The DOI matches its Crossref record; 233 of the 233 references it cites were found in a registry or an index.
VDAC1, mitochondrial dysfunction, and Alzheimer’s disease
Abstract
Alzheimer's disease (AD) is an age-related neurodegenerative disorder. Although an accumulation of brain amyloid-β (Aβ) peptide and hyperphosphorylated tau protein have been implicated in the pathogenesis of AD, the etiology of the disease remains unclear. Mitochondrial dysfunction has been identified as an early event in AD pathogenesis and is reflected by reduced metabolism, disruption of Ca 2+ homeostasis, and increased levels of reactive oxygen species, lipid peroxidation, and apoptosis. The focus of this review is the involvement of mitochondrial dysfunction in AD, and specifically, the role of the voltage-dependent anion channel 1 (VDAC1), which has been linked to AD pathogenesis. VDAC1 is a multi-functional protein, expressed in the mitochondria and other cell compartments, including the plasma membrane. The protein regulates the main metabolic and energetic functions of the cell, including Ca 2+ homeostasis, oxidative stress, and mitochondria-mediated apoptosis. VDAC1 represents a hub protein that interacts with over 150 other proteins including phosphorylated tau, Aβ, and γ-secretase, and participates in their toxicity. The high levels of VDAC1 demonstrated post-mortem in the brains of AD patients and in amyloid precursor protein (APP) transgenic mice prompted the hypothesis that the protein may be associated with neuronal cell destruction since over-expression of VDAC1 triggers cell death. Thus, targeting mitochondrial dysfunction via VDAC1, to prevent this pro-apoptotic activity, could represent a novel strategy for inhibiting cell death. In addition, the review also discusses possible VDAC1 involvement in the link between AD and diabetes and the inverse association between cancer and AD.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The voltage-dependent anion channel 1 (VDAC1), located in the outer mitochondrial membrane, regulates mitochondrial membrane permeability [94]”
From Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease (2020) · cites this paper as [94]
In the citing paper
“A dynamic equilibrium between monomeric and oligomeric states of the protein exist, with the oligomeric state being formed upon apoptotic induction resulting in a channel through which cytochrome c efflux can occur [94].”
From Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease (2020) · cites this paper as [94]
Citations
Cites
1 retracted
RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
Lesné, S., Koh, M. T., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., Gallagher, M., & Ashe, K. H. (2006) · Nature · doi:10.1038/nature04533 · Cited by 2,769
RetractedHallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 9,051
The amyloid hypothesis of Alzheimer's disease at 25 years
Selkoe, D. J., & Hardy, J. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606210 · Cited by 6,164
Hengartner, M. O. (2000) · Nature · doi:10.1038/35037710 · Cited by 5,779
Global prevalence of dementia: a Delphi consensus study
Ferri, C. P., Prince, M. J., Brayne, C., Brodaty, H., Fratiglioni, L., Ganguli, M., Hall, K. S., Hasegawa, K., Hendrie, H. C., Huang, Y., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67889-0 · Cited by 5,336
2016 Alzheimer's disease facts and figures
Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619
Lipid rafts as a membrane-organizing principle
Lingwood, D., & Simons, K. (2010) · Science · doi:10.1126/science.1174621 · Cited by 4,417
Research works printed but not linked: 1
- Shoshan-Barmatz, 2008, VDAC, the voltage-dependent anion channel: function, regulation & mitochondrial signaling in cell life and death, Cell Sci., 4, 74
Cited by
Sorted by citations
Items 201–287 of 287
Deng, Y. L., Chen, C., Li, H., Wang, T., Zhang, X., Wang, X., & Pan, G. (2025) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266347052250407110353 · Cited by 3
