An update on the physiological and therapeutic relevance of GPCR oligomers

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL.

Monod, J., Wyman, J., & Changeux, J. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80285-6 · Cited by 7,681 · see citing works

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

Palczewski, K., Kumasaka, T., Hori, T., Behnke, C. A., Motoshima, H., Fox, B. A., Trong, I. L., Teller, D. C., Okada, T., Stenkamp, R. E., et al. (2000) · Science · doi:10.1126/science.289.5480.739 · Cited by 5,637 · see citing works

High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor

Cherezov, V., Rosenbaum, D. M., Hanson, M. A., Rasmussen, S. G. F., Thian, F. S., Kobilka, T. S., Choi, H., Kühn, P., Weis, W. I., Kobilka, B. K., et al. (2007) · Science · doi:10.1126/science.1150577 · Cited by 3,280 · see citing works

Crystal structure of the β2 adrenergic receptor–Gs protein complex

Rasmussen, S. G. F., DeVree, B. T., Zou, Y., Kruse, A. C., Chung, K. Y., Kobilka, T. S., Thian, F. S., Chae, P. S., Pardon, E., Calinski, D., et al. (2011) · Nature · doi:10.1038/nature10361 · Cited by 3,009 · see citing works

Crystal structure of the human β2 adrenergic G-protein-coupled receptor

Rasmussen, S. G. F., Choi, H., Rosenbaum, D. M., Kobilka, T. S., Thian, F. S., Edwards, P. C., Burghammer, M. C., Ratnala, V. R. P., Sanishvili, R., Fischetti, R. F., et al. (2007) · Nature · doi:10.1038/nature06325 · Cited by 1,935 · see citing works

The 2.6 Angstrom Crystal Structure of a Human A 2A Adenosine Receptor Bound to an Antagonist

Jaakola, V., Griffith, M. T., Hanson, M. A., Cherezov, V., Chien, E. Y. T., Lane, J. R., IJzerman, A. P., & Stevens, R. C. (2008) · Science · doi:10.1126/science.1164772 · Cited by 1,786 · see citing works

Mammalian sweet taste receptors

Nelson, G., Hoon, M. A., Chandrashekar, J., Zhang, Y., Ryba, N. J. P., & Zuker, C. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00451-2 · Cited by 1,702 · see citing works

EGFR exon 20 insertion A763-Y764insFQEA and response to erlotinib-letter

Xu, S., Garofalo, A., Neamati, N., & GRANDE, F. (2011) · National University of Singapore · doi:10.1158/1535-7163 · Cited by 1,690 · see citing works

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

Rasmussen, S. G. F., Choi, H., Fung, J. J., Pardon, E., Casarosa, P., Chae, P. S., DeVree, B. T., Rosenbaum, D. M., Thian, F. S., Kobilka, T. S., et al. (2011) · Nature · doi:10.1038/nature09648 · Cited by 1,663 · see citing works

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

Manglik, A., Kruse, A. C., Kobilka, T. S., Thian, F. S., Mathiesen, J. M., Sunahara, R. K., Pardo, L., Weis, W. I., Kobilka, B. K., & Granier, S. (2012) · Nature · doi:10.1038/nature10954 · Cited by 1,362 · see citing works

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

Chien, E. Y. T., Liu, W., Zhao, Q., Katritch, V., Han, G. W., Hanson, M. A., Shi, L., Newman, A. H., Javitch, J. A., Cherezov, V., et al. (2010) · Science · doi:10.1126/science.1197410 · Cited by 1,134 · see citing works

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

Liu, W., Chun, E., Thompson, A. A., Chubukov, P., Xu, F., Katritch, V., Han, G. W., Roth, C., Heitman, L. H., IJzerman, A. P., et al. (2012) · Science · doi:10.1126/science.1219218 · Cited by 948 · see citing works

Hallucinogens Recruit Specific Cortical 5-HT2A Receptor-Mediated Signaling Pathways to Affect Behavior

González-Maeso, J., Weisstaub, N. V., Zhou, M., Chan, P., Ivic, L., Ang, R., Lira, A., Bradley-Moore, M., Ge, Y., Zhou, Q., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.008 · Cited by 925 · see citing works

Structural insights into µ-opioid receptor activation

Huang, W., Manglik, A., Venkatakrishnan, A., Laeremans, T., Feinberg, E. N., Sanborn, A. L., KATO, H. E., Livingston, K. E., Thorsen, T. S., Kling, R. C., et al. (2015) · Nature · doi:10.1038/nature14886 · Cited by 895 · see citing works

Receptors for Dopamine and Somatostatin: Formation of Hetero-Oligomers with Enhanced Functional Activity

Rocheville, M., Lange, D. C., Kumar, U., Patel, S. C., Patel, R. C., & Patel, Y. (2000) · Science · doi:10.1126/science.288.5463.154 · Cited by 887 · see citing works

Structure of the human κ-opioid receptor in complex with JDTic

Wu, H., Wacker, D., Mileni, M., Katritch, V., Han, G. W., Vardy, E., Liu, W., Thompson, A. A., Huang, X., Carroll, F. I., et al. (2012) · Nature · doi:10.1038/nature10939 · Cited by 885 · see citing works

Is allostery an intrinsic property of all dynamic proteins?

Gunasekaran, K., Ma, B., & Nussinov, R. (2004) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.20232 · Cited by 882 · see citing works

Structure and dynamics of the M3 muscarinic acetylcholine receptor

Kruse, A. C., Hu, J., Pan, A. C., Arlow, D. H., Rosenbaum, D. M., Rosemond, E., Green, H. F., Liu, T., Chae, P. S., Dror, R. O., et al. (2012) · Nature · doi:10.1038/nature10867 · Cited by 813 · see citing works

Structure of the human histamine H1 receptor complex with doxepin

Shimamura, T., Shiroishi, M., Weyand, S. N., Tsujimoto, H., Winter, G., Katritch, V., Abagyan, R. A., Cherezov, V., Liu, W., Han, G. W., et al. (2011) · Nature · doi:10.1038/nature10236 · Cited by 805 · see citing works

Identification of a serotonin/glutamate receptor complex implicated in psychosis

González-Maeso, J., Ang, R. L., Yuen, T., Chan, P., Weisstaub, N. V., López-Giménez, J. F., Zhou, M., Okawa, Y., Callado, L. F., Milligan, G., et al. (2008) · Nature · doi:10.1038/nature06612 · Cited by 803 · see citing works

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

Haga, K., Kruse, A. C., Asada, H., Yurugi-Kobayashi, T., Shiroishi, M., Zhang, C., Weis, W. I., Okada, T., Kobilka, B. K., Haga, T., et al. (2012) · Nature · doi:10.1038/nature10753 · Cited by 786 · see citing works

Rhodopsin dimers in native disc membranes

Fotiadis, D., Liang, Y., Filipek, S., Saperstein, D. A., Engel, A., & Palczewski, K. (2003) · Nature · doi:10.1038/421127a · Cited by 749 · see citing works

A Trafficking Checkpoint Controls GABAB Receptor Heterodimerization

Margeta, M., Jan, Y. N., & Jan, L. Y. (2000) · Neuron · doi:10.1016/s0896-6273(00)00012-x · Cited by 680 · see citing works

Structure of the δ-opioid receptor bound to naltrindole

Granier, S., Manglik, A., Kruse, A. C., Kobilka, T. S., Thian, F. S., Weis, W. I., & Kobilka, B. K. (2012) · Nature · doi:10.1038/nature11111 · Cited by 670 · see citing works

Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors

Pin, J.-P., Galvez, T., & Prézeau, L. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(03)00038-x · Cited by 662 · see citing works

Organization of the G Protein-coupled Receptors Rhodopsin and Opsin in Native Membranes

Liang, Y., Fotiadis, D., Filipek, S., Saperstein, D. A., Palczewski, K., & Engel, A. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302536200 · Cited by 591 · see citing works

Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery

Kenakin, T., & Miller, L. J. (2010) · Pharmacological Reviews · doi:10.1124/pr.108.000992 · Cited by 573 · see citing works

Oligomerization of μ- and δ-Opioid Receptors

George, S. R., Fan, T., Xie, Z., Tse, R., Tam, V. C., Varghese, G. K., & O’Dowd, B. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000345200 · Cited by 557 · see citing works

Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator

Wu, H., Wang, C., Gregory, K. J., Han, G. W., Cho, H. P., Xia, Y., Niswender, C. M., Katritch, V., Meiler, J., Cherezov, V., et al. (2014) · Science · doi:10.1126/science.1249489 · Cited by 539 · see citing works

Dopamine receptors – IUPHAR R eview 13

Beaulieu, J., Espinoza, S., & Gainetdinov, R. R. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12906 · Cited by 529 · see citing works

Coaggregation, Cointernalization, and Codesensitization of Adenosine A2A Receptors and Dopamine D2Receptors

Hillion, J., Canals, M., Torvinen, M., Casadó, V., Scott, R. P., Terasmaa, A., Hansson, A. C., Watson, S. J., Olah, M. E., Mallol, J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107731200 · Cited by 499 · see citing works

Diversity and Modularity of G Protein-Coupled Receptor Structures

Katritch, V., Cherezov, V., & Stevens, R. (2011) · TIPS - Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.09.003 · Cited by 495 · see citing works

D1–D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of G q /11 in the striatum

Rashid, A. J., So, C. H., Kong, M. M. C., Furtak, T., El-Ghundi, M., Cheng, R., O’Dowd, B. F., & George, S. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604049104 · Cited by 492 · see citing works

Crystal structure of the human σ1 receptor

Schmidt, H. R., Zheng, S., Gurpinar, E., Koehl, A., Manglik, A., & Kruse, A. C. (2016) · Nature · doi:10.1038/nature17391 · Cited by 482 · see citing works

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

Thompson, A. A., Liu, W., Chun, E., Katritch, V., Wu, H., Vardy, E., Huang, X., Trapella, C., Guerrini, R., Calò, G., et al. (2012) · Nature · doi:10.1038/nature11085 · Cited by 480 · see citing works

Heterodimerization of mu and delta opioid receptors: A role in opiate synergy.

