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Endothelial function and dysfunction: Impact of metformin
Abstract
Cardiovascular and metabolic diseases remain the leading cause of morbidity and mortality worldwide. Endothelial dysfunction is a key player in the initiation and progression of cardiovascular and metabolic diseases. Current evidence suggests that the anti-diabetic drug metformin improves insulin resistance and protects against endothelial dysfunction in the vasculature. Hereby, we provide a timely review on the protective effects and molecular mechanisms of metformin in preventing endothelial dysfunction and cardiovascular and metabolic diseases.
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“Based on evidence from both clinical and pre-clinical studies metformin, independent of its anti-hyperglycemic actions, directly protects the endothelium (33–35).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [33]
In the citing paper
“There is an extensive literature based on data from pre-clinical and clinical studies that indicates metformin protects endothelial function from the effects of diabetes (33).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [33]
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Cites
1 retracted
Wang, S., Xu, J. C., Song, P., Viollet, B., & Zou, M. (2009) · Diabetes · doi:10.2337/db09-0267 · Cited by 137
RetractedHeart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064
A novel potent vasoconstrictor peptide produced by vascular endothelial cells
Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y. I., Kobayashi, M., Mitsui, Y., Yazaki, Y., Goto, K., & Masaki, T. (1988) · Nature · doi:10.1038/332411a0 · Cited by 10,716
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724
Heart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., Das, S. R., de Ferranti, S., Després, J.-P., Fullerton, H. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000350 · Cited by 6,596
HEART DISEASE AND STROKE STATISTICS–2014 UPDATE: A REPORT FROM THE AMERICAN HEART ASSOCIATION
Tarver, T. (2014) · Journal of Consumer Health on the Internet · doi:10.1080/15398285.2014.902284 · Cited by 5,595
Oxidative stress and diabetic complications
Giacco, F., & Brownlee, M. (2010) · Circulation Research · doi:10.1161/circresaha.110.223545 · Cited by 5,461
The Pathobiology of Diabetic Complications
Brownlee, M. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1615 · Cited by 5,339
Mitochondrial formation of reactive oxygen species
Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074
The Pathogenesis of Atherosclerosis — An Update
Ross, R. (1986) · New England Journal of Medicine · doi:10.1056/nejm198602203140806 · Cited by 4,885
Vascular endothelial cells synthesize nitric oxide from L-arginine
Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,786
Adipokines in inflammation and metabolic disease
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625
Progress and challenges in translating the biology of atherosclerosis
Libby, P., Ridker, P. M., & Hansson, G. K. (2011) · Nature · doi:10.1038/nature10146 · Cited by 4,010
Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress
Cai, H., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.87.10.840 · Cited by 3,839
Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis
Gimbrone, M. A., & García‐Cardeña, G. (2016) · Circulation Research · doi:10.1161/circresaha.115.306301 · Cited by 3,694
Moncada, S., Gryglewski, R. J., Bunting, S., & Vane, J. R. (1976) · Nature · doi:10.1038/263663a0 · Cited by 3,593
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., & Zeiher, A. M. (1999) · Nature · doi:10.1038/21224 · Cited by 3,591
Role of Endothelial Dysfunction in Atherosclerosis
Davignon, J., & Ganz, P. (2004) · Circulation · doi:10.1161/01.cir.0000131515.03336.f8 · Cited by 2,513
Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280
Four faces of cellular senescence
Rodier, F., & Campisi, J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009094 · Cited by 2,070
The clinical implications of endothelial dysfunction
Widlansky, M. E., Gokce, N., Keaney, J. F., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00994-x · Cited by 1,749
Bailey, C. J., & Turner, R. C. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602293340906 · Cited by 1,726
Creager, M. A., Lüscher, T. F., of, P. W. T. A., Cosentino, F., & Beckman, J. A. (2003) · Circulation · doi:10.1161/01.cir.0000091257.27563.32 · Cited by 1,675
Kim, J.-A., Montagnani, M., Koh, K. K., & Quon, M. J. (2006) · Circulation · doi:10.1161/circulationaha.105.563213 · Cited by 1,652
Oxidative Stress and Vascular Disease
Madamanchi, N. R., Vendrov, A., & Runge, M. S. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000150649.39934.13 · Cited by 1,618
Stamler, J. S., Simon, D. I., Osborne, J. A., Mullins, M. E., Jaraki, O., Michel, T. M., Singel, D. J., & Loscalzo, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.444 · Cited by 1,471
Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I
Paneni, F., Beckman, J. A., Creager, M. A., & Cosentino, F. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht149 · Cited by 1,455
Risk Factors Contributing to Type 2 Diabetes and Recent Advances in the Treatment and Prevention
Wu, Y., Ding, Y., Tanaka, Y., & Zhang, W. (2014) · International Journal of Medical Sciences · doi:10.7150/ijms.10001 · Cited by 1,420
Adipose tissue dysfunction in obesity, diabetes, and vascular diseases
Hajer, G. R., van Haeften, T. W., & Visseren, F. L. J. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn387 · Cited by 1,410
Tabas, I., Williams, K. J., & Borén, J. (2007) · Circulation · doi:10.1161/circulationaha.106.676890 · Cited by 1,399
The pathogenesis of atherosclerosis
(1972) · American Heart Journal · doi:10.1016/0002-8703(72)90090-7 · Cited by 1,329
Smoking and Cardiovascular Disease
Meßner, B., & Bernhard, D. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.300156 · Cited by 1,215
Endemann, D. H., & Schiffrin, E. L. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000132474.50966.da · Cited by 1,198
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus
Stumvoll, M., Nurjhan, N., Perriello, G., Dailey, G., & Gerich, J. E. (1995) · New England Journal of Medicine · doi:10.1056/nejm199508313330903 · Cited by 1,148
Inflammation and cardiovascular disease mechanisms
Libby, P. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.456s · Cited by 1,114
Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE
Wautier, M., Chappey, O., Corda, S., Stern, D. M., Schmidt, A. M., & Wautier, J. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.5.e685 · Cited by 1,088
Endothelial Cell Senescence in Human Atherosclerosis: Role of Telomere in Endothelial Dysfunction
Minamino, T., Miyauchi, H., Yoshida, T., Ishida, Y., Yoshida, H., & Komuro, I. (2002) · Circulation · doi:10.1161/01.cir.0000013836.85741.17 · Cited by 1,061
Wang (2012) · doi:10.1161/circresaha.111.261388 · Cited by 957
Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP
Rapoport, R. M., & Murad, F. (1983) · Circulation Research · doi:10.1161/01.res.52.3.352 · Cited by 928
Du, X. L., Edelstein, D., Dimmeler, S., Ju, Q., Sui, C., & Brownlee, M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11235 · Cited by 907
Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets
Drummond, G. R., Selemidis, S., Griendling, K. K., & Sobey, C. G. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3403 · Cited by 899
How leukocytes cross the vascular endothelium
Vestweber, D. (2015) · Nature Reviews Immunology · doi:10.1038/nri3908 · Cited by 858
Du, X., Matsumura, T., Edelstein, D., Rossetti, L., Zsengellér, Z. K., Szabó, C., & Brownlee, M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18127 · Cited by 843
Endothelial dysfunction — A major mediator of diabetic vascular disease
Sena, C. M., Pereira, A. M., & Seiça, R. M. F. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.08.006 · Cited by 819
Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture)
Félétou, M., & Vanhoutte, P. M. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00292.2006 · Cited by 818
Activation of Receptor for Advanced Glycation End Products
Schmidt, A. M., Yan, S. D., Wautier, J., & Stern, D. M. (1999) · Circulation Research · doi:10.1161/01.res.84.5.489 · Cited by 799
Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System
Lassegue, B. P., Martín, A. S., & Griendling, K. K. (2012) · Circulation Research · doi:10.1161/circresaha.111.243972 · Cited by 780
Novel Clinical Markers of Vascular Wall Inflammation
Blake, G. J., & Ridker, P. M. (2001) · Circulation Research · doi:10.1161/hh2101.099270 · Cited by 756
Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism
Ježek, P., & Plecitá‐Hlavatá, L. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.05.013 · Cited by 753
Nishida, K., Harrison, D. G., Navas, J. P., Fisher, A. A., Dockery, S., Uematsu, M., Nerem, R. M., Alexander, R. W., & Murphy, T. J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116092 · Cited by 735
Jiang, Z. Y., Lin, Y.-W., Clemont, A., Feener, E. P., Hein, K. D., Igarashi, M., Yamauchi, T., White, M. F., & King, G. L. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5971 · Cited by 604
Role of insulin resistance in endothelial dysfunction
Muniyappa, R., & Sowers, J. R. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-012-9229-1 · Cited by 539
Endothelial Dysfunction as a Target for Prevention of Cardiovascular Disease
Versari, D., Daghini, E., Virdis, A., Ghiadoni, L., & Taddei, S. (2009) · Diabetes Care · doi:10.2337/dc09-s330 · Cited by 520
Improved Endothelial Function With Metformin in Type 2 Diabetes Mellitus
Mather, K. J., Verma, S., & Anderson, T. J. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01129-9 · Cited by 513
Endothelial dysfunction: a comprehensive appraisal.
