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Cited by 18Biochemical Analysis and Sensing TechniquesNeuroscience and Neural EngineeringIon Channels and Receptors

Long-term recordings from afferent taste fibers

Shimatani, Yuichi, Nikles, Stefan A., Najafi, Khalil, Bradley, Robert M.·2003·Physiology & Behavior
DOI 10.1016/j.physbeh.2003.08.009
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Abstract

The receptor cells of taste buds have a life span of about 10 days but it is not known if response characteristics of these receptors alter during the turnover cycle. To examine taste cell responses over time, a micromachined polyimide sieve electrode array was implanted between the cut ends of the rat chorda tympani nerve, which then regenerated through the electrode array. Long-term stable recordings from regenerated single afferent fibers innervating taste buds were possible using this technique for up to 21 days. Responses to taste stimuli recorded from the same fiber changed with time. The changes occurred in both the magnitude of response and the relative response profiles to four chemical stimuli, NaCl, sucrose, HCl, and quinine HCl. These changes in response characteristics were hypothesized to result from changes in the taste receptor cells as the receptor cells turnover in the taste buds.

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  • Silicon sieves were observed to lead to extensive axon death after implantation and were replaced by more flexible materials such as polyimide in later designs.

    “Silicon sieves were observed to lead to extensive axon death after implantation and were replaced by more flexible materials such as polyimide in later designs (Shimatani et al., 2003; Ramachandran et al., 2006).”

    From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Shimatani et al., 2003

  • Sieve electrodes implanted into regenerating nerves in rodent models have been successfully used to record gustatory and sensorimotor signals weeks after implantation.

    “Sieve electrodes implanted into regenerating nerves in rodent models have been successfully used to record gustatory (Shimatani et al., 2003) as well as sensorimotor (Ramachandran et al., 2006) signals weeks after implantation.”

    From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Shimatani et al., 2003

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Authors
Shimatani, Y., Nikles, S. A., Najafi, K., & Bradley, R. M.
Affiliations
  • Tokyo Women's Medical University (JP)
  • University of Michigan (US)
Corresponding author
Bradley, Robert M.
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
2003-11
Volume
80
Issue
2-3
Pages
309-315
ISSN
0031-9384 (ISSN-L)
DOI
10.1016/j.physbeh.2003.08.009
OpenAlex
W2077374317
Cited by
18
References
19
Citations by year
2025: 1 · 2023: 1 · 2021: 4 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2012: 1
FWCI
1.17
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Physiology & Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01dc004198-05)
  • National Institute on Deafness and Other Communication Disorders (DC04198)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
taste cells, taste buds, chorda tympani nerve, nerve regeneration, single fiber recording, sodium chloride, sucrose, hydrochloric acid, quinine, rats
MeSH terms
Action Potentials, Animals, Chorda Tympani Nerve, Dose-Response Relationship, Drug, Electrodes, Implanted, Female, Hydrochloric Acid, Nerve Fibers, Quinine, Reaction Time, Sodium Chloride, Stimulation, Chemical, Sucrose, Taste, Taste Buds, Time Factors, Rats, Sprague-Dawley, Rats

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