Gomes, I., Jordan, B. A., Gupta, A., Trapaidze, N., Nagy, V., & Devi, L. A. (2000) · PubMed Central · doi:10.1523/jneurosci.20-22-j0007.2000 · Cited by 471 · see citing works

Dopamine D1 and D2 Receptor Co-activation Generates a Novel Phospholipase C-mediated Calcium Signal

Lee, S. P., So, C. H., Rashid, A. J., Varghese, G. K., Cheng, R., Lança, A. J., O’Dowd, B. F., & George, S. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401923200 · Cited by 468 · see citing works

Allostery: Absence of a change in shape does not imply that allostery is not at play

Tsai, C.-J., del Sol, A., & Nussinov, R. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.02.034 · Cited by 453 · see citing works

Dopamine D 1 and adenosine A 1 receptors form functionally interacting heteromeric complexes

Ginés, S., Hillion, J., Torvinen, M., Crom, S. L., Casadó, V., Canela, E. I., Rondin, S., Lew, J. Y., Watson, S. J., Zoli, M., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.150241097 · Cited by 444 · see citing works

Adenosine A2A-Dopamine D2 Receptor-Receptor Heteromerization

Canals, M., Marcellino, D. J., Fanelli, F., Ciruela, F., de Benedetti, P., Goldberg, S. R., Neve, K. A., Fuxé, K., Agnati, L. F., Woods, A. S., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306451200 · Cited by 432 · see citing works

Anatomical and physiological evidence for D1 and D2 dopamine receptor colocalization in neostriatal neurons

Aizman, O., Brismar, H., Uhlén, P., Zettergren-Markus, E., Levey, A. I., Forssberg, H., Greengard, P., & Aperia, A. C. (2000) · Nature Neuroscience · doi:10.1038/72929 · Cited by 415 · see citing works

A role for heterodimerization of μ and δ opiate receptors in enhancing morphine analgesia

Gomes, I., Gupta, A., Filipovska, J., Szeto, H. H., Pintar, J. E., & Devi, L. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307601101 · Cited by 386 · see citing works

Allosteric interactions between GB1 and GB2 subunits are required for optimal GABAB receptor function

Galvez, T., Duthey, B., Kniazeff, J., Blahoš, J., Rovelli, G., Bettler, B., Prézeau, L., & Pin, J. (2001) · The EMBO Journal · doi:10.1093/emboj/20.9.2152 · Cited by 383 · see citing works

Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine

Qin, L., Kufareva, I., Holden, L. G., Wang, C., Zheng, Y., Zhao, C., Fenalti, G., Wu, H., Han, G. W., Cherezov, V., et al. (2015) · Science · doi:10.1126/science.1261064 · Cited by 382 · see citing works

Two disparate ligand-binding sites in the human P2Y1 receptor

Zhang, D., Gao, Z., Zhang, K., Kiselev, E., Crane, S., Wang, J., Paoletta, S., Yi, C., Ma, L., Zhang, W., et al. (2015) · Nature · doi:10.1038/nature14287 · Cited by 369 · see citing works

Concurrent Stimulation of Cannabinoid CB1 and Dopamine D2 Receptors Enhances Heterodimer Formation: A Mechanism for Receptor Cross-Talk?

Kearn, C. S., Blake-Palmer, K. G., Daniel, E., Mackie, K., & Glass, M. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.006882 · Cited by 358 · see citing works

Target validation of G-protein coupled receptors

Wise, A., Gearing, K. L., & Rees, S. (2002) · Drug Discovery Today · doi:10.1016/s1359-6446(01)02131-6 · Cited by 357 · see citing works

A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers

Waldhoer, M., Fong, J. C., Jones, R. M., Lunzer, M. M., Sharma, S. K., Kostenis, E., Portoghese, P. S., & Whistler, J. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501112102 · Cited by 351 · see citing works

Agonist-bound structure of the human P2Y12 receptor

Zhang, J., Zhang, K., Gao, Z., Paoletta, S., Zhang, D., Han, G. W., Li, T., Ma, L., Zhang, W., Müller, C. E., et al. (2014) · Nature · doi:10.1038/nature13288 · Cited by 349 · see citing works

Allosteric Modulation as a Unifying Mechanism for Receptor Function and Regulation

Changeux, J., & Christopoulos, A. (2016) · Cell · doi:10.1016/j.cell.2016.08.015 · Cited by 341 · see citing works

Time-resolved FRET between GPCR ligands reveals oligomers in native tissues

Albizu, L., Cottet, M., Králíková, M., Stoev, S. B., Seyer, R., Brabet, I., Roux, T., Bazin, H., Bourrier, E., Lamarque, L., et al. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.396 · Cited by 340 · see citing works

Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation

Han, Y., Moreira, I. S., Urizar, E., Weinstein, H., & Javitch, J. A. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.199 · Cited by 339 · see citing works

The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization

Levoye, A., Dam, J., Ayoub, M. A., Guillaume, J., Couturier, C., Delagrange, P., & Jockers, R. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601193 · Cited by 335 · see citing works

Dopamine D2 receptors form higher order oligomers at physiological expression levels

Guo, W. X., Urizar, E., Králíková, M., Mobarec, J. C., Shi, L., Filizola, M., & Javitch, J. A. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.153 · Cited by 334 · see citing works

Allostery: an illustrated definition for the ‘second secret of life’

Fenton, A. W. (2008) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2008.05.009 · Cited by 320 · see citing works

Apo-Ghrelin Receptor Forms Heteromers with DRD2 in Hypothalamic Neurons and Is Essential for Anorexigenic Effects of DRD2 Agonism

Kern, A., Albarran-Zeckler, R. G., Walsh, H. E., & Smith, R. G. (2012) · Neuron · doi:10.1016/j.neuron.2011.10.038 · Cited by 316 · see citing works

Electron crystallography reveals the structure of metarhodopsin I

Ruprecht, J. J., Mielke, T., Vogel, R., Villa, C., & Schertler, G. F. X. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600374 · Cited by 298 · see citing works

Homodimerization of the β2-Adrenergic Receptor as a Prerequisite for Cell Surface Targeting

Salahpour, A., Angers, S., Mercier, J.-F., Lagacé, M., Marullo, S., & Bouvier, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403363200 · Cited by 297 · see citing works

Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series

Daniels, D. J., Lenard, N. R., Etienne, C. L., Law, P., Roerig, S. C., & Portoghese, P. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506627102 · Cited by 297 · see citing works

Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity

Urizar, E., Montanelli, L., Loy, T., Bonomi, M., Swillens, S., Galès, C., Bouvier, M., Smits, G., Vassart, G., & Costagliola, S. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600686 · Cited by 294 · see citing works

Detection of heteromerization of more than two proteins by sequential BRET-FRET

Carriba, P., Navarro, G., Ciruela, F., Ferré, S., Casadó, V., Agnati, L. F., Cortés, A., Mallol, J., Fuxé, K., Canela, E. I., et al. (2008) · Nature Methods · doi:10.1038/nmeth.1229 · Cited by 281 · see citing works

International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the Recognition and Nomenclature of G Protein-Coupled Receptor Heteromultimers

Pin, J., Neubig, R. R., Bouvier, M., Devi, L. A., Filizola, M., Javitch, J. A., Lohse, M. J., Milligan, G., Palczewski, K., Parmentier, M., et al. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.1.5 · Cited by 276 · see citing works

Crystal structure of oligomeric β1-adrenergic G protein–coupled receptors in ligand-free basal state

Huang, J., Chen, S., Zhang, J. J., & Huang, X. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2504 · Cited by 261 · see citing works

Allostery at G Protein-Coupled Receptor Homo- and Heteromers: Uncharted Pharmacological Landscapes

Smith, N. J., & Milligan, G. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002667 · Cited by 261 · see citing works

An Update on Adenosine A2A-Dopamine D2 Receptor Interactions: Implications for the Function of G Protein-Coupled Receptors

Ferré, S., Quiroz, C., Woods, A. S., Cunha, R. A., Popoli, P., Ciruela, F., Lluı́s, C., Franco, R., Azdad, K., & Schiffmann, S. N. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208784480108 · Cited by 254 · see citing works

Adenosine A2 receptors regulate the gene expression of striatopallidal and striatonigral neurons

Schiffmann, S., & Vanderhaeghen, J. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-03-01080.1993 · Cited by 253 · see citing works

Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher‐order oligomers in living cells

Cabello, N., Gandía, J., Bertarelli, D. C. G., Watanabe, M., Lluı́s, C., Franco, R., Ferré, S., Luján, R., & Ciruela, F. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06078.x · Cited by 253 · see citing works

Dual Inhibition of β-Adrenergic and Angiotensin II Receptors by a Single Antagonist

Barki‐Harrington, L., Luttrell, L. M., & Rockman, H. A. (2003) · Circulation · doi:10.1161/01.cir.0000092166.30360.78 · Cited by 252 · see citing works

Identification of Dopamine D1–D3 Receptor Heteromers

Marcellino, D. J., Ferré, S., Casadó, V., Cortés, A., Foll, B. L., Mazzola, C., Drago, F., Saur, O., Stark, H., Soriano, A., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710349200 · Cited by 232 · see citing works

Heteromeric association creates a P2Y-like adenosine receptor

Yoshioka, K., Saitoh, O., & Nakata, H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121587098 · Cited by 232 · see citing works

Inhibition of cyclin-dependent kinases 2 and 4 activities as well as induction of cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (?)-epigallocatechin-3-gallate

Liang, Y., Lin‐Shiau, S., Chen, C.-F., & Lin, J. (1999) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19991001)75:1 · Cited by 222 · see citing works

GABA B2 Is Essential for G-Protein Coupling of the GABA B Receptor Heterodimer

Robbins, M. J., Calver, A. R., Filippov, A. K., Hirst, W. D., Russell, R. B., Wood, M. D., Nasir, S., Couve, A., Brown, D. A., Moss, S. J., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08043.2001 · Cited by 221 · see citing works

Receptor heterodimerization leads to a switch in signaling: β‐arrestin2‐mediated ERK activation by μ‐δ opioid receptor heterodimers

Rozenfeld, R., & Devi, L. A. (2007) · The FASEB Journal · doi:10.1096/fj.06-7793com · Cited by 220 · see citing works

D2/D3 Dopamine Receptor Heterodimers Exhibit Unique Functional Properties

Scarselli, M., Novi, F., Schallmach, E., Lin, R., Baragli, A., Colzi, A., Griffon, N., Corsini, G. U., Sokoloff, P., Levenson, R. G., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102297200 · Cited by 214 · see citing works

Identification of a GABAB Receptor Subunit, gb2, Required for Functional GABAB Receptor Activity

Ng, G., Clark, J. E., Coulombe, N., Éthier, N., Hébert, T. E., Sullivan, R. J., Kargman, S., Châteauneuf, A., Tsukamoto, N., McDonald, T., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.7607 · Cited by 212 · see citing works

Reciprocal Regulation of Dopamine D1 and D3 Receptor Function and Trafficking by Heterodimerization

