.J. Barrios A. Glia-Derived Neurons Are Required for Sex-Specific Learning in C. Elegans Nature 2015 526 385 390 10.1038/nature15700 26469050 PMC4650210 · DOI
  39. [39]De Vault L. Li T. Izabel S. Thompson-Peer K.L. Jan L.Y. Jan Y.N. Dendrite Regeneration of Adult Drosophila Sensory Neurons Diminishes with Aging and Is Inhibited by Epidermal-Derived Matrix Metalloproteinase 2 Genes Dev. 2018 32 402 414 10.1101/gad.308270.117 29563183 PMC5900713 · DOI
  40. [40]Davison A. Neiman M. Mobilizing Molluscan Models and Genomes in Biology Philos. Trans. R. Soc. B Biol. Sci. 2021 376 20200163 10.1098/rstb.2020.0163 PMC8059959 33813892 · DOI
  41. [41]Imperadore P. Fiorito G. Cephalopod Tissue Regeneration: Consolidating over a Century of Knowledge Front. Physiol. 2018 9 593 10.3389/fphys.2018.00593 29875692 PMC5974545 · DOI
  42. [42]Imperadore P. Parazzoli D. Oldani A. Duebbert M. Büschges A. Fiorito G. From Injury to Full Repair: Nerve Regeneration and Functional Recovery in the Common Octopus, Octopus Vulgaris J. Exp. Biol. 2019 222 jeb209965 10.1242/jeb.209965 31527179 · DOI
  43. [43]Matsukawa T. Arai K. Koriyama Y. Liu Z. Kato S. Axonal Regeneration of Fish Optic Nerve after Injury Biol. Pharm. Bull. 2004 27 445 451 10.1248/bpb.27.445 15056844 · DOI
  44. [44]Stuermer C.A. Bastmeyer M. Bähr M. Strobel G. Paschke K. Trying to Understand Axonal Regeneration in the CNS of Fish J. Neurobiol. 1992 23 537 550 10.1002/neu.480230508 1431836 · DOI
  45. [45]Ju Y. Janmey P.A. Mccormick M.E. Sawyer E.S. Flanagan L.A. Enhanced Neurite Growth from Mammalian Neurons in Three-Dimensional Salmon Fibrin Gels Biomaterials 2007 28 2097 2108 10.1016/j.biomaterials.2007.01.008 17258313 PMC1991290 · DOI
  46. [46]Dowding A.J. Maggs A. Scholes J. Diversity amongst the Microglia in Growing and Regenerating Fish CNS: Immunohistochemical Characterization Using FL. 1, an Anti-macrophage Monoclonal Antibody Glia 1991 4 345 364 10.1002/glia.440040403 1834558 · DOI
  47. [47]Var S.R. Byrd-Jacobs C.A. Role of Macrophages and Microglia in Zebrafish Regeneration Int. J. Mol. Sci. 2020 21 4768 10.3390/ijms21134768 PMC7369716 32635596 · DOI
  48. [48]Rasmussen J.P. Sagasti A. Learning to Swim, Again: Axon Regeneration in Fish Exp. Neurol. 2017 287 318 330 10.1016/j.expneurol.2016.02.022 26940084 · DOI
  49. [49]Yin G. Du M. Li R. Li K. Huang X. Duan D. Ai X. Yao F. Zhang L. Hu Z. Glia Maturation Factor Beta Is Required for Reactive Gliosis after Traumatic Brain Injury in Zebrafish Exp. Neurol. 2018 305 129 138 10.1016/j.expneurol.2018.04.008 29655639 · DOI
  50. [50]Inoue J.G. Miya M. Miller J. Sado T. Hanel R. Deep-Ocean Origin of the Freshwater Eels Biol. Lett. 2010 6 363 366 10.1098/rsbl.2009.0989 20053660 PMC2880065 · DOI
  51. [51]Watanabe S. Shinozuka K. Spatial Learning in Japanese Eels (Anguilla japonica) Anim. Cogn. 2020 23 233 236 10.1007/s10071-019-01320-y 31650291 PMC6981313 · DOI
  52. [53]Tsubokawa T. Saito K. Kawano H. Kawamura K. Shinozuka K. Watanabe S. Pharmacological Effects on Mirror Approaching Behavior and Neurochemical Aspects of the Telencephalon in the Fish, Medaka (Oryzias latipes) Soc. Neurosci. 2009 4 276 286 10.1080/17470910802625215 19274578 · DOI
