VDAC1, mitochondrial dysfunction, and Alzheimer’s disease

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Decoding Cancer through Silencing the Mitochondrial Gatekeeper VDAC1

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Effect of Human Milk Oligosaccharides on Learning and Memory in Mice with Alzheimer’s Disease

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Glucose 6 phosphate dehydrogenase overexpression rescues the loss of cognition in the double transgenic APP/PS1 mouse model of Alzheimer’s disease

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Voltage-dependent anion channels mediated apoptosis in refractory epilepsy

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Pharmacogenomics of Alzheimer’s Disease: Novel Strategies for Drug Utilization and Development

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Molecular mechanisms of Alzheimer’s disease: From therapeutic targets to promising drugs

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Mitochondria‐Associated Membranes: A Key Point of Neurodegenerative Diseases

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Tangles and Plaques: A deep dive into the pathological hallmarks of Alzheimer’s disease

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Mitochondrial damage-induced abnormal glucose metabolism with ageing in the hippocampus of APP/PS1 mice

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Not So Dead Genes—Retrocopies as Regulators of Their Disease-Related Progenitors and Hosts

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The Impact of ESCRT on Aβ1-42 Induced Membrane Lesions in a Yeast Model for Alzheimer’s Disease

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Modulation of mitochondrial dysfunction: Mechanisms and strategies for the use of natural products to treat stroke

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miRNA-874-3p inhibits the migration, invasion and proliferation of breast cancer cells by targeting VDAC1

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Upregulation of the ERRγ–VDAC1 axis underlies the molecular pathogenesis of pancreatitis

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Effect of VBIT-4 on the functional activity of isolated mitochondria and cell viability

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Neuroenergetic alterations in neurodegenerative diseases: A systematic review and meta-analysis of in vivo 31P-MRS studies

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Dynamic Interplay between Copper Toxicity and Mitochondrial Dysfunction in Alzheimer’s Disease

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VDAC1 negatively regulates melanogenesis through the Ca2+-calcineurin-CRTC1-MITF pathway

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The Role of a Pathological Interaction between β-amyloid and Mitochondria in the Occurrence and Development of Alzheimer’s Disease

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Modulation of the mitochondrial voltage-dependent anion channel (VDAC) by hydrogen peroxide and its recovery by curcumin

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Setbacks and promises for drugs against Alzheimer's disease

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Ischemic preconditioning/ischemic postconditioning alleviates anoxia/reoxygenation injury via the Notch1/Hes1/VDAC1 axis

Wang, L., Lai, S., Zou, H.-X., Zhou, X., Wan, Q., Luo, Y., Wu, Q., Wan, L., Liu, J., & Huang, H. (2022) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23199 · Cited by 13

Targeting the Nrf2/HO-1 aixs: A therapeutic strategy against regulated cell death in Alzheimer’s disease

Wang, Z., Feng, W., Li, X., Yun, X., Wu, S., Du, L., & Wang, H. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103035 · Cited by 15

Lidocaine promotes apoptosis in breast cancer cells by affecting VDAC1 expression

Long, D., Fang, X., Yuan, P., Cheng, L., Li, H., & Qu, L. (2022) · BMC Anesthesiology · doi:10.1186/s12871-022-01818-y · Cited by 12

ER-organelle contacts: A signaling hub for neurological diseases

Wang, Y., & Yang, J. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107149 · Cited by 15

The association between methylmalonic acid, a biomarker of mitochondrial dysfunction, and cause-specific mortality in Alzheimer's disease and Parkinson's disease

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Aerobic Exercise Ameliorates Cognitive Disorder and Declined Oxidative Stress via Modulating the Nrf2 Signaling Pathway in d-galactose Induced Aging Mouse Model

Xie, G., Xu, Z., Li, F., Kong, M., Wang, P., & Shao, Y. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04164-2 · Cited by 12

Small-Molecule Modulators of Mitochondrial Channels as Chemotherapeutic Agents

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Innovations in Alzheimer’s disease diagnostic technologies: clinical prospects of novel biomarkers, multimodal integration, and non-invasive detection

Wang, R., Peng, S., Zhu, J., Xu, Y., Wang, M., Zhang, L., Qiu, Y., Hou, D., Wang, Q., & Liu, R. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1651708 · Cited by 11

