The DOI matches its Crossref record; 218 of the 222 references it cites were found in a registry or an index.
Endothelial function and dysfunction: Impact of metformin
Abstract
Cardiovascular and metabolic diseases remain the leading cause of morbidity and mortality worldwide. Endothelial dysfunction is a key player in the initiation and progression of cardiovascular and metabolic diseases. Current evidence suggests that the anti-diabetic drug metformin improves insulin resistance and protects against endothelial dysfunction in the vasculature. Hereby, we provide a timely review on the protective effects and molecular mechanisms of metformin in preventing endothelial dysfunction and cardiovascular and metabolic diseases.
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In the citing paper
“Based on evidence from both clinical and pre-clinical studies metformin, independent of its anti-hyperglycemic actions, directly protects the endothelium (33–35).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [33]
In the citing paper
“There is an extensive literature based on data from pre-clinical and clinical studies that indicates metformin protects endothelial function from the effects of diabetes (33).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [33]
Citations
Cites
1 retracted
Items 201–218 of 218
Kamato, D., Rostam, M. A., Piva, T. J., Babaahmadi‐Rezaei, H., Getachew, R., Thach, L., Bernard, R., Zheng, W., Little, P. J., & Osman, N. (2014) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12298 · Cited by 30
Factors involved in the maintenance of endothelial function
Drexler, H. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)90420-9 · Cited by 28
Sasson, S., Gorowits, N., Joost, H., King, G. L., Cerasi, E., & Kaiser, N. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb16731.x · Cited by 26
Pathogenetic Loop Between Diabetes and Cell Senescence
Testa, R., & Ceriello, A. (2007) · Diabetes Care · doi:10.2337/dc07-1534 · Cited by 22
Metformin inhibits monocyte adhesion to endothelial cells and foam cell formation
Mamputu, J., Wiernsperger, N. F., & Renier, G. (2003) · The British Journal of Diabetes · doi:10.1177/14746514030030041501 · Cited by 21
Glycated and carboxy-methylated proteins do not directly activate human vascular smooth muscle cells
Ballinger, M. L., Thomas, M. C., Nigro, J., Ivey, M. E., Dilley, R. J., & Little, P. J. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00746.x · Cited by 20
The Endothelium, Part II: EDHF-Mediated Responses "The Classical Pathway"
Félétou, M. (2011) · Colloquium Series on Integrated Systems Physiology From Molecule to Function · doi:10.4199/c00032ed1v01y201105isp020 · Cited by 20
Update on SGLT2 Inhibitors—New Data Released at the American Diabetes Association
Lee, S. (2017) · Critical Pathways in Cardiology A Journal of Evidence-Based Medicine · doi:10.1097/hpc.0000000000000125 · Cited by 20
Little, P. J., Osman, N., de Dios, S. T., Cemerlang, N., Ballinger, M. L., & Nigro, J. (2007) · Cardiovascular Diabetology · doi:10.1186/1475-2840-6-33 · Cited by 17
Zhang, J., Cao, M., Yang, W., Sun, F., Xu, C., Yin, L., & Pu, Y. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3912515 · Cited by 17
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Safe prescribing of metformin in diabetes
Davoren, P. M. (2014) · Australian Prescriber · doi:10.18773/austprescr.2014.001 · Cited by 13
Luk, T.-H., Dai, Y.-L., Siu, C., Yiu, K., Li, S.-W., Fong, B. M.-W., Wong, W.-K., Tam, S., & Tse, H. (2012) · Circulation Journal · doi:10.1253/circj.cj-12-0364 · Cited by 12
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Diabetes, Obesity and Metabolism
(2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12772 · Cited by 6
Flagged first, then by citations
4 of the 222 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Félétou, 2006, Endothelial dysfunction: A multifaceted disorder (the Wiggers Award Lecture), American Journal of Physiology. Heart and Circulatory Physiology, 291, H985, 10.1152/ajpheart.00292.2006 · DOI · Paper page
- Sena, 2013, Endothelial dysfunction — A major mediator of diabetic vascular disease, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1832, 2216, 10.1016/j.bbadis.2013.08.006 · DOI
Cited by
Sorted by citations
Xu, S., Ilyas, I., Little, P. J., Li, H., Kamato, D., Zheng, X., Luo, S., Li, Z., Liu, P., Han, J., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000096 · Cited by 1,205
Medina-Leyte, D. J., Zepeda-García, Ó., Domínguez‐Pérez, M., González-Garrido, A., Villarreal-Molina, M. T., & Jacobo‐Albavera, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083850 · Cited by 678
Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics
Feng, X., Sureda, A., Jafari, S., Memariani, Z., Tewari, D., Annunziata, G., Barrea, L., Hassan, S. T. S., Šmejkal, K., Malaník, M., et al. (2019) · Theranostics · doi:10.7150/thno.30787 · Cited by 465
Mechanisms of long COVID and the path toward therapeutics
Peluso, M. J., & Deeks, S. G. (2024) · Cell · doi:10.1016/j.cell.2024.07.054 · Cited by 399
Mohammed, I., Hollenberg, M. D., Ding, H., & Triggle, C. R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.718942 · Cited by 278
Metadata
- Authors
- Nafisa, A., Gray, S. G., Cao, Y., Wang, T., Xu, S., Wattoo, F. H., Barras, M., Cohen, N., Kamato, D., & Little, P. J.
- Affiliations
- The University of Queensland (AU)
- Sun Yat-sen University (CN)
- University of Rochester Medicine (US)
- Pir Mehr Ali Shah Arid Agriculture University (PK)
- Princess Alexandra Hospital (AU)
- Baker Heart and Diabetes Institute (AU)
- Corresponding author
- Little, Peter J.
- ORCID
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 192
- Pages
- 150-162
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W2884428355
- Cited by
- 128
- References
- 222
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 22 · 2023: 15 · 2022: 19 · 2021: 25 · 2020: 19 · 2019: 10 · 2018: 1
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council of Australia (#1022800)
- National Heart Foundation of Australia (G09M4385)
- Diabetes Australia Research Trust
- RMIT University
- University of Queensland
- Australian Government Scholarships
- American Heart Association (18CDA34110359)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- metformin, endothelial dysfunction, endothelial function, insulin resistance, cardiovascular disease, metabolic disorders, molecular mechanisms
- MeSH terms
- Animals, Cardiovascular Diseases, Endothelium, Vascular, Humans, Hypoglycemic Agents, Metabolic Diseases, Metformin
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