  53. [54]Morris R.J. Thy-1, a Pathfinder Protein for the Post-Genomic Era Front. Cell Dev. Biol. 2018 6 173 10.3389/fcell.2018.00173 30619853 PMC6305390 · DOI
  54. [55]Hermosilla T. Muñoz D. Herrera-Molina R. Valdivia A. Muñoz N. Nham S.U. Schneider P. Burridge K. Quest A.F.G. Leyton L. Direct Thy-1/αVβ3 Integrin Interaction Mediates Neuron to Astrocyte Communication Biochim. Biophys. Acta Mol. Cell Res. 2008 1783 1111 1120 10.1016/j.bbamcr.2008.01.034 PMC2587321 18346467 · DOI
  55. [56]Herrera-Molina R. Frischknecht R. Maldonado H. Seidenbecher C.I. Gundelfinger E.D. Hetz C. de la Luz Aylwin M. Schneider P. Quest A.F.G. Leyton L. Astrocytic αvβ3 Integrin Inhibits Neurite Outgrowth and Promotes Retraction of Neuronal Processes by Clustering Thy-1 PLoS ONE 2012 7 e34295 10.1371/journal.pone.0034295 22479590 PMC3316703 · DOI
  56. [57]Maldonado H. Calderon C. Burgos-Bravo F. Kobler O. Zuschratter W. Ramirez O. Härtel S. Schneider P. Quest A.F.G. Herrera-Molina R. Astrocyte-to-Neuron Communication through Integrin-Engaged Thy-1/CBP/Csk/Src Complex Triggers Neurite Retraction via the RhoA/ROCK Pathway Biochim. Biophys. Acta Mol. Cell Res. 2017 1864 243 254 10.1016/j.bbamcr.2016.11.006 27842221 · DOI
  57. [58]Burgos-Bravo F. Martínez-Meza S. Quest A.F.G. Wilson C.A.M. Leyton L. Application of Force to a Syndecan-4 Containing Complex with Thy-1–AVβ3 Integrin Accelerates Neurite Retraction Front. Mol. Biosci. 2020 7 582257 10.3389/fmolb.2020.582257 33134319 PMC7550751 · DOI
  58. [59]Lagos-Cabré R. Brenet M. Díaz J. Pérez R.D. Pérez L.A. Herrera-Molina R. Quest A.F.G. Leyton L. Intracellular Ca2+ Increases and Connexin 43 Hemichannel Opening Are Necessary but Not Sufficient for Thy-1-Induced Astrocyte Migration Int. J. Mol. Sci. 2018 19 2179 10.3390/ijms19082179 PMC6121259 30049932 · DOI
  59. [60]Lagos-Cabré R. Burgos-Bravo F. Avalos A.M. Leyton L. Connexins in Astrocyte Migration Front. Pharmacol. 2020 10 1546 10.3389/fphar.2019.01546 32009957 PMC6974553 · DOI
  60. [61]Campos L.S. B1 Integrins and Neural Stem Cells: Making Sense of the Extracellular Environment BioEssays 2005 27 698 707 10.1002/bies.20256 15954093 · DOI
  61. [62]Brooker S.M. Bond A.M. Peng C.Y. Kessler J.A. B1-Integrin Restricts Astrocytic Differentiation of Adult Hippocampal Neural Stem Cells Glia 2016 64 1235 1251 10.1002/glia.22996 27145730 PMC7575343 · DOI
  62. [63]Hirota S. Liu Q. Lee H.S. Hossain M.G. Lacy-Hulbert A. Mccarty J.H. The Astrocyte-Expressed Integrin αvβ8 Governs Blood Vessel Sprouting in the Developing Retina Development 2011 138 5157 5166 10.1242/dev.069153 22069187 PMC3253036 · DOI
  63. [64]Fujioka T. Kaneko N. Ajioka I. Nakaguchi K. Omata T. Ohba H. Fässler R. García-Verdugo J.M. Sekiguchi K. Matsukawa N. B1 Integrin Signaling Promotes Neuronal Migration along Vascular Scaffolds in the Post-Stroke Brain EBioMedicine 2017 16 195 203 10.1016/j.ebiom.2017.01.005 28153772 PMC5474439 · DOI
  64. [65]Cheah M. Andrews M.R. Integrin Activation: Implications for Axon Regeneration Cells 2018 7 20 10.3390/cells7030020 PMC5870352 29534450 · DOI
  65. [66]Jaudon F. Thalhammer A. Cingolani L.A. Integrin adhesion in brain assembly: From molecular structure to neuropsychiatric disorders Eur. J. Neurosci. 2021 53 3831 3850 10.1111/ejn.14859 32531845 · DOI