Fiorentini, C., Busi, C., Gorruso, E., Gotti, C., Spano, P., & Missale, C. (2008) · Molecular Pharmacology · doi:10.1124/mol.107.043885 · Cited by 209 · see citing works

Structural mechanism of ligand activation in human GABAB receptor

Geng, Y., Bush, M. W., Mosyak, L., Wang, F., & Fan, Q. (2013) · Nature · doi:10.1038/nature12725 · Cited by 207 · see citing works

Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors

Viñals, X., Moreno, E., Lanfumey, L., Cordomí, A., Pastor, A., de la Torre, R., Gasperini, P., Navarro, G., Howell, L. A., Pardo, L., et al. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002194 · Cited by 207 · see citing works

Receptor–receptor interactions within receptor mosaics. Impact on neuropsychopharmacology

Fuxé, K., Marcellino, D. J., Rivera, A., Dı́az-Cabiale, Z., Filip, M., Gago, B., Roberts, D. C. S., Langel, Ü., Genedani, S., Ferraro, L., et al. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.11.007 · Cited by 199 · see citing works

A Single Subunit (GB2) Is Required for G-protein Activation by the Heterodimeric GABAB Receptor

Duthey, B., Caudron, S., Perroy, J., Bettler, B., Fagni, L., Pin, J., & Prézeau, L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108900200 · Cited by 198 · see citing works

Evidence for Negative Binding Cooperativity within CCR5-CCR2b Heterodimers

Asmar, L. E., Springael, J., Ballet, S., Andrieu, E. U., Vassart, G., & Parmentier, M. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.003624 · Cited by 195 · see citing works

Combining Mass Spectrometry and Pull-Down Techniques for the Study of Receptor Heteromerization. Direct Epitope−Epitope Electrostatic Interactions between Adenosine A2Aand Dopamine D2Receptors

Ciruela, F., Burgueño, J., Casadó, V., Canals, M., Marcellino, D. J., Goldberg, S. R., Bäder, M., Fuxé, K., Agnati, L. F., Lluís, C., et al. (2004) · Analytical Chemistry · doi:10.1021/ac049295f · Cited by 192 · see citing works

Constitutive and Agonist-dependent Homo-oligomerization of the Thyrotropin-releasing Hormone Receptor

Kroeger, K. M., Hanyaloglu, A. C., Seeber, R. M., Miles, L. E. C., & Eidne, K. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011311200 · Cited by 190 · see citing works

Hypersensitization of the Orexin 1 Receptor by the CB1 Receptor

Hilairet, S., Bouaboula, M., Carrière, D., Fur, G. L., & Casellas, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212369200 · Cited by 188 · see citing works

The Dopamine D1-D2 Receptor Heteromer Localizes in Dynorphin/Enkephalin Neurons

Perreault, M. L., Hasbi, A., Alijaniaram, M., Fan, T., Varghese, G. K., Fletcher, P. J., Seeman, P. M., O’Dowd, B. F., & George, S. R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.159954 · Cited by 187 · see citing works

Dopamine D2 and Adenosine A2A Receptors Regulate NMDA-Mediated Excitation in Accumbens Neurons Through A2A–D2 Receptor Heteromerization

Azdad, K., Gall, D., Woods, A. S., Ledent, C. A., Ferré, S., & Schiffmann, S. N. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.144 · Cited by 185 · see citing works

Ligand‐regulated oligomerization of β2‐adrenoceptors in a model lipid bilayer

Fung, J. J., Deupí, X., Pardo, L., Xiao, Y., Vélez-Ruiz, G. A., DeVree, B. T., Sunahara, R. K., & Kobilka, B. K. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.267 · Cited by 181 · see citing works

50 years of allosteric interactions: the twists and turns of the models

Changeux, J. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3695 · Cited by 177 · see citing works

Identification of cholesterol recognition amino acid consensus (CRAC) motif in G-protein coupled receptors

Jafurulla, M., Tiwari, S., & Chattopadhyay, A. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.12.031 · Cited by 174 · see citing works

Caveolin-1 Interacts with 5-HT2A Serotonin Receptors and Profoundly Modulates the Signaling of Selected Gαq-coupled Protein Receptors

Bhatnagar, A., Sheffler, D. J., Kroeze, W. K., Compton-Toth, B. A., & Roth, B. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404673200 · Cited by 171 · see citing works

Expression of Dopamine D3 Receptor Dimers and Tetramers in Brain and in Transfected Cells

Nimchinsky, E. A., Hof, P. R., Janssen, W. G. M., Morrison, J. H., & Schmauss, C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.46.29229 · Cited by 168 · see citing works

Autosomal-Dominant Mode of Inheritance of a Melanocortin-4 Receptor Mutation in a Patient with Severe Early-Onset Obesity Is Due to a Dominant-Negative Effect Caused by Receptor Dimerization

Biebermann, H., Krude, H., Elsner, A., Chubanov, V., Gudermann, T. W., & Grüters, A. (2003) · Diabetes · doi:10.2337/diabetes.52.12.2984 · Cited by 166 · see citing works

Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysis

Marcellino, D. J., Carriba, P., Filip, M., Borgkvist, A., Frankowska, M., Bellido-Estévez, I., Tanganelli, S., Müller, C. E., Fisone, G., Lluı́s, C., et al. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.12.011 · Cited by 164 · see citing works

Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the Protean Effects of “Selective” Antagonists

Sohy, D., Yano, H., de Nadaı̈, P., Urizar, E., Guillabert, A., Javitch, J. A., Parmentier, M., & Springael, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.054809 · Cited by 163 · see citing works

Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR

Hlaváčková, V., Goudet, C., Kniazeff, J., Ziková, A., Maurel, D., Vol, C., Trojanova, J., Prézeau, L., Pin, J., & Blahoš, J. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600557 · Cited by 163 · see citing works

Cellular assays as portals to seven-transmembrane receptor-based drug discovery

Kenakin, T. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2838 · Cited by 156 · see citing works

Dimerization of the class A G protein-coupled neurotensin receptor NTS1 alters G protein interaction

White, J. F., Grodnitzky, J. A., Louis, J. M., Trinh, L. B., Shiloach, J., Gutierrez, J., Northup, J. K., & Grisshammer, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705312104 · Cited by 156 · see citing works

Oligomerization of the α1a- and α1b-Adrenergic Receptor Subtypes

Stanasila, L., Perez, J.-B., Vogel, H., & Cotecchia, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306085200 · Cited by 154 · see citing works

Cell surface targeting of μ-δ opioid receptor heterodimers by RTP4

Décaillot, F. M., Rozenfeld, R., Gupta, A., & Devi, L. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804106105 · Cited by 152 · see citing works

Allosteric Transinhibition by Specific Antagonists in CCR2/CXCR4 Heterodimers

Sohy, D., Parmentier, M., & Springael, J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705302200 · Cited by 150 · see citing works

Allosteric interactions between agonists and antagonists within the adenosine A 2A receptor-dopamine D 2 receptor heterotetramer

Bonaventura, J., Navarro, G., Casadó-Anguera, V., Azdad, K., Rea, W. P., Moreno, E., Brugarolas, M., Mallol, J., Canela, E. I., Lluı́s, C., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1507704112 · Cited by 149 · see citing works

Asymmetric conformational changes in a GPCR dimer controlled by G‐proteins

Damian, M., Martin, A., Mesnier, D., Pin, J., & Banères, J. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601449 · Cited by 145 · see citing works

Heteromeric MT 1 /MT 2 Melatonin Receptors Modulate Photoreceptor Function

Baba, K., Benleulmi‐Chaachoua, A., Journé, A., Kamal, M. T., Guillaume, J., Dussaud, S., Gbahou, F., Yettou, K., Liu, C., Contreras‐Alcantara, S., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004302 · Cited by 145 · see citing works

Membrane-Mediated Oligomerization of G Protein Coupled Receptors and Its Implications for GPCR Function

Gahbauer, S., & Böckmann, R. A. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00494 · Cited by 143 · see citing works

A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes

Cristóvão‐Ferreira, S., Navarro, G., Brugarolas, M., Pérez‐Capote, K., Vaz, S. H., Fattorini, G., Conti, F., Lluís, C., Ribeiro, J. A., McCormick, P. J., et al. (2013) · Purinergic Signalling · doi:10.1007/s11302-013-9364-5 · Cited by 140 · see citing works

Structure and ligand recognition of class C GPCRs

Chun, L., Zhang, W., & Liu, J. (2012) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.186 · Cited by 136 · see citing works

The Neuromedin U-Growth Hormone Secretagogue Receptor 1b/Neurotensin Receptor 1 Oncogenic Signaling Pathway as a Therapeutic Target for Lung Cancer

Takahashi, K., Furukawa, C., Takano, A., Ishikawa, N., Kato, T., Hayama, S., Suzuki, C., Yasui, W., Inai, K., Sone, S., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1349 · Cited by 136 · see citing works

Dimerization and Domain Swapping in G-Protein-Coupled Receptors A Computational Study

Gouldson, P. R. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00153-6 · Cited by 136 · see citing works

The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components

Borroto-Escuela, D., Brito, I., Romero-Fernandez, W., Di Palma, M., Oflijan, J., Skieterska, K., Duchou, J., Van Craenenbroeck, K., Suárez-Boomgaard, D., Rivera, A., et al. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15058570 · Cited by 134 · see citing works

Asymmetric Functioning of Dimeric Metabotropic Glutamate Receptors Disclosed by Positive Allosteric Modulators

Goudet, C., Kniazeff, J., Hlaváčková, V., Malhaire, F., Maurel, D., Acher, F., Blahoš, J., Prézeau, L., & Pin, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502642200 · Cited by 133 · see citing works

D2 Dopamine Receptor Homodimerization Is Mediated by Multiple Sites of Interaction, Including an Intermolecular Interaction Involving Transmembrane Domain 4

Lee, S. P., O’Dowd, B. F., Rajaram, R. D., Nguyen, T., & George, S. R. (2003) · Biochemistry · doi:10.1021/bi0345539 · Cited by 133 · see citing works

Domain swapping in G-protein coupled receptor dimers

Gouldson, P. R., Snell, C. R., Bywater, R. P., Higgs, C. J., & Reynolds, C. A. (1998) · Protein Engineering Design and Selection · doi:10.1093/protein/11.12.1181 · Cited by 133 · see citing works

Receptor heteromerization and drug discovery

Rozenfeld, R., & Devi, L. A. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.11.008 · Cited by 130 · see citing works

Aspects on receptor regulation and isoreceptor identification.