Lu, J., Feng, Y., Wang, Y., Yu, Y., Zhao, W., Cao, X., Li, Z., & Lu, Y. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05361-5 · Cited by 3
Lin, B., Xie, G., Fu, J., Zhang, C., Qin, M., Wang, L., Wang, F., & Zhang, J. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000003607 · Cited by 3
From Lipids to Mitochondria: Shared Metabolic Alterations in Obesity and Alzheimer’s Disease
Uranga, R. M., & Allani, S. K. (2026) · Cells · doi:10.3390/cells15080672 · Cited by 3
Management of Alzheimer’s Disease with nutraceuticals
Yadav, J. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820593-8.00028-8 · Cited by 3
Brokate-Llanos, A. M., Sanchez-Ibañez, M., Pérez‐Jiménez, M. M., Monje, J. M., Gómez-Marín, C., Caro, C., Vivar‐Rios, C., Moreno-Mateos, M. A., García‐Martín, M. L., Muñoz, M. J., et al. (2024) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkae040 · Cited by 3
Yan, G., Huang, N., Chen, C., Huang, H., & Cheng, J. (2024) · Oncology Letters · doi:10.3892/ol.2024.14507 · Cited by 3
Duan, X., Shi, J., Hou, R., Huang, Y., Wang, C., & Du, H. (2025) · Scientific Reports · doi:10.1038/s41598-025-85646-3 · Cited by 3
Azarfarin, M., Moradikor, N., Salatin, S., Sarailoo, M., & Dadkhah, M. (2025) · Progress in brain research · doi:10.1016/bs.pbr.2025.01.011 · Cited by 3
Neumann, S., Kuteykin‐Teplyakov, K. B., & Heumann, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25053030 · Cited by 4
Neurons Structure and Cytokine Expression after Lithium Carbonate Treatment on Melanoma Mice Model
Obanina, N. A., Bgatova, N. P., & Ivanov, I. D. (2024) · Cell and Tissue Biology · doi:10.1134/s1990519x2470041x · Cited by 3
Su, J., Wei, J., Zhang, B., Wang, X., Tang, L., Yuan, Y., Sun, X., Qi, S., Yang, J., Xue, Y., et al. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108502 · Cited by 3
Structural basis of bioenergetic protein complexes in Alzheimer's disease pathogenesis
McGregor, L., & Soler‐López, M. (2023) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2023.102573 · Cited by 3
Mitochondrial Dysregulation and the Influence in Neurodegenerative Diseases
Zuccoli, G. S., & Carregari, V. C. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-05460-0_8 · Cited by 3
Huang, H., Zeng, X., Zhang, L., Cheng, H., Hu, K., Shang, X., & Yao, C. (2025) · Food & Function · doi:10.1039/d5fo00054h · Cited by 2
VDAC1 oligomerization activates PANoptosis via mtDNA-STING axis in age-related macular degeneration
Wang, J.-N., Wei, T., Qiu, Z.-Y., Yin, H., Xie, T., Yao, Y., & Zhu, L. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.10.285 · Cited by 2
Therapeutic efficacy of rehmannioside A on 5×FAD mice in Alzheimer’s disease
Lai, Y., & Zhao, H. (2025) · Scientific Reports · doi:10.1038/s41598-025-23434-9 · Cited by 2
Peng, Q., Hao, L., Li, S., Yu, F., Li, N., Luo, X., Yue, J., Luo, Q., Zheng, K., & Hu, X. (2026) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-026-05500-6 · Cited by 2
Amyloid-β and Mitochondrial Membranes: A Missing Link in Alzheimer’s Pathogenesis
Houfkova, A., & Schmidt, M. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05786-z · Cited by 2
DEHP disrupts lipid metabolism via autophagy hyperactivation and mitochondrial dysfunction
Yu, S.-Y., Liu, Q., Gu, Y.-H., Han, W.-Z., Han, A.-J., Xiong, J., Li, T.-Z., Hu, Q.-S., Gang, F.-Y., Zhao, C.-Q., et al. (2026) · Autophagy · doi:10.1080/15548627.2026.2668651 · Cited by 2
Metformin in COVID-19: a magical role beyond the hyperglycemia
Chaubey, G. K., Dilawari, R., Modanwal, R., Talukdar, S., Dhiman, A., & Raje, M. (2024) · Exploration of Drug Science · doi:10.37349/eds.2024.00055 · Cited by 2
Соколик, Е. П., & Prozorova, G. O. (2022) · Neuroscience Research Notes · doi:10.31117/neuroscirn.v5i3.151 · Cited by 2
Personalized Perturbation Profiles Reveal Concordance between Autism Blood Transcriptome DatasetsPreprint
Laird, J., & Maertens, A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.25.427953 · Cited by 2
Voltage-Dependent Anion Channel (VDAC) in Health and Disease