  66. [67]Sethna S. Scott P.A. Giese A.P.J. Duncan T. Jian X. Riazuddin S. Randazzo P.A. Redmond T.M. Bernstein S.L. Riazuddin S. CIB2 Regulates MTORC1 Signaling and Is Essential for Autophagy and Visual Function Nat. Commun. 2021 12 3906 10.1038/s41467-021-24056-1 34162842 PMC8222345 · DOI
  67. [68]Riazuddin S. Belyantseva I.A. Giese A.P.J. Lee K. Indzhykulian A.A. Nandamuri S.P. Yousaf R. Sinha G.P. Lee S. Terrell D. Alterations of the CIB2 Calcium-and Integrin-Binding Protein Cause Usher Syndrome Type 1J and Nonsyndromic Deafness DFNB48 Nat. Genet. 2012 44 1265 1271 10.1038/ng.2426 23023331 PMC3501259 · DOI
  68. [69]Reich D.S. Lucchinetti C.F. Calabresi P.A. Multiple Sclerosis N. Engl. J. Med. 2018 378 169 180 10.1056/NEJMra1401483 29320652 PMC6942519 · DOI · Paper page
  69. [70]Glatigny S. Duhen R. Arbelaez C. Kumari S. Bettelli E. Integrin Alpha L Controls the Homing of Regulatory T Cells during CNS Autoimmunity in the Absence of Integrin Alpha 4 Sci. Rep. 2015 5 7834 10.1038/srep07834 25592296 PMC4296287 · DOI
  70. [71]Polman C. O’connor P. Havrdova E. Hutchinson M. Kappos L. Miller D. Phillips J. Lublin F. Giovannoni G. Wajgt A. A Randomized, Placebo-Controlled Trial of Natalizumab for Relapsing Multiple Sclerosis N. Engl. J. Med. 2006 354 899 910 10.1056/NEJMoa044397 16510744 · DOI
  71. [72]Zondler L. Herich S. Kotte P. Körner K. Schneider-Hohendorf T. Wiendl H. Schwab N. Zarbock A. MCAM/CD146 Signaling via PLCγ1 Leads to Activation of β1-Integrins in Memory T-Cells Resulting in Increased Brain Infiltration Front. Immunol. 2020 11 599936 10.3389/fimmu.2020.599936 33381120 PMC7767877 · DOI
  72. [73]Franssen E.H.P. Zhao R.R. Koseki H. Kanamarlapudi V. Hoogenraad C.C. Eva R. Fawcett J.W. Exclusion of Integrins from CNS Axons Is Regulated by Arf6 Activation and the AIS J. Neurosci. 2015 35 8359 8375 10.1523/JNEUROSCI.2850-14.2015 26019348 PMC4444552 · DOI
  73. [74]Andrews M.R. Soleman S. Cheah M. Tumbarello D.A. Mason M.R.J. Moloney E. Verhaagen J. Bensadoun J.C. Schneider B. Aebischer P. Axonal Localization of Integrins in the CNS Is Neuronal Type and Age Dependent eNeuro 2016 3 5546 5557 10.1523/ENEURO.0029-16.2016 PMC4987411 27570822 · DOI
  74. [75]Eva R. Koseki H. Kanamarlapudi V. Fawcett J.W. EFA6 Regulates Selective Polarised Transport and Axon Regeneration from the Axon Initial Segment J. Cell Sci. 2017 130 3663 3675 10.1242/jcs.207423 28935671 PMC5702059 · DOI
  75. [76]Koseki H. Donegá M. Lam B.Y. Petrova V. van Erp S. Yeo G.S. Kwok J.C. Ffrench-Constant C. Eva R. Fawcett J.W. Selective Rab11 Transport and the Intrinsic Regenerative Ability of CNS Axons eLife 2017 6 e26956 10.7554/eLife.26956 28829741 PMC5779230 · DOI
  76. [78]Cheah M. Andrews M.R. Chew D.J. Moloney E.B. Verhaagen J. Fässler R. Fawcett J.W. Expression of an Activated Integrin Promotes Long-Distance Sensory Axon Regeneration in the Spinal Cord J. Neurosci. 2016 36 7283 7297 10.1523/JNEUROSCI.0901-16.2016 27383601 PMC4938867 · DOI
  77. [80]Bond A.M. Ming G. Song H. Ontogeny of Adult Neural Stem Cells in the Mammalian Brain Current Topics in Developmental Biology Academic Press Inc. Cambridge, MA, USA 2021 Volume 142 67 98 9780128152812 PMC8363052 33706926
  78. [81]Belvindrah R. Hankel S. Walker J. Patton B.L. Müller U. B1 Integrins Control the Formation of Cell Chains in the Adult Rostral Migratory Stream J. Neurosci. 2007 27 2704 2717 10.1523/JNEUROSCI.2991-06.2007 17344408 PMC6672488 · DOI
