Cited by 287Alzheimer's disease research and treatmentsMitochondrial Function and PathologyDementia and Cognitive Impairment Research

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VDAC1, mitochondrial dysfunction, and Alzheimer’s disease

Shoshan-Barmatz, Varda, Nahon-Crystal, Edna, Shteinfer-Kuzmine, Anna, Gupta, Rajeev·2018·Pharmacological Research

DOI 10.1016/j.phrs.2018.03.010

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Abstract

Alzheimer's disease (AD) is an age-related neurodegenerative disorder. Although an accumulation of brain amyloid-β (Aβ) peptide and hyperphosphorylated tau protein have been implicated in the pathogenesis of AD, the etiology of the disease remains unclear. Mitochondrial dysfunction has been identified as an early event in AD pathogenesis and is reflected by reduced metabolism, disruption of Ca 2+ homeostasis, and increased levels of reactive oxygen species, lipid peroxidation, and apoptosis. The focus of this review is the involvement of mitochondrial dysfunction in AD, and specifically, the role of the voltage-dependent anion channel 1 (VDAC1), which has been linked to AD pathogenesis. VDAC1 is a multi-functional protein, expressed in the mitochondria and other cell compartments, including the plasma membrane. The protein regulates the main metabolic and energetic functions of the cell, including Ca 2+ homeostasis, oxidative stress, and mitochondria-mediated apoptosis. VDAC1 represents a hub protein that interacts with over 150 other proteins including phosphorylated tau, Aβ, and γ-secretase, and participates in their toxicity. The high levels of VDAC1 demonstrated post-mortem in the brains of AD patients and in amyloid precursor protein (APP) transgenic mice prompted the hypothesis that the protein may be associated with neuronal cell destruction since over-expression of VDAC1 triggers cell death. Thus, targeting mitochondrial dysfunction via VDAC1, to prevent this pro-apoptotic activity, could represent a novel strategy for inhibiting cell death. In addition, the review also discusses possible VDAC1 involvement in the link between AD and diabetes and the inverse association between cancer and AD.

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Authors: Shoshan-Barmatz, V., Nahon-Crystal, E., Shteinfer-Kuzmine, A., & Gupta, R.
Affiliations: Ben-Gurion University of the Negev (IL)
ORCID: Gupta, Rajeev
Venue: Pharmacological Research
Publisher: Elsevier BV
Published: 2018-05
Volume: 131
Pages: 87-101
ISSN: 1043-6618 (ISSN-L)
DOI: 10.1016/j.phrs.2018.03.010
OpenAlex: W2790842992
Cited by: 286
References: 233
Citations by year: 2026: 44 · 2025: 46 · 2024: 38 · 2023: 40 · 2022: 43 · 2021: 33 · 2020: 20 · 2019: 13 · 2018: 9
FWCI: 2.46
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Pharmacological Research (publishedVersion)
PubMed (publishedVersion)
Funders: Phil and Sima Needleman Funds
Israel Science Foundation (307/13)
National Institute for Biotechnology in the Negev
Ben-Gurion University
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Alzheimer's disease, VDAC1, mitochondrial dysfunction, voltage-dependent anion channel, amyloid-beta, tau hyperphosphorylation, calcium homeostasis, oxidative stress, mitochondrial apoptosis, gamma-secretase, amyloid precursor protein, diabetes mellitus, cancer, neurodegeneration
MeSH terms: Alzheimer Disease, Animals, Calcium, Gene Expression Regulation, Humans, Mitochondria, Models, Molecular, Apoptosis, Voltage-Dependent Anion Channel 1, Protein Interaction Maps

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VDAC1, mitochondrial dysfunction, and Alzheimer’s disease

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