Identification of neutrophil extracellular traps and crosstalk genes linking inflammatory bowel disease and osteoporosis by integrated bioinformatics analysis and machine learning

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Nanotechnology in Parkinson’s Disease: overcoming drug delivery challenges and enhancing therapeutic outcomes

Ali, I., Adil, M., Imran, M., Qureshi, S. A., Qureshi, S., Hasan, N., & Ahmad, F. J. (2025) · Drug Delivery and Translational Research · doi:10.1007/s13346-025-01799-8 · Cited by 11

Unraveling the mystery of citrate transporters in Alzheimer’s disease: An updated review

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Brain Mitochondrial Dysfunction: A Possible Mechanism Links Early Life Anxiety to Alzheimer’s Disease in Later Life

Wang, Q., Lu, M., Zhu, X., Gu, X., Zhang, T., Xia, C., Li, Y., Xu, Y., & Zhou, M. (2022) · Aging and Disease · doi:10.14336/ad.2022.0221 · Cited by 11

Multi-omics analysis revealed the role of CCT2 in the induction of autophagy in Alzheimer’s disease

Ma, X., Feng, Y., Quan, X., Geng, B., Li, G., Fu, X., & Zeng, L. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2022.967730 · Cited by 11

A novel regulator in Alzheimer's disease progression: The astrocyte-derived extracellular vesicles

Li, B., Ma, Z., & Li, Z. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101871 · Cited by 11

Amyloid β perturbs elevated heme flux induced with neuronal development

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Chebulic Acid Prevents Methylglyoxal-Induced Mitochondrial Dysfunction in INS-1 Pancreatic β-Cells

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VDAC1 Conversely Correlates with Cytc Expression and Predicts Poor Prognosis in Human Breast Cancer Patients

Chen, F., Yin, S., Luo, B., Wu, X., Yan, H., Yan, D., Chen, C., Guan, F., & Yuan, J. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/7647139 · Cited by 11

A new circular RNA–encoded protein BIRC6-236aa inhibits transmissible gastroenteritis virus (TGEV)–induced mitochondrial dysfunction

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Multifunctions of CRIF1 in cancers and mitochondrial dysfunction

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ROCK Inhibitor Fasudil Attenuates Neuroinflammation and Associated Metabolic Dysregulation in the Tau Transgenic Mouse Model of Alzheimer’s Disease

Ouyang, X., Collu, R., Benavides, G. A., Tian, R., Darley-Usmar, V. M., Xia, W., & Zhang, J. (2024) · Current Alzheimer Research · doi:10.2174/0115672050317608240531130204 · Cited by 9

Reduced 17β-estradiol following ovariectomy induces mitochondrial dysfunction and degradation of synaptic proteins in the entorhinal cortex

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The role of mitochondria-associated ER membranes in disease pathology: protein complex and therapeutic targets

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Liquiritigenin alleviates inflammation and mitochondrial dysfunction in acute pancreatitis via ERβ–VDAC1 signaling

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Protective effects of crocin against endogenous Aβ-induced neurotoxicity in N2a/APP695swe cells

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The roles of natural triterpenoid saponins against Alzheimer's disease

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The Effects of PK11195 and Protoporphyrin IX Can Modulate Chronic Alcohol Intoxication in Rat Liver Mitochondria under the Opening of the Mitochondrial Permeability Transition Pore

Baburina, Y. L., Odinokova, I. V., & Krestinina, O. V. (2020) · Cells · doi:10.3390/cells9081774 · Cited by 9

Pathophysiology Associated with Diabetes-induced Tauopathy and Development of Alzheimer’s Disease

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Mitochondria Transfer in Mesenchymal Stem Cells: Unraveling the Mechanism and Therapeutic Potential

Chen, J., Xie, Z., Zhou, H., Ou, Y., Tan, W., Zhang, A., Li, Y., & Fan, X. (2025) · Current Stem Cell Research & Therapy · doi:10.2174/011574888x362739250416153254 · Cited by 11

Mitochondrial Damage and Autophagy Dysregulation in Alzheimer’s Disease: Mechanisms and Therapeutic Opportunities

Yu, Q., Li, L., Yu, S., Han, J., Cheng, Q., Cui, Z., Chen, H., Li, M., & Lu, Z. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04490-z · Cited by 9

Inhibition of VDAC1 prevents oxidative stress and apoptosis induced by bisphenol A in spermatogonia via AMPK/mTOR signaling pathway

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Pro-Apoptotic and Anti-Cancer Activity of the Vernonanthura Nudiflora Hydroethanolic Extract

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Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia

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Potential mechanisms underlying lithium treatment for Alzheimer's disease and COVID-19.

