Endothelial function and dysfunction: Impact of metformin

Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association

Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y. I., Kobayashi, M., Mitsui, Y., Yazaki, Y., Goto, K., & Masaki, T. (1988) · Nature · doi:10.1038/332411a0 · Cited by 10,716

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704

Biochemistry and molecular cell biology of diabetic complications

Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)

(1998) · The Lancet · doi:10.1016/s0140-6736(98)07037-8 · Cited by 8,247

Inflammation and Atherosclerosis

Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724

Heart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association

Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., Das, S. R., de Ferranti, S., Després, J.-P., Fullerton, H. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000350 · Cited by 6,596

HEART DISEASE AND STROKE STATISTICS–2014 UPDATE: A REPORT FROM THE AMERICAN HEART ASSOCIATION

Tarver, T. (2014) · Journal of Consumer Health on the Internet · doi:10.1080/15398285.2014.902284 · Cited by 5,595

Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies

Xu, S., Ilyas, I., Little, P. J., Li, H., Kamato, D., Zheng, X., Luo, S., Li, Z., Liu, P., Han, J., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000096 · Cited by 1,205

Endothelial Dysfunction, Inflammation and Coronary Artery Disease: Potential Biomarkers and Promising Therapeutical Approaches

Medina-Leyte, D. J., Zepeda-García, Ó., Domínguez‐Pérez, M., González-Garrido, A., Villarreal-Molina, M. T., & Jacobo‐Albavera, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083850 · Cited by 678

Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics

Feng, X., Sureda, A., Jafari, S., Memariani, Z., Tewari, D., Annunziata, G., Barrea, L., Hassan, S. T. S., Šmejkal, K., Malaník, M., et al. (2019) · Theranostics · doi:10.7150/thno.30787 · Cited by 465

Mechanisms of long COVID and the path toward therapeutics

Peluso, M. J., & Deeks, S. G. (2024) · Cell · doi:10.1016/j.cell.2024.07.054 · Cited by 399

A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan

Mohammed, I., Hollenberg, M. D., Ding, H., & Triggle, C. R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.718942 · Cited by 278

Metformin: Is it a drug for all reasons and diseases?

Triggle, C. R., Mohammed, I., Bshesh, K., Marei, I., Ye, K., Ding, H., MacDonald, R. S., Hollenberg, M. D., & Hill, M. A. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155223 · Cited by 300

Targeting Foam Cell Formation in Atherosclerosis: Therapeutic Potential of Natural Products

Wang, D., Yang, Y., Lei, Y., Tzvetkov, N. T., Liu, X., Yeung, A. W. K., Xu, S., & Atanasov, A. G. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.017178 · Cited by 223

Mitochondria as an important target of metformin: The mechanism of action, toxic and side effects, and new therapeutic applications

Feng, J., Wang, X., Ye, X., Arés, I., López-Torres, B., Martínez, M., Martínez‐Larrañaga, M., Wang, X., Anadón, A., & Martínez, M. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106114 · Cited by 201

Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms

Chen, S., Gan, D., Lin, S., Zhong, Y., Chen, M., Zou, X., Shao, Z., & Xiao, G. (2022) · Theranostics · doi:10.7150/thno.71360 · Cited by 205

Rutaecarpine: A promising cardiovascular protective alkaloid from Evodia rutaecarpa (Wu Zhu Yu)

Tian, K., Li, J., & Xu, S. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2018.12.019 · Cited by 178

The Current and Potential Therapeutic Use of Metformin—The Good Old Drug

Drzewoski, J., & Hanefeld, M. (2021) · Pharmaceuticals · doi:10.3390/ph14020122 · Cited by 173

Metformin, Macrophage Dysfunction and Atherosclerosis

Feng, X., Chen, W., Ni, X., Little, P. J., Xu, S., Tang, L., & Weng, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.682853 · Cited by 156

Mitochondrial contributions to vascular endothelial dysfunction, arterial stiffness, and cardiovascular diseases

Kirkman, D. L., Robinson, A. T., Rossman, M. J., Seals, D. R., & Edwards, D. G. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00917.2020 · Cited by 150