Esper, R. J., Nordaby, R. A., Vilariño, J. O., Paragano, A. J., Cacharrón, J. L., & Machado, R. A. (2006) · Cardiovascular Diabetology · doi:10.1186/1475-2840-5-4 · Cited by 508
Metformin Inhibits Proinflammatory Responses and Nuclear Factor-κB in Human Vascular Wall Cells
Isoda, K., Young, J. L., Zirlik, A., MacFarlane, L. A., Tsuboi, N., Gerdes, N., Schönbeck, U., & Libby, P. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000201938.78044.75 · Cited by 499
Metformin pathways: pharmacokinetics and pharmacodynamics
Gong, L., Goswami, S., Giacomini, K. M., Altman, R. B., & Klein, T. E. (2012) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e3283559b22 · Cited by 495
Endothelium-Derived Hyperpolarizing Factor
Félétou, M., & Vanhoutte, P. M. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000217611.81085.c5 · Cited by 489
Hattori, Y., Suzuki, K., Hattori, S., & Kasai, K. (2006) · Hypertension · doi:10.1161/01.hyp.0000221429.94591.72 · Cited by 487
Inflammatory networks in ageing, age-related diseases and longevity
Vasto, S., Candore, G., Balistreri, C. R., Caruso, M., Colonna‐Romano, G., Grimaldi, M. P., Listı̀, F., Nuzzo, D., Lio, D., & Caruso, C. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.015 · Cited by 481
Davis, B. J., Xie, Z., Viollet, B., & Zou, M. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-1064 · Cited by 465
Yu, T., Sheu, S.-S., Robotham, J. L., & Yoon, Y. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn104 · Cited by 462
Cornwell, T. L., Arnold, E., Boerth, N. J., & Lincoln, T. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.267.5.c1405 · Cited by 455
Metformin Action: Concentrations Matter
He, L., & Wondisford, F. E. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.01.003 · Cited by 448
Role of free fatty acids in endothelial dysfunction
Ghosh, A., Gao, L., Thakur, A., Siu, P. M., & Lai, C. W. K. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0357-5 · Cited by 432
Accumulation of Metformin by Tissues of the Normal and Diabetic Mouse
Wilcock, C., & Bailey, C. J. (1994) · Xenobiotica · doi:10.3109/00498259409043220 · Cited by 418
Vascular endothelial senescence: from mechanisms to pathophysiology
Erusalimsky, J. D. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91353.2008 · Cited by 399
The role of endothelial glycocalyx components in mechanotransduction of fluid shear stress
Pahakis, M. Y., Kosky, J. R., Dull, R. O., & Tarbell, J. M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.137 · Cited by 391
Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus
van den Oever, I. A., Raterman, H. G., Nurmohamed, M. T., & Şimşek, S. (2010) · Mediators of Inflammation · doi:10.1155/2010/792393 · Cited by 378
Homocysteine-Induced Endothelial Dysfunction
Lai, W. K. C., & Kan, M. Y. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000437098 · Cited by 368
Insulin signal transduction through protein kinase cascades
Avruch, J. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006823109415 · Cited by 365
Aging Enhances the Sensitivity of Endothelial Cells Toward Apoptotic Stimuli
Hoffmann, J., Haendeler, J., Aicher, A., Rössig, L., Vasa‐Nicotera, M., Zeiher, A. M., & Dimmeler, S. (2001) · Circulation Research · doi:10.1161/hh2001.097796 · Cited by 360
Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity
Bakker, W., Eringa, E. C., Sipkema, P., & van Hinsbergh, V. W. M. (2008) · Cell and Tissue Research · doi:10.1007/s00441-008-0685-6 · Cited by 359
Petrie, J. R., Chaturvedi, N., Ford, I., Brouwers, M. C. G. J., Greenlaw, N., Tillin, T., Hramiak, I., Hughes, A. D., Jenkins, A. J., Klein, B. E. K., et al. (2017) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30194-8 · Cited by 357
Ungvari, Z. I., Orosz, Z. Z., Labinskyy, N., Rivera, A., Xiangmin, Z., Smith, K. E., & Csiszár, A. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01346.2006 · Cited by 352
TNF-α-induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-XL
Kim, J. J., Lee, S. B., Park, J. K., & Yoo, Y. D. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2010.19 · Cited by 344
Nitric oxide functions as an inhibitor of platelet adhesion under flow conditions.
de Graaf, J. C., Banga, J. D., Moncada, S., Palmer, R. M. J., de Groot, P. G., & Sixma, J. J. (1992) · Circulation · doi:10.1161/01.cir.85.6.2284 · Cited by 338
Montagnani, M., Golovchenko, I., Kim, I., Koh, G. Y., Goalstone, M. L., Mundhekar, A. N., Johansen, M. L., Kucik, D. F., Quon, M. J., & Draznin, B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m103728200 · Cited by 332
Insulin Resistance and Atherosclerosis
Nigro, J., Osman, N., Dart, A. M., & Little, P. J. (2006) · Endocrine Reviews · doi:10.1210/er.2005-0007 · Cited by 321
Montezano, A. C. I., & Touyz, R. M. (2011) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2011.00785.x · Cited by 320