  79. [82]Boato F. Hendrix S. Huelsenbeck S.C. Hofmann F. Große G. Djalali S. Klimaschewski L. Auer M. Just I. Ahnert-Hilger G. C3 Peptide Enhances Recovery from Spinal Cord Injury by Improved Regenerative Growth of Descending Fiber Tracts J. Cell Sci. 2010 123 1652 1662 10.1242/jcs.066050 20406886 · DOI
  80. [83]Loske P. Boato F. Hendrix S. Piepgras J. Just I. Ahnert-Hilger G. Höltje M. Minimal Essential Length of Clostridium Botulinum C3 Peptides to Enhance Neuronal Regenerative Growth and Connectivity in a Non-Enzymatic Mode J. Neurochem. 2012 120 1084 1096 10.1111/j.1471-4159.2012.07657.x 22239108 · DOI
  81. [84]Adolf A. Rohrbeck A. Münster-Wandowski A. Johansson M. Kuhn H.G. Kopp M.A. Brommer B. Schwab J.M. Just I. Ahnert-Hilger G. Release of Astroglial Vimentin by Extracellular Vesicles: Modulation of Binding and Internalization of C3 Transferase in Astrocytes and Neurons Glia 2019 67 703 717 10.1002/glia.23566 30485542 · DOI
  82. [85]Quillen S. Schaub J. Quigley H. Pease M. Korneva A. Kimball E. Astrocyte Responses to Experimental Glaucoma in Mouse Optic Nerve Head PLoS ONE 2020 15 e0238104 10.1371/journal.pone.0238104 32822415 PMC7442264 · DOI
  83. [86]Nio-Kobayashi J. Itabashi T. Galectins and Their Ligand Glycoconjugates in the Central Nervous System Under Physiological and Pathological Conditions Front. Neuroanat. 2021 15 767330 10.3389/fnana.2021.767330 34720894 PMC8554236 · DOI
  84. [87]Sakaguchi M. Imaizumi Y. Shingo T. Tada H. Hayama K. Yamada O. Morishita T. Kadoya T. Uchiyama N. Shimazaki T. Regulation of Adult Neural Progenitor Cells by Galectin-1/β1 Integrin Interaction J. Neurochem. 2010 113 1516 1524 10.1111/j.1471-4159.2010.06712.x 20367753 · DOI
  85. [88]Götz M. Sirko S. Beckers J. Irmler M. Reactive Astrocytes as Neural Stem or Progenitor Cells: In Vivo Lineage, In Vitro Potential, and Genome-Wide Expression Analysis Glia 2015 63 1452 1468 10.1002/glia.22850 25965557 PMC5029574 · DOI
  86. [90]Escartin C. Guillemaud O. Carrillo-de Sauvage M.A. Questions and (Some) Answers on Reactive Astrocytes Glia 2019 67 2221 2247 10.1002/glia.23687 31429127 · DOI · Paper page
  87. [91]Pekny M. Wilhelmsson U. Tatlisumak T. Pekna M. Astrocyte Activation and Reactive Gliosis—A New Target in Stroke? Neurosci. Lett. 2019 689 45 55 10.1016/j.neulet.2018.07.021 30025833 · DOI
  88. [92]Sofroniew M.V. Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity Trends Immunol. 2020 41 758 770 10.1016/j.it.2020.07.004 32819810 PMC7484257 · DOI · Paper page
  89. [93]Williamson M.R. Fuertes C.J.A. Dunn A.K. Drew M.R. Jones T.A. Reactive Astrocytes Facilitate Vascular Repair and Remodeling after Stroke Cell Rep. 2021 35 109048 10.1016/j.celrep.2021.109048 33910014 PMC8142687 · DOI
  90. [94]Adams K.L. Gallo V. The Diversity and Disparity of the Glial Scar Nat. Neurosci. 2018 21 9 15 10.1038/s41593-017-0033-9 29269757 PMC5937232 · DOI
  91. [96]Silver J. Miller J.H. Regeneration beyond the Glial Scar Nat. Rev. Neurosci. 2004 5 146 156 10.1038/nrn1326 14735117 · DOI