INTERDISCIPLINARY CLINICAL PRACTICE GUIDELINES "MANAGEMENT OF OBESITY AND ITS COMORBIDITIES"

Dedov, I. I., Shestakova, M. V., Mel'nichenko, G. A., Mazurina, N. V., Andreeva, E. N., Bondarenko, I. Z., Руслановна, Г. З., Dzgoeva, F. K., Елисеев, М. С., Ershova, E. V., et al. (2021) · Obesity and metabolism · doi:10.14341/omet12714 · Cited by 163

Cellular senescence and cardiovascular diseases: moving to the “heart” of the problem

Evangelou, K., Vasileiou, P. V. S., Papaspyropoulos, A., Hazapis, O. G., Petty, R., Demaria, M., & Gorgoulis, V. G. (2022) · Physiological Reviews · doi:10.1152/physrev.00007.2022 · Cited by 127

Metformin: Therapeutic profile in the treatment of type 2 diabetes

Bailey, C. J. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15663 · Cited by 143

Inflammatory Mediators of Endothelial Dysfunction

Dri, E., Lampas, E., Lazaros, G. A., Lazarou, E., Theofilis, P., Tsioufis, C. P., & Tousoulis, D. (2023) · Life · doi:10.3390/life13061420 · Cited by 132

Mechanisms and Clinical Implications of Endothelial Dysfunction in Arterial Hypertension

Ambrosino, P., Bachetti, T., D’Anna, S. E., Galloway, B., Bianco, A., D’Agnano, V., Papa, A., Motta, A., Perrotta, F., & Maniscalco, M. (2022) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd9050136 · Cited by 113

Can Metformin Exert as an Active Drug on Endothelial Dysfunction in Diabetic Subjects

Salvatore, T., Pafundi, P. C., Galiero, R., Rinaldi, L., Caturano, A., Vetrano, E., Aprea, C., Albanese, G., Di Martino, A., Ricozzi, C., et al. (2020) · Biomedicines · doi:10.3390/biomedicines9010003 · Cited by 97

Endothelial Dysfunction in Diabetes

Takeda, Y., Matoba, K., Sekiguchi, K., Nagai, Y., Yokota, T., Utsunomiya, K., & Nishimura, R. (2020) · Biomedicines · doi:10.3390/biomedicines8070182 · Cited by 96

A novel human arterial wall-on-a-chip to study endothelial inflammation and vascular smooth muscle cell migration in early atherosclerosis

Su, C., Menon, N. V., Xu, X., Teo, Y. R., Cao, H., Dalan, R., Tay, C. Y., & Hou, H. W. (2021) · Lab on a Chip · doi:10.1039/d1lc00131k · Cited by 84

Cognitive Impairment in Frail Hypertensive Elderly Patients: Role of Hyperglycemia

Mone, P., Gambardella, J., Pansini, A., Donato, A. D., Martinelli, G., Boccalone, E., Matarese, A., Frullone, S., & Santulli, G. (2021) · Cells · doi:10.3390/cells10082115 · Cited by 72

Advances in the Role of Endothelial Cells in Cerebral Small Vessel Disease

Bai, T., Yu, S., & Feng, J. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.861714 · Cited by 72

A simple protocol for isolating mouse lung endothelial cells

Wang, J., Niu, N., Xu, S., & Jin, Z. G. (2019) · Scientific Reports · doi:10.1038/s41598-018-37130-4 · Cited by 68

Metformin regulates inflammation and fibrosis in diabetic kidney disease through TNC/TLR4/NF-κB/miR-155-5p inflammatory loop

Zhou, Y., Ma, X., Han, J., Yang, M. H., Lv, C., Shao, Y., Wang, Y., Kang, J.-Y., & Wang, Q. (2021) · World Journal of Diabetes · doi:10.4239/wjd.v12.i1.19 · Cited by 65

Metformin Alleviates LPS-Induced Acute Lung Injury by Regulating the SIRT1/NF-κB/NLRP3 Pathway and Inhibiting Endothelial Cell Pyroptosis

