The changing world of G protein-coupled receptors: From monomers to dimers and receptor mosaics with allosteric receptor-receptor interactions

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL.

Monod, J., Wyman, J., & Changeux, J. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80285-6 · Cited by 7,681 · see citing works

EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.

Dahlstroem, A., & Fuxé, K. (1964) · PubMed · Cited by 5,143 · see citing works

Lipid rafts as a membrane-organizing principle

Lingwood, D., & Simons, K. (2010) · Science · doi:10.1126/science.1174621 · Cited by 4,417 · see citing works

High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor

Cherezov, V., Rosenbaum, D. M., Hanson, M. A., Rasmussen, S. G. F., Thian, F. S., Kobilka, T. S., Choi, H., Kühn, P., Weis, W. I., Kobilka, B. K., et al. (2007) · Science · doi:10.1126/science.1150577 · Cited by 3,280 · see citing works

Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits *

Koshland, D. E., Némethy, G., & Filmer, D. (1966) · Biochemistry · doi:10.1021/bi00865a047 · Cited by 3,019 · see citing works

The structure and function of G-protein-coupled receptors

Rosenbaum, D. M., Rasmussen, S. G. F., & Kobilka, B. K. (2009) · Nature · doi:10.1038/nature08144 · Cited by 2,534 · see citing works

Crystal structure of the human β2 adrenergic G-protein-coupled receptor

Rasmussen, S. G. F., Choi, H., Rosenbaum, D. M., Kobilka, T. S., Thian, F. S., Edwards, P. C., Burghammer, M. C., Ratnala, V. R. P., Sanishvili, R., Fischetti, R. F., et al. (2007) · Nature · doi:10.1038/nature06325 · Cited by 1,935 · see citing works

Transduction of Receptor Signals by ß-Arrestins

Lefkowitz, R. J., & Shenoy, S. K. (2005) · Science · doi:10.1126/science.1109237 · Cited by 1,729 · see citing works

Evidence for the existence of monoamine neurons in the central nervous system

Fuxé, K. (1965) · Cell and Tissue Research · doi:10.1007/bf00337069 · Cited by 1,567 · see citing works

EVIDENCE FOR THE EXISTENCE OF MONOAMINE NEURONS IN THE CENTRAL NERVOUS SYSTEM. IV. DISTRIBUTION OF MONOAMINE NERVE TERMINALS IN THE CENTRAL NERVOUS SYSTEM.

Fuxé, K. (1965) · PubMed · Cited by 1,544 · see citing works

G Protein-coupled Receptors

Ji, T. H., Grossmann, M., & Ji, I. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.28.17299 · Cited by 1,291 · see citing works

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

Dixon, R. A. F., Kobilka, B. K., Strader, D. J., Benovic, J., Dohlman, H. G., Frielle, T., Bolanowski, M. A., Bennett, C. D., Rands, E., Diehl, R. E., et al. (1986) · Nature · doi:10.1038/321075a0 · Cited by 1,275 · see citing works

β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

Lohse, M. J., Benovic, J., Codina, J., Caron, M. G., & Lefkowitz, R. J. (1990) · Science · doi:10.1126/science.2163110 · Cited by 1,222 · see citing works

Cholinergic and inhibitory synapses in a pathway from motor‐axon collaterals to motoneurones

Eccles, J. C., Fatt, P., & KOKETSU, K. (1954) · The Journal of Physiology · doi:10.1113/jphysiol.1954.sp005226 · Cited by 1,198 · see citing works

G Protein-coupled Receptors

Lefkowitz, R. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.30.18677 · Cited by 1,067 · see citing works

Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization

Ferguson, S. S. G., Downey, W. E., Colapietro, A.-M., Barak, L. S., Ménard, L., & Caron, M. G. (1996) · Science · doi:10.1126/science.271.5247.363 · Cited by 974 · see citing works

Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A 1 –A 2A Receptor Heteromers

Ciruela, F., Casadó, V., Rodrigues, R. J., Luján, R., Burgueño, J., Canals, M., Borycz, J., Rebola, N., Goldberg, S. R., Mallol, J., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3574-05.2006 · Cited by 591 · see citing works

Sustained cyclic AMP production by parathyroid hormone receptor endocytosis

Ferrandon, S., Feinstein, T. N., Castro, M., Wang, B., Bouley, R., Potts, J. T. J., Gardella, T. J., & Vilardaga, J. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.206 · Cited by 573 · see citing works

Akt/GSK3 Signaling in the Action of Psychotropic Drugs

Beaulieu, J., Gainetdinov, R. R., & Caron, M. G. (2008) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.011008.145634 · Cited by 523 · see citing works

AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration

AbdAlla, S., Lother, H., & Quitterer, U. (2000) · Nature · doi:10.1038/35024095 · Cited by 503 · see citing works

Coaggregation, Cointernalization, and Codesensitization of Adenosine A2A Receptors and Dopamine D2Receptors

Hillion, J., Canals, M., Torvinen, M., Casadó, V., Scott, R. P., Terasmaa, A., Hansson, A. C., Watson, S. J., Olah, M. E., Mallol, J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107731200 · Cited by 499 · see citing works

Increased AT1 receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness

AbdAlla, S., Lother, H., el Massiery, A., & Quitterer, U. (2001) · Nature Medicine · doi:10.1038/nm0901-1003 · Cited by 496 · see citing works

Quantitative Assessment of β1- and β2-Adrenergic Receptor Homo- and Heterodimerization by Bioluminescence Resonance Energy Transfer

Mercier, J.-F., Salahpour, A., Angers, S., Breit, A., & Bouvier, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205767200 · Cited by 474 · see citing works

Measurement of the millisecond activation switch of G protein–coupled receptors in living cells

Vilardaga, J., Bünemann, M., Krasel, C., Castro, M., & Lohse, M. J. (2003) · Nature Biotechnology · doi:10.1038/nbt838 · Cited by 432 · see citing works

MOLECULAR MECHANISM OF 7TM RECEPTOR ACTIVATION—A GLOBAL TOGGLE SWITCH MODEL

Schwartz, T. W., Frimurer, T. M., Holst, B., ROSENKILDE, M. M., & Elling, C. (2006) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.46.120604.141218 · Cited by 407 · see citing works

Building a new conceptual framework for receptor heteromers

Ferré, S., Baler, R., Bouvier, M., Caron, M. G., Devi, L. A., Durroux, T., Fuxé, K., George, S. R., Javitch, J. A., Lohse, M. J., et al. (2009) · Nature Chemical Biology · doi:10.1038/nchembio0309-131 · Cited by 395 · see citing works