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The molecular mechanisms and intervention strategies of mitophagy in cardiorenal syndrome

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Novel cuproptosis metabolism-related molecular clusters and diagnostic signature for Alzheimer’s disease

Jia, F., Han, W., Gao, S., Huang, J., Zhao, W., Lu, Z., Zhao, W., Li, Z., Wang, Z., & Guo, Y. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1478611 · Cited by 7

A potential therapeutic approach for ulcerative colitis: targeted regulation of mitochondrial dynamics and mitophagy through phytochemicals

Zhou, J., Xi, Y., Wu, T., Zeng, X., Yuan, J., Peng, L., Fu, H., & Zhou, C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1506292 · Cited by 10

Acupuncture treatment of vascular cognitive impairment through peripheral nerve stimulation pathway: a scoping review

Yang, X., Li, B., Wu, L., & Cui, Y. J. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1515327 · Cited by 7

Absorption enhancer approach for protein delivery by various routes of administration: a rapid review

Salehi, T., Estabragh, M. A. R., Salarpour, S., Ohadi, M., & Dehghannoudeh, G. (2023) · Journal of drug targeting · doi:10.1080/1061186x.2023.2271680 · Cited by 7

Biomarker Identification for Alzheimer’s Disease Using a Multi-Filter Gene Selection Approach

Pashaei, E., Pashaei, E., & Aydın, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26051816 · Cited by 8

Arsenic and Oxidative Stress: An Overview

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Mitochondrial DNA-dependent inflammation in kidney diseases

Luo, S., Yang, M., Zhao, H., Han, Y., Liu, Y., Xiong, X., Chen, W., Li, C., & Sun, L. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108637 · Cited by 7

Trends of mitochondrial changes in AD: a bibliometric study

Song, R., Guo, Y., Fu, Y., Ren, H., Wang, H., Yan, H., & Ge, Y. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1136400 · Cited by 7

APP/PS1 Gene-Environment Noise Interaction Aggravates AD-like Neuropathology in Hippocampus Via Activation of the VDAC1 Positive Feedback Loop

Chi, H., Zhai, Q., Zhang, M., Su, D., Cao, W., Li, W., She, X., Yang, H., Wang, K., Gao, X., et al. (2021) · Current Alzheimer Research · doi:10.2174/1567205018666210324114153 · Cited by 7

Valosin-containing protein: A potential therapeutic target for cardiovascular diseases

Rakhe, N., & Bhatt, L. K. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102511 · Cited by 7

Pleiotropic regulatory mechanisms and targeted therapeutic prospects of Galectin-3 in aging-related diseases

Yuan, J., Dong, X., Gao, Y. L., & Nao, J. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00744 · Cited by 7

Ganoderma lucidum polysaccharides target the gut-brain axis: Unveiling a novel mechanism for ameliorating aging-induced cognitive impairment and oxidative stress

Chen, Y., Zeng, X., Gong, X., Chen, Y., Zhang, X., & Luo, S. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.149519 · Cited by 7

Electropositive Citric Acid-Polyethyleneimine Carbon Dots Carrying the PINK1 Gene Regulate ATP-Related Metabolic Dysfunction in APP/PS1-N2a Cells

Si, Y., Guo, F., Luo, Y., Zhang, X., Wang, C.-Y., Liu, Y., & Zhang, H. (2024) · Molecules · doi:10.3390/molecules29091907 · Cited by 6

The Role of Protein S-Nitrosylation in Mitochondrial Quality Control in Central Nervous System Diseases

Qiu, F., Liu, Y., & Liu, Z. (2024) · Aging and Disease · doi:10.14336/ad.2024.0099 · Cited by 6

The role and mechanism of VDAC1 in type 2 diabetes: An underestimated target of environmental pollutants