Agnati, L. F., Fuxé, K., Zini, I., Lenzi, P., & Hökfelt, T. (1980) · PubMed · Cited by 130 · see citing works

Airway smooth muscle prostaglandin-EP1 receptors directly modulate 2-adrenergic receptors within a unique heterodimeric complex

McGraw, D. W. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25840 · Cited by 129 · see citing works

Heterooligomerization of human dopamine receptor 2 and somatostatin receptor 2

Baragli, A., Alturaihi, H., Watt, H. L., Abdallah, A., & Kumar, U. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.07.007 · Cited by 128 · see citing works

New vistas on synaptic plasticity: the receptor mosaic hypothesis of the engram.

Agnati, L. F., Fuxé, K., Zoli, M., Rondanini, C., & Ögren, S. O. (1982) · PubMed · Cited by 127 · see citing works

Single Molecule Analysis of Functionally Asymmetric G Protein-coupled Receptor (GPCR) Oligomers Reveals Diverse Spatial and Structural Assemblies

Jonas, K., Fanelli, F., Huhtaniemi, I. T., & Hanyaloglu, A. C. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.622498 · Cited by 125 · see citing works

Do orphan G‐protein‐coupled receptors have ligand‐independent functions?

Levoye, A., Dam, J., Ayoub, M. A., Guillaume, J., & Jockers, R. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400838 · Cited by 123 · see citing works

Functional Selectivity of Allosteric Interactions within G Protein–Coupled Receptor Oligomers: The Dopamine D1-D3 Receptor Heterotetramer

Guitart, X., Navarro, G., Moreno, E., Yano, H., Cai, N.-S., Sánchez‐Soto, M., Barodia, S. K., Naidu, Y. T., Mallol, J., Cortés, A., et al. (2014) · Molecular Pharmacology · doi:10.1124/mol.114.093096 · Cited by 122 · see citing works

Detection of Heteromers Formed by Cannabinoid CB1, Dopamine D2, and Adenosine A2AG-Protein-Coupled Receptors by Combining Bimolecular Fluorescence Complementation and Bioluminescence Energy Transfer

Navarro, G., Carriba, P., Gandía, J., Ciruela, F., Casadó, V., Cortés, A., Mallol, J., Canela, E. I., Lluís, C., & Franco, R. (2008) · The Scientific World JOURNAL · doi:10.1100/tsw.2008.136 · Cited by 121 · see citing works

Phosphorylation-independent attenuation of GPCR signalling

Ferguson, S. S. G. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.02.008 · Cited by 120 · see citing works

Dimerization of CXCR4 in living malignant cells: control of cell migration by a synthetic peptide that reduces homologous CXCR4 interactions

Wang, J., He, L., Combs, C. A., Roderiquez, G., & Norcross, M. A. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0261 · Cited by 120 · see citing works

Basic Pharmacological and Structural Evidence for Class A G-Protein-Coupled Receptor Heteromerization

Franco, R., Martínez‐Pinilla, E., Lanciego, J. L., & Navarro, G. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00076 · Cited by 120 · see citing works

GPCR structures in drug design, emerging opportunities with new structures

Tautermann, C. S. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.07.009 · Cited by 117 · see citing works

Serotonin 5-HT2C Receptor Homodimer Biogenesis in the Endoplasmic Reticulum

Herrick‐Davis, K., Weaver, B. A., Grinde, E., & Mazurkiewicz, J. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604390200 · Cited by 117 · see citing works

Interactions between Intracellular Domains as Key Determinants of the Quaternary Structure and Function of Receptor Heteromers

Navarro, G., Ferré, S., Cordomí, A., Moreno, E., Mallol, J., Casadó, V., Cortés, A., Hoffmann, H. M., Ortiz, J., Canela, E. I., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.115634 · Cited by 116 · see citing works

Position of Transmembrane Helix 6 Determines Receptor G Protein Coupling Specificity

Rose, A., Elgeti, M., Zachariae, U., Grubmüller, H., Hofmann, K. P., Scheerer, P., & Hildebrand, P. W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja5055109 · Cited by 116 · see citing works

D1 and D2 Dopamine Receptors Form Heterooligomers and Cointernalize after Selective Activation of Either Receptor

So, C. H., Varghese, G. K., Curley, K. J., Kong, M. M. C., Alijaniaram, M., Ji, X., Nguyen, T., O’Dowd, B. F., & George, S. R. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.012229 · Cited by 116 · see citing works

Functional crosstalk between GPCRs: with or without oligomerization

Prézeau, L., Rives, M., Comps‐Agrar, L., Maurel, D., Kniazeff, J., & Pin, J. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.10.009 · Cited by 111 · see citing works

Neurochemical basis of cannabis addiction

Maldonado, R. J., Berrendero, F., Ozaita, A., & Robledo, P. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.02.035 · Cited by 110 · see citing works

The Adenosine A2A Receptor Interacts with the Actin-binding Protein α-Actinin

Burgueño, J., Blake, D. J., Benson, M. A., Tinsley, C. L., Esapa, C. T., Canela, E. I., Penela, P., Mallol, J., Mayor, F., Lluís, C., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302809200 · Cited by 110 · see citing works

Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs

Navarro, G., Cordomí, A., Zelman-Femiak, M., Brugarolas, M., Moreno, E., Aguinaga, D., Pérez‐Benito, L., Cortés, A., Casadó, V., Mallol, J., et al. (2016) · BMC Biology · doi:10.1186/s12915-016-0247-4 · Cited by 108 · see citing works

Dipyridamole in the treatment of schizophrenia: adenosine-dopamine receptor interactions

Akhondzadeh, S., Shasavand, Jamilian, H., Shabestari, & Kamalipour (2000) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1046/j.1365-2710.2000.00273.x · Cited by 106 · see citing works

The study of G‐protein coupled receptor oligomerization with computational modeling and bioinformatics

Filizola, M., & Weinstein, H. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.04730.x · Cited by 105 · see citing works

Detection of higher‐order G protein‐coupled receptor oligomers by a combined BRET–BiFC technique

Gandía, J., Galino, J., Amaral, O. B., Soriano, A., Lluı́s, C., Franco, R., & Ciruela, F. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.07.045 · Cited by 104 · see citing works

Molecular basis for activation of G protein‐coupled receptor kinases

Boguth, C. A., Singh, P., Huang, C., & Tesmer, J. J. G. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.206 · Cited by 104 · see citing works

Asymmetry of GPCR oligomers supports their functional relevance

Maurice, P., Kamal, M., & Jockers, R. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.05.006 · Cited by 103 · see citing works

Hetero-oligomerization of the P2Y11 receptor with the P2Y1 receptor controls the internalization and ligand selectivity of the P2Y11 receptor

Ecke, D., Hanck, T., Tulapurkar, M. E., Schäfer, R., Kassack, M. U., Stricker, R., & Reiser, G. (2007) · Biochemical Journal · doi:10.1042/bj20070671 · Cited by 103 · see citing works

Oligomeric forms of G protein-coupled receptors (GPCRs)

Palczewski, K. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.05.002 · Cited by 102 · see citing works

Fluorescent Methods to Study Biological Membranes

Mély, Y., & Duportail, G. (2012) · Springer series on fluorescence · doi:10.1007/978-3-642-33128-2 · Cited by 100 · see citing works

Allosteric mechanisms within the adenosine A2A–dopamine D2 receptor heterotetramer

Ferré, S., Bonaventura, J., Tomasi, D. G., Navarro, G., Moreno, E., Cortés, A., Lluı́s, C., Casadó, V., & Volkow, N. D. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.05.028 · Cited by 99 · see citing works

Structured and disordered facets of the GPCR fold

Venkatakrishnan, A., Flock, T., Prado, D. E., Oates, M. E., Gough, J., & Babu, M. M. (2014) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2014.08.002 · Cited by 99 · see citing works

Galanin receptor-1 modulates 5-hydroxtryptamine-1A signaling via heterodimerization

Borroto‐Escuela, D. O., Narváez, M., Marcellino, D. J., Parrado, C., Narváez, J. Á., Tarakanov, A. O., Agnati, L. F., Dı́az-Cabiale, Z., & Fuxé, K. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.078 · Cited by 98 · see citing works

Rhodopsin self-associates in asolectin liposomes

Mansoor, S., Palczewski, K., & Farrens, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511010103 · Cited by 97 · see citing works

Dimerization and oligomerization of G-protein-coupled receptors: debated structures with established and emerging functions

Szidonya, L. K., Cserző, M., & Hunyady, L. (2008) · Journal of Endocrinology · doi:10.1677/joe-07-0573 · Cited by 95 · see citing works

Dynamic Cholesterol-Conditioned Dimerization of the G Protein Coupled Chemokine Receptor Type 4

Pluháčková, K., Gahbauer, S., Kranz, F., Wassenaar, T. A., & Böckmann, R. A. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005169 · Cited by 95 · see citing works

Taking two to tango: a role for ghrelin receptor heterodimerization in stress and reward

Schellekens, H., Dinan, T. G., & Cryan, J. F. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00148 · Cited by 94 · see citing works

Dopamine D4 receptor, but not the ADHD-associated D4.7 variant, forms functional heteromers with the dopamine D2S receptor in the brain

González, S., Rangel‐Barajas, C., Peper, M., Lorenzo, R., Moreno, E., Ciruela, F., Borycz, J. A., Ortiz, J., Lluís, C., Franco, R., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.93 · Cited by 93 · see citing works

G protein-coupled receptors--recent advances.