A G protein-coupled receptor at work: the rhodopsin model

Hofmann, K. P., Scheerer, P., Hildebrand, P. W., Choe, H.-W., Park, J. H., Heck, M., & Ernst, O. P. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.07.005 · Cited by 376 · see citing works

Ligand binding and micro-switches in 7TM receptor structures

Nygaard, R., Frimurer, T. M., Holst, B., ROSENKILDE, M. M., & Schwartz, T. W. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.02.006 · Cited by 347 · see citing works

GABAB receptors – the first 7TM heterodimers

Marshall, F. H., JONES, K. A., Kaupmann, K., & Bettler, B. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01383-8 · Cited by 345 · see citing works

Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation

Han, Y., Moreira, I. S., Urizar, E., Weinstein, H., & Javitch, J. A. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.199 · Cited by 339 · see citing works

Dopamine D2 receptors form higher order oligomers at physiological expression levels

Guo, W. X., Urizar, E., Králíková, M., Mobarec, J. C., Shi, L., Filizola, M., & Javitch, J. A. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.153 · Cited by 334 · see citing works

Protein allostery, signal transmission and dynamics: a classification scheme of allosteric mechanisms

Tsai, C., del Sol, A., & Nussinov, R. (2009) · Molecular BioSystems · doi:10.1039/b819720b · Cited by 324 · see citing works

Molecular Mechanisms and Therapeutical Implications of Intramembrane Receptor/Receptor Interactions among Heptahelical Receptors with Examples from the Striatopallidal GABA Neurons

Agnati, L. F., Ferré, S., Lluı́s, C., Franco, R., & Fuxé, K. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.3.2 · Cited by 322 · see citing works

New Concepts in Drug Discovery: Collateral Efficacy and Permissive Antagonism

Kenakin, T. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1875 · Cited by 319 · see citing works

The discovery of central monoamine neurons gave volume transmission to the wired brain

Fuxé, K., Dahlström, A. B., JONSSON, G., Marcellino, D. J., Guescini, M., Dam, M., Manger, P. R., & Agnati, L. F. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.10.012 · Cited by 285 · see citing works

Understanding wiring and volume transmission

Agnati, L. F., Guidolin, D., Guescini, M., Genedani, S., & Fuxé, K. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.03.003 · Cited by 283 · see citing works

Detection of heteromerization of more than two proteins by sequential BRET-FRET

Carriba, P., Navarro, G., Ciruela, F., Ferré, S., Casadó, V., Agnati, L. F., Cortés, A., Mallol, J., Fuxé, K., Canela, E. I., et al. (2008) · Nature Methods · doi:10.1038/nmeth.1229 · Cited by 281 · see citing works

Integrated events in central dopamine transmission as analyzed at multiple levels. Evidence for intramembrane adenosine A2A/dopamine D2 and adenosine A1/dopamine D1 receptor interactions in the basal ganglia1Published on the World Wide Web on 12 January 1998.1

Fuxé, K., Ferré, S., Zoli, M., & Agnati, L. F. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00049-0 · Cited by 277 · see citing works

Conformational cross-talk between α2A-adrenergic and μ-opioid receptors controls cell signaling

Vilardaga, J., Nikolaev, V. O., Lorenz, K., Ferrandon, S., Zhuang, Z., & Lohse, M. J. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.64 · Cited by 264 · see citing works

Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher‐order oligomers in living cells

Cabello, N., Gandía, J., Bertarelli, D. C. G., Watanabe, M., Lluı́s, C., Franco, R., Ferré, S., Luján, R., & Ciruela, F. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06078.x · Cited by 253 · see citing works

Dual Inhibition of β-Adrenergic and Angiotensin II Receptors by a Single Antagonist

Barki‐Harrington, L., Luttrell, L. M., & Rockman, H. A. (2003) · Circulation · doi:10.1161/01.cir.0000092166.30360.78 · Cited by 252 · see citing works

From the Golgi–Cajal mapping to the transmitter-based characterization of the neuronal networks leading to two modes of brain communication: Wiring and volume transmission

Fuxé, K., Dahlström, A. B., Höistad, M., Marcellino, D. J., Jansson, A., Rivera, A., Dı́az-Cabiale, Z., Jacobsen, K. R., Tinner, B., Hagman, B., et al. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.02.009 · Cited by 247 · see citing works

Adenosine A2A and Dopamine D2 Heteromeric Receptor Complexes and Their Function

Fuxé, K., Ferré, S., Canals, M., Torvinen, M., Terasmaa, A., Marcellino, D. J., Goldberg, S. R., Staines, W. A., Jacobsen, K. X., Lluís, C., et al. (2005) · Journal of Molecular Neuroscience · doi:10.1385/jmn:26:2-3:209 · Cited by 234 · see citing works

Identification of Dopamine D1–D3 Receptor Heteromers

Marcellino, D. J., Ferré, S., Casadó, V., Cortés, A., Foll, B. L., Mazzola, C., Drago, F., Saur, O., Stark, H., Soriano, A., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710349200 · Cited by 232 · see citing works

The superfamily of heptahelical receptors

Lefkowitz, R. J. (2000) · Nature Cell Biology · doi:10.1038/35017152 · Cited by 231 · see citing works

GPCR monomers and oligomers: it takes all kinds

Gurevich, V. V., & Gurevich, E. V. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2007.11.007 · Cited by 219 · see citing works

How and why do GPCRs dimerize?

Gurevich, V. V., & Gurevich, E. V. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.02.004 · Cited by 218 · see citing works

β1/β2-Adrenergic Receptor Heterodimerization Regulates β2-Adrenergic Receptor Internalization and ERK Signaling Efficacy

Lavoie, C. H., Mercier, J.-F., Salahpour, A., Umapathy, D., Breit, A., Villeneuve, L.-R., Zhu, W., Xiao, R., Lakatta, E. G., Bouvier, M., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204163200 · Cited by 214 · see citing works

β-Adrenergic receptors: Evidence for negative cooperativity

Limbird, L. E., MEYTS, P. D., & Lefkowitz, R. J. (1975) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(75)90815-3 · Cited by 211 · see citing works

Reciprocal Regulation of Dopamine D1 and D3 Receptor Function and Trafficking by Heterodimerization

Fiorentini, C., Busi, C., Gorruso, E., Gotti, C., Spano, P., & Missale, C. (2008) · Molecular Pharmacology · doi:10.1124/mol.107.043885 · Cited by 209 · see citing works

Receptor–receptor interactions within receptor mosaics. Impact on neuropsychopharmacology