Zhang, Y., Zhang, H., Li, S., Huang, K., Jiang, L., & Wang, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.801337 · Cited by 65

Metformin as a Potential Agent in the Treatment of Multiple Sclerosis

Dziedzic, A., Saluk, J., Miller, E. D., & Bijak, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175957 · Cited by 62

Metformin: A Dual-Role Player in Cancer Treatment and Prevention

Galal, M. A., Al-Rimawi, M., Hajeer, A., Dahman, H., Alouch, S. S., & Aljada, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074083 · Cited by 73

Metformin and Vascular Diseases: A Focused Review on Smooth Muscle Cell Function

Deng, M., Su, D., Xu, S., Little, P. J., Feng, X., Tang, L., & Shen, A. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00635 · Cited by 58

Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation

Kuchler, T., Günthner, R., Ribeiro, A., Hausinger, R. I., Streese, L., Wöhnl, A., Kesseler, V., Negele, J., Assali, T., Carbajo-Lozoya, J., et al. (2023) · Angiogenesis · doi:10.1007/s10456-023-09885-6 · Cited by 60

Endothelial Dysfunction and Cardiovascular Risk in Obstructive Sleep Apnea: A Review Article

Peracaula, M., Torres, D., Poyatos, P., Luque, N., Rojas, E., Legarés, A. O., Orriols, R., & Tura-Ceide, O. (2022) · Life · doi:10.3390/life12040537 · Cited by 58

Metformin decreases bacterial trimethylamine production and trimethylamine N-oxide levels in db/db mice

Kuka, J., Ozola, M., Makrecka‐Kuka, M., Liepinsh, E., Grīnberga, S., Sevostjanovs, E., Vilks, K., Liepinsh, E., & Dambrova, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-71470-4 · Cited by 54

Targeting mitochondrial fitness as a strategy for healthy vascular aging

Rossman, M. J., Gioscia‐Ryan, R. A., Clayton, Z. S., Murphy, M. P., & Seals, D. R. (2020) · Clinical Science · doi:10.1042/cs20190559 · Cited by 51

Why the endothelium? The endothelium as a target to reduce diabetes-associated vascular disease

Triggle, C. R., Ding, H., Marei, I., Anderson, T. J., & Hollenberg, M. D. (2020) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2019-0677 · Cited by 49

Cardiovascular effects of non-insulin glucose-lowering agents: a comprehensive review of trial evidence and potential cardioprotective mechanisms

Savarese, G., Butler, J., Lund, L. H., Bhatt, D. L., & Anker, S. D. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab271 · Cited by 45

Targeting oxidative stress in preeclampsia

Afrose, D., Alfonso-Sánchez, S., & McClements, L. (2024) · Hypertension in Pregnancy · doi:10.1080/10641955.2024.2445556 · Cited by 45

Utility of the cold pressor test to predict future cardiovascular events

Pouwels, S., van Genderen, M. E., Kreeftenberg, H. G., Ribeiro, R. J. D. S., Parmar, C. D., Topal, B., Çelik, A., & Ugale, S. M. (2019) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2019.1598262 · Cited by 39

Metabolic adaptations of cells at the vascular-immune interface during atherosclerosis

Bonacina, F., Dalt, L. D., Catapano, A. L., & Norata, G. D. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100918 · Cited by 37

Enhancing immunity during ageing by targeting interactions within the tissue environment

Bracken, O. V., Maeyer, R. P. H. D., & Akbar, A. N. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01126-9 · Cited by 43

Sirtuins family as a target in endothelial cell dysfunction: implications for vascular ageing

Zhang, H., Dai, Y., Zhang, C., Alfred, M. O., Ghosh, A., Khanra, I., Chakraborty, M., Yu, X., & Liang, J. L. (2020) · Biogerontology · doi:10.1007/s10522-020-09873-z · Cited by 35

Endothelial dysfunction in the kidney transplant population: Current evidence and management strategies

Prabhahar, A., Batta, A., Hatwal, J., Kumar, V., Ramachandran, R., & Batta, A. (2025) · World journal of transplantation · doi:10.5500/wjt.v15.i1.97458 · Cited by 33