Latek, D., Modzelewska, A., Trzaskowski, B., Palczewski, K., & Filipek, S. (2012) · Acta Biochimica Polonica · doi:10.18388/abp.2012_2086 · Cited by 93 · see citing works

Modular architecture of protein structures and allosteric communications: potential implications for signaling proteins and regulatory linkages

del Sol, A., Araúzo-Bravo, M. J., Amoros, D., & Nussinov, R. (2007) · Genome biology · doi:10.1186/gb-2007-8-5-r92 · Cited by 92 · see citing works

Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release

Park, S., Jiang, H. F., Zhang, H., & Smith, R. G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209590109 · Cited by 91 · see citing works

Hetero‐oligomerization of adenosine A1 receptors with P2Y1 receptors in rat brains

Yoshioka, K., Hosoda, R., Kuroda, Y., & Nakata, H. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03540-8 · Cited by 91 · see citing works

Ligand-Dependent Oligomerization of Dopamine D2 and Adenosine A2A Receptors in Living Neuronal Cells

Vidi, P., Chemel, B. R., Hu, C., & Watts, V. J. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.047472 · Cited by 91 · see citing works

Dimerization with Cannabinoid Receptors Allosterically Modulates Delta Opioid Receptor Activity during Neuropathic Pain

Bushlin, I., Gupta, A., Stockton, S. D., Miller, L. K., & Devi, L. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049789 · Cited by 90 · see citing works

Schizophrenia, amphetamine-induced sensitized state and acute amphetamine exposure all show a common alteration: increased dopamine D2 receptor dimerization

Wang, M., Pei, L., Fletcher, P. J., Kapur, S., Seeman, P. M., & Liu, F. (2010) · Molecular Brain · doi:10.1186/1756-6606-3-25 · Cited by 87 · see citing works

The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms

Müller, T. D., Müller, A., Yi, C., Habegger, K. M., Meyer, C. W., Gaylinn, B. D., Finan, B., Heppner, K. M., Trivedi, C. J., Bielohuby, M., et al. (2013) · Nature Communications · doi:10.1038/ncomms2968 · Cited by 82 · see citing works

Proteins flex to function

Huang, Y. J., & Montelione, G. T. (2005) · Nature · doi:10.1038/438036a · Cited by 79 · see citing works

Domain coupling in GPCRs: the engine for induced conformational changes

Ünal, H., & Karnik, S. S. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.09.007 · Cited by 79 · see citing works

Interactions between the Mas-Related Receptors MrgD and MrgE Alter Signalling and Trafficking of MrgD

Milasta, S., Pediani, J. D., Appelbe, S., Trim, S. A., Wyatt, M., Cox, P. J., Fidock, M. D., & Milligan, G. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.018788 · Cited by 79 · see citing works

Revealing G‐protein‐coupled receptor oligomerization at the single‐molecule level through a nanoscopic lens: methods, dynamics and biological function

Scarselli, M., Annibale, P., McCormick, P. J., Kolachalam, S., Aringhieri, S., Rađenović, A., Corsini, G. U., & Maggio, R. (2015) · FEBS Journal · doi:10.1111/febs.13577 · Cited by 79 · see citing works

Orexin–Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine

Navarro, G., Quiroz, C., Moreno‐Delgado, D., Sierakowiak, A., McDowell, K. A., Moreno, E., Rea, W. P., Cai, N.-S., Aguinaga, D., Howell, L. A., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4364-14.2015 · Cited by 75 · see citing works

The changing world of G protein-coupled receptors: From monomers to dimers and receptor mosaics with allosteric receptor-receptor interactions

Fuxe, K., Marcellino, D., Borroto-Escuela, D. O., Frankowska, M., Ferraro, L., Guidolin, D., Ciruela, F., & Agnati, L. F. (2010) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2010.506191 · Cited by 74 · see citing works

Dopamine D2–D3 receptor heteromers: pharmacological properties and therapeutic significance

Maggio, R., & Millan, M. J. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.10.001 · Cited by 73 · see citing works

Receptor–Receptor Interactions, Receptor Mosaics, and Basic Principles of Molecular Network Organization: Possible Implications for Drug Development

Agnati, L. F., Tarakanov, A. O., Ferré, S., Fuxé, K., & Guidolin, D. (2005) · Journal of Molecular Neuroscience · doi:10.1385/jmn:26:2-3:193 · Cited by 73 · see citing works

Possible role of intramembrane receptor-receptor interactions in memory and learning via formation of long-lived heteromeric complexes: focus on motor learning in the basal ganglia

Agnati, L. F., Franzén, O. G., Ferré, S., Leo, G., Franco, R., & Fuxé, K. (2003) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-0643-3_1 · Cited by 72 · see citing works

G‐protein‐coupled receptor heteromers: function and ligand pharmacology

Franco, R., Casadó, V., Cortés, A., Mallol, J., Ciruela, F., Ferré, S., Lluı́s, C., & Canela, E. I. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707571 · Cited by 71 · see citing works

Heterodimerization of Hypothalamic G-Protein-Coupled Receptors Involved in Weight Regulation

Rediger, A., Tarnow, P., Bickenbach, A., Schaefer, M., Krude, H., ters, A. G. U., & Biebermann, H. (2009) · Obesity Facts · doi:10.1159/000209862 · Cited by 70 · see citing works

Adenosine receptor containing oligomers: Their role in the control of dopamine and glutamate neurotransmission in the brain

Ciruela, F., Gómez‐Soler, M., Guidolin, D., Borroto‐Escuela, D. O., Agnati, L. F., Fuxé, K., & Fernández‐Dueñas, V. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2011.02.007 · Cited by 70 · see citing works

Cocaine Disrupts Histamine H3Receptor Modulation of Dopamine D1Receptor Signaling: σ1-D1-H3Receptor Complexes as Key Targets for Reducing Cocaine's Effects

Moreno, E., Moreno‐Delgado, D., Navarro, G., Hoffmann, H. M., Fuentes, S., Rosell-Vilar, S., Gasperini, P., Rodríguez-Ruiz, M., Medrano, M., Mallol, J., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4147-13.2014 · Cited by 70 · see citing works

Molecular organization and dynamics of the melatonin MT1 receptor/RGS20/Gi protein complex reveal asymmetry of receptor dimers for RGS and Gi coupling

Maurice, P., Daulat, A. M., Tureček, R., Ivankova-Susankova, K., Zamponi, F., Kamal, M. T., Clément, N., Guillaume, J., Bettler, B., Galès, C., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.236 · Cited by 70 · see citing works

Repeated cocaine administration changes the function and subcellular distribution of adenosine A1receptor in the rat nucleus accumbens

Toda, S., Alguacil, L. F., & Kalivas, P. W. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02121.x · Cited by 68 · see citing works

Seven transmembrane receptors—A brief personal retrospective

Lefkowitz, R. J. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.11.001 · Cited by 67 · see citing works

Constitutive Formation of Oligomeric Complexes between Family B G Protein-Coupled Vasoactive Intestinal Polypeptide and Secretin Receptors

Harikumar, K. G., Morfis, M. M., Lisenbee, C. S., Sexton, P. M., & Miller, L. J. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.015776 · Cited by 67 · see citing works

Structures for G-Protein-Coupled Receptor Tetramers in Complex with G Proteins

Cordomí, A., Navarro, G., Aymerich, M. S., & Franco, R. (2015) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.07.007 · Cited by 67 · see citing works

Impact of Lipid Composition and Receptor Conformation on the Spatio-temporal Organization of μ-Opioid Receptors in a Multi-component Plasma Membrane Model

Marino, K. A., Prada‐Gracia, D., Provasi, D., & Filizola, M. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005240 · Cited by 66 · see citing works

Dimerization and ligand binding affect the structure network of A2A adenosine receptor

Fanelli, F., & Felline, A. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.08.006 · Cited by 65 · see citing works

Constitutive Dimerization of the G-Protein Coupled Receptor, Neurotensin Receptor 1, Reconstituted into Phospholipid Bilayers

Harding, P. J., Attrill, H. L., Boehringer, J., Ross, S., Wadhams, G. H., Smith, E., Armitage, J. P., & Watts, A. G. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2008.09.054 · Cited by 65 · see citing works

Heterodimerization Between the Lutropin and Follitropin Receptors is Associated With an Attenuation of Hormone-Dependent Signaling

Feng, X., Zhang, M., Guan, R., & Segaloff, D. L. (2013) · Endocrinology · doi:10.1210/en.2013-1407 · Cited by 64 · see citing works

Receptor–receptor interactions: A novel concept in brain integration

Agnati, L. F., Guidolin, D., Leo, G., Carone, C., Genedani, S., & Fuxé, K. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.10.004 · Cited by 63 · see citing works

Bioinformatics and molecular modelling approaches to GPCR oligomerization

Breckels, L. M., Taddese, B., Wall, I. D., & Reynolds, C. A. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.11.001 · Cited by 62 · see citing works

Bioinformatics and type II G-protein-coupled receptors

Foord, S. M., Jupe, S., & Holbrook, J. D. (2002) · Biochemical Society Transactions · doi:10.1042/bst0300473 · Cited by 62 · see citing works

A peptide targeting an interaction interface disrupts the dopamine D1‐D2 receptor heteromer to block signaling and function in vitro and in vivo: effective selective antagonism

Hasbi, A., Perreault, M. L., Shen, M. Y. F., Zhang, L., To, R., Fan, T., Nguyen, T., Ji, X., O’Dowd, B. F., & George, S. R. (2014) · The FASEB Journal · doi:10.1096/fj.14-254037 · Cited by 62 · see citing works

Functions of Heteromeric Association Between Adenosine and P2Y Receptors

Nakata, H., Yoshioka, K., Kamiya, T., Tsuga, H., & Oyanagi, K. (2005) · Journal of Molecular Neuroscience · doi:10.1385/jmn:26:2-3:233 · Cited by 62 · see citing works

Silencing of secretin receptor function by dimerization with a misspliced variant secretin receptor in ductal pancreatic adenocarcinoma.

Ding, W.-Q., Cheng, Z. J., McElhiney, J., Kuntz, S. M., & Miller, L. J. (2002) · PubMed · Cited by 61 · see citing works

Single-Molecule Analyses of Fully Functional Fluorescent Protein-Tagged Follitropin Receptor Reveal Homodimerization and Specific Heterodimerization with Lutropin Receptor1

Mazurkiewicz, J. E., Herrick‐Davis, K., Barroso, M., Ulloa‐Aguirre, A., Lindau‐Shepard, B., Thomas, R. M., & Dias, J. A. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.114.125781 · Cited by 60 · see citing works

G-protein-coupled receptor heteromer dynamics

Vilardaga, J., Agnati, L. F., Fuxé, K., & Ciruela, F. (2010) · Journal of Cell Science · doi:10.1242/jcs.063354 · Cited by 59 · see citing works

The splice variant D3nf reduces ligand binding to the D3 dopamine receptor: evidence for heterooligomerization

Elmhurst, J. L., Xie, Z., O’Dowd, B. F., & George, S. R. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00120-0 · Cited by 58 · see citing works

Chemokine Receptor Oligomerization and Allostery

Stephens, B. S., & Handel, T. M. (2013) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-394587-7.00009-9 · Cited by 58 · see citing works

Novel Ergopeptides as Dual Ligands for Adenosine and Dopamine Receptors

Vendrell, M., Angulo-Pueyo, E., Casadó, V., Lluı́s, C., Franco, R., Alberício, F., & Royo, M. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm060947x · Cited by 57 · see citing works

An indispensable role of secretin in mediating the osmoregulatory functions of angiotensin II