Fuxé, K., Marcellino, D. J., Rivera, A., Dı́az-Cabiale, Z., Filip, M., Gago, B., Roberts, D. C. S., Langel, Ü., Genedani, S., Ferraro, L., et al. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.11.007 · Cited by 199 · see citing works

CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling

Magalhães, A. C., Holmes, K. D., Dale, L. B., Comps‐Agrar, L., Lee, D., Yadav, P. N., Drysdale, L., Poulter, M. O., Roth, B. L., Pin, J., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2529 · Cited by 198 · see citing works

Combining Mass Spectrometry and Pull-Down Techniques for the Study of Receptor Heteromerization. Direct Epitope−Epitope Electrostatic Interactions between Adenosine A2Aand Dopamine D2Receptors

Ciruela, F., Burgueño, J., Casadó, V., Canals, M., Marcellino, D. J., Goldberg, S. R., Bäder, M., Fuxé, K., Agnati, L. F., Lluís, C., et al. (2004) · Analytical Chemistry · doi:10.1021/ac049295f · Cited by 192 · see citing works

Dopamine D2 and Adenosine A2A Receptors Regulate NMDA-Mediated Excitation in Accumbens Neurons Through A2A–D2 Receptor Heteromerization

Azdad, K., Gall, D., Woods, A. S., Ledent, C. A., Ferré, S., & Schiffmann, S. N. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.144 · Cited by 185 · see citing works

Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism

Castro, M., Nikolaev, V. O., Palm, D., Lohse, M. J., & Vilardaga, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503942102 · Cited by 175 · see citing works

Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act?

Schwartz, T. W., & Holst, B. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.06.008 · Cited by 173 · see citing works

Adenosine–Dopamine Interactions in the Pathophysiology and Treatment of CNS Disorders

Fuxé, K., Marcellino, D. J., Borroto‐Escuela, D. O., Guescini, M., Fernández‐Dueñas, V., Tanganelli, S., Rivera, A., Ciruela, F., & Agnati, L. F. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2009.00126.x · Cited by 170 · see citing works

Modulation by cholecystokinins of 3H‐spiroperidol binding in rat striatum: evidence for increased affinity and reduction in the number of binding sites

Fuxé, K., Agnati, L. F., Benfenati, F., CIMMINO, M., Algeri, S., Hökfelt, T. G. M., & Mutt, V. (1981) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1981.tb06942.x · Cited by 157 · see citing works

Hetero-oligomerization between β2- and β3-Adrenergic Receptors Generates a β-Adrenergic Signaling Unit with Distinct Functional Properties

Breit, A., Lagacé, M., & Bouvier, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313310200 · Cited by 153 · see citing works

Evidence for the existence of receptor--receptor interactions in the central nervous system. Studies on the regulation of monoamine receptors by neuropeptides.

Fuxé, K., Agnati, L. F., Benfenati, F., Celani, M. F., Zini, I., Zoli, M., & Mutt, V. (1983) · PubMed · Cited by 153 · see citing works

Receptor heteromerization and drug discovery

Rozenfeld, R., & Devi, L. A. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.11.008 · Cited by 130 · see citing works

Aspects on receptor regulation and isoreceptor identification.

Agnati, L. F., Fuxé, K., Zini, I., Lenzi, P., & Hökfelt, T. (1980) · PubMed · Cited by 130 · see citing works

Receptor-receptor interactions as an integrative mechanism in nerve cells

Zoli, M., Agnati, L. F., Hedlund, P. B., Li, X., Ferré, S., & Fuxé, K. (1993) · Molecular Neurobiology · doi:10.1007/bf02769180 · Cited by 129 · see citing works

GS Activation Is Time-limiting in Initiating Receptor-mediated Signaling

Hein, P., Rochais, F., Hoffmann, C., Dorsch, S., Nikolaev, V. O., Engelhardt, S. H., Berlot, C. H., Lohse, M. J., & Bünemann, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606713200 · Cited by 127 · see citing works

New vistas on synaptic plasticity: the receptor mosaic hypothesis of the engram.

Agnati, L. F., Fuxé, K., Zoli, M., Rondanini, C., & Ögren, S. O. (1982) · PubMed · Cited by 127 · see citing works

‘7TM Receptor Allostery: Putting Numbers to Shapeshifting Proteins

Kenakin, T. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.06.007 · Cited by 126 · see citing works

Adenosine A2A Receptor and Dopamine D3 Receptor Interactions: Evidence of Functional A2A/D3 Heteromeric Complexes

Torvinen, M., Marcellino, D. J., Canals, M., Agnati, L. F., Lluís, C., Franco, R., & Fuxé, K. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.003376 · Cited by 124 · see citing works

Intramembrane receptor–receptor interactions: a novel principle in molecular medicine

Fuxé, K., Canals, M., Torvinen, M., Marcellino, D. J., Terasmaa, A., Genedani, S., Leo, G., Guidolin, D., Dı́az-Cabiale, Z., Rivera, A., et al. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0589-0 · Cited by 118 · see citing works

The Mighty Arginine, the Stable Quaternary Amines, the Powerful Aromatics, and the Aggressive Phosphate: Their Role in the Noncovalent Minuet

Woods, A. S. (2004) · Journal of Proteome Research · doi:10.1021/pr034091l · Cited by 102 · see citing works

Mesangial AT1/B2 Receptor Heterodimers Contribute to Angiotensin II Hyperresponsiveness in Experimental Hypertension

AbdAlla, S., Abdel-Baset, A., Lother, H., el Massiery, A., & Quitterer, U. (2005) · Journal of Molecular Neuroscience · doi:10.1385/jmn:26:2-3:185 · Cited by 93 · see citing works

How sphingolipids bind and shape proteins: molecular basis of lipid-protein interactions in lipid shells, rafts and related biomembrane domains

Fantini, J. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3003-1 · Cited by 90 · see citing works

Ago-Allosteric Modulation and Other Types of Allostery in Dimeric 7TM Receptors

Schwartz, T. W., & Holst, B. (2006) · Journal of Receptors and Signal Transduction · doi:10.1080/10799890600567570 · Cited by 86 · see citing works

Role of Electrostatic Interaction in Receptor–Receptor Heteromerization

Woods, A. S., Ciruela, F., Fuxé, K., Agnati, L. F., Lluís, C., Franco, R., & Ferré, S. (2005) · Journal of Molecular Neuroscience · doi:10.1385/jmn:26:2-3:125 · Cited by 82 · see citing works