Metformin in Antiviral Therapy: Evidence and Perspectives

Halabitska, I., Petakh, P., Lushchak, O. V., Kamyshna, I. I., Oksenych, V., & Kamyshnyi, O. (2024) · Viruses · doi:10.3390/v16121938 · Cited by 37

Metformin Protects against Diabetic Cardiomyopathy: An Association between Desmin–Sarcomere Injury and the iNOS/mTOR/TIMP-1 Fibrosis Axis

Dawood, A. F., AlZamil, N. M., Hewett, P. W., Momenah, M. A., Dallak, M. A., Kamar, S. S., Kader, D. H. A., Yassin, H. Z., Haidara, M. A., Maarouf, A., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10050984 · Cited by 34

Ginsenoside Rh1 Protects Human Endothelial Cells Against Lipopolysaccharide-Induced Inflammatory Injury Through Inhibiting TLR2/4-Mediated STAT3, NF-κB, and ER Stress Signaling Pathways

Jin, Y., Nguyen, T. L. L., Myung, C., & Heo, K. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120973 · Cited by 34

Minimizing Hyperglycemia-Induced Vascular Endothelial Dysfunction by Inhibiting Endothelial Sodium-Glucose Cotransporter 2 and Attenuating Oxidative Stress: Implications for Treating Individuals With Type 2 Diabetes

Venu, V. K. P., El‐Daly, M., Saifeddine, M., Hirota, S. A., Ding, H., Triggle, C. R., & Hollenberg, M. D. (2019) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2019.01.005 · Cited by 30

Effect of Metformin on Cardiac Metabolism and Longevity in Aged Female Mice

Zhu, X., Shen, W., Liu, Z., Sheng, S., Xiong, W., He, R., Zhang, X., Ma, L., & Ju, Z. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.626011 · Cited by 30

Metformin alleviates monoamine oxidase-related vascular oxidative stress and endothelial dysfunction in rats with diet-induced obesity

Ionică, L. N., Gaiţă, L., Bînă, A. M., Șoșdean, R., Lighezan, R., Sima, A. C., Malita, D. C., Cretu, O. M., Burlacu, O. N., Muntean, D. M., et al. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04194-2 · Cited by 30

A Clinical Perspective of the Multifaceted Mechanism of Metformin in Diabetes, Infections, Cognitive Dysfunction, and Cancer

Chow, E., Yang, A., Chung, C. H. L., & Chan, J. C. N. (2022) · Pharmaceuticals · doi:10.3390/ph15040442 · Cited by 30

Targeting Peptide, Fluorescent Reagent Modified Magnetic Liposomes Coated with Rapamycin Target Early Atherosclerotic Plaque and Therapy

Huang, C., Huang, W., Zhang, L., Zhang, C., Zhou, C., Wei, W., Li, Y., Zhou, Q., Chen, W., & Tang, Y. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14051083 · Cited by 32

An investigation into the pleiotropic activity of metformin. A glimpse of haemostasis

Markowicz-Piasecka, M., Sadkowska, A., Huttunen, K. M., Podsiedlik, M., Mikiciuk‐Olasik, E., & Sikora, J. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.172984 · Cited by 31

Metformin Prevents Hyperglycemia-Associated, Oxidative Stress-Induced Vascular Endothelial Dysfunction: Essential Role for the Orphan Nuclear Receptor Human Nuclear Receptor 4A1 (Nur77)

Venu, V. K. P., Saifeddine, M., Mihara, K., Faiza, M., Gorobets, E., Flewelling, A. J., Derksen, D. J., Hirota, S. A., Marei, I., Al-Majid, D., et al. (2021) · Molecular Pharmacology · doi:10.1124/molpharm.120.000148 · Cited by 30

Renal Delivery of Pharmacologic Agents During Machine Perfusion to Prevent Ischaemia-Reperfusion Injury: From Murine Model to Clinical Trials

Franzin, R., Stasi, A., Fiorentino, M., Simone, S., Oberbauer, R. W., Castellano, G., & Gesualdo, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.673562 · Cited by 28

The Hormetic Effect of Metformin: “Less Is More”?