Lee, V. H. Y., Lee, L. T. O., Chu, J., Lam, I. P. Y., Siu, F. K. Y., Vaudry, H., & Chow, B. (2010) · The FASEB Journal · doi:10.1096/fj.10-165399 · Cited by 57 · see citing works

Oligomeric potential of the M2 muscarinic cholinergic receptor

Park, P. S. ‐., & Wells, J. W. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02536.x · Cited by 56 · see citing works

Native Serotonin 5-HT2C Receptors Are Expressed as Homodimers on the Apical Surface of Choroid Plexus Epithelial Cells

Herrick‐Davis, K., Grinde, E., Lindsley, T. A., Teitler, M., Mancia, F., Cowan, A. E., & Mazurkiewicz, J. E. (2015) · Molecular Pharmacology · doi:10.1124/mol.114.096636 · Cited by 56 · see citing works

G Protein-Coupled Receptor Heteromers as New Targets for Drug Development

Ferré, S., Navarro, G., Casadó, V., Cortés, A., Mallol, J., Canela, E. I., Lluı́s, C., & Franco, R. (2010) · Progress in molecular biology and translational science · doi:10.1016/s1877-1173(10)91002-8 · Cited by 56 · see citing works

A Novel Dopamine Receptor Signaling Unit in Brain: Heterooligomers of D1 And D2 Dopamine Receptors

George, S. R., & O’Dowd, B. F. (2007) · The Scientific World JOURNAL · doi:10.1100/tsw.2007.223 · Cited by 53 · see citing works

Improvements in G protein-coupled receptor purification yield light stable rhodopsin crystals

Salom, D., Trong, I. L., Pohl, E., Ballesteros, J. A., Stenkamp, R. E., Palczewski, K., & Lodowski, D. T. (2006) · Journal of Structural Biology · doi:10.1016/j.jsb.2006.05.003 · Cited by 53 · see citing works

Orphan Receptor GPR179 Forms Macromolecular Complexes With Components of Metabotropic Signaling Cascade in Retina ON-Bipolar Neurons

Orlandi, C., Cao, Y., & Martemyanov, K. A. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-12907 · Cited by 53 · see citing works

Dimerization and Phosphorylation of Thyrotropin-releasing Hormone Receptors Are Modulated by Agonist Stimulation

Zhu, C.-C., Cook, L. B., & Hinkle, P. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204221200 · Cited by 52 · see citing works

Heterodimers and Receptor Mosaics of Different Types of G-Protein-Coupled Receptors

Fuxé, K., Marcellino, D. J., Guidolin, D., Woods, A. S., & Agnati, L. F. (2008) · Physiology · doi:10.1152/physiol.00028.2008 · Cited by 52 · see citing works

Synthesis and Pharmacological Evaluation of Dual Acting Ligands Targeting the Adenosine A2A and Dopamine D2 Receptors for the Potential Treatment of Parkinson’s Disease

Jörg, M., May, L. T., Mak, F. S., Lee, K. C. K., Miller, N. D., Scammells, P. J., & Capuano, B. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm501254d · Cited by 52 · see citing works

Mechanisms of signalling and biased agonism in G protein-coupled receptors

Wootten, D. L., Christopoulos, A., Martí-Solano, M., Babu, M. M., & Sexton, P. M. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0049-3 · Cited by 730 · see citing works

G protein-coupled receptors (GPCRs): advances in structures, mechanisms and drug discovery

Zhang, M., Chen, T., Lu, X., Lan, X., Chen, K., & Lu, S. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01803-6 · Cited by 520 · see citing works

Emerging Diversity in Lipid–Protein Interactions

Corradi, V., Sejdiu, B. I., Galloso, H. M., Abdizadeh, H., Noskov, S. Y., Marrink, ‪. J., & Tieleman, D. P. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00451 · Cited by 458 · see citing works

Structural insights into G-protein-coupled receptor allostery

Thal, D. M., Glukhova, A., Sexton, P. M., & Christopoulos, A. (2018) · Nature · doi:10.1038/s41586-018-0259-z · Cited by 320 · see citing works

Role of Short Chain Fatty Acid Receptors in Intestinal Physiology and Pathophysiology

Priyadarshini, M., Kumar, K. U., Dudeja, P. K., & Layden, B. T. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170050 · Cited by 272 · see citing works

An Update on Non-CB 1 , Non-CB 2 Cannabinoid Related G-Protein-Coupled Receptors

Morales, P., & Reggio, P. H. (2017) · Cannabis and Cannabinoid Research · doi:10.1089/can.2017.0036 · Cited by 168 · see citing works

GPCR homo-oligomerization

Milligan, G., Ward, R. J., & Marsango, S. (2018) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2018.10.007 · Cited by 148 · see citing works

The Endocannabinoid System as a Target in Cancer Diseases: Are We There Yet?

Moreno, E., Cavic, M. R., Krivokuća, A., Casadó, V., & Canela, E. I. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00339 · Cited by 126 · see citing works

Membrane proteins structures: A review on computational modeling tools

de Almeida, J. G., Preto, A. J., Koukos, P. I., Bonvin, A. M. J. J., & Moreira, I. S. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.07.008 · Cited by 115 · see citing works

The Angiotensin AT2 Receptor: From a Binding Site to a Novel Therapeutic Target

Steckelings, U. M., Widdop, R. E., Sturrock, E. D., Lubbe, L., Hussain, T., Kaschina, E., Unger, T., Hallberg, A., Carey, R. M., & Sumners, C. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000281 · Cited by 97 · see citing works

Functional dynamics of G protein-coupled receptors reveal new routes for drug discovery

Conflitti, P., Lyman, E. R., Sansom, M. S. P., Hildebrand, P. W., Gutiérrez‐de‐Terán, H., Carloni, P., Ansell, T. B., Yuan, S., Barth, P., Robinson, A. S., et al. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01083-3 · Cited by 97 · see citing works

Crosstalk between receptor tyrosine kinases (RTKs) and G protein-coupled receptors (GPCR) in the brain: Focus on heteroreceptor complexes and related functional neurotrophic effects

Liberto, V. D., Mudò, G., & Belluardo, N. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.11.018 · Cited by 83 · see citing works

Role of Short Chain Fatty Acid Receptors in Intestinal Physiology and Pathophysiology

Priyadarshini, M., Kumar, K. U., Dudeja, P. K., & Layden, B. T. (2018) · Comprehensive physiology · doi:10.1002/j.2040-4603.2018.tb00038.x · Cited by 69 · see citing works

Temporal reprogramming of calcium signalling via crosstalk of gonadotrophin receptors that associate as functionally asymmetric heteromers

Jonas, K., Chen, S., Virta, M., Mora, J. M., Franks, S., Huhtaniemi, I. T., & Hanyaloglu, A. C. (2018) · Scientific Reports · doi:10.1038/s41598-018-20722-5 · Cited by 63 · see citing works

Bioluminescence Resonance Energy Transfer as a Method to Study Protein-Protein Interactions: Application to G Protein Coupled Receptor Biology

Khamlichi, C. E., Reverchon, F., Hervouet, N., Blot, L., Reiter, É., & Morisset‐Lopez, S. (2019) · Molecules · doi:10.3390/molecules24030537 · Cited by 62 · see citing works

G protein-coupled receptors function as cell membrane receptors for the steroid hormone 20-hydroxyecdysone

Zhao, X.-F. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00620-y · Cited by 60 · see citing works

Exploiting the Multifaceted Effects of Cannabinoids on Mood to Boost Their Therapeutic Use Against Anxiety and Depression

Bassi, M. S., Gilio, L., Maffei, P., Dolcetti, E., Bruno, A., Buttari, F., Centonze, D., & Iezzi, E. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00424 · Cited by 49 · see citing works

Light-activated chimeric GPCRs: limitations and opportunities

Tichy, A., Gerrard, E. J., Sexton, P. M., & Janovjak, H. (2019) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2019.05.006 · Cited by 47 · see citing works

Receptor-Receptor Interactions as a Widespread Phenomenon: Novel Targets for Drug Development?

Guidolin, D., Marcoli, M., Tortorella, C., Maura, G., & Agnati, L. F. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00053 · Cited by 47 · see citing works

Design of a True Bivalent Ligand with Picomolar Binding Affinity for a G Protein-Coupled Receptor Homodimer

Pulido, D., Casadó-Anguera, V., Pérez‐Benito, L., Moreno, E., Cordomí, A., López, L., Cortés, A., Ferré, S., Pardo, L., Casadó, V., et al. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01249 · Cited by 46 · see citing works

Polypharmacological Approaches for CNS Diseases: Focus on Endocannabinoid Degradation Inhibition

Papa, A., Pasquini, S., Contri, C., Gemma, S., Campiani, G., Butini, S., Varani, K., & Vincenzi, F. (2022) · Cells · doi:10.3390/cells11030471 · Cited by 45 · see citing works

The Role of G-proteins and G-protein Regulating Proteins in Depressive Disorders

Senese, N. B., Rasenick, M. M., & Traynor, J. R. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01289 · Cited by 41 · see citing works

G protein-coupled receptor-receptor interactions give integrative dynamics to intercellular communication

Guidolin, D., Marcoli, M., Tortorella, C., Maura, G., & Agnati, L. F. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0087 · Cited by 42 · see citing works

l-DOPA and Its Receptor GPR143: Implications for Pathogenesis and Therapy in Parkinson’s Disease

Goshima, Y., Masukawa, D., Kasahara, Y., Hashimoto, T., & Aladeokin, A. C. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01119 · Cited by 42 · see citing works

Tissue-specific transcriptome analyses provide new insights into GPCR signalling in adult Schistosoma mansoni

Hahnel, S. R., Wheeler, N. J., Lu, Z., Wangwiwatsin, A., McVeigh, P., Maule, A. G., Berriman, M., Day, T. A., Ribeiro, P., & Grevelding, C. G. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006718 · Cited by 38 · see citing works

Understanding GPCR dimerization

Faron‐Górecka, A., Szlachta, M., Kolasa, M., Solich, J., Górecki, A., Kuśmider, M., Żurawek, D., & Dziedzicka‐Wasylewska, M. (2018) · Methods in cell biology · doi:10.1016/bs.mcb.2018.08.005 · Cited by 36 · see citing works

Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function?