Minireview: GPCR and G Proteins: Drug Efficacy and Activation in Live Cells

Vilardaga, J., Bünemann, M., Feinstein, T. N., Lambert, N. A., Nikolaev, V. O., Engelhardt, S. H., Lohse, M. J., & Hoffmann, C. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0204 · Cited by 80 · see citing works

A serine point mutation in the adenosine A2AR C-terminal tail reduces receptor heteromerization and allosteric modulation of the dopamine D2R

Borroto‐Escuela, D. O., Marcellino, D. J., Narváez, M., Flajolet, M., Heintz, N., Agnati, L. F., Ciruela, F., & Fuxé, K. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.168 · Cited by 77 · see citing works

Molecular integration via allosteric interactions in receptor heteromers. A working hypothesis

Fuxé, K., Marcellino, D. J., Leo, G., & Agnati, L. F. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.10.010 · Cited by 74 · see citing works

Possible role of intramembrane receptor-receptor interactions in memory and learning via formation of long-lived heteromeric complexes: focus on motor learning in the basal ganglia

Agnati, L. F., Franzén, O. G., Ferré, S., Leo, G., Franco, R., & Fuxé, K. (2003) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-0643-3_1 · Cited by 72 · see citing works

Operational Analysis

Bridgman, P. W. (1938) · Philosophy of Science · doi:10.1086/286496 · Cited by 72 · see citing works

Interactions between Calmodulin, Adenosine A2A, and Dopamine D2 Receptors

Navarro, G., Aymerich, M., Marcellino, D. J., Cortés, A., Casadó, V., Mallol, J., Canela, E. I., Agnati, L. F., Woods, A. S., Fuxé, K., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.034231 · Cited by 65 · see citing works

Receptor–receptor interactions: A novel concept in brain integration

Agnati, L. F., Guidolin, D., Leo, G., Carone, C., Genedani, S., & Fuxé, K. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.10.004 · Cited by 63 · see citing works

Chapter 20 Morphofunctional studies on the neuropeptide Y/adrenaline costoring terminal systems in the dorsal cardiovascular region of the medulla oblongata. Focus on receptor-receptor interactions in cotransmission

Fuxé, K., Agnati, L. F., Härfstrand, A., Janson, A. M., Neumeyer, A. M., Andersson, K., Ruggeri, M., Zoli, M., & Goldstein, M. (1986) · Progress in brain research · doi:10.1016/s0079-6123(08)60246-0 · Cited by 62 · see citing works

Combining Mass Spectrometry and Pull-Down Techniques for the Study of Receptor Heteromerization

Burgueñeno, J., Casadó, V., Bäder, M., Goldberg, S. P., Canals, M., Franco, R., Woods, A. S., Ciruela, F., Lluís, C., Fuxe, K., et al. (2004) · Analytical Chemistry · Cited by 62 · see citing works

Chapter 19 Aspects on the information handling by the central nervous system: focus on cotransmission in the aged rat brain

Agnati, L. F., Fuxé, K., Zoli, M., Pich, E. M., Benfenati, F., Zini, I., & Goldstein, M. (1986) · Progress in brain research · doi:10.1016/s0079-6123(08)60245-9 · Cited by 60 · see citing works

G-protein-coupled receptor heteromer dynamics

Vilardaga, J., Agnati, L. F., Fuxé, K., & Ciruela, F. (2010) · Journal of Cell Science · doi:10.1242/jcs.063354 · Cited by 59 · see citing works

Heterodimers and Receptor Mosaics of Different Types of G-Protein-Coupled Receptors

Fuxé, K., Marcellino, D. J., Guidolin, D., Woods, A. S., & Agnati, L. F. (2008) · Physiology · doi:10.1152/physiol.00028.2008 · Cited by 52 · see citing works

Receptor-Receptor Interactions

Fuxé, K., & Agnati, L. F. (1987) · Palgrave Macmillan UK eBooks · doi:10.1007/978-1-349-08949-9 · Cited by 52 · see citing works

Central Catecholamine-Neuropeptide Y Interactions at the Pre- and Postsynaptic Level in Cardiovascular Centers

Fuxé, K., Härfstrand, A., Agnati, L. F., Kalia, M., Fredholm, B. B., Svensson, T. H., Gustafsson, J., Lang, R. E., & Ganten, D. (1987) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-198709002-00001 · Cited by 50 · see citing works

Receptor-Receptor Interactions

Fuxé, K., & Agnati, L. F. (1987) · Springer eBooks · doi:10.1007/978-1-4684-5415-4 · Cited by 48 · see citing works

Reciprocal interactions between α2-adrenoceptor agonist and neuropeptide Y binding sites in the nucleus tractus solitarius of the rat

Härfstrand, A., Fuxé, K., Agnati, L. F., & Fredholm, B. B. (1989) · Journal of Neural Transmission · doi:10.1007/bf01677422 · Cited by 47 · see citing works

A boolean network modelling of receptor mosaics relevance of topology and cooperativity

Agnati, L. F., Guidolin, D., Leo, G., & Fuxé, K. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0567-6 · Cited by 45 · see citing works

How Calmodulin Interacts with the Adenosine A2A and the Dopamine D2 Receptors

Woods, A. S., Marcellino, D. J., Jackson, S. N., Franco, R., Ferré, S., Agnati, L. F., & Fuxé, K. (2008) · Journal of Proteome Research · doi:10.1021/pr8001782 · Cited by 40 · see citing works

Integrated signaling in heterodimers and receptor mosaics of different types of GPCRs of the forebrain: relevance for schizophrenia

Fuxé, K., Marcellino, D. J., Woods, A. S., Leo, G., Antonelli, T., Ferraro, L., Tanganelli, S., & Agnati, L. F. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-008-0174-9 · Cited by 40 · see citing works

Is the GABAB Heterodimer a Good Drug Target?