Panfoli, I., Puddu, A., Bertola, N., Ravera, S., & Maggi, D. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126297 · Cited by 29

Metformin-mediated epigenetic modifications in diabetes and associated conditions: Biological and clinical relevance

Giordo, R., Posadino, A. M., Mangoni, A. A., & Pintus, G. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115732 · Cited by 28

Salvianolic Acid B Attenuates Apoptosis of HUVEC Cells Treated with High Glucose or High Fat via Sirt1 Activation

Zhai, J., Tao, L., Zhang, Y., Gao, H., Qu, X., Song, Y., & Zhang, S. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/9846325 · Cited by 26

Metformin Reverses Hashimoto's Thyroiditis by Regulating Key Immune Events

Jia, X., Zhai, T., Qu, C., Ye, J., Zhao, J., Liu, X., Zhang, J., & Qian, Q. (2021) · Frontiers in Cell and Developmental Biology · doi:10.2139/ssrn.3782444 · Cited by 26

Endothelial Autophagy Dysregulation in Diabetes

Salemkour, Y., & Lenoir, O. (2023) · Cells · doi:10.3390/cells12060947 · Cited by 28

The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome

Javed, Z., Papageorgiou, M., Madden, L. A., Rigby, A. S., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (2020) · Endocrine Connections · doi:10.1530/ec-20-0173 · Cited by 24

Endothelial dysfunction. Do we understand this term properly?

Vlasov, T. D., Petrischev, N. N., & Lazovskaya, O. A. (2020) · Messenger of Anesthesiology and Resuscitation · doi:10.21292/2078-5658-2020-17-2-76-84 · Cited by 24

Metformin Preconditioning and Postconditioning to Reduce Ischemia Reperfusion Injury in an Isolated Ex Vivo Rat and Porcine Kidney Normothermic Machine Perfusion Model

Huijink, T. M., Venema, L. H., Posma, R. A., de Vries, N. J., Westerkamp, A. C., Ottens, P. J., Touw, D. J., Nijsten, M. W., & Leuvenink, H. G. D. (2020) · Clinical and Translational Science · doi:10.1111/cts.12846 · Cited by 26

Repurposing Metformin for Vascular Disease

Triggle, C. R., Marei, I., Ye, K., Ding, H., Anderson, T. J., Hollenberg, M. D., & Hill, M. A. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220729154615 · Cited by 22

Metformin protects against vascular calcification through the selective degradation of Runx2 by the p62 autophagy receptor

Phadwal, K., Koo, E., Jones, R. A., Forsythe, R. O., Tang, K., Tang, Q., CORCORAN, B. M., Caporali, A., & MacRae, V. E. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30887 · Cited by 24

Combination of hyperglycaemia and hyperlipidaemia induces endothelial dysfunction: Role of the endothelin and nitric oxide systems

Abu‐Saleh, N., Yaseen, H., Kinaneh, S., Khamaisi, M., & Abassi, Z. A. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15787 · Cited by 20

Endothelial Dysfunction in Patients Undergoing Cardiac Surgery: A Narrative Review and Clinical Implications

Knežević, D., Ćurko‐Cofek, B., Batinac, T., Laškarin, G., Rakić, M., Šoštarič, M., Zdravković, M., Šustić, A., Tokmadžić, V. S., & Batičić, L. (2023) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd10050213 · Cited by 19

The association between chronic stress, hair cortisol, and angiographically documented coronary atherosclerosis, a case-control study

Nafisa, A., Wattoo, F. H., Qayyum, M., & Gulfraz, M. (2021) · Stress · doi:10.1080/10253890.2021.1985994 · Cited by 18

Association of Preadmission Metformin Use and Prognosis in Patients With Sepsis and Diabetes Mellitus: A Systematic Review and Meta-Analysis

Li, Y., Zhao, H., Guo, Y., Duan, Y., Guo, Y., & Ding, X. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.811776 · Cited by 18

Influence of metformin on hyperandrogenism in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials

Fontes, A. F. D. S., dos Reis, F. M., Cândido, A. L., Gomes, K. B., & Tosatti, J. A. G. (2023) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-023-03461-z · Cited by 16

Exploring the clinical connections between epilepsy and diabetes mellitus: Promising therapeutic strategies utilizing agmatine and metformin

Nangia, A., Saravanan, J. S., Hazra, S., Priya, V., Sudesh, R., Rana, S. S., & Ahmad, F. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03295-1 · Cited by 14

Evaluating oxidative stress targeting treatments in in vitro models of placental stress relevant to preeclampsia

Afrose, D., Johansen, M. D., Nikolic, V. N., Orlić, N. K., Miković, Ž., Stefanović, M., Cakic, Z., Hansbro, P. M., & McClements, L. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1539496 · Cited by 14

Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery

Kršek, A., Batičić, L., Ćurko‐Cofek, B., Batinac, T., Laškarin, G., Gršković, S. M., & Tokmadžić, V. S. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46050236 · Cited by 13

The potential therapeutic value of the natural plant compounds matrine and oxymatrine in cardiovascular diseases

Chen, S., WU, S. M., & Lin, B. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1417672 · Cited by 14

Common Pathological Mechanisms and Risk Factors for Alzheimer’s Disease and Type-2 Diabetes: Focus on Inflammation

Moyse, E., Haddad, M., Benlabiod, C., Ramassamy, C., & Krantic, S. M. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666191106094356 · Cited by 14

Metformin modulates microbiota and improves blood pressure and cardiac remodeling in a rat model of hypertension

Wimmer, M. I., Bartolomaeus, H., Anandakumar, H., Chen, C., Vecera, V., Kedziora, S. M., Kamboj, S., Schumacher, F., Pals, S., Rauch, A., et al. (2024) · Acta Physiologica · doi:10.1111/apha.14226 · Cited by 12

Association of Metformin Use With Risk of Venous Thromboembolism in Adults With Type 2 Diabetes: A General-Population–Based Cohort Study

Sha, T., Zhang, Y., Li, C., Lei, G., Wu, J., Li, X., Yang, Z., Zeng, C., & Wei, J. (2021) · American Journal of Epidemiology · doi:10.1093/aje/kwab291 · Cited by 12

Mechanistic insights into the regression of atherosclerotic plaques

Song, J., Cao, C., Wang, Z., Li, H., Yang, L., Kang, J., Meng, H., Li, L., & Liu, J. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1473709 · Cited by 12

A Brief Overview of lncRNAs in Endothelial Dysfunction-Associated Diseases: From Discovery to Characterization

Islam, R., & Lai, C. W. K. (2019) · Epigenomes · doi:10.3390/epigenomes3030020 · Cited by 9

Metformin effect on internal carotid artery blood flow assessed by area under the curve of carotid artery Doppler in women with polycystic ovarian syndrome

Akram, W., Nori, W., & Zghair, M. A. G. (2023) · World Journal of Clinical Cases · doi:10.12998/wjcc.v11.i6.1318 · Cited by 9

Panduratin A Inhibits TNF Alpha-Stimulated Endothelial Cell Activation Through Suppressing the NF-κB Pathway

Kiatsoonthon, K., Phimthong, N., Potikanond, S., Wikan, N., & Nimlamool, W. (2024) · Biomolecules · doi:10.3390/biom15010034 · Cited by 15

The Role of Polymorphism in the Endothelial Homeostasis and Vitamin D Metabolism Genes in the Severity of Coronary Artery Disease

Ponasenko, A. V., Sinitskaya, А. V., Sinitsky, M. Y., Khutornaya, M. V., & Барбараш, О. Л. (2023) · Biomedicines · doi:10.3390/biomedicines11092382 · Cited by 9

Impact of currently used anti-diabetic drugs on myoendothelial communication

Ding, H., Ye, K., & Triggle, C. R. (2018) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2018.11.002 · Cited by 9

Novel Targets of Metformin in Cardioprotection: Beyond the Effects Mediated by AMPK