Protein kinase C and the development of diabetic vascular complications
Way, K. J., Katai, N., & King, G. L. (2001) · Diabetic Medicine · doi:10.1046/j.0742-3071.2001.00638.x · Cited by 313
Rask‐Madsen, C., Li, Q., Freund, B., Feather, D., Abramov, R., Wu, I., Chen, K., Hiraoka‐Yamamoto, J., Goldenbogen, J., Sotiropoulos, K. B., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.013 · Cited by 313
Salpeter, S. R., Greyber, E., Pasternak, G. A., & Salpeter, E. E. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.21.2594 · Cited by 312
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers
Xu, S., Ogura, S., Chen, J., Little, P. J., Moss, J., & Liu, P. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1194-z · Cited by 300
Cellular signaling and NO production
Michel, T. M., & Vanhoutte, P. M. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0765-9 · Cited by 296
Williams, B., Gallacher, B., Patel, H., & Orme, C. (1997) · Diabetes · doi:10.2337/diab.46.9.1497 · Cited by 294
Quehenberger, P., Bierhaus, A., Fasching, P., Muellner, C., Klevesath, M. S., Hong, M., Stier, G., Sattler, M., Schleicher, E., Speiser, W., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.9.1561 · Cited by 290
NADPH oxidase and endothelial cell function
Ray, R., & Shah, A. M. (2005) · Clinical Science · doi:10.1042/cs20050067 · Cited by 280
Endothelial Dysfunction in Diabetes: From Mechanisms to Therapeutic Targets
Potenza, M., Gagliardi, S., Nacci, C., Carratu, M., & Montagnani, M. (2009) · Current Medicinal Chemistry · doi:10.2174/092986709787002853 · Cited by 280
Xie, Z., Dong, Y., Scholz, R., Neumann, D., & Zou, M.-H. (2008) · Circulation · doi:10.1161/circulationaha.107.744490 · Cited by 273
Role of endothelial dysfunction in insulin resistance
Hsueh, W. A., & Quiñones, M. J. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00611-8 · Cited by 271
Detaille, D., Guigas, B., Chauvin, C., Batandier, C., Fontaine, E., Wiernsperger, N., & Leverve, X. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2179 · Cited by 263
Christensen, M. M. H., Brasch‐Andersen, C., Gréen, H., Nielsen, F., Damkier, P., Beck‐Nielsen, H., & Brøsen, K. (2011) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e32834c0010 · Cited by 259
Ho, F. M., Lin, W., Chen, B. C., Chao, C. M., Yang, C., Lin, L., Lai, C. C., Liu, S., & Liau, C. S. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2005.05.009 · Cited by 237
Ota, H., Eto, M., Kano, M. R., Ogawa, S., Iijima, K., Akishita, M., & Ouchi, Y. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.164368 · Cited by 227
Metformin modulates hyperglycaemia‐induced endothelial senescence and apoptosis through SIRT1
Arunachalam, G., Samuel, S. M., Marei, I., Ding, H., & Triggle, C. R. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12496 · Cited by 221
Oxidative risk for atherothrombotic cardiovascular disease
Leopold, J. A., & Loscalzo, J. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.09.009 · Cited by 218
Methylglyoxal promotes oxidative stress and endothelial dysfunction
Sena, C. M., Matafome, P. N., Crisóstomo, J., Rodrigues, L., Fernandes, R., Pereira, P., & Seiça, R. M. F. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.03.004 · Cited by 212
Piconi, L., Quagliaro, L., ROS, R. D., Assaloni, R., Giugliano, D., Esposito, K., Szabó, C., & Ceriello, A. (2004) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2004.00835.x · Cited by 198
EDHF: spreading the influence of the endothelium
Garland, C. J., Hiley, C. R., & Dora, K. A. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01148.x · Cited by 195
Kruithof, E. K. O., Nicolosa, G., & Bachmann, F. (1987) · Blood · doi:10.1182/blood.v70.5.1645.1645 · Cited by 191
Gano, L. B., Donato, A. J., Pasha, H. M., Hearon, C. M., Sindler, A. L., & Seals, D. R. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00377.2014 · Cited by 190
Epigenetic effects of metformin: from molecular mechanisms to clinical implications
Bridgeman, S. C., Ellison, G. C., Melton, P. E., Newsholme, P., & Mamotte, C. D. S. (2018) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13262 · Cited by 190
Santhanam, L., Lim, H. K., Lim, H. K., Miriel, V. A., Brown, T. R., Patel, M. D., Balanson, S., Ryoo, S., Anderson, M., Irani, K., et al. (2007) · Circulation Research · doi:10.1161/circresaha.107.157727 · Cited by 188
Yu, J., Deng, Y., Han, X., Ren, G., Cai, J., & Jiang, G. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0408-3 · Cited by 188
Ding, Y., Vaziri, N. D., Coulson, R., Kamanna, V. S., & Roh, D. D. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.1.e11 · Cited by 184
Piga, R., Naito, Y., Kokura, S., Handa, O., & Yoshikawa, T. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.09.016 · Cited by 182