Marshall, F. H. (2005) · Journal of Molecular Neuroscience · doi:10.1385/jmn:26:2-3:169 · Cited by 39 · see citing works

An integrated view on the role of receptor mosaics at perisynaptic level: focus on adenosine A2A, dopamine D2, cannabinoid CB1, and metabotropic glutamate mGlu5receptors

Agnati, L. F., Guidolin, D., Albertin, G., Trivello, E., Ciruela, F., Genedani, S., Tarakanov, A. O., & Fuxé, K. (2010) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2010.487492 · Cited by 34 · see citing works

On the expanding terminology in the GPCR field: The meaning of receptor mosaics and receptor heteromers

Agnati, L. F., Guidolin, D., Vilardaga, J., Ciruela, F., & Fuxé, K. (2010) · Journal of Receptors and Signal Transduction · doi:10.3109/10799891003786226 · Cited by 34 · see citing works

Antagonistic regulation of α2-adrenoceptors by neuropeptide Y receptor subtypes in the nucleus tractus solitarii

Yang, S.-N., Fior, D. R., Hedlund, P. B., Agnati, L. F., & Fuxé, K. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90281-x · Cited by 28 · see citing works

Coexistence of neuronal messengers : a new principle in chemical transmission : proceedings of the Marcus Wallenberg Symposium, held at the Grand Hotel, Saltsjöbaden, Stockholm, on 26-28 June 28, 1985

Hökfelt, T. G. M., Fuxé, K., & Pernow, B. (1986) · Medical Entomology and Zoology · Cited by 27 · see citing works

Receptor-receptor interactions : a new intramembrane integrative mechanism : proceedings of an international symposium held at the Wenner-Gren Center, Stockholm, October 9th-11th, 1986

Fuxé, K., & Agnati, L. F. (1987) · Macmillan eBooks · Cited by 23 · see citing works

Autoradiographic evidence for a bradykinin/angiotensin II receptor-receptor interaction in the rat brain

Fior, D. R., Hedlund, P. B., & Fuxé, K. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90228-d · Cited by 21 · see citing works

Calcium-mediated modulation of the quaternary structure and function of adenosine A2A–dopamine D2 receptor heteromers

Ferré, S., Woods, A. S., Navarro, G., Aymerich, M., Lluı́s, C., & Franco, R. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.10.002 · Cited by 21 · see citing works

Simultaneous central administration of adrenaline and neuropeptide Y leads to antagonistic interactions in vasodepressor responses in awake male rats

Härfstrand, A., & Fuxé, K. (1987) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1987.tb08172.x · Cited by 20 · see citing works

Seven Transmembrane Receptors as Nature’s Prototype Allosteric Protein: De-emphasizing the Geography of Binding

Kenakin, T. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.050062 · Cited by 18 · see citing works

On the Role of Receptor-Receptor Interactions in Synaptic Transmission: Biochemical and Autoradiographical Studies on the Interactions between α2-adrenergic and Neuropeptide Y Receptors in the Nucleus Tractus Solitarius

Fuxé, K., Agnati, L. F., Härfstrand, A., Fredholm, B. B., Kalia, M., & Goldstein, M. (1987) · Palgrave Macmillan UK eBooks · doi:10.1007/978-1-349-08949-9_18 · Cited by 6 · see citing works

The Significance of G Protein-Coupled Receptor Crystallography for Drug Discovery

Salon, J. A., Lodowski, D. T., & Palczewski, K. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.003350 · Cited by 221 · see citing works

The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components

Borroto-Escuela, D., Brito, I., Romero-Fernandez, W., Di Palma, M., Oflijan, J., Skieterska, K., Duchou, J., Van Craenenbroeck, K., Suárez-Boomgaard, D., Rivera, A., et al. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15058570 · Cited by 134 · see citing works

Biased Signaling at Chemokine Receptors

Corbisier, J., Galès, C., Huszagh, A., Parmentier, M., & Springael, J. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.596098 · Cited by 121 · see citing works

An update on the physiological and therapeutic relevance of GPCR oligomers

Farran, B. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.01.008 · Cited by 115 · see citing works

Interactions between NMDA and dopamine receptors: A potential therapeutic target

Wang, M., Wong, A. H. C., & Liu, F. (2012) · Brain Research · doi:10.1016/j.brainres.2012.03.029 · Cited by 113 · see citing works

Bioluminescence Resonance Energy Transfer Methods to Study G Protein-Coupled Receptor–Receptor Tyrosine Kinase Heteroreceptor Complexes

Borroto‐Escuela, D. O., Flajolet, M., Agnati, L. F., Greengard, P., & Fuxé, K. (2013) · Methods in cell biology · doi:10.1016/b978-0-12-408143-7.00008-6 · Cited by 103 · see citing works

Volume transmission and its different forms in the central nervous system

Fuxé, K., Borroto‐Escuela, D. O., Romero‐Fernandez, W., Zhang, W., & Agnati, L. F. (2013) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-013-1455-1 · Cited by 96 · see citing works

Crosstalk between receptor tyrosine kinases (RTKs) and G protein-coupled receptors (GPCR) in the brain: Focus on heteroreceptor complexes and related functional neurotrophic effects

Liberto, V. D., Mudò, G., & Belluardo, N. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.11.018 · Cited by 83 · see citing works

On the role of volume transmission and receptor-receptor interactions in social behaviour: focus on central catecholamine and oxytocin neurons

Fuxe, K., Borroto-Escuela, D. O., Romero-Fernandez, W., Ciruela, F., Manger, P., Leo, G., Díaz-Cabiale, Z., & Agnati, L. F. (2012) · Brain Research · doi:10.1016/j.brainres.2012.01.062 · Cited by 81 · see citing works

Extrasynaptic Neurotransmission in the Modulation of Brain Function. Focus on the Striatal Neuronal–Glial Networks

Fuxé, K., Borroto‐Escuela, D. O., Romero‐Fernandez, W., Dı́az-Cabiale, Z., Rivera, A., Ferraro, L., Tanganelli, S., Tarakanov, A. O., Garriga, P., Narváez, J. Á., et al. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00136 · Cited by 73 · see citing works

Heteromerization of angiotensin receptors changes trafficking and arrestin recruitment profiles

Porrello, E. R., Pfleger, K. D. G., Seeber, R. M., Qian, H., Oro, C., Abogadie, F. C., Delbridge, L. M. D., & Thomas, W. G. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.06.011 · Cited by 72 · see citing works

On the existence and function of galanin receptor heteromers in the central nervous system

Fuxé, K., Borroto‐Escuela, D. O., Romero‐Fernandez, W., Tarakanov, A. O., Calvo, F., Garriga, P., Tena, M., Narváez, M., Millón, C., Parrado, C., et al. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00127 · Cited by 69 · see citing works

Allosteric modulators of rhodopsin-like G protein-coupled receptors: Opportunities in drug development

Müller, C. E., Schiedel, A. C., & Baqi, Y. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.06.002 · Cited by 62 · see citing works

Moonlighting characteristics of G protein‐coupled receptors: Focus on receptor heteromers and relevance for neurodegeneration

Borroto‐Escuela, D. O., Tarakanov, A. O., Guidolin, D., Ciruela, F., Agnati, L. F., & Fuxé, K. (2011) · IUBMB Life · doi:10.1002/iub.473 · Cited by 60 · see citing works