Bolívar, S., Noriega, L., Ortega, S., Osorio-Llanes, E., Rosales, W., Sánchez, X. M., & Mendoza‐Torres, E. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200509232610 · Cited by 7

Effects of Drugs, Phytoestrogens, Nutrients and Probiotics on Endothelial Dysfunction in the Estrogen-Deficient State

Oliveira, P. W. C., Couto, M. R., de Sousa, G. J., Peixoto, P., Moraes, F. S. A., de Andrade, T. U., & Bissoli, N. S. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200331084338 · Cited by 8

LONG-TERM COVID-19 EFFECT TO ENDOTHELIAL DAMAGE TROUGH EXTRINSIC APOPTOSIS LED TO CARDIOVASCULAR DISEASE PROGRESSION: AN UPDATE REVIEW

Justyn, M., Yulianti, T., & Wilar, G. (2023) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2023v15i6.48889 · Cited by 6

Effect of Saxagliptin on Endothelial Function in Patients with Type 2 Diabetes: A Prospective Multicenter Study

Kajikawa, M., Maruhashi, T., Hidaka, T., Matsui, S., Hashimoto, H., Takaeko, Y., Nakano, Y., Kurisu, S., Kihara, Y., Yusoff, F. M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-46726-3 · Cited by 6

Causal role of endothelial dysfunction in ischemic stroke and its subtypes: A two-stage analysis

Wu, Q., Cui, J., Jiang, Y., Li, X., & You, C. (2025) · SLAS TECHNOLOGY · doi:10.1016/j.slast.2025.100322 · Cited by 5

Endothelial function in obesity and effects of bariatric and metabolic surgery

Sanches, E. E., Topal, B., Proczko, M., Stepaniak, P. S., Severin, R. S., Phillips, S. A., Sabbahi, A., Pujol‐Rafols, J., & Pouwels, S. (2020) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2020.1767594 · Cited by 5

SWATH-proteomics reveals Mathurameha, a traditional anti-diabetic herbal formula, attenuates high glucose-induced endothelial dysfunction through the EGF/NO/IL-1β regulatory axis

Aluksanasuwan, S., Somsuan, K., Chiangjong, W., Rongjumnong, A., Jaidee, W., Rujanapun, N., Chutipongtanate, S., Laphookhieo, S., & Charoensup, R. (2024) · Journal of Proteomics · doi:10.1016/j.jprot.2024.105263 · Cited by 5

Myo-Inositol Enhances the Inhibitory Effect of Metformin on Gonadotropin Levels in Postmenopausal Women

Krysiak, R. G., Kowalcze, K. E., & Okopień, B. (2022) · Gynecologic and Obstetric Investigation · doi:10.1159/000527365 · Cited by 4

Cardiovascular-related proteomic changes in ECFCs exposed to the serum of COVID-19 patients

Beltrán-Camacho, L., Bhosale, S. D., Morillo, D., Sánchez-Gomar, I., Rojas-Torres, M., Eslava-Alcón, S., Martínez-Torija, M., de Infante, M. A. R., Nieto‐Martín, M. D., Rodríguez‐Iglesias, M., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.78864 · Cited by 5

Investigation of the Dysfunction Caused by High Glucose, Advanced Glycation End Products, and Interleukin‐1 Beta and the Effects of Therapeutic Agents on the Microphysiological Artery Model

Nam, U., Kim, J., Yi, H., & Jeon, J. S. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202302682 · Cited by 4

Endothelial Protein Changes Indicative of Endometriosis in Unexplained Infertility, an Exploratory Study

Malik, H., Zamouri, S., Akkawi, S., Mehra, S., Mouaki, R., Sathyapalan, T., Nandakumar, M., Butler, A. E., & Atkin, S. L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136485 · Cited by 4

Obesity induces extracellular vesicle release from the endothelium as a contributor to brain damage after cerebral ischemia in rats

Perez-Corredor, P. A., Oluwatomilayo-Ojo, P., Vargas, J. A. G., & Cardona‐Gómez, G. P. (2022) · Nutritional Neuroscience · doi:10.1080/1028415x.2022.2078173 · Cited by 4