Cheang, W. S., Tian, X. Y., Wong, W. T., Lau, C. W., Lee, S. S. T., Chen, Z., Yao, X., Wang, N., & Huang, Y. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301938 · Cited by 180
Tabit, C. E., Shenouda, S. M., Holbrook, M., Fetterman, J. L., Kiani, S., Frame, A. A., Kluge, M. A., Held, A., Dohadwala, M. M., Gokce, N., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.127514 · Cited by 170
Yokoi, T., Fukuo, K., Yasuda, O., Hotta, M., Miyazaki, J., Takemura, Y., Kawamoto, H., Ichijo, H., & Ogihara, T. (2006) · Diabetes · doi:10.2337/db05-1607 · Cited by 169
Metformin restores endothelial function in aorta of diabetic rats
Sena, C. M., Matafome, P. N., Louro, T. M., Nunes, E., Fernandes, R., & Seiça, R. M. F. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01230.x · Cited by 168
Metformin improves endothelial function in patients with metabolic syndrome
VITALE, C., MERCURO, G., CORNOLDI, A., FINI, M., VOLTERRANI, M., & ROSANO, G. M. C. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01531.x · Cited by 164
Carbamylated low-density lipoprotein induces endothelial dysfunction
Speer, T., Owala, F. O., Holy, E. W., Zewinger, S., Frenzel, F., Stähli, B. E., Razavi, M., Triem, S., Cvija, H., Rohrer, L., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu111 · Cited by 164
Agarwal, N., Rice, S., Bolusani, H., Luzio, S. D., Dunseath, G. J., Ludgate, M., & Rees, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1985 · Cited by 162
Peng, N., Meng, N., Wang, S., Zhao, F. L., Zhao, J., Su, L., Zhang, S., Zhang, Y. L., Zhao, B., & Miao, J. (2014) · Scientific Reports · doi:10.1038/srep05519 · Cited by 161
Karnewar, S., Neeli, P. K., Panuganti, D., Kotagiri, S., Mallappa, S., Jain, N., Jerald, M. K., & Kotamraju, S. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.01.018 · Cited by 161
C-Reactive Protein Enhances LOX-1 Expression in Human Aortic Endothelial Cells
Li, L., Roumeliotis, N., Sawamura, T., & Renier, G. (2004) · Circulation Research · doi:10.1161/01.res.0000147309.54227.42 · Cited by 160
Therapeutic Concentrations of Metformin: A Systematic Review
Kajbaf, F., Broe, M. E. D., & Lalau, J. (2015) · Clinical Pharmacokinetics · doi:10.1007/s40262-015-0323-x · Cited by 160
Endothelial Cell Gene Regulation
Minami, T., & Aird, W. C. (2005) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2005.06.002 · Cited by 147
Endothelium-Derived Hyperpolarizing Factor
Komori, K., & Vanhoutte, P. M. (2008) · Blood Vessels · doi:10.1159/000158815 · Cited by 146
Paradoxic effects of metformin on endothelial cells and angiogenesis
Dallaglio, K., Bruno, A., Cantelmo, A. R., Esposito, A. I., Ruggiero, L., Orecchioni, S., Calleri, A., Bertolini, F., Pfeffer, U., Noonan, D. M., et al. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu001 · Cited by 146
Huijberts, M. S., Wolffenbuttel, B. H. R., Struijker-Boudier, H. A. J., Crijns, F. R. L., Kruseman, A. C. N., Poitevin, P., & Levy, B. I. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116716 · Cited by 140
EDHF: new therapeutic targets?
Félétou, M. (2004) · Pharmacological Research · doi:10.1016/j.phrs.2003.10.017 · Cited by 136
DeFronzo, R. A., Buse, J. B., Kim, T., Burns, C. M., Skare, S., Baron, A., & Fineman, M. S. (2016) · Diabetologia · doi:10.1007/s00125-016-3992-6 · Cited by 135
Vascular Endothelium and Atherosclerosis
Libby, P., Aikawa, M., & Jain, M. K. (2006) · Springer eBooks · doi:10.1007/3-540-36028-x_9 · Cited by 133
de Jager, J., Kooy, A., Schalkwijk, C., van der Kolk, J., Lehert, P., Bets, D., Wulffelé, M. G., Donker, A. J., & Stehouwer, C. D. A. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12128 · Cited by 129
OxLDL induces endothelial dysfunction and death via TRAF3IP2: Inhibition by HDL3 and AMPK activators
Valente, A. J., Irimpen, A. M., Siebenlist, U. K., & Chandrasekar, B. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.02.014 · Cited by 127
White, S. J., Hayes, E. M., Lehoux, S., Jeremy, J. Y., Horrevoets, A. J. G., & Newby, A. C. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22629 · Cited by 127
Zhang, E., Guo, Q., Gao, H., Xu, R., Teng, S., & Wu, Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143814 · Cited by 125
Atheroprotective Effects and Molecular Targets of Tanshinones Derived From Herbal Medicine Danshen
Fang, J., Little, P. J., & Xu, S. (2017) · Medicinal Research Reviews · doi:10.1002/med.21438 · Cited by 122
The STAT3-IGFBP5 axis is critical for IL-6/gp130-induced premature senescence in human fibroblasts
Kojima, H., Kunimoto, H., Inoue, T., & Nakajima, K. (2012) · Cell Cycle · doi:10.4161/cc.11.4.19172 · Cited by 120
Effects of α‐lipoic acid on endothelial function in aged diabetic and high‐fat fed rats