Rajendran, M., Bezrukov, S. M., & Rostovtseva, T. K. (2023) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190932183.013.6 · Cited by 1
Age-related hearing loss: possible associations with Alzheimer’s disease
Ma, Y., Yang, Y., Zhou, Y.-F., Le, W., & Chai, R. (2024) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2024.24 · Cited by 1
Li, Y., Guo, L., Li, Y., An, C., Zhu, Q., Zheng, L., Zhao, J., & Wang, Y. (2026) · Biological Trace Element Research · doi:10.1007/s12011-025-04971-w · Cited by 1
Identification of CTHRC1 as a novel candidate for neurodevelopmental disorders
Xu, J., He, Y., Li, Z., Zhou, W.-X., Huang, C., Lu, L., Bajpai, A. K., & Li, M. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1737003 · Cited by 1
Gu, L., Liu, J., Wang, C., Shan, X., Li, S., Zhang, X., Xia, L., & Li, J. (2026) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2026.100503 · Cited by 3
Zhao, M., Qu, Y., Zhang, S., Zhang, M., Wang, H. H., Yang, Y., Gu, X. F., Hou, X., & Yan, X. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1707688 · Cited by 1
Targeting STAT3 in Alzheimer's disease: Potential mechanisms and therapeutic implications
Chen, P., Wang, R., Zhou, T., Sun, Y. N., Kirchhoff, F., Miao, Z., & Zhuang, C. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.118785 · Cited by 1
Mitochondrial interplay with membrane organelles in health and disease
Liu, S.-H., Wang, Y., Tong, C., & Liu, X. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02843-x · Cited by 1
Bu, X., Cao, X., Yao, X., Li, B., Lai, W., Zhao, Z., Hao, T., Chen, Z., Du, J., Li, Y., et al. (2026) · Advanced Science · doi:10.1002/advs.76060 · Cited by 1
PolyQ-expanded ataxin-3 is associated with mitochondrial alterations in Machado–Joseph disease
Simó, I., Robinson, K. J., Kam, J. Y., Wang, Y., Kuriakose, A., Parić, E., Cheng, F., Potapenko, A., An, Y., Watchon, M., et al. (2026) · Disease Models & Mechanisms · doi:10.1242/dmm.052757 · Cited by 1
Multi-target neuroprotection by dl-PHPB in APP/PS1 mice: a proteomic analysis
Sun, Y., Bai, G., Yang, K., Feng, Y., Sun, H., Xian, L., & Gao, H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1554168 · Cited by 1
dos Santos, C. R. G., & Cardoso, C. K. D. S. (2020) · HU Revista · doi:10.34019/1982-8047.2019.v45.27797 · Cited by 1
Coenzyme Q10 deficiency in elderly: Can nutritional supplementation play a role? Mini review
Am, C., Teresa, M., Pumpo, M. D., Giovanni, M., & Benvenuto, A. (2018) · The European Research Journal · doi:10.18621/eurj.411682 · Cited by 1
CERAMIDE-ENRICHED EXTRACELLULAR VESICLES
Elsherbini, A. M. (2020) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2020.474
Lv, X., Qiu, J., Hao, T., Zhang, H., Jiang, H., & Tan, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-526939/v1
Li, C., Wei, F., Shen, C., Wang, X., Gao, X., Chen, Z., Han, T., & Wang, X. (2021) · Research Square · doi:10.21203/rs.3.rs-144989/v1
Caffeine and mitochondria with a focus on the central nervous system
Momtaz, S., Hassani, S., Maghsoudi, A. S., Abdolghaffari, A. H., & Abdollahi, M. R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821562-3.00021-6 · Cited by 1
Mass Spectrometry‐Driven Lipidomics for Biomarker, Molecular Mechanism, and Therapy
Yang, Q., Qiu, S., Zhang, A., & Wang, X. (2021) · doi:10.1002/9783527835751.ch16
Najbauer, E. É. (2022) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-52
Babylon, L., Meißner, J., & Eckert, G. P. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.24.538048
Parallel Computing-Based Genome-Wide Epistasis Analysis of CSF Total Tau in ADNI Cohort
Zhang, Q., Liu, J., Chen, Y., Ao, L., & Chen, D. (2024) · IEEE International Conference on Medical Artificial Intelligence (MedAI) · doi:10.1109/medai62885.2024.00032
Thattil, H. J., Arunkumar, M. N., & Antony, F. (2025) · IEEE Access · doi:10.1109/access.2025.3560216
Mitochondrial dysfunction in Machado Joseph Disease: insights from a multi-model systemPreprint