  92. [97]Guttenplan K.A. Weigel M.K. Prakash P. Wijewardhane P.R. Hasel P. Rufen-Blanchette U. Münch A.E. Blum J.A. Fine J. Neal M.C. Neurotoxic Reactive Astrocytes Induce Cell Death via Saturated Lipids Nature 2021 599 102 107 10.1038/s41586-021-03960-y 34616039 PMC12054010 · DOI · Paper page
  93. [98]Rolls A. Shechter R. Schwartz M. The Bright Side of the Glial scar in CNS Repair Nat. Rev. Neurosci. 2009 10 235 241 10.1038/nrn2591 19229242 · DOI · Paper page
  94. [99]Sofroniew M.V. Molecular Dissection of Reactive Astrogliosis and Glial Scar Formation Trends Neurosci. 2009 32 638 647 10.1016/j.tins.2009.08.002 19782411 PMC2787735 · DOI · Paper page
  95. [100]Zamanian J.L. Xu L. Foo L.C. Nouri N. Zhou L. Giffard R.G. Barres B.A. Genomic Analysis of Reactive Astrogliosis J. Neurosci. 2012 32 6391 6410 10.1523/JNEUROSCI.6221-11.2012 22553043 PMC3480225 · DOI · Paper page
  96. [101]Hayakawa K. Pham L.D.D. Arai K. Lo E.H. Reactive Astrocytes Promote Adhesive Interactions between Brain Endothelium and Endothelial Progenitor Cells via HMGB1 and Beta-2 Integrin Signaling Stem Cell Res. 2014 12 531 538 10.1016/j.scr.2013.12.008 24480450 PMC3966549 · DOI
  97. [102]Li K. Li J. Zheng J. Qin S. Reactive Astrocytes in Neurodegenerative Diseases Aging Dis. 2019 10 664 675 10.14336/AD.2018.0720 31165009 PMC6538217 · DOI · Paper page
  98. [103]Nathan F.M. Li S. Environmental Cues Determine the Fate of Astrocytes after Spinal Cord Injury Neural Regen. Res. 2017 12 1964 1970 29323029 PMC5784338
  99. [104]Okada S. Hara M. Kobayakawa K. Matsumoto Y. Nakashima Y. Astrocyte Reactivity and Astrogliosis after Spinal Cord Injury Neurosci. Res. 2018 126 39 43 10.1016/j.neures.2017.10.004 29054466 · DOI · Paper page
  100. [105]Hara M. Kobayakawa K. Ohkawa Y. Kumamaru H. Yokota K. Saito T. Kijima K. Yoshizaki S. Harimaya K. Nakashima Y. Interaction of Reactive Astrocytes with Type I Collagen Induces Astrocytic Scar Formation through the Integrin-N-Cadherin Pathway after Spinal Cord Injury Nat. Med. 2017 23 818 828 10.1038/nm.4354 28628111 · DOI
  101. [106]Pérez L.A. Rashid A. Combs J.D. Schneider P. Rodríguez A. Salaita K. Leyton L. An Outside-In Switch in Integrin Signaling Caused by Chemical and Mechanical Signals in Reactive Astrocytes Front. Cell Dev. Biol. 2021 9 712627 10.3389/fcell.2021.712627 34497806 PMC8419233 · DOI
  102. [107]Schiweck J. Murk K. Ledderose J. Münster-Wandowski A. Ornaghi M. Vida I. Eickholt B.J. Drebrin Controls Scar Formation and Astrocyte Reactivity upon Traumatic Brain Injury by Regulating Membrane Trafficking Nat. Commun. 2021 12 1490 10.1038/s41467-021-21662-x 33674568 PMC7935889 · DOI
  103. [108]Bellahcène A. Castronovo V. Ogbureke K.U.E. Fisher L.W. Fedarko N.S. Small Integrin-Binding LIgand N-Linked Glycoproteins (SIBLINGs): Multifunctional Proteins in Cancer Nat. Rev. Cancer 2008 8 212 226 10.1038/nrc2345 18292776 PMC2484121 · DOI
  104. [109]Gao H. Fan S. Xie L. Hu S. Zhang Y. Overexpression of DSPP Promotes the Proliferation and Migration of Astrocytes Neurosci. Lett. 2021 754 135775 10.1016/j.neulet.2021.135775 33647395 · DOI
  105. [110]Linnerbauer M. Wheeler M.A. Quintana F.J. Astrocyte Crosstalk in CNS Inflammation Neuron 2020 108 608 622 10.1016/j.neuron.2020.08.012 32898475 PMC7704785 · DOI · Paper page
  106. [111]Liu L.R. Liu J.C. Bao J.S. Bai Q.Q. Wang G.Q. Interaction of Microglia and Astrocytes in the Neurovascular Unit Front. Immunol. 2020 11 1024 10.3389/fimmu.2020.01024 32733433 PMC7362712 · DOI