Allosteric Interactions between δ and κ Opioid Receptors in Peripheral Sensory Neurons

Berg, K. A., Rowan, M. P., Gupta, A., Sanchez, T. A., Silva, M., Gomes, I., McGuire, B. A., Portoghese, P. S., Hargreaves, K., Devi, L. A., et al. (2011) · Molecular Pharmacology · doi:10.1124/mol.111.072702 · Cited by 61 · see citing works

Regulation of G Protein-Coupled Receptors by Ubiquitination

Skieterska, K., Rondou, P., & Craenenbroeck, K. V. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18050923 · Cited by 59 · see citing works

Receptor–Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment

Borroto‐Escuela, D. O., Narváez, M., Ambrogini, P., Ferraro, L., Brito, I., Romero‐Fernandez, W., Andrade‐Talavera, Y., Flores‐Burgess, A., Millón, C., Gago, B., et al. (2018) · Molecules · doi:10.3390/molecules23061341 · Cited by 50 · see citing works

Recent Advances in the Realm of Allosteric Modulators for Opioid Receptors for Future Therapeutics

Remesic, M., Hruby, V. J., Porreca, F., & Lee, Y. S. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00090 · Cited by 48 · see citing works

Receptor-Receptor Interactions as a Widespread Phenomenon: Novel Targets for Drug Development?

Guidolin, D., Marcoli, M., Tortorella, C., Maura, G., & Agnati, L. F. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00053 · Cited by 47 · see citing works

G-protein-coupled receptor type A heteromers as an emerging therapeutic target

Guidolin, D., Agnati, L. F., Marcoli, M., Borroto‐Escuela, D. O., & Fuxé, K. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.981155 · Cited by 43 · see citing works

G protein-coupled receptor-receptor interactions give integrative dynamics to intercellular communication

Guidolin, D., Marcoli, M., Tortorella, C., Maura, G., & Agnati, L. F. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0087 · Cited by 42 · see citing works

Cannabinoid-induced enhanced interaction and protein levels of serotonin 5-HT2A and dopamine D2 receptors in rat prefrontal cortex

Franklin, J. M., & Carrasco, G. A. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112450786 · Cited by 42 · see citing works

Allosteric Interactions between Adenosine A2A and Dopamine D2 Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics, and Opportunities for PET Imaging

Prasad, K., de Vries, E. F. J., Elsinga, P. H., Dierckx, R., & van Waarde, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041719 · Cited by 39 · see citing works

Oligomeric Receptor Complexes and Their Allosteric Receptor-Receptor Interactions in the Plasma Membrane Represent a New Biological Principle for Integration of Signals in the CNS

Borroto‐Escuela, D. O., & Fuxé, K. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00230 · Cited by 39 · see citing works

The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: Potential relevance for brain and behavior

Borroto-Escuela, D. O., Cuesta-Marti, C., Lopez-Salas, A., Chruścicka-Smaga, B., Crespo-Ramírez, M., Tesoro-Cruz, E., Palacios-Lagunas, D. A., Perez de la Mora, M., Schellekens, H., & Fuxe, K. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1055344 · Cited by 38 · see citing works

Receptor-receptor interactions in heteroreceptor complexes: a new principle in biology. Focus on their role in learning and memory

Fuxé, K., Borroto-Escuela, D. O., Ciruela, F., Guidolin, D., & Agnati, L. F. (2014) · Neuroscience Discovery · doi:10.7243/2052-6946-2-6 · Cited by 38 · see citing works

Central Nervous System and Computation

Guidolin, D., Albertin, G., Guescini, M., Fuxé, K., & Agnati, L. F. (2011) · The Quarterly Review of Biology · doi:10.1086/662456 · Cited by 36 · see citing works

Regulation of antral follicular growth by an interplay between gonadotropins and their receptors

Casarini, L., Paradiso, E., Lazzaretti, C., D’Alessandro, S., Roy, N., Mascolo, E., Zaręba, K. T., Garcı́a-Gasca, A., & Simoni, M. (2022) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-022-02456-6 · Cited by 35 · see citing works

Dynamic modulation of FGFR1–5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2

Borroto‐Escuela, D. O., Corrales, F., Narváez, M., Oflijan, J., Agnati, L. F., Palkovits, M., & Fuxé, K. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.10.067 · Cited by 32 · see citing works

On the Role of the Balance of GPCR Homo/ Heteroreceptor Complexes in the Brain

Borroto-Escuela, D., Brito, I., Palma, M. D., Jimenez‐Beristain, A., Narváez, M., Corrales, F., Pita-Rodríguez, M., Sartini, S., Ambrogini, P., Lattanzi, D., et al. (2015) · Journal of Advanced Neuroscience Research · doi:10.15379/2409-3564.2015.02.01.5 · Cited by 27 · see citing works

Cannabinoid 1 G protein-coupled receptor (periphero-)neutral antagonists: emerging therapeutics for treating obesity-driven metabolic disease and reducing cardiovascular risk

Janero, D. R., Lindsley, L., Vemuri, K. V., & Makriyannis, A. (2011) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2011.608063 · Cited by 25 · see citing works

Opportunities and Challenges in the Discovery of Allosteric Modulators of GPCRs

Bartuzi, D., Kaczor, A. A., & Matosiuk, D. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7465-8_13 · Cited by 23 · see citing works

Multiple Adenosine-Dopamine (A2A-D2 Like) Heteroreceptor Complexes in the Brain and Their Role in Schizophrenia

Borroto‐Escuela, D. O., Ferraro, L., Narváez, M., Tanganelli, S., Beggiato, S., Liu, F., Rivera, A., & Fuxé, K. (2020) · Cells · doi:10.3390/cells9051077 · Cited by 23 · see citing works

Neurotensin regulates cortical glutamate transmission by modulating N‐methyl‐D‐aspartate receptor functional activity: An in vivo microdialysis study

Ferraro, L., Beggiato, S., Tomasini, M. C., Fuxé, K., Tanganelli, S., & Antonelli, T. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22686 · Cited by 23 · see citing works

Information handling by the brain: proposal of a new “paradigm” involving the roamer type of volume transmission and the tunneling nanotube type of wiring transmission

Agnati, L. F., Guidolin, D., Maura, G., Marcoli, M., Leo, G., Carone, C., De, R., Genedani, S., Borroto‐Escuela, D. O., & Fuxé, K. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1240-0 · Cited by 22 · see citing works

Allosterism within δ Opioid–κ Opioid Receptor Heteromers in Peripheral Sensory Neurons: Regulation of κ Opioid Agonist Efficacy