Sena, C. M., Nunes, E., Louro, T. M., Proença, T., Fernandes, R., Boarder, M. R., & Seiça, R. M. F. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707474 · Cited by 109
Diet diversity and gastric cancer
Vecchia, C. L., Muñoz, S. E., Braga, C., Fernández, E., & Decarli, A. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19970717)72:2 · Cited by 107
Fanelli, A., Ghisi, D., Aprile, P. L., & Lapi, F. (2017) · Therapeutic Advances in Drug Safety · doi:10.1177/2042098617690485 · Cited by 105
Effects of vildagliptin twice daily vs. sitagliptin once daily on 24-hour acute glucose fluctuations
Marfella, R., Barbieri, M., Grella, R., Rizzo, M. R., Nicoletti, G. F., & Paolisso, G. (2009) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2009.01.004 · Cited by 103
Triggle, C. R., & Ding, H. (2015) · Acta Physiologica · doi:10.1111/apha.12644 · Cited by 101
NADPH Oxidase in Endothelial Cells: Impact on Atherosclerosis
Rueckschloss, U., Duerrschmidt, N., & Morawietz, H. (2003) · Antioxidants and Redox Signaling · doi:10.1089/152308603764816532 · Cited by 100
Modulating endothelial nitric oxide synthase: a new cardiovascular therapeutic strategy
Zhang, Y., Janssens, S. P., Wingler, K., Schmidt, H. H. H. W., & Moens, A. L. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01315.2010 · Cited by 99
Chen, S., Apostolova, M. D., Cherian, M. G., & Chakrabarti, S. (2000) · Laboratory Investigation · doi:10.1038/labinvest.3780139 · Cited by 95
Hyperelongated biglycan: the surreptitious initiator of atherosclerosis
Little, P. J., Osman, N., & O’Brien, K. D. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32830dd7c4 · Cited by 92
Soccio, M., Toniato, E., Evangelista, V., Carluccio, M. A., & Caterina, R. D. (2005) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2005.01500.x · Cited by 91
Luppi, P., Cifarelli, V., Tse, H. M., Piganelli, J. D., & Trucco, M. (2008) · Diabetologia · doi:10.1007/s00125-008-1032-x · Cited by 89
Lv, Y.-C., Tang, Y., Zhang, P., Wan, W., Yao, F., He, P., Xie, W., Mo, Z., Shi, J., Wu, J., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157265 · Cited by 88
Roberge, S., Roussel, J., Andersson, D. C., Méli, A. C., Vidal, B., Blandel, F., Lanner, J. T., Guennec, J. L., Katz, A., Westerblad, H., et al. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu112 · Cited by 86
Haffner, S. M. (1997) · Diabetes Care · doi:10.2337/diacare.20.4.469 · Cited by 86
Critical effect of VEGF in the process of endothelial cell apoptosis induced by high glucose
Yang, Z., Mo, X., Gong, Q., Pan, Q., Yang, X., Cai, W., Li, C., Ma, J., He, Y.-S., & Gao, G. (2008) · APOPTOSIS · doi:10.1007/s10495-008-0257-y · Cited by 86
Targeting hydrogen sulfide as a promising therapeutic strategy for atherosclerosis
Xu, S., Liu, Z., & Liu, P. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.01.068 · Cited by 85
Role of mitochondria ROS and DNA damage in arsenic induced carcinogenesis
Yu, H. (2016) · Frontiers in Bioscience-Scholar · doi:10.2741/s465 · Cited by 82
Xu, S., Xu, Y., Yin, M., Zhang, S., Liu, P., Koroleva, M., Si, S., Little, P. J., Pelisek, J., & Jin, Z. G. (2018) · Theranostics · doi:10.7150/thno.21966 · Cited by 82
Endothelial dysfunction: causes and consequences in patients with diabetes mellitus.
Avogaro, A., Kreutzenberg, S. V. D., & Fadini, G. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.09.021 · Cited by 81
Naka, K. Κ., Kalantaridou, S., Kravariti, M., Bechlioulis, A., Kazakos, N., Calis, K. A., Makrigiannakis, A., Katsouras, C. S., Chrousos, G. P., Tsatsoulis, A. A., et al. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.06.058 · Cited by 80
Eskens, B. J. M., Zuurbier, C. J., van Haare, J., Vink, H., & van Teeffelen, J. W. G. E. (2013) · Cardiovascular Diabetology · doi:10.1186/1475-2840-12-175 · Cited by 80
Matsui‐Hirai, H., Hayashi, T., Yamamoto, S., Ina, K., Maeda, M., Kotani, H., Iguchi, A., Ignarro, L. J., & Hattori, Y. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.177584 · Cited by 79
Takata, F., Dohgu, S., Matsumoto, J., Machida, T., Kaneshima, S., Matsuo, M., Sakaguchi, S., Takeshige, Y., Yamauchi, A., & Kataoka, Y. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.03.036 · Cited by 77
Jensterle, M., Šebeštjen, M., Janež, A., Preželj, J., Kocjan, T., Keber, I., & Pfeifer, M. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0507 · Cited by 76
Little, P. J., Chait, A., & Bobik, A. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.04.001 · Cited by 73
Pitocco, D., Zaccardi, F., Tarzia, P., Milo, M., Scavone, G., Rizzo, P., Pagliaccia, F., Nerla, R., Franco, A. D., Manto, A., et al. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12041 · Cited by 73
Chistiakov, D. A., Ревин, В. В., Sobenin, I. A., Orekhov, A. N., & Bobryshev, Y. V. (2015) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557515666150226114031 · Cited by 71