Gastrodin protects endothelial cells against high glucose-induced injury through up-regulation of PPARβ and alleviation of nitrative stress

Yang, C., Qiu, H., Lv, M., Yang, J., Wu, K., Huang, J., & Jiang, Q. (2023) · Microvascular Research · doi:10.1016/j.mvr.2023.104531 · Cited by 4

A Perspective on the Role of Metformin in Treating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID

Fineberg, D., Moreau, A., Schneider‐Futschik, E. K., & Armstrong, C. W. (2025) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.5c00229 · Cited by 3

Angiotensin II Exposure In Vitro Reduces High Salt-Induced Reactive Oxygen Species Production and Modulates Cell Adhesion Molecules’ Expression in Human Aortic Endothelial Cell Line

Kolobarić, N., Kozina, N., Mihaljević, Z., & Drenjančević, I. (2024) · Biomedicines · doi:10.3390/biomedicines12122741 · Cited by 3

Metformin – régi motoros erősebb motorral

Winkler, G. (2022) · Diabetologia Hungarica · doi:10.24121/dh.2022.24 · Cited by 2

Poor glycemic control impairs the cardioprotective effects of red blood cells on myocardial ischemia/reperfusion injury

Muessig, J. M., Moellhoff, L., Noelle, J., Kaya, S., Pareja, L. H., Masyuk, M., Roden, M., Kelm, M., & Jung, C. (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.01.008 · Cited by 3

The cardiometabolic benefits of curcumin: a focus on endothelial dysfunction and arterial stiffness in metabolic syndrome

Dimeji, I. Y., Jabba, H. L., Adeoye, S. W., Audu, N. M., Baba, Z. M., Ayodeji, A. S., & Samson, A. O. (2025) · Clinical Phytoscience · doi:10.1186/s40816-025-00404-2 · Cited by 2

The impact of perindopril and metformin on the markers of endothelial dysfunction in rats with acute intracerebral hemorrhage and type 2 diabetes mellitus

Zhylіuk, V. I., Лєвих, А. Е., Шевцова, А. И., Ткаченко, В. А., & Kharchenko, Y. (2021) · Medicni perspektivi · doi:10.26641/2307-0404.2021.4.248055 · Cited by 2

Metformin in COVID-19: a magical role beyond the hyperglycemia

Chaubey, G. K., Dilawari, R., Modanwal, R., Talukdar, S., Dhiman, A., & Raje, M. (2024) · Exploration of Drug Science · doi:10.37349/eds.2024.00055 · Cited by 2

Insulin Resistance as a Therapeutic Target for Improved Endothelial Function:Metformin

Brame, L. A., Verma, S., Anderson, T. J., Lteif, A. A., & Mather, K. J. (2004) · Cardiovascular & Haematological Disorders - Drug Targets · doi:10.2174/1568006043481275 · Cited by 15

Metformin in cardiovascular diabetology: a focused review of its impact on endothelial function

Ding, Y., Zhou, Y., Ling, P., Feng, X., Luo, S., Zheng, X., Little, P. J., Xu, S., & Weng, J. (2021) · Theranostics · doi:10.7150/thno.64706 · Cited by 121

Can Metformin Exert as an Active Drug on Endothelial Dysfunction in Diabetic Subjects

Salvatore, T., Pafundi, P. C., Galiero, R., Rinaldi, L., Caturano, A., Vetrano, E., Aprea, C., Albanese, G., Di Martino, A., Ricozzi, C., et al. (2020) · Biomedicines · doi:10.3390/biomedicines9010003 · Cited by 97

Pathogenetic basis of treating endothelial dysfunction with metformin in patients with diabetes (literature review and own data)

Sokolova, A. M., PUSHKAREV, V. V., SOKOLOVA, L. K., Pushkarev, V. M., & Tronko, M. D. (2024) · INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) · doi:10.22141/2224-0721.20.3.2024.1391

Suppressing endothelial senescence: A comprehensive analysis of metformin's mechanisms and implications

Shang, D., zhang, X., Liu, H., & Tu, Z. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123730 · Cited by 5