Jacobs, B. A., Pando, M. M., Jennings, E. M., Chavera, T. A., Clarke, W. P., & Berg, K. A. (2018) · Molecular Pharmacology · doi:10.1124/mol.117.109975 · Cited by 22 · see citing works

Adenosine A2A-dopamine D2 receptor-receptor interaction in neurons and astrocytes: Evidence and perspectives

Guidolin, D., Marcoli, M., Tortorella, C., Maura, G., & Agnati, L. F. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.11.004 · Cited by 21 · see citing works

Bioinformatics and mathematical modelling in the study of receptor–receptor interactions and receptor oligomerization

Guidolin, D., Ciruela, F., Genedani, S., Guescini, M., Tortorella, C., Albertin, G., Fuxé, K., & Agnati, L. F. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.09.022 · Cited by 21 · see citing works

G Protein-Coupled Receptor Heteromer Identification Technology: Identification and Profiling of GPCR Heteromers

Mustafa, S., & Pfleger, K. D. G. (2011) · JALA Journal of the Association for Laboratory Automation · doi:10.1016/j.jala.2011.03.002 · Cited by 20 · see citing works

Class A and C GPCR Dimers in Neurodegenerative Diseases

Moreira, I. S., Caniceiro, A. B., Bueschbell, B., & Schiedel, A. C. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220327221830 · Cited by 18 · see citing works

Do certain signal transduction mechanisms explain the comorbidity of epilepsy and mood disorders?

Rocha, L., Alonso‐Vanegas, M., Orozco-Suárez, S. A., Alcantara‐Gonzalez, D., Cruzblanca, H., & Castro, E. (2014) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2014.01.001 · Cited by 20 · see citing works

Possible new targets for GPCR modulation: allosteric interactions, plasma membrane domains, intercellular transfer and epigenetic mechanisms

Agnati, L. F., Guidolin, D., Leo, G., Guescini, M., Pizzi, M., Stocchi, V., Spano, P., Ghidoni, R., Ciruela, F., Genedani, S., et al. (2011) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2011.599393 · Cited by 20 · see citing works

Neuronal Calcium and cAMP Cross-Talk Mediated by Cannabinoid CB1 Receptor and EF-Hand Calcium Sensor Interactions

Angelats, E., Requesens, M., Aguinaga, D., Kreutz, M. R., Franco, R., & Navarro, G. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00067 · Cited by 20 · see citing works

Reinterpreting anomalous competitive binding experiments within G protein-coupled receptor homodimers using a dimer receptor model

Casadó-Anguera, V., Moreno, E., Mallol, J., Ferré, S., Canela, E. I., Cortés, A., & Casadó, V. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.11.032 · Cited by 20 · see citing works

Insilico study of the A2AR–D2R kinetics and interfacial contact surface for heteromerization

Prakash, A., & Luthra, P. M. (2012) · Amino Acids · doi:10.1007/s00726-012-1218-x · Cited by 19 · see citing works

Signaling characteristics and functional regulation of delta opioid-kappa opioid receptor (DOP-KOP) heteromers in peripheral sensory neurons

Jacobs, B. A., Pando, M. M., Jennings, E. M., Jamshidi, R. J., Zamora, J. C., Chavera, T. S., Clarke, W. P., & Berg, K. A. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.02.019 · Cited by 19 · see citing works

Striatal NTS1, dopamine D2and NMDA receptor regulation of pallidal GABA and glutamate release – a dual‐probe microdialysis study in the intranigral 6‐hydroxydopamine unilaterally lesioned rat

Ferraro, L., O'Connor, W. T., Beggiato, S., Tomasini, M. C., Fuxé, K., Tanganelli, S., & Antonelli, T. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07949.x · Cited by 18 · see citing works

Evidence for the existence of facilitatory interactions between the dopamine D2 receptor and the oxytocin receptor in the amygdala of the rat relevance for anxiolytic actions

Hernández-Mondragón, J. C., Hernández-Hernández, D. A., Crespo-Ramírez, M., Prospero-García, O., Rocha-Arrieta, L., Fuxe, K., Borroto-Escuela, D. O., & Perez de la Mora, M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1251922 · Cited by 17 · see citing works

Contributions of fluorescence techniques to understanding G protein-coupled receptor dimerisation

Goddard, A. D., & Watts, A. G. (2012) · Biophysical Reviews · doi:10.1007/s12551-012-0073-z · Cited by 17 · see citing works

Genetic variants of dopamine D2 receptor impact heterodimerization with dopamine D1 receptor

Błasiak, E., Łukasiewicz, S., Szafran‐Pilch, K., & Dziedzicka‐Wasylewska, M. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2016.10.016 · Cited by 16 · see citing works

DIMERBOW: exploring possible GPCR dimer interfaces

García‐Recio, A., Navarro, G., Franco, R., Olivella, M., Guixà-González, R., & Cordomí, A. (2020) · Bioinformatics · doi:10.1093/bioinformatics/btaa117 · Cited by 16 · see citing works

Structural Characterization of Receptor–Receptor Interactions in the Allosteric Modulation of G Protein-Coupled Receptor (GPCR) Dimers

Lazim, R., Suh, D., Lee, J. W., Vu, T. N. L., Yoon, S.-H., & Choi, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063241 · Cited by 15 · see citing works

Receptor-receptor interactions and microvesicle exchange as mechanisms modulating signaling between neurons and astrocytes

Guidolin, D., Tortorella, C., Marcoli, M., Cervetto, C., Maura, G., & Agnati, L. F. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109509 · Cited by 14 · see citing works

5HT1AR-FGFR1 Heteroreceptor Complexes Differently Modulate GIRK Currents in the Dorsal Hippocampus and the Dorsal Raphe Serotonin Nucleus of Control Rats and of a Genetic Rat Model of Depression

Ambrogini, P., Lattanzi, D., Pagliarini, M., Palma, M. D., Sartini, S., Cuppini, R., Fuxé, K., & Borroto‐Escuela, D. O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087467 · Cited by 14 · see citing works

Membrane Heteroreceptor Complexes as Second-Order Protein Modulators: A Novel Integrative Mechanism through Allosteric Receptor–Receptor Interactions

Mirchandani‐Duque, M., Choucri, M., Hernández-Mondragón, J. C., Crespo‐Ramírez, M., Pérez-Olives, C., Ferraro, L., Franco, R., de la Mora, M. P., Fuxé, K., & Borroto‐Escuela, D. O. (2024) · Membranes · doi:10.3390/membranes14050096 · Cited by 14 · see citing works