Lesniewski, L. A., Durrant, J., Connell, M., Folian, B. J., Donato, A. J., & Seals, D. R. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq233 · Cited by 69
Prevention and endothelial therapy of coronary artery disease
Barton, M. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.05.005 · Cited by 68
Du, J., Fan, L. M., Mai, A., & Li, J. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12336 · Cited by 67
Factors involved in the maintenance of endothelial function
Drexler, H. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00667-5 · Cited by 67
Li, Q., Atochin, D. N., Kashiwagi, S., Earle, J., Wang, A., Mandeville, E. T., Hayakawa, K., d’Uscio, L. V., Lo, E. H., Katušić, Z. S., et al. (2013) · Stroke · doi:10.1161/strokeaha.113.002073 · Cited by 65
Metformin inhibits ovarian cancer via decreasing H3K27 trimethylation
Tang, G., Guo, J., Zhu, Y., Huang, Z., Liu, T., Cai, J., Yu, L., & Wang, Z. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4343 · Cited by 65
Maeno, Y., Li, Q., Park, K., Rask‐Madsen, C., Gao, B., Matsumoto, M., Liu, Y., Wu, I., White, M. F., Feener, E. P., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.286591 · Cited by 63
Metformin versus insulin for gestational diabetes mellitus: a meta-analysis
Zhao, L., Sheng, X., Zhou, S., Yang, T., Ma, L., Zhou, Y., & Cui, Y. (2015) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12672 · Cited by 63
Rogers, S. C., Zhang, X., Azhar, G., Luo, S., & Wei, J. Y. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt033 · Cited by 62
Yang, S. N. Y., Burch, M. L., Tannock, L. R., Evanko, S. P., Osman, N., & Little, P. J. (2010) · Journal of Diabetes · doi:10.1111/j.1753-0407.2010.00089.x · Cited by 62
AMPKα2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6
Gongol, B., Marin, T., Peng, I.-C., Woo, B., Martin, M., King, S., Sun, W., Johnson, D. A., Chien, S., & Shyy, J. Y.-J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222051110 · Cited by 61
Just, A., Whitten, C. L., & Arendshorst, W. J. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00506.2007 · Cited by 59
Long-term exposure to high glucose up-regulates VCAM-induced endothelial cell adhesiveness to PBMC
Esposito, C., Fasoli, G., Plati, A., Bellotti, N., Conte, M. M., Cornacchia, F., Foschi, A., Mazzullo, T., Semeraro, L., & Canton, A. D. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.0590051842.x · Cited by 58
An, H., Wei, R., Ke, J., Yang, J., Liu, Y., Wang, X., Wang, G., & Hong, T. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.04.018 · Cited by 58
Böger, R. H., Tsikas, D., Bode‐Böger, S. M., Phivthong‐ngam, L., Schwedhelm, E., & Frölich, J. C. (2004) · Nitric Oxide · doi:10.1016/j.niox.2004.07.008 · Cited by 56
Pournaghi, P., Sadrkhanlou, R., Hasanzadeh, S., & Foroughi, A. (2012) · Europe PMC (PubMed Central) · Cited by 55
New Insight Into Metformin Action: Regulation of ChREBP and FOXO1 Activities in Endothelial Cells
Li, X., Kover, K. L., Heruth, D. P., Watkins, D. J., Moore, W. V., Jackson, K., Zang, M., Clements, M. A., & Yan, Y. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1090 · Cited by 54
Glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells
Weikel, K., Cacicedo, J. M., Ruderman, N. B., & Ido, Y. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00265.2014 · Cited by 53
Eicosanoids and the Vascular Endothelium
Egan, K. M., & FitzGerald, G. A. (2006) · Springer eBooks · doi:10.1007/3-540-32967-6_6 · Cited by 52
Sasser, J. M., Cunningham, M., & Baylis, C. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00407.2014 · Cited by 52
Jiang, J., Gan, Z., Li, Y., Zhao, W., Li, H., Zheng, J., & Ke, Y. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182746 · Cited by 52
Cell death induced by serum deprivation in luteal cells involves the intrinsic pathway of apoptosis
Goyeneche, A. A., Harmon, J. M., & Telleria, C. M. (2005) · Reproduction · doi:10.1530/rep.1.00751 · Cited by 51
Endothelium and Atherogenesis: Endothelial Therapy Revisited
Barton, M., & Haudenschild, C. C. (2001) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200111002-00007 · Cited by 49
Shishavan, M. H., Henning, R. H., van Buiten, A., Goris, M., Deelman, L. E., & Buikema, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-11430-7 · Cited by 48
Moncada, S., & Higgs, A. (2006) · Springer eBooks · doi:10.1007/3-540-32967-6 · Cited by 44
Hung, C., Chan, S., Chu, P., Lin, H.-C., & Tsai, K. (2016) · Oncotarget · doi:10.18632/oncotarget.7387 · Cited by 41
Nemoto, S., Kobayashi, T., Taguchi, K., Matsumoto, T., & Kamata, K. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00178.2011 · Cited by 40
The emerging role of metformin in gestational diabetes mellitus