Simo, I., Robinson, K. J., Kam, J. Y., Kuriakose, A., Parić, E., Cheng, F., Potapenko, A., An, Y., Lee, A., & Laird, A. S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.01.651800
Metabolic disorders associated with mitochondrial dysfunction
Akash, M. S. H., & Rehman, K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-36312-2.00011-5
Introduction to mitochondrial toxicity: Form, function, and signaling
Fink, D. M., Hanson, R. L., Moncada-Restrepo, M., & Chambers, J. W. (2025) · Advances in neurotoxicology · doi:10.1016/bs.ant.2025.05.002
Caruso, A. C., Kavanagh, T., Waardenberg, A. J., Graham, M. E., Drummond, E., & Nisbet, R. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.13.665777
Tsakiri, E. N., Samiotaki, M. K., Skoulakis, E. M. C., & Papanikolopoulou, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199741
Alaoui, A. A. E., Buhl, E., Galizia, S., Hodge, J. J. L., de Vivo, L., & Bellesi, M. (2023) · Figshare · doi:10.6084/m9.figshare.22598977
Chang, Y., Wang, C., Zhu, J., Zheng, S., Sun, S., Wu, Y., Jiang, X., Li, L., Ma, R., & Li, G. (2024) · Figshare · doi:10.6084/m9.figshare.26605984
Long, D., Fang, X., Yuan, P., Cheng, L., Li, H., & Qu, L. (2022) · Figshare · doi:10.6084/m9.figshare.20742263
Alaoui, A. A. E., Buhl, E., Galizia, S., Hodge, J. J. L., de Vivo, L., & Bellesi, M. (2023) · Figshare · doi:10.6084/m9.figshare.22598968
Chang, Y., Wang, C., Zhu, J., Zheng, S., Sun, S., Wu, Y., Jiang, X., Li, L., Ma, R., & Li, G. (2024) · Figshare · doi:10.6084/m9.figshare.26605987
Zhang, H.-X., & Li, H.-Y. (2026) · Medicine · doi:10.1097/md.0000000000048105
Yang, L., Song, G., Parker, E., & Yang, L. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05832-w
Research progress on carotid artery changes and cognitive impairment in Alzheimer's disease patients
Li, X., Feng, X., Cai, A., Guo, X., Li, J., Liao, W., Long, H., & Luan, P. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103127
Développement de peptides ciblant VDAC pour l’étude et le traitement de maladies démyélinisantes
Jacquard, M. F. (2023) · theses.fr (ABES) · doi:10.70675/33c8bd67z22cfz47b0zb14bz58b975b2f7d4
Li, B., Zhang, Z., Wang, Y., Bao, H., Ye, X., & Wen, F. (2026) · International Journal of Clinical Practice · doi:10.1155/ijcp/9947491
Li, Y.-P., Gong, J., Yang, L., Peng, R.-R., Jin, L., wang, F., Zhao, X., & Wang, L. (2026) · Research Square · doi:10.21203/rs.3.rs-9230899/v1
Early proteomic signatures of Alzheimer’s disease in the retina and brain of 3xTg-AD mice
Puja, A., McNeel, R., Xu, R., Zhu, S., Hansman, D., & Du, J. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1827348
Li, L., Fu, F., Li, R., Zhou, H., Huang, R., Lu, J., Guo, F., Chen, H., Lei, T., Han, J., et al. (2026) · Human Mutation · doi:10.1155/humu/8889386
Kumari, S., Włodkowic, D., & Singh, D. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.115854
Multitarget Actions of Pentacyclic Triterpenic Acids in Alzheimer’s Disease: Mechanistic Insights
Sharma, N., & An, S. S. A. (2026) · Molecules · doi:10.3390/molecules31122018
Wang, H., Li, K., Pu, H., Xiong, Y., Luo, D., Song, J., Jiang, H., Yu, X., & Deng, T. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158455
Targeting mtDNA to Modulate Mitochondrial Dysfunction in Neurodegenerative Diseases
Pramanik, S., Debnath, B., Chakraborty, A. J., Islam, A., Mullick, S., Chaudhary, P., Nath, R., Chellappan, D. K., Mondal, M., & Ashique, S. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06008-2
The Tau-mitochondria connection and its impact on cellular energy metabolism in Alzheimer’s disease
Singh, A. K., Supraja, M. R., Amal, P. S., Krishnamoorthi, S., Iyaswamy, A., & Durairajan, S. S. K. (2026) · International review of neurobiology · doi:10.1016/bs.irn.2026.06.002
Guo, X., Jiang, H., Lu, Y., Lin, Y., Liu, J., Qin, Z., & Tao, T. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.07.010
Sun, F., Yu, N., Yu, L., Tian, X., Ma, Y., Xie, Y., Wang, T., & Ma, C. (2026) · Advanced Science · doi:10.1002/advs.202523223
Advances in the Core Role and Mechanisms of Mitochondrial Dysfunction in Alzheimer's Disease