  107. [112]Yoshizaki S. Tamaru T. Hara M. Kijima K. Tanaka M. Konno D. Matsumoto Y. Nakashima Y. Okada S. Microglial Inflammation after Chronic Spinal Cord Injury Is Enhanced by Reactive Astrocytes via the Fibronectin/β1 Integrin Pathway J. Neuroinflamm. 2021 18 12 10.1186/s12974-020-02059-x PMC7789752 33407620 · DOI
  108. [113]Edwards D.N. Salmeron K. Lukins D.E. Trout A.L. Fraser J.F. Bix G.J. Integrin α5β1 Inhibition by ATN-161 Reduces Neuroinflammation and Is Neuroprotective in Ischemic Stroke J. Cereb. Blood Flow Metab. 2020 40 1695 1708 10.1177/0271678X19880161 31575337 PMC7370357 · DOI
  109. [114]Yun J.H. Park S.W. Kim J.H. Park Y.J. Cho C.H. Kim J.H. Angiopoietin 2 Induces Astrocyte Apoptosis via αvβ5-Integrin Signaling in Diabetic Retinopathy Cell Death Dis. 2016 7 e2101 10.1038/cddis.2015.347 26890140 PMC5399183 · DOI
  110. [115]Dossi E. Vasile F. Rouach N. Human Astrocytes in the Diseased Brain Brain Res. Bull. 2018 136 139 156 10.1016/j.brainresbull.2017.02.001 28212850 PMC5766741 · DOI · Paper page
  111. [120]Ahuja C.S. Wilson J.R. Nori S. Kotter M.R.N. Druschel C. Curt A. Fehlings M.G. Traumatic Spinal Cord Injury Nat. Rev. Dis. Primers 2017 3 17018 10.1038/nrdp.2017.18 28447605 · DOI · Paper page
  112. [121]Roll L. Faissner A. Tenascins in CNS Lesions Semin. Cell Dev. Biol. 2019 89 118 124 10.1016/j.semcdb.2018.09.012 30287388 · DOI
  113. [122]Tucić M. Stamenković V. Andjus P. The Extracellular Matrix Glycoprotein Tenascin C and Adult Neurogenesis Front. Cell Dev. Biol. 2021 9 674199 10.3389/fcell.2021.674199 33996833 PMC8117239 · DOI
  114. [123]Wiemann S. Reinhard J. Faissner A. Immunomodulatory Role of the Extracellular Matrix Protein Tenascin-C in Neuroinflammation Biochem. Soc. Trans. 2019 47 1651 1660 10.1042/BST20190081 31845742 · DOI
  115. [124]Fawcett J.W. An Integrin Approach to Axon Regeneration Eye 2017 31 206 208 10.1038/eye.2016.293 28009347 PMC5306470 · DOI
  116. [125]Forbes L.H. Andrews M.R. Grafted Human IPSC-Derived Neural Progenitor Cells Express Integrins and Extend Long-Distance Axons within the Developing Corticospinal Tract Front. Cell. Neurosci. 2019 13 26 10.3389/fncel.2019.00026 30809126 PMC6380224 · DOI
  117. [126]Sutter P.A. Rouillard M.E. Alshawi S.A. Crocker S.J. Extracellular Matrix Influences Astrocytic Extracellular Vesicle Function in Wound Repair Brain Res. 2021 1763 147462 10.1016/j.brainres.2021.147462 33811843 · DOI
  118. [127]Quraishe S. Forbes L.H. Andrews M.R. The Extracellular Environment of the CNS: Influence on Plasticity, Sprouting, and Axonal Regeneration after Spinal Cord Injury Neural Plast. 2018 2018 2952386 10.1155/2018/2952386 29849554 PMC5932463 · DOI
  119. [128]Uede T. Osteopontin, Intrinsic Tissue Regulator of Intractable Inflammatory Diseases Pathol. Int. 2011 61 265 280 10.1111/j.1440-1827.2011.02649.x 21501293 · DOI
  120. [129]Icer M.A. Gezmen-Karadag M. The Multiple Functions and Mechanisms of Osteopontin Clin. Biochem. 2018 59 17 24 10.1016/j.clinbiochem.2018.07.003 30003880 · DOI · Paper page
  121. [130]Zhou Y. Yao Y. Sheng L. Zhang J. Zhang J.H. Shao A. Osteopontin as a Candidate of Therapeutic Application for the Acute Brain Injury J. Cell. Mol. Med. 2020 24 8918 8929 10.1111/jcmm.15641 32657030 PMC7417697 · DOI
