In vivo growth-inhibition of S180 tumor by mixture of 5-Fu and low molecular ?-carrageenan from
Abstract
Lambda-carrageenan is a sulfated galactan isolated from some red algae and have been reported to have many kinds of biological activities. Chondrus ocellatus is an important economic alga in China and many other parts of the world. The sample was obtained after lambda-carrageenan from the alga was degraded by microwave and its molecular weight is 9.3 kDa. In this study, tumor inhibiting activity of low molecular weight lambda-carrageenan and its mixture with 5-Fu on mice transplanted with S180 tumor was investigated. Weight of immune organ, proliferation ratio of lymphocyte concentration of TNF-alpha and histopathology of spleen and tumor from the transplanted S180 tumor mice were also determined. Results indicated that the degraded lambda-carrageenan could enhance antitumor activity of 5-Fu and improve immunocompetence damaged by 5-Fu.
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The main mechanism of polysaccharides cytotoxic effect is activation of the innate immune system.
“The main mechanism of action of polysaccharides cytotoxic effect is the activation of the innate immune system [165,166,167,168], leading to attraction of macrophages and natural killer cells to the target site and production of tumoricidal cytokines [166,169,170,171].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [167]
In vivo antitumor activities for κ-carrageenan oligosaccharides and low molecular λ-carrageenan from Chondrus ocellatus have been established.
“In vivo antitumor activities for κ-carrageenan oligosachharides and low molecular λ-carrageenan from Chondrus ocellatus have been established.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [96]
Low molecular λ-carrageenan from Chondrus ocellatus potentiated the antitumor effect of 5-FU.
“The latter also potentiated the antitumor effect of 5-FU [96,97].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [96]
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Marine Natural Products: A Source of Novel Anticancer Drugs
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Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects
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- Authors
- ZHOU, G., XIN, H., SHENG, W., SUN, Y., LI, Z., & XU, Z.
- Affiliations
- Qingdao Agricultural University (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- XU, Z
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 2005-02
- Volume
- 51
- Issue
- 2
- Pages
- 153-157
- ISSN
- 1043-6618 (ISSN-L)
- OpenAlex
- W1554935884
- Cited by
- 95
- References
- 14
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 7 · 2020: 5 · 2019: 10 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 1 · 2014: 5 · 2013: 3 · 2012: 5
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- lambda-carrageenan, Chondrus ocellatus, 5-fluorouracil, S180 tumor, anticancer activity, sulfated galactans, immunocompetence, lymphocyte proliferation, TNF-α, spleen histopathology, combination therapy
- MeSH terms
- Animals, Carrageenan, Drug Therapy, Combination, Fluorouracil, Growth Inhibitors, Mice, Inbred ICR, Sarcoma 180, Chondrus, Mice
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