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Integrin activity in neuronal connectivity

Lilja, Johanna, Ivaska, Johanna·2018·Journal of Cell Science
DOI 10.1242/jcs.212803
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Abstract

The formation of correct synaptic structures and neuronal connections is paramount for normal brain development and a functioning adult brain. The integrin family of cell adhesion receptors and their ligands play essential roles in the control of several processes regulating neuronal connectivity – including neurite outgrowth, the formation and maintenance of synapses, and synaptic plasticity – that are affected in neurodevelopmental disorders, such as autism spectrum disorders (ASDs) and schizophrenia. Many ASD- and schizophrenia-associated genes are linked to alterations in the genetic code of integrins and associated signalling pathways. In non-neuronal cells, crosstalk between integrin-mediated adhesions and the actin cytoskeleton, and the regulation of integrin activity (affinity for extracellular ligands) are widely studied in healthy and pathological settings. In contrast, the roles of integrin-linked pathways in the central nervous system remains less well defined. In this Review, we will provide an overview of the known pathways that are regulated by integrin–ECM interaction in developing neurons and in adult brain. We will also describe recent advances in the identification of mechanisms that regulate integrin activity in neurons, and highlight the interesting emerging links between integrins and neurodevelopment.

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  • β1-integrin plays key roles in neurite outgrowth, axon guidance, and in the formation and maintenance of synapses.

    “β1-integrin plays key roles in neurite outgrowth, axon guidance, and in the formation and maintenance of synapses (Cheah and Andrews, 2018; Lilja and Ivaska, 2018; Park and Goda, 2016).”

    From Recruitment of the SNX17-Retriever recycling pathway regulates synaptic function and plasticity (2023) · cites this paper as Lilja and Ivaska, 2018

  • β1-integrin is a well-characterized SNX17-Retriever cargo in non-neuronal cells.

    “We chose to test β1-integrin, which is a well-characterized SNX17-Retriever cargo in non-neuronal cells and plays several roles in regulating neuronal function and synaptic plasticity.”

    From Recruitment of the SNX17-Retriever recycling pathway regulates synaptic function and plasticity (2023) · cites this paper as Lilja and Ivaska, 2018

    Box 2 discusses β1-integrin ligands and neuronal signaling, but does not identify β1-integrin as an SNX17-Retriever cargo in non-neuronal cells. Searches for “SNX17-Retriever cargo” and β1-integrin recycling did not find a passage addressing that relationship. (LLM, conf=0.74)

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Metadata

Authors
Lilja, J., & Ivaska, J.
Affiliations
Turku Centre for Biotechnology, University of Turku 1 , FIN-20520 Turku , Finland
ORCID
Ivaska, Johanna
Venue
Journal of Cell Science
Publisher
The Company of Biologists
Published
2018-06-15
Volume
131
Issue
12
ISSN
  • 1477-9137
  • 0021-9533
DOI
10.1242/jcs.212803
Cited by
107
References
14
Language
en
Licence
www.biologists.com/user-licence-1-1 (vor, 183 d)
Funders
  • Academy of Finland
  • European Research Council
  • Sigrid Juséliuksen Säätiö
  • Syöpäjärjestöt
  • Suomen Aivosäätiö

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