Gray, S. G., McGuire, T. M., Cohen, N., & Little, P. J. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12893 · Cited by 40
Eriksson, L., & Nyström, T. (2014) · Cardiovascular Diabetology · doi:10.1186/s12933-014-0152-5 · Cited by 39
Forkhead Box O-1 Modulation Improves Endothelial Insulin Resistance in Human Obesity
Karki, S., Farb, M. G., Ngo, D. T. M., Myers, S. J., Puri, V., Hamburg, N. M., Carmine, B. J., Hess, D. T., & Gokce, N. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.305139 · Cited by 39
Ke, J., Liu, Y., Yang, J., Lu, R., Tian, Q., Hou, W., Wang, G., Wei, R., & Hong, T. (2017) · Scientific Reports · doi:10.1038/srep41085 · Cited by 38
Xiaoling, Y., Zhao, L., Li, S., Ma, S., Anning, Y., Ding, N., Li, N., Yue-xia, J., Xiaoming, Y., Li, G., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167744 · Cited by 37
Samuel, S. M., Ghosh, S., Majeed, Y., Arunachalam, G., Emara, M. M., Ding, H., & Triggle, C. R. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.03.001 · Cited by 37
Metformin improves endothelial function and carotid intima media thickness in patients with PCOS
Kaya, M. G., Yıldırım, S., Çalapkorur, B., Akpek, M., Ünlühızarcı, K., & Keleştimur, F. (2015) · Gynecological Endocrinology · doi:10.3109/09513590.2015.1006188 · Cited by 36
Advanced-glycation end products in insulin-resistant states
Soldatos, G., Cooper, M. E., & Jandeleit-Dahm, K. A. M. (2005) · Current Hypertension Reports · doi:10.1007/s11906-005-0081-5 · Cited by 35
Maintenance of Endothelial Guanosine Triphosphate Cyclohydrolase I Ameliorates Diabetic Nephropathy
Kidokoro, K., Satoh, M., Channon, K. M., Yada, T., Sasaki, T., & Kashihara, N. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012080783 · Cited by 34
The Role of Incretin Therapy at Different Stages of Diabetes
Cernea, S. (2011) · The Review of Diabetic Studies · doi:10.1900/rds.2011.8.323 · Cited by 30
Flagged first, then by citations
4 of the 222 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Félétou, 2006, Endothelial dysfunction: A multifaceted disorder (the Wiggers Award Lecture), American Journal of Physiology. Heart and Circulatory Physiology, 291, H985, 10.1152/ajpheart.00292.2006 · DOI · Paper page
- Sena, 2013, Endothelial dysfunction — A major mediator of diabetic vascular disease, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1832, 2216, 10.1016/j.bbadis.2013.08.006 · DOI
Cited by
Sorted by citations
Xu, S., Ilyas, I., Little, P. J., Li, H., Kamato, D., Zheng, X., Luo, S., Li, Z., Liu, P., Han, J., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000096 · Cited by 1,205
Medina-Leyte, D. J., Zepeda-García, Ó., Domínguez‐Pérez, M., González-Garrido, A., Villarreal-Molina, M. T., & Jacobo‐Albavera, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083850 · Cited by 678
Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics
Feng, X., Sureda, A., Jafari, S., Memariani, Z., Tewari, D., Annunziata, G., Barrea, L., Hassan, S. T. S., Šmejkal, K., Malaník, M., et al. (2019) · Theranostics · doi:10.7150/thno.30787 · Cited by 465
Mechanisms of long COVID and the path toward therapeutics
Peluso, M. J., & Deeks, S. G. (2024) · Cell · doi:10.1016/j.cell.2024.07.054 · Cited by 399
Mohammed, I., Hollenberg, M. D., Ding, H., & Triggle, C. R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.718942 · Cited by 278
Metadata
- Authors
- Nafisa, A., Gray, S. G., Cao, Y., Wang, T., Xu, S., Wattoo, F. H., Barras, M., Cohen, N., Kamato, D., & Little, P. J.
- Affiliations
- The University of Queensland (AU)
- Sun Yat-sen University (CN)
- University of Rochester Medicine (US)
- Pir Mehr Ali Shah Arid Agriculture University (PK)
- Princess Alexandra Hospital (AU)
- Baker Heart and Diabetes Institute (AU)
- Corresponding author
- Little, Peter J.
- ORCID
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 192
- Pages
- 150-162
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W2884428355
- Cited by
- 128
- References
- 222
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 22 · 2023: 15 · 2022: 19 · 2021: 25 · 2020: 19 · 2019: 10 · 2018: 1
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council of Australia (#1022800)
- National Heart Foundation of Australia (G09M4385)
- Diabetes Australia Research Trust
- RMIT University
- University of Queensland
- Australian Government Scholarships
- American Heart Association (18CDA34110359)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- metformin, endothelial dysfunction, endothelial function, insulin resistance, cardiovascular disease, metabolic disorders, molecular mechanisms
- MeSH terms
- Animals, Cardiovascular Diseases, Endothelium, Vascular, Humans, Hypoglycemic Agents, Metabolic Diseases, Metformin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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