Mikusic, N. L. R., Silva, M. G., Pineda, A. M., & Gironacci, M. M. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01179 · Cited by 36 · see citing works

Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870

Zhou, Y., Cao, C., He, L., Wang, X., & Zhang, X. C. (2019) · eLife · doi:10.7554/elife.48822 · Cited by 35 · see citing works

Distinct Dopamine D2 Receptor Antagonists Differentially Impact D2 Receptor Oligomerization

Wouters, E., Marín, A. R., Dalton, J. A. R., Giraldo, J., & Stove, C. P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071686 · Cited by 34 · see citing works

The Evolution of Oxytocin and Vasotocin Receptor Genes in Jawed Vertebrates: A Clear Case for Gene Duplications Through Ancestral Whole-Genome Duplications

Daza, D. O., Bergqvist, C. A., & Larhammar, D. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.792644 · Cited by 33 · see citing works

Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t

Ward, R. J., Pediani, J. D., Marsango, S., Jolly, R., Stoneman, M. R., Biener, G., Handel, T. M., Raicu, V., & Milligan, G. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.016612 · Cited by 32 · see citing works

International Union of Basic and Clinical Pharmacology CXIV: Orexin Receptor Function, Nomenclature and Pharmacology

Kukkonen, J. P., Jacobson, L. H., Hoyer, D., Rinne, M. K., & Borgland, S. L. (2024) · Pharmacological Reviews · doi:10.1124/pharmrev.123.000953 · Cited by 30 · see citing works

Spatial Intensity Distribution Analysis: Studies of G Protein-Coupled Receptor Oligomerisation

Pediani, J. D., Ward, R. J., Marsango, S., & Milligan, G. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.09.001 · Cited by 29 · see citing works

Heteromerization of dopaminergic receptors in the brain: Pharmacological implications

Misganaw, D. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105600 · Cited by 28 · see citing works

Protein oligomerization as a metabolic control mechanism: Application to apoE

Frieden, C. (2019) · Protein Science · doi:10.1002/pro.3583 · Cited by 26 · see citing works

Reprogramming G protein coupled receptor structure and function

Kéri, D., & Barth, P. (2018) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2018.07.008 · Cited by 25 · see citing works

Striatal astrocytic A2A-D2 receptor-receptor interactions and their role in neuropsychiatric disorders

Cervetto, C., Maura, G., Guidolin, D., Amato, S., Ceccoli, C., Agnati, L. F., & Marcoli, M. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109636 · Cited by 24 · see citing works

Muscarinic receptor oligomerization

Marsango, S., Ward, R. J., Alvarez‐Curto, E., & Milligan, G. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.023 · Cited by 24 · see citing works

Dopamine Receptor Type 2 and Ghrelin Receptor Coexpression Alters CaV2.2 Modulation by G Protein Signaling Cascades

González, S. C., Mustafá, E. R., Rodríguez, S. S., Perelló, M., & Raingo, J. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00426 · Cited by 24 · see citing works

Central nervous system interaction and crosstalk between nAChRs and other ionotropic and metabotropic neurotransmitter receptors

Bono, F., Fiorentini, C., Mutti, V., Tomasoni, Z., Sbrini, G., Trebesova, H., Marchi, M., Grilli, M., & Missale, C. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106711 · Cited by 22 · see citing works

Adenosine A2A-dopamine D2 receptor-receptor interaction in neurons and astrocytes: Evidence and perspectives

Guidolin, D., Marcoli, M., Tortorella, C., Maura, G., & Agnati, L. F. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.11.004 · Cited by 21 · see citing works

Class A and C GPCR Dimers in Neurodegenerative Diseases

Moreira, I. S., Caniceiro, A. B., Bueschbell, B., & Schiedel, A. C. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220327221830 · Cited by 18 · see citing works

Functional Cross-Talk between Adenosine and Metabotropic Glutamate Receptors

León, D., Albasanz, J. L., & Martı́n, M. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180416093717 · Cited by 20 · see citing works

Homo-oligomerization of the human adenosine A2A receptor is driven by the intrinsically disordered C-terminus

Nguyen, K. D. Q., Vigers, M. P., Sefah, E., Seppälä, S., Hoover, J. P., Schonenbach, N. S., Mertz, B., O'Malley, M. A., & Han, S. (2021) · eLife · doi:10.7554/elife.66662 · Cited by 20 · see citing works

Identifying G protein-coupled receptor dimers from crystal packings

Stenkamp, R. E. (2018) · Acta Crystallographica Section D Structural Biology · doi:10.1107/s2059798318008136 · Cited by 18 · see citing works

Integrating Endocannabinoid Signalling In Depression

Rana, T., Behl, T., Sehgal, A., Mehta, V., Singh, S., Kumar, R., & BUNGAU, S. G. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01774-7 · Cited by 20 · see citing works

The novel hybrid agonist HyNDA-1 targets the D3R-nAChR heteromeric complex in dopaminergic neurons

Matera, C., Bono, F., Pelucchi, S., Collo, G., Bontempi, L., Gotti, C., Zoli, M., Amici, M. D., Missale, C., Fiorentini, C., et al. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.02.019 · Cited by 18 · see citing works

Computational prediction of GPCR oligomerization

Townsend‐Nicholson, A., Altwaijry, N. A., Potterton, A., Morao, I., & Heifetz, A. (2019) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2019.04.005 · Cited by 18 · see citing works

G Protein-Coupled Receptor Heteromers as Putative Pharmacotherapeutic Targets in Autism

DelaCuesta-Barrutia, J., Peñagarikano, O., & Erdozain, A. M. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.588662 · Cited by 18 · see citing works

Homobivalent Dopamine D 2 Receptor Ligands Modulate the Dynamic Equilibrium of D 2 Monomers and Homo- and Heterodimers

Ullmann, T., Gienger, M., Budzinski, J., Hellmann, J., Hübner, H., Gmeiner, P., & Weikert, D. (2021) · ACS Chemical Biology · doi:10.1021/acschembio.0c00895 · Cited by 18 · see citing works

G Protein–Coupled Receptor Heteromers in Brain: Functional and Therapeutic Importance in Neuropsychiatric Disorders

Sun, Y., Hasbi, A., & George, S. R. (2025) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-061724-080727 · Cited by 16 · see citing works

Unmasking allosteric-binding sites: novel targets for GPCR drug discovery

Casadó-Anguera, V., & Casadó, V. (2022) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2022.2085684 · Cited by 16 · see citing works

Modulation of Neuron and Astrocyte Dopamine Receptors via Receptor–Receptor Interactions

Guidolin, D., Tortorella, C., Marcoli, M., Cervetto, C., De, R., Maura, G., & Agnati, L. F. (2023) · Pharmaceuticals · doi:10.3390/ph16101427 · Cited by 16 · see citing works

Disrupting GPCR Complexes with Smart Drug-like Peptides

Gallo, M., Defaus, S., & Andreu, D. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14010161 · Cited by 16 · see citing works

Homo‐molecular Fluorescence Complementation for Direct Visualization of Receptor Oligomerization in Living Cells

Song, D., & Jung, Y. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201812780 · Cited by 16 · see citing works

The in vivo transcriptome of Schistosoma mansoni in the prominent vector species Biomphalaria pfeifferi with supporting observations from Biomphalaria glabrata

Buddenborg, S. K., Kamel, B., Hanelt, B., Bu, L., Zhang, S., Mkoji, G. M., & Loker, E. S. (2019) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0007013 · Cited by 16 · see citing works

Engineered Allosteric Regulation of Protein Function

Fauser, J., Leschinsky, N., Szynal, B. N., & Karginov, A. V. (2022) · Journal of Molecular Biology · doi:10.1016/j.jmb.2022.167620 · Cited by 15 · see citing works

The heterotetrameric structure of the adenosine A1-dopamine D1 receptor complex: Pharmacological implication for restless legs syndrome

Cortés, A., Casadó-Anguera, V., Moreno, E., & Casadó, V. (2019) · Advances in pharmacology · doi:10.1016/bs.apha.2019.01.001 · Cited by 15 · see citing works

Receptor-receptor interactions and microvesicle exchange as mechanisms modulating signaling between neurons and astrocytes

Guidolin, D., Tortorella, C., Marcoli, M., Cervetto, C., Maura, G., & Agnati, L. F. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109509 · Cited by 14 · see citing works

Intercellular Communication in the Central Nervous System as Deduced by Chemical Neuroanatomy and Quantitative Analysis of Images: Impact on Neuropharmacology

Guidolin, D., Tortorella, C., Marcoli, M., Maura, G., & Agnati, L. F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105805 · Cited by 13 · see citing works

Role of Translocator 18 KDa Ligands in the Activation of Leukotriene B4 Activated G-Protein Coupled Receptor and Toll Like Receptor-4 Pathways in Neutrophils

Kupa, L. D. V. K., Drewes, C. C., Barioni, É. D., Neves, C. L., Sampaio, S. C., & Farsky, S. H. P. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00766 · Cited by 12 · see citing works

Receptor–Receptor Interactions of G Protein-Coupled Receptors in the Carotid Body: A Working Hypothesis

Porzionato, A., Stocco, E., Guidolin, D., Agnati, L. F., Macchi, V., & De, R. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00697 · Cited by 13 · see citing works

URB597 abrogates anxiogenic and depressive behaviors in the methamphetamine-withdrawal mice: Role of the cannabinoid receptor type 1, cannabinoid receptor type 2, and transient receptor potential vanilloid 1 channels

Ebrahimi-Ghiri, M., Khakpai, F., & Zarrindast, M. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120965934 · Cited by 13 · see citing works

Receptor–Receptor Interactions and Glial Cell Functions with a Special Focus on G Protein-Coupled Receptors

Guidolin, D., Tortorella, C., Marcoli, M., Cervetto, C., Maura, G., & Agnati, L. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168656 · Cited by 12 · see citing works

The M 1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes

Marsango, S., Jenkins, L., Pediani, J. D., Bradley, S. J., Ward, R. J., Hesse, S., Biener, G., Stoneman, M. R., Tobin, A. B., Raicu, V., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2201103119 · Cited by 12 · see citing works

Evidence for Protein–Protein Interaction between Dopamine Receptors and the G Protein-Coupled Receptor 143

Bueschbell, B., Manga, P., Penner, E., & Schiedel, A. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158328 · Cited by 11 · see citing works

Spatiotemporally resolved GPCR interactome uncovers unique mediators of receptor agonism

Shchepinova, M. M., Richardson, R. E., Houghton, J. W., Walker, A. R., Safar, M., Conole, D., Hanyaloglu, A. C., & Tate, E. W. (2025) · Cell chemical biology · doi:10.1016/j.chembiol.2025.04.006 · Cited by 10 · see citing works

Brain Structure and Function: Insights from Chemical Neuroanatomy

Agnati, L. F., Guidolin, D., Cervetto, C., Maura, G., & Marcoli, M. (2023) · Life · doi:10.3390/life13040940 · Cited by 10 · see citing works