Gu, T., Guo, H., Guo, Z., & Hua, S. (2026) · Brain and Behavior · doi:10.1002/brb3.71418
Meng, G., Cai, L., Mo, Z., An, S., Sun, W., Shen, P., & Xie, Y. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261465779
Liu, Y., Fu, T., Li, W., Peng, K., Li, M., Li, W., Feng, Y., & Wu, X. (2026) · Letters in Drug Design & Discovery · doi:10.1016/j.lddd.2026.100455
Advances in the clinical application of mesenchymal stem cells for neurological disorders
Jamali, M. C., Shafie, A., Alqahtani, A. J., Al-Samawi, R. I., Alyami, H. M., Ashour, A. A., Felemban, M. F., Mansuri, N., Tayeb, F. J., Ahmad, I., et al. (2026) · Stem Cell Research & Therapy · doi:10.1186/s13287-026-05229-5
Integrative Proteomics and Ubiquitomics Reveal on-Targets and off-Targets of PROTAC dBET1
Wen, H., Liu, H., Liu, J., Yang, B., Dai, J., Chang, L., Li, Y., Zhang, Y., Yu, L., & Xu, P. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.6c00787
Song, J., Yuan, Y., Wang, M., Li, J., Ding, R., Jia, Y., Wang, Z. M., Xie, Z., Li, Z., & Zhang, Z. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1873606
Li, X., Wan, R., Wu, Y., Zhao, Y., Chen, X., Li, Y., Yang, R., Zhang, D., Li, Q., & Luo, C. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103359
Islam, M. S., Islam, M. T., Mondol, M., Islam, I., Fuad, K. M., Abid, M. F., Tajim, S., & Ferdous, R. (2026) · Advances in Redox Research · doi:10.1016/j.arres.2026.100196
Non-coding RNAs and Mitochondrial Dysfunction in Alzheimer’s Disease: A Systematic Review
Mocrei-Rebrean, Ș.-M., Răzniceanu, V., Pintilie, S. R., & Berindan‐Neagoe, I. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06198-9
Brain energy metabolism in neurodegenerative disease
Lahr, C. M., Wilson, E., SENGUPTA, M., Bernini, M., & Skupin, A. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107615
A Neutrophil Defensin–VDAC1 Axis Drives Steatotic Liver DiseasePreprint
Zhang, J., Luo, G., Wang, G., Rao, J., Li, X., & Lu, W. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.19.752841
窦报敏, Chen, J., Zhao, H., Sun-Yan, A., Zhu, X., & Xu, Y. (2026) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2026.109130
Du, X., Zhang, J., Li, W., & Li, Q. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1948381
Pyrophosphatase 2 Deficiency: Clinical Presentation, Diagnosis and Management
Nehoff, H. L., Crozier, I., Vernon, H. J., James, C., Fernández, A. I., Bowes, M., González-López, E., Phoon, C. K. L., DiLoreto, K., Matsumura, M. E., et al. (2026) · Circulation Genomic and Precision Medicine · doi:10.1161/circgen.125.005673
Rostovtseva, T. K., Rajendran, M., Rosencrans, W. M., Queralt-Martín, M., Wolfe, M. S., Bautista, N. A., Beyene, B. G., Larimi, M. G., Sodt, A. J., & Bezrukov, S. M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.13.758914
Metadata
- Authors
- Shoshan-Barmatz, V., Nahon-Crystal, E., Shteinfer-Kuzmine, A., & Gupta, R.
- Affiliations
- Ben-Gurion University of the Negev (IL)
- ORCID
- Gupta, Rajeev
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 131
- Pages
- 87-101
- ISSN
- 1043-6618 (ISSN-L)
- OpenAlex
- W2790842992
- Cited by
- 286
- References
- 233
- Citations by year
- 2026: 44 · 2025: 46 · 2024: 38 · 2023: 40 · 2022: 43 · 2021: 33 · 2020: 20 · 2019: 13 · 2018: 9
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Phil and Sima Needleman Funds
- Israel Science Foundation (307/13)
- National Institute for Biotechnology in the Negev
- Ben-Gurion University
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, VDAC1, mitochondrial dysfunction, voltage-dependent anion channel, amyloid-beta, tau hyperphosphorylation, calcium homeostasis, oxidative stress, mitochondrial apoptosis, gamma-secretase, amyloid precursor protein, diabetes mellitus, cancer, neurodegeneration
- MeSH terms
- Alzheimer Disease, Animals, Calcium, Gene Expression Regulation, Humans, Mitochondria, Models, Molecular, Apoptosis, Voltage-Dependent Anion Channel 1, Protein Interaction Maps
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