  122. [131]Denhardt D.T. Noda M. Osteopontin Expression and Function: Role in Bone Remodeling J. Cell. Biochem. 1998 72 92 102 10.1002/(SICI)1097-4644(1998)72:30/31+<92::AID-JCB13>3.0.CO;2-A 29345811 · DOI
  123. [132]Weber G.F. The Metastasis Gene Osteopontin: A Candidate Target for Cancer Therapy Biochim. Biophys. Acta 2001 1552 61 85 10.1016/S0304-419X(01)00037-3 11825687 · DOI
  124. [133]Von Neuhoff N. Oumeraci T. Wolf T. Kollewe K. Bewerunge P. Neumann B. Brors B. Bufler J. Wurster U. Schlegelberger B. Monitoring CSF Proteome Alterations in Amyotrophic Lateral Sclerosis: Obstacles and Perspectives in Translating a Novel Marker Panel to the Clinic PLoS ONE 2012 7 e44401 10.1371/journal.pone.0044401 22970211 PMC3435306 · DOI
  125. [134]Mary Varghese A. Sharma A. Mishra P. Vijayalakshmi K. Chandregowda Harsha H. Sathyaprabha T.N. Bharath S.M. Nalini A. Anand Alladi P. Raju T.R. Chitotriosidase-a Putative Biomarker for Sporadic Amyotrophic Lateral Sclerosis Clin. Proteom. 2013 10 19 10.1186/1559-0275-10-19 24295388 PMC4220794 · DOI
  126. [135]Kariya Y. Kariya Y. Saito T. Nishiyama S. Honda T. Tanaka K. Yoshida M. Fujihara K. Hashimoto Y. Increased Cerebrospinal Fluid Osteopontin Levels and Its Involvement in Macrophage Infiltration in Neuromyelitis Optica BBA Clin. 2015 3 126 134 10.1016/j.bbacli.2015.01.003 26673877 PMC4661545 · DOI
  127. [136]Broom L. Jenner P. Rose S. Increased Neurotrophic Factor Levels in Ventral Mesencephalic Cultures Do Not Explain the Protective Effect of Osteopontin and the Synthetic 15-Mer RGD Domain against MPP + Toxicity Exp. Neurol. 2015 263 1 7 10.1016/j.expneurol.2014.09.005 25218309 · DOI
  128. [137]Zhu P.J. Chen C.J. Mays J. Stoica L. Costa-Mattioli M. MTORC2, but Not MTORC1, Is Required for Hippocampal MGluR-LTD and Associated Behaviors Nat. Neurosci. 2018 21 799 802 10.1038/s41593-018-0156-7 29786082 PMC6467217 · DOI
  129. [138]Switon K. Kotulska K. Janusz-Kaminska A. Zmorzynska J. Jaworski J. Molecular Neurobiology of MTOR Neuroscience 2017 341 112 153 10.1016/j.neuroscience.2016.11.017 27889578 · DOI
  130. [139]Calvez M. Hseeh G. Benzer S. Brown A.M. Osteopontin Counters Human Immunodeficiency Virus Type 1–Induced Impairment of Neurite Growth through Mammalian Target of Rapamycin and Beta-Integrin Signaling Pathways J. Neurovirol. 2019 25 384 396 10.1007/s13365-019-00729-y 30758811 PMC6647884 · DOI
  131. [140]Morita K. Sasaki H. Furuse M. Tsukita S. Endothelial Claudin: Claudin-5/TMVCF Constitutes Tight Junction Strands in Endothelial Cells J. Cell Biol. 1999 147 185 194 10.1083/jcb.147.1.185 10508865 PMC2164984 · DOI
  132. [141]Nitta T. Hata M. Gotoh S. Seo Y. Sasaki H. Hashimoto N. Furuse M. Tsukita S. Size-Selective Loosening of the Blood-Brain Barrier in Claudin-5-Deficient Mice J. Cell Biol. 2003 161 653 660 10.1083/jcb.200302070 12743111 PMC2172943 · DOI · Paper page
  133. [142]Yamashiro Y. Bui T.Q. Ramirez K. Shin J. Kohata T. Ohata S. Nguyen A.V. Ohtsuki S. Nagayama K. Yanagisawa H. Matrix Mechanotransduction Mediated by Thrombospondin-1/Integrin/YAP in the Vascular Remodeling Proc. Natl. Acad. Sci. USA 2020 117 9896 9905 10.1073/pnas.1919702117 32321834 PMC7211957 · DOI