Ma, Y., Sun, X., & Yao, X. (2024) · Mitochondrion · doi:10.1016/j.mito.2024.101929 · Cited by 6

The role of rapamycin in the PINK1/Parkin signaling pathway in mitophagy in podocytes

Yu, S., Zhu, W., & Yu, L. (2024) · Open Life Sciences · doi:10.1515/biol-2022-0958 · Cited by 6

A Deep Dive into VDAC1 Conformational Diversity Using All-Atom Simulations Provides New Insights into the Structural Origin of the Closed States

Preto, J., Gorny, H., & Krimm, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031175 · Cited by 7

Nutraceuticals for Cognitive Dysfunction

Gupta, R. C., Doss, R. B., Srivastava, A., Lall, R., & Sinha, A. (2019) · Springer eBooks · doi:10.1007/978-3-030-04624-8_26 · Cited by 6

Mitochondrial dysfunctions and neurodegenerative diseases: a mini-review

Kumari, R., Shekhar, N., Tyagi, S., & Thakur, A. K. (2021) · Journal of Analytical & Pharmaceutical Research · doi:10.15406/japlr.2021.10.00378 · Cited by 6

Metabolism, molecular hypometabolism and inflammation: Complications of proliferative physiology include metabolic acidosis, pulmonary hypertension, T reg cell deficiency, insulin resistance and neuronal injury

Shoemaker, R. C. (2020) · Trends in Diabetes and Metabolism · doi:10.15761/tdm.1000118 · Cited by 6

Octadecaneuropeptide Ameliorates Cognitive Impairments Through Inhibiting Oxidative Stress in Alzheimer’s Disease Models

He, Y., Li, J., Yi, L., Li, X., Luo, M., Pang, Y., Wang, M., Li, Z., Mingliang, X., Dong, Z., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221115 · Cited by 6

Anxa10 and neuropathic pain: Insights into dysregulation of endoplasmic reticulum-mitochondria contact tethering complex and therapeutic potential

Wu, F., Liu, B.-Z., Huang, Y.-Q., Zhu, C.-L., Xia, Y.-L., Zhang, K.-L., Li, S., Yang, Y., & Wang, Y. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167856 · Cited by 5

RfeA from Streptococcus suis serotype 2 triggers NLRP3/Caspase-1-dependent pyroptosis leading to blood–brain barrier disruption

Gao, S., Wu, W., Xiao, X., Li, J., Lei, S., Wang, L., Han, X., & Lou, Y. (2025) · Veterinary Research · doi:10.1186/s13567-025-01620-x · Cited by 5

Potential Role of Membrane Contact Sites in the Dysregulation of the Crosstalk Between Mitochondria and Lysosomes in Alzheimer’s Disease

Girolimetti, G., Calcagnile, M., & Bucci, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26209858 · Cited by 7

Advances in fluorescent probe design and imaging applications for Alzheimer's disease biomarker

Li, Y., Liu, H., Yin, C., & Huo, F. (2025) · Dyes and Pigments · doi:10.1016/j.dyepig.2025.113411 · Cited by 5

Selective antagonism of adenosine A2A receptor reduces hypobaric hypoxia-induced neuroinflammation by inhibiting cGAS-STING pathway

Cheng, H., Gao, Y., Han, W., Zhang, X., Zhang, X., Gao, R., Dang, W., Ma, Z., Liu, X., & Gao, Y. (2026) · Scientific Reports · doi:10.1038/s41598-025-30717-8 · Cited by 5

VDAC1-enriched apoptotic extracellular vesicles emerge as an autophagy activator orchestrating PDLSC-based bone regeneration

Deng, Y., Xiao, J., Xie, J., Sun, J., Liu, H., Huang, X. Y., & Cao, Z. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.154625 · Cited by 5

VDAC genes down-regulation in brain samples of individuals with schizophrenia is revealed by a systematic meta-analysis

Segev, S., Yitzhaky, A., Ben‐Shachar, D., & Hertzberg, L. (2023) · Neuroscience Research · doi:10.1016/j.neures.2023.01.012 · Cited by 5

Functional analysis of two SLC9A6 frameshift variants in lymphoblastoid cells from patients with Christianson syndrome