Molecular and functional insights into gonadotropin hormone receptor dimerization and oligomerization

Agwuegbo, U., & Jonas, K. (2018) · Minerva Obstetrics and Gynecology · doi:10.23736/s0026-4784.18.04287-9 · Cited by 10 · see citing works

Targeting the receptor-based interactome of the dopamine D1 receptor: looking for heteromer-selective drugs

Casadó-Anguera, V., Cortés, A., Casadó, V., & Moreno, E. (2019) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2019.1664469 · Cited by 10 · see citing works

G Protein-Dependent Activation of the PKA-Erk1/2 Pathway by the Striatal Dopamine D1/D3 Receptor Heteromer Involves Beta-Arrestin and the Tyrosine Phosphatase Shp-2

Bono, F., Tomasoni, Z., Mutti, V., Sbrini, G., Kumar, R., Longhena, F., Fiorentini, C., & Missale, C. (2023) · Biomolecules · doi:10.3390/biom13030473 · Cited by 9 · see citing works

A group II metabotropic glutamate receptor 3 (mGlu3, GRM3) isoform implicated in schizophrenia interacts with canonical mGlu3 and reduces ligand binding

García‐Bea, A., Bermúdez, I., Harrison, P. J., & Lane, T. A. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117715597 · Cited by 9 · see citing works

The Neurokinin-1 Receptor: A Promising Antitumor Target

Coveñas, R., Rodriguez, F. D., & Muñoz, M. (2022) · Receptors · doi:10.3390/receptors1010005 · Cited by 10 · see citing works

Interaction of POPC, DPPC, and POPE with the μ opioid receptor: A coarse-grained molecular dynamics study

Angladon, M.-A., Fossepré, M., Leherte, L., & Vercauteren, D. P. (2019) · PLoS ONE · doi:10.1371/journal.pone.0213646 · Cited by 9 · see citing works

Advances in the allostery of angiotensin II type 1 receptor

Zhang, X., Zhang, S., Wang, M., Chen, H., & Liu, H. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01063-x · Cited by 8 · see citing works

Control of Dopamine Signal in High-Order Receptor Complex on Striatal Astrocytes

Amato, S., Averna, M., Farsetti, E., Guidolin, D., Pedrazzi, M., Gatta, E., Candiani, S., Maura, G., Agnati, L. F., Cervetto, C., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168610 · Cited by 7 · see citing works

Bivalent and bitopic ligands of the opioid receptors: The prospects of a dual approach

Hovah, M. E. L., & Holzgrabe, U. (2024) · Medicinal Research Reviews · doi:10.1002/med.22050 · Cited by 7 · see citing works

Recent Advances in Dopamine D3 Receptor Heterodimers: Focus on Dopamine D3 and D1 Receptor–Receptor Interaction and Striatal Function

Bono, F., Mutti, V., Tomasoni, Z., Sbrini, G., Missale, C., & Fiorentini, C. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_353 · Cited by 7 · see citing works

Modulating brain integrative actions as a new perspective on pharmacological approaches to neuropsychiatric diseases

Marcoli, M., Agnati, L. F., Franco, R., Cortelli, P., Anderlini, D., Guidolin, D., Cervetto, C., & Maura, G. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1038874 · Cited by 7 · see citing works

Receptor dimers and biased ligands: Novel strategies for targeting G protein-coupled receptors

Liu, W., Wang, D., Wang, L., Hu, S., Jiang, Y., Wang, Y., Cai, X., & Chen, J. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108829 · Cited by 6 · see citing works

The Dual Role of A2aR in Neuroinflammation: Modulating Microglial Polarization in White Matter Lesions

Cheng, C., Cheng, W., Wang, Y., Chen, X., Zhang, L., Li, Y., Shen, F., Yuan, D., Hong, P., & Huang, W. S. (2025) · eNeuro · doi:10.1523/eneuro.0579-24.2025 · Cited by 6 · see citing works

Mechanistic insights from the atomic-level quaternary structure of short-lived GPCR oligomers of the human secretin receptor in live cells

Stoneman, M. R., Killeen, T. D., Yokoi, K., Biener, G., Bista, S., Adhikari, D. P., Rahman, S., Harikumar, K. G., Miller, L. J., Popa, I., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-08374-4 · Cited by 5 · see citing works

G Protein-coupled receptors: key targets for maintaining the function of basal ganglia-thalamus-cortical circuits in Parkinson’s disease

Wang, J., Qiao, Z., Cao, X., Li, H., Wang, Y., Jiao, Q., Chen, X., & Du, X. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117303 · Cited by 5 · see citing works

New insights into the functional impact of G protein–coupled receptor oligomerization

Johnson, G. P., Agwuegbo, U., & Jonas, K. (2020) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2020.08.005 · Cited by 5 · see citing works

Apelin Receptor Dimerization and Oligomerization

Yeganeh‐Hajahmadi, M., Moosavi-Saeed, Y., & Rostamzadeh, F. (2023) · Current Molecular Pharmacology · doi:10.2174/1874467217666230818113538 · Cited by 5 · see citing works

Proposal for simultaneous analysis of fluorescence intensity fluctuations and resonance energy transfer (IFRET) measurements

Stoneman, M. R., Biener, G., & Raicu, V. (2020) · Methods and Applications in Fluorescence · doi:10.1088/2050-6120/ab9b68 · Cited by 5 · see citing works

Fluorescence Intensity Fluctuation Analysis of Protein Oligomerization in Cell Membranes

Killeen, T. D., Rahman, S., Badu, D. N., Biener, G., Stoneman, M., & Raicu, V. (2022) · Current Protocols · doi:10.1002/cpz1.384 · Cited by 4 · see citing works

α1-adrenoceptor ligands inhibit chemokine receptor heteromerization partners of α1B/D-adrenoceptors via interference with heteromer formation

Gao, X., Enten, G. A., McGee, M. Y., Weche, M., & Majetschak, M. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106730 · Cited by 4 · see citing works

Profiling novel pharmacology of receptor complexes using Receptor-HIT

Johnstone, E. K. M., & Pfleger, K. D. G. (2021) · Biochemical Society Transactions · doi:10.1042/bst20201110 · Cited by 3 · see citing works

Possible roles of heteroreceptor complexes in excitotoxic processes

Guidolin, D., Tortorella, C., Marcoli, M., Cervetto, C., De, R., Maura, G., & Agnati, L. F. (2024) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2024.00089 · Cited by 3 · see citing works

G-Protein-Coupled Receptor-Based Drugs Rediscovered

Lundstrom, K. H. (2017) · Future Medicinal Chemistry · doi:10.4155/fmc-2017-0045 · Cited by 3 · see citing works

Super-Resolution Imaging as a Method to Study GPCR Dimers and Higher-Order Oligomers

Jonas, K., & Hanyaloglu, A. C. (2018) · Neuromethods · doi:10.1007/978-1-4939-8576-0_21 · Cited by 3 · see citing works

Drug Receptor Interactions, Metabolism, and Preclinical Drugs for SARS COV 2

Angayarkanni, T., Varghese, C. A., & J, H. N. D. (2021) · International Journal of Pharmaceutical Sciences Review and Research · doi:10.47583/ijpsrr.2021.v66i01.013 · Cited by 2 · see citing works

Unlocking the therapeutic capabilities of GPCR in the treatment of ischemic stroke: A translational literature

Girish, B. S., Nikitha, B. S., Roopa, K., Meghana, C. S., & Srinivasan, R. (2024) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2024.100197 · Cited by 2 · see citing works

Oligomerization of the Human Adenosine A 2A Receptor is Driven by the Intrinsically Disordered C-terminusPreprint

Nguyen, K. D. Q., Vigers, M. P., Sefah, E., Seppälä, S., Hoover, J. P., Schonenbach, N. S., Mertz, B., O'Malley, M. A., & Han, S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.21.423144 · Cited by 2 · see citing works

Allosteric modulation of dimeric GPR3 by ligands in the dimerization interfacePreprint

Qiu, Z., Wang, W., Nie, Y., Lin, J., Zhang, B., Xing, H., & Zheng, S. (2025) · eLife · doi:10.7554/elife.107185 · Cited by 2 · see citing works

Allosteric modulation of dimeric GPR3 by ligands in the dimerization interfacePreprint

Qiu, Z., Wang, W., Nie, Y., Lin, J., Zhang, B., Xing, H., & Zheng, S. (2025) · eLife · doi:10.7554/elife.107185.1 · Cited by 2 · see citing works

Unveiling the complexity of G protein-coupled receptor heteromers: advances in live cell imaging technologies and biochemical methods

Kim, H., Lee, H., & Seong, J. (2024) · Med-X · doi:10.1007/s44258-024-00029-z · Cited by 1 · see citing works

Development of cannabinoid-based therapies for Parkinson’s disease: emphasis on targeting cannabinoid receptors as CB2, PPAR-γ and GPR55 receptors

Burgaz, S., Rodríguez-Carreiro, S., Navarro, E., Lastres‐Becker, I., Garcı́a-Arencibia, M., Palomo‐Garo, C., Gómez‐Gálvez, Y., Gómez‐Cañas, M., García, C., & Fernández‐Ruíz, J. (2026) · Molecular Neurodegeneration Advances · doi:10.1186/s44477-025-00016-7 · Cited by 1 · see citing works

Dopamine D2 Receptor Isoform Heteroreceptor Complexes with the Growth Hormone Secretagogue Receptor 1a Reveals Isoform-Specific Interaction Interface Dynamics

Cáceres-Quezada, Á., Borroto‐Escuela, D. O., & Fierro, A. (2026) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.6c00308 · Cited by 1 · see citing works

Methods of G protein-coupled receptor oligomers

Bai, B. (2012) · Journal of Jining Medical University

G Protein–Coupled Receptor Oligomerization Revisited: Functional and Pharmacological Perspectives

Ferré, S., Casadó, V., Devi, L. A., Filizola, M., Jockers, R., Lohse, M. J., Milligan, G., Pin, J., & Guitart, X. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008052 · Cited by 574 · see citing works

The impact of G-protein-coupled receptor hetero-oligomerization on function and pharmachology

Maggio, R., Novi, F., & U., S. M. A. C. G. (2005) · Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila

The impact of G‐protein‐coupled receptor hetero‐oligomerization on function and pharmacology

Maggio, R., Novi, F., Scarselli, M., & Corsini, G. U. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.04729.x · Cited by 87 · see citing works

Formation of oligomers by G protein-coupled receptors.

Gazi, L., López‐Giménez, J. F., & Strange, P. G. (2002) · PubMed · Cited by 30 · see citing works