  134. [143]Mrugacz M. Bryl A. Falkowski M. Zorena K. Integrins: An Important Link between Angiogenesis, Inflammation and Eye Diseases Cells 2021 10 1703 10.3390/cells10071703 34359873 PMC8305893 · DOI
  135. [144]Welser J. Halder S.K. Kant R. Boroujerdi A. Milner R. Endothelial α6β4 Integrin Protects during Experimental Autoimmune Encephalomyelitis-Induced Neuroinflammation by Maintaining Vascular Integrity and Tight Junction Protein Expression J. Neuroinflamm. 2017 14 217 10.1186/s12974-017-0987-2 PMC5679365 29121970 · DOI
  136. [145]Labus J. Wöltje K. Stolte K.N. Häckel S. Kim K.S. Hildmann A. Danker K. IL-1β Promotes Transendothelial Migration of PBMCs by Upregulation of the FN/α5β1 Signalling Pathway in Immortalised Human Brain Microvascular Endothelial Cells Exp. Cell Res. 2018 373 99 111 10.1016/j.yexcr.2018.10.002 30342992 · DOI
  137. [146]Edwards D.N. Bix G.J. Roles of Blood-Brain Barrier Integrins and Extracellular Matrix in Stroke Am. J. Physiol. Cell Physiol. 2019 316 C252 C263 10.1152/ajpcell.00151.2018 30462535 PMC6397343 · DOI
  138. [147]Bhowmick S. D’Mello V. Caruso D. Wallerstein A. Abdul-Muneer P.M. Impairment of Pericyte-Endothelium Crosstalk Leads to Blood-Brain Barrier Dysfunction Following Traumatic Brain Injury Exp. Neurol. 2019 317 260 270 10.1016/j.expneurol.2019.03.014 30926390 · DOI
  139. [148]Nakamura K. Ikeuchi T. Nara K. Rhodes C.S. Zhang P. Chiba Y. Kazuno S. Miura Y. Ago T. Arikawa-Hirasawa E. Perlecan Regulates Pericyte Dynamics in the Maintenance and Repair of the Blood-Brain Barrier J. Cell Biol. 2019 218 3506 3525 10.1083/jcb.201807178 31541017 PMC6781430 · DOI
  140. [149]Larochelle C. Uphaus T. Broux B. Gowing E. Paterka M. Michel L. Dudvarski Stankovic N. Bicker F. Lemaître F. Prat A. EGFL7 Reduces CNS Inflammation in Mouse Nat. Commun. 2018 9 819 10.1038/s41467-018-03186-z 29483510 PMC5827652 · DOI
  141. [150]Halder S.K. Kant R. Milner R. Chronic Mild Hypoxia Promotes Profound Vascular Remodeling in Spinal Cord Blood Vessels, Preferentially in White Matter, via an A5β1 Integrin-Mediated Mechanism Angiogenesis 2018 21 251 266 10.1007/s10456-017-9593-2 29299782 PMC6084789 · DOI

Cited by

Sorted by citations

Authors
Ikeshima-Kataoka, H., Sugimoto, C., & Tsubokawa, T.
Affiliations
  • Department of Biology, Keio University, 4-1-1, Hiyoshi, Kohoku-ku, Yokohama-shi 223-8521, Japan
  • Keio University (JP)
ORCID
Sugimoto, Chikatoshi
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2022-01-27
Volume
23
Issue
3
Pages
1435
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms23031435
PMC
PMC8836133
OpenAlex
W4212786780
Cited by
24
References
8
Citations by year
2026: 4 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 4
FWCI
0.78
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Keio Gijuku Academic Development Funds (none)
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
integrin signaling, central nervous system, reactive astrocytes, tenascin-C, osteopontin, extracellular matrix, neurodegenerative diseases, brain injury, invertebrate models
MeSH terms
Animals, Central Nervous System, Fishes, Gene Expression Regulation, Humans, Phylogeny, Signal Transduction, Integrins, Extracellular Matrix Proteins, Fish Proteins

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