The DOI matches its Crossref record; 218 of the 222 references it cites were found in a registry or an index.
Endothelial function and dysfunction: Impact of metformin
Abstract
Cardiovascular and metabolic diseases remain the leading cause of morbidity and mortality worldwide. Endothelial dysfunction is a key player in the initiation and progression of cardiovascular and metabolic diseases. Current evidence suggests that the anti-diabetic drug metformin improves insulin resistance and protects against endothelial dysfunction in the vasculature. Hereby, we provide a timely review on the protective effects and molecular mechanisms of metformin in preventing endothelial dysfunction and cardiovascular and metabolic diseases.
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“Based on evidence from both clinical and pre-clinical studies metformin, independent of its anti-hyperglycemic actions, directly protects the endothelium (33–35).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [33]
In the citing paper
“There is an extensive literature based on data from pre-clinical and clinical studies that indicates metformin protects endothelial function from the effects of diabetes (33).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [33]
Citations
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Metadata
- Authors
- Nafisa, A., Gray, S. G., Cao, Y., Wang, T., Xu, S., Wattoo, F. H., Barras, M., Cohen, N., Kamato, D., & Little, P. J.
- Affiliations
- The University of Queensland (AU)
- Sun Yat-sen University (CN)
- University of Rochester Medicine (US)
- Pir Mehr Ali Shah Arid Agriculture University (PK)
- Princess Alexandra Hospital (AU)
- Baker Heart and Diabetes Institute (AU)
- Corresponding author
- Little, Peter J.
- ORCID
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 192
- Pages
- 150-162
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W2884428355
- Cited by
- 128
- References
- 222
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 22 · 2023: 15 · 2022: 19 · 2021: 25 · 2020: 19 · 2019: 10 · 2018: 1
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council of Australia (#1022800)
- National Heart Foundation of Australia (G09M4385)
- Diabetes Australia Research Trust
- RMIT University
- University of Queensland
- Australian Government Scholarships
- American Heart Association (18CDA34110359)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- metformin, endothelial dysfunction, endothelial function, insulin resistance, cardiovascular disease, metabolic disorders, molecular mechanisms
- MeSH terms
- Animals, Cardiovascular Diseases, Endothelium, Vascular, Humans, Hypoglycemic Agents, Metabolic Diseases, Metformin
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