He, H., Zhang, H., Chen, H., He, F. P., Yin, F., Stauber, T., Zou, X., & Peng, J. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14329 · Cited by 4

Promotion of mitochondrial fragmentation suppresses the formation of mitochondrial spherical compartmentation in PINK1 Drosophila melanogaster

Li, Y., Chen, W., & Wang, D. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.07.022 · Cited by 5

The Protective Effect of Aromatase on NSC-34 Cells with Stably Expressed hSOD1-G93A

Yan, L., Qi, W., Liu, Y., Zhou, F., Wang, Y., Bai, L., Zhou, X., Sun, C., Nie, X., Shiru, D., et al. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.05.022 · Cited by 5

The Janus face of CaMKII: from memory consolidation to neurotoxic switch in Alzheimer’s disease

Tang, L., Liu, F., Sun, X., Yang, J., Liu, Y., Pan, X., Hao, L., Lou, F., & Su, J. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-04160-7 · Cited by 5

Molecular Mechanisms Underlying Alzheimer’s Disease Pathogenesis: Comprehensive Overview

Vecchio, F. L., la Torre, A., Gravina, C., D’Onofrio, G., & Greco, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27104651 · Cited by 5

Visual Analysis of Research Hotspots and Trends on Mitochondria-Associated Membranes in the Past 20 Years—Focused on Neurodegenerative Diseases

Du, Y., Duan, C., Zhu, X., Lyu, M., Chen, J., Yi, W., & Hu, Y. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04722-x · Cited by 4

VDAC1 Inhibition Mitigates Inflammatory Status and Oxidative Stress in Epileptic Mice Treated with the Ketogenic Diet

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Is the Voltage-Dependent Anion Channel a Major Player in Neurodegenerative Diseases?

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N-Methyl-(2S, 4R)-trans-4-hydroxy-L-proline, the major bioactive compound from Sideroxylon obtusifolium, attenuates pilocarpine-induced injury in cultured astrocytes

de Aquino, P. E. A., de Siqueira, E. A., Paes, L. C. F., Magalhães, E. P., Barbosa, T. M., Carvalho, M. A., Azul, F. V. C. S., Lustosa, Í. R., Mottin, M., Sampaio, T. L., et al. (2022) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x2022e12381 · Cited by 4

Alleviating Neurodegenerative Diseases Associated with Mitochondrial Defects by Therapeutic Biomolecules

Roy, T., Padhi, S., Mazumder, R., Majee, C., Das, S., Monika, Mishra, R., & Kapoor, B. (2024) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266299148240329062647 · Cited by 5

6‴-Feruloylspinosin alleviates Aβ-induced toxicity by modulating relevant neurotransmitter and the AMPK/mTOR signaling pathway

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3-Monochloropropane-1,2-diol esters induce HepG2 cells necroptosis via CTSB/TFAM/ROS pathway

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Progress of Mitochondrial Function Regulation in Cardiac Regeneration

Chen, Y. G., Zhao, A.-R., Wei, T., Wang, H., & Wang, L.-S. (2024) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-024-10514-w · Cited by 4

Neuroprotective comparisons and bioactive profiles of green tea and black tea: in vitro cellular experiments, metabolomics, and network pharmacology analysis

Wu, H., Wan, J., Yuan, J., Xie, M., Nie, Q., Liu, Z., & Cai, S. (2024) · Beverage Plant Research · doi:10.48130/bpr-0024-0019 · Cited by 4

Is the mitochondrial outermembrane protein VDAC1 therapeutic target for Alzheimer's disease?

Reddy, P. H. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.09.003 · Cited by 88

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer’s disease

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P1‐102: THE NEUROPROTECTIVE ROLE OF VDAC1 IN ALZHEIMER'S DISEASE

Anderson, A. J., Itaman, S., Davis, S. A., & Gitcho, M. A. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.06.105

The voltage-dependent anion channel 1 mediates amyloid β toxicity and represents a potential target for Alzheimer disease therapy

Smilansky, A., Dangoor, L., Nakdimon, I., Ben-Hail, D., Mizrachi, D., & Shoshan-Barmatz, V. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.691493 · Cited by 143

Dysfunction of Mitochondria in Alzheimer’s Disease: ANT and VDAC Interact with Toxic Proteins and Aid to Determine the Fate of Brain Cells

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