Receptor–Receptor Interactions of G Protein-Coupled Receptors in the Carotid Body: A Working Hypothesis

Porzionato, A., Stocco, E., Guidolin, D., Agnati, L. F., Macchi, V., & De, R. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00697 · Cited by 13 · see citing works

Receptor–Receptor Interactions and Glial Cell Functions with a Special Focus on G Protein-Coupled Receptors

Guidolin, D., Tortorella, C., Marcoli, M., Cervetto, C., Maura, G., & Agnati, L. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168656 · Cited by 12 · see citing works

Efficiency of Homology Modeling Assisted Molecular Docking in G-protein Coupled Receptors

Bhunia, S. S., & Saxena, A. K. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200908165250 · Cited by 12 · see citing works

Click Modification in theN6Region of A3Adenosine Receptor-Selective Carbocyclic Nucleosides for Dendrimeric Tethering that Preserves Pharmacophore Recognition

Tosh, D. K., Phan, K., Deflorian, F., Wei, Q., Yoo, L. S., Gao, Z., & Jacobson, K. A. (2011) · Bioconjugate Chemistry · doi:10.1021/bc200526c · Cited by 9 · see citing works

Medicinal Chemistry

Imming, P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-417205-0.00001-8 · Cited by 9 · see citing works

Bioinformatics aggregation predictors in the study of protein conformational diseases of the human nervous system

Guidolin, D., Agnati, L. F., Albertin, G., Tortorella, C., & Fuxé, K. (2012) · Electrophoresis · doi:10.1002/elps.201200290 · Cited by 8 · see citing works

The adenosine A2A receptor is a therapeutic target in neurological, heart and oncogenic diseases

Franco, R., Lillo, A., Navarro, G., & Reyes‐Resina, I. (2022) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2022.2136570 · Cited by 8 · see citing works

Receptor and Channel Heteromers as Pain Targets

Berg, K. A., Patwardhan, A. M., & Akopian, A. N. (2012) · Pharmaceuticals · doi:10.3390/ph5030249 · Cited by 8 · see citing works

Membrane estrogen receptor and follicle-stimulating hormone receptor

Casarini, L., & Simoni, M. (2022) · Vitamins and hormones · doi:10.1016/bs.vh.2022.12.005 · Cited by 7 · see citing works

Modulating brain integrative actions as a new perspective on pharmacological approaches to neuropsychiatric diseases

Marcoli, M., Agnati, L. F., Franco, R., Cortelli, P., Anderlini, D., Guidolin, D., Cervetto, C., & Maura, G. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1038874 · Cited by 7 · see citing works

Reflections on the theory of "silver bullet" octreotide tracers: implications for ligand-receptor interactions in the age of peptides, heterodimers, receptor mosaics, truncated receptors, and multifractal analysis

Moncayo, R. (2011) · EJNMMI Research · doi:10.1186/2191-219x-1-9 · Cited by 6 · see citing works

Neuropeptide Receptors in Pain Circuitries: Useful Targets for CNS Imaging with Non-Peptide Ligands Suitable for PET?

Pissarek, M. (2014) · World Journal of Neuroscience · doi:10.4236/wjns.2014.44040 · Cited by 1 · see citing works

Susceptibility of GPCR Heteroreceptor Complexes to Neurotoxins. Relevance for Neurodegenerative and Psychiatric Disorders

Borroto‐Escuela, D. O., Beltran-Casanueva, R., López‐Salas, A., & Fuxé, K. (2022) · Springer eBooks · doi:10.1007/978-3-030-71519-9_222-1 · Cited by 1 · see citing works

Beta-Adrenergic Receptor Polymorphism and Patho-Genetics of Trauma: A Transformational Frontier of Personalized Medicine in Neurotrauma

El-Menyar, A. A., Khan, N. A., Asim, M., Rizoli, S. B., & Al-Thani, H. A. S. (2023) · Journal of Neurotrauma · doi:10.1089/neu.2023.0432 · Cited by 1 · see citing works

Susceptibility of GPCR Heteroreceptor Complexes to Neurotoxins. Relevance for Neurodegenerative and Psychiatric Disorders

Borroto‐Escuela, D. O., Beltran-Casanueva, R., López‐Salas, A., & Fuxé, K. (2022) · Springer eBooks · doi:10.1007/978-3-031-15080-7_222 · Cited by 1 · see citing works

Serotoninergic agonists and antagonists are the modulators of α1-Adrenoceptor activity in rat brain cortical membranes

Нестерова, Л. А., & Manukhin, B. N. (2013) · Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology · doi:10.1134/s1990747812030154

Cannabinoid Regulation of Serotonin 2A (5-HT 2A ) Receptor Signaling

Franklin, J. M. (2013)

PET Imaging of the Interaction between Adenosine A2A and Dopamine D2 Receptors in Animal Models of Brain Diseases

Prasad, K. (2023) · doi:10.33612/diss.784924964

Moonlighting proteins in neurobiology signaling mediated by G protein-coupled receptors

Mirchandani‐Duque, M., Choucri, M., Laffita‐Mesa, J. M., Hernández-García, A., Danielson, A., Martínez-Cortés, A., Berrocoso, E., Fuxé, K., & Borroto-Escuela, D. O. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-15719-6.00003-9

GPCR Heteromers and their Allosteric Receptor-Receptor Interactions

Fuxé, K., Borroto-Escuela, D. O., Marcellino, D. J., Romero‐Fernandez, W., Frankowska, M., Guidolin, D., Filip, M., Ferraro, L., Woods, A. S., Tarakanov, A. O., et al. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712803414259 · Cited by 88 · see citing works

Oligomeric Receptor Complexes and Their Allosteric Receptor-Receptor Interactions in the Plasma Membrane Represent a New Biological Principle for Integration of Signals in the CNS

Borroto‐Escuela, D. O., & Fuxé, K. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00230 · Cited by 39 · see citing works

Allostery at G Protein-Coupled Receptor Homo- and Heteromers: Uncharted Pharmacological Landscapes

Smith, N. J., & Milligan, G. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002667 · Cited by 261 · see citing works

Class A GPCR heterodimers: evidence from binding studies

Birdsall, N. J. M. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.08.003 · Cited by 78 · see citing works

Heterodimers and Receptor Mosaics of Different Types of G-Protein-Coupled Receptors

Fuxé, K., Marcellino, D. J., Guidolin, D., Woods, A. S., & Agnati, L. F. (2008) · Physiology · doi:10.1152/physiol.00028.2008 · Cited